Gene
Name:	sufE
Synonym(s):	ECK1675, G6905, b1679, ynhA
Genome position(nucleotides):	1758874 <-- 1759290 Genome Browser
Strand:	reverse
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	48.68
External database links:

ASAP:	ABE-0005608
ECHOBASE:	EB3719
OU-MICROARRAY:	b1679
PortEco:	sufE
STRING:	511145.b1679
COLOMBOS:	sufE

Transcriptional Regulation
	Display Regulation
Activated by:	IHF, IscR, OxyR
Repressed by:	NsrR, Fur

Type	Name	Post Left	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References
promoter	TSS_1984	1758859	reverse	nd	[RS-EPT-CBR]	[7]
promoter	TSS_1985	1758864	reverse	nd	[RS-EPT-CBR]	[7]
promoter	ynhGp7	1758944	reverse	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: high homology. Score: 5.733. P-value: 6.007e-5 Read more >	[ICWHO]	[8]
promoter	ynhGp4	1758945	reverse	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: poor homology. Score: 3.585. P-value: 4.406e-5 Read more >	[ICWHO]	[8]
promoter	sufEp3	1759481	reverse	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: high homology. Score: 4.688. P-value: 4.027e-5 Read more >	[ICWHO]	[8]

Evidence
[RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates
[ICWHO] Inferred computationally without human oversight

Reference(s)
[1] Arunasri K., Adil M., Venu Charan K., Suvro C., Himabindu Reddy S., Shivaji S., 2013, Effect of simulated microgravity on E. coli K12 MG1655 growth and gene expression., PLoS One 8(3):e57860
[2] Dunkle JA., Bruno MR., Outten FW., Frantom PA., 2019, Structural Evidence for Dimer-Interface-Driven Regulation of the Type II Cysteine Desulfurase, SufS., Biochemistry 58(6):687-696
[3] Kim D., Singh H., Dai Y., Dong G., Busenlehner LS., Outten FW., Frantom PA., 2018, Changes in Protein Dynamics in Escherichia coli SufS Reveal a Possible Conserved Regulatory Mechanism in Type II Cysteine Desulfurase Systems., Biochemistry 57(35):5210-5217
[4] Kim S., Park S., 2013, Structural changes during cysteine desulfurase CsdA and sulfur acceptor CsdE interactions provide insight into the trans-persulfuration., J Biol Chem 288(38):27172-80
[5] Liu G., Li Z., Chiang Y., Acton T., Montelione GT., Murray D., Szyperski T., 2005, High-quality homology models derived from NMR and X-ray structures of E. coli proteins YgdK and Suf E suggest that all members of the YgdK/Suf E protein family are enhancers of cysteine desulfurases., Protein Sci 14(6):1597-608
[6] Outten FW., Wood MJ., Munoz FM., Storz G., 2003, The SufE protein and the SufBCD complex enhance SufS cysteine desulfurase activity as part of a sulfur transfer pathway for Fe-S cluster assembly in Escherichia coli., J Biol Chem 278(46):45713-9
[7] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.
[8] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78