RegulonDB

Gene
Name:	rspA
Synonym(s):	ECK1576, G6839, b1581
Genome position(nucleotides):	1653927 <-- 1655141
Strand:	reverse
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	50.7
External database links:

ASAP:	ABE-0005275
ECHOBASE:	EB2345
ECOLIHUB:	rspA
OU-MICROARRAY:	b1581
STRING:	511145.b1581
COLOMBOS:	rspA

Product

Name:

mandelate racemase/muconate lactonizing enzyme family protein RspA

Synonym(s):

RspA, starvation-sensing protein RspA

Sequence:

Get amino acid sequence Fasta Format

Cellular location:

cytosol

Molecular weight:

45.968

Isoelectric point:

5.982

Motif(s):

Type	Positions	Sequence	Comment
	13 -> 110	PGRNFVTLKITTEDGITGLGDATLNGRELSVASYLQDHLCPQLIGRDAHRIEDIWQFFYKGAYWRRGPVTMSAISAVDMALWDIKAKAANMPLYQLLG
	195 -> 379	LFDAVRNKFGFNEHLLHDMHHRLTPIEAARFGKSIEDYRMFWMEDPTPAENQECFRLIRQHTVTPIAVGEVFNSIWDCKQLIEEQLIDYIRTTLTHAGGITGMRRIADFASLYQVRTGSHGPSDLSPVCMAAALHFDLWVPNFGVQEYMGYSEQMLEVFPHNWTFDNGYMHPGDKPGLGIEFDEK

Classification:

Multifun Terms (GenProtEC)
Multifun Terms (GenProtEC)		5 - cell processes --> 5.5 - adaptations --> 5.5.3 - starvation
Gene Ontology Terms (GO)
	cellular_component	GO:0005829 - cytosol
	biological_process	GO:0009063 - cellular amino acid catabolic process

Note(s):

Note(s): ...[more].

Evidence:

[AS-NAS] Non-traceable author statement
[EXP-IGI] Inferred from genetic interaction

Reference(s):

[1] Gerlt JA., et al., 2005
[2] Huisman GW., et al., 1994

External database links:

ALPHAFOLD:

DIP:

ECOCYC:

ECOLIWIKI:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

MODBASE:

PANTHER:

PANTHER:

PFAM:

PFAM:

PRIDE:

PRODB:

PROSITE:

PROSITE:

REFSEQ:

SMART:

SMR:

UNIPROT:

Operon

Name:

rspAB

Operon arrangement:

Transcription unit	Promoter
rspA-rspB	rspAp

Transcriptional Regulation
	Display Regulation
Activated by:	CRP
Repressed by:	RspR

Elements in the selected gene context region unrelated to any object in RegulonDB

	Type	Name	Post Left	Post Right	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References

Reference(s)
[1] Gerlt JA., Babbitt PC., Rayment I., 2005, Divergent evolution in the enolase superfamily: the interplay of mechanism and specificity., Arch Biochem Biophys 433(1):59-70
[2] Huisman GW., Kolter R., 1994, Sensing starvation: a homoserine lactone--dependent signaling pathway in Escherichia coli., Science 265(5171):537-9