RegulonDB

Gene
Name:	slyB
Synonym(s):	ECK1637, G6881, b1641
Genome position(nucleotides):	1719876 --> 1720343 Genome Browser
Strand:	forward
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	51.28
External database links:

ASAP:	ABE-0005493
ECHOBASE:	EB3185
ECOLIHUB:	slyB
OU-MICROARRAY:	b1641
STRING:	511145.b1641
COLOMBOS:	slyB

Product

Name:

outer membrane lipoprotein SlyB

Synonym(s):

SlyB

Sequence:

Get amino acid sequence Fasta Format

Cellular location:

outer membrane

Molecular weight:

15.602

Isoelectric point:

9.794

Motif(s):

Type	Positions	Sequence
	62 -> 102	IGAIGGAVLGGFLGNTVGGGTGRSLATAAGAVAGGVAGQGV
	18 -> 155	CVNNDTLSGDVYTASEAKQVQNVSYGTIVNVRPVQIQGGDDSNVIGAIGGAVLGGFLGNTVGGGTGRSLATAAGAVAGGVAGQGVQSAMNKTQGVELEIRKDDGNTIMVVQKQGNTRFSPGQRVVLASNGSQVTVSPR
	1 -> 17	MIKRVLVVSMVGLSLVG

Classification:

Multifun Terms (GenProtEC)
Gene Ontology Terms (GO)
Gene Ontology Terms (GO)	cellular_component	GO:0009279 - cell outer membrane GO:0019867 - outer membrane GO:0016020 - membrane

Note(s):

Note(s): ...[more].

Evidence:

[IDA] Inferred from direct assay

Reference(s):

[1] Maddalo G., et al., 2011
[2] Rao S., et al., 2020

External database links:

ECOCYC:

ECOLIWIKI:

INTERPRO:

PFAM:

PRIDE:

PRODB:

PROSITE:

REFSEQ:

SMR:

UNIPROT:

Operon

Name:

slyB

Operon arrangement:

Transcription unit	Promoter
slyB	slyBp2
slyB	slyBp1

Transcriptional Regulation
	Display Regulation
Activated by:	PhoP
Repressed by:	PhoP

Elements in the selected gene context region unrelated to any object in RegulonDB

Type	Name	Post Left	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References
promoter	TSS_1917 (cluster)	1719631	reverse	nd	[RS-EPT-CBR]	[3]
promoter	anmKp9	1719673	reverse	nd	[ICWHO]	[4]
promoter	TSS_1918 (cluster)	1719751	forward	nd	[RS-EPT-CBR]	[3]
promoter	TSS_1919	1719770	forward	nd	[RS-EPT-CBR]	[3]
promoter	TSS_1921	1719780	forward	nd	[RS-EPT-CBR]	[3]
promoter	TSS_1922	1719799	forward	nd	[RS-EPT-CBR]	[3]
promoter	TSS_1923	1719807	forward	nd	[RS-EPT-CBR]	[3]
promoter	TSS_1924	1719829	forward	nd	[RS-EPT-CBR]	[3]
promoter	TSS_1925	1719831	forward	nd	[RS-EPT-CBR]	[3]
promoter	TSS_1926	1720091	forward	nd	[RS-EPT-CBR]	[3]

Evidence
[RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates
[ICWHO] Inferred computationally without human oversight

Reference(s)
[1] Maddalo G., Stenberg-Bruzell F., Gotzke H., Toddo S., Bjorkholm P., Eriksson H., Chovanec P., Genevaux P., Lehtio J., Ilag LL., Daley DO., 2011, Systematic analysis of native membrane protein complexes in Escherichia coli., J Proteome Res 10(4):1848-59
[2] Rao S., Bates GT., Matthews CR., Newport TD., Vickery ON., Stansfeld PJ., 2020, Characterizing Membrane Association and Periplasmic Transfer of Bacterial Lipoproteins through Molecular Dynamics Simulations., Structure 28(4):475-487.e3
[3] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.
[4] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78