RegulonDB RegulonDB 10.10: Gene Form
   

yeaE gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

yeaD yeaE mipA NsrR anti-anti-terminator anti-terminator terminator yeaEp yeaEp TSS_2121 TSS_2121 TSS_2120 TSS_2120

Gene      
Name: yeaE    Texpresso search in the literature
Synonym(s): ECK1779, G6967, b1781
Genome position(nucleotides): 1864782 <-- 1865636 Genome Browser
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 50.53
External database links:  
ASAP:
 ABE-0005925
ECHOBASE:
 EB3264
ECOLIHUB:
 yeaE
OU-MICROARRAY:
 b1781
STRING:
 511145.b1781
COLOMBOS: yeaE


Product      
Name: methylglyoxal reductase YeaE
Synonym(s): YeaE
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 30.987
Isoelectric point: 5.957
Motif(s):
 
Type Positions Sequence
17 -> 271 VGQGTWYMGEDASQRKTEVAALRAGIELGLTLIDTAEMYADGGAEKVVGEALTGLREKVFLVSKVYPWNAGGQKAINACEASLRRLNTDYLDLYLLHWSGSFAFEETVAAMEKLIAQGKIRRWGVSNLDYADMQELWQLPGGNQCATNQVLYHLGSRGIEYDLLPWCQQQQMPVMAYSPLAQAGRLRNGLLKNAVVNEIAHAHNISAAQVLLAWVISHQGVMAIPKAATIAHVQQNAAVLEVELSSAELAMLDKA

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.7 - central intermediary metabolism --> 1.7.23 - methylglyoxal metabolism
  5 - cell processes --> 5.6 - protection --> 5.6.2 - detoxification
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
molecular_function GO:0047834 - D-threo-aldose 1-dehydrogenase activity
GO:0016491 - oxidoreductase activity
biological_process GO:0051596 - methylglyoxal catabolic process
Note(s): Note(s): ...[more].
Reference(s): [1] Lee C., et al., 2013
External database links:  
ECOCYC:
 G6967-MONOMER
ECOLIWIKI:
 b1781
INTERPRO:
 IPR020471
INTERPRO:
 IPR036812
INTERPRO:
 IPR023210
MODBASE:
 P76234
PFAM:
 PF00248
PRIDE:
 P76234
PRINTS:
 PR00069
REFSEQ:
 NP_416295
SMR:
 P76234
UNIPROT:
 P76234


Operon      
Name: yeaE         
Operon arrangement:
Transcription unit        Promoter
yeaE


Transcriptional Regulation      
Display Regulation             
Repressed by: NsrR


RNA cis-regulatory element    
Attenuation: Transcriptional


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_2120 1864487 forward nd [RS-EPT-CBR] [2]
  promoter TSS_2121 1865653 reverse nd [RS-EPT-CBR] [2]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates


Reference(s)    

 [1] Lee C., Kim I., Park C., 2013, Glyoxal detoxification in Escherichia coli K-12 by NADPH dependent aldo-keto reductases., J Microbiol 51(4):527-30

 [2] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

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