RegulonDB RegulonDB 11.1: Gene Form
   

leuE gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

dmlR leuE yeaR Lrp Lrp Lrp Lrp Fis NarL NarP NarL NarP Fis NsrR anti-terminator terminator dmlAp4 dmlAp4 leuEp leuEp leuEp4 leuEp4 yeaRp yeaRp

Gene      
Name: leuE    Texpresso search in the literature
Synonym(s): ECK1796, G6984, b1798, yeaS
Genome position(nucleotides): 1880121 <-- 1880759
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 45.23
External database links:  
ASAP:
 ABE-0005984
ECHOBASE:
 EB3278
ECOLIHUB:
 leuE
OU-MICROARRAY:
 b1798
STRING:
 511145.b1798
COLOMBOS: leuE


Product      
Name: leucine exporter
Synonym(s): LeuE, LeuE leucine RhtB transporter, YeaS
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 23.201
Isoelectric point: 9.999
Motif(s):
 
Type Positions Sequence Comment
12 -> 32 TYLVGAIFIVLVPGPNTLFVL UniProt: Helical.
18 -> 209 IFIVLVPGPNTLFVLKNSVSSGMKGGYLAACGVFIGDAVLMFLAWAGVATLIKTTPILFNIVRYLGAFYLLYLGSKILYATLKGKNSEAKSDEPQYGAIFKRALILSLTNPKAILFYVSFFVQFIDVNAPHTGISFFILAATLELVSFCYLSFLIISGAFVTQYIRTKKKLAKVGNSLIGLMFVGFAARLAT
49 -> 69 GVFIGDAVLMFLAWAGVATLI UniProt: Helical.
71 -> 91 TTPILFNIVRYLGAFYLLYLG UniProt: Helical.
122 -> 142 ILSLTNPKAILFYVSFFVQFI UniProt: Helical.

 
Classification:
Multifun Terms (GenProtEC)  
  4 - transport --> 4.9.B - Putative uncharacterized transport protein
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0015171 - amino acid transmembrane transporter activity
GO:0015190 - L-leucine transmembrane transporter activity
biological_process GO:0006865 - amino acid transport
GO:0015807 - L-amino acid transport
GO:0015711 - organic anion transport
GO:0015820 - leucine transport
GO:0003333 - amino acid transmembrane transport
GO:1902475 - L-alpha-amino acid transmembrane transport
GO:0098655 - cation transmembrane transport
Note(s): Note(s): ...[more].
External database links:  
ALPHAFOLD:
 P76249
ECOCYC:
 G6984-MONOMER
ECOLIWIKI:
 b1798
INTERPRO:
 IPR001123
PANTHER:
 PTHR30086
PFAM:
 PF01810
PRIDE:
 P76249
PRODB:
 PRO_000023085
REFSEQ:
 NP_416312
UNIPROT:
 P76249


Operon      
Name: leuE         
Operon arrangement:
Transcription unit        Promoter
leuE


Transcriptional Regulation      
Display Regulation             
Repressed by: Lrp


RNA cis-regulatory element    
Attenuation: Transcriptional


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter leuEp4 1880767 reverse nd [COMP-AINF] [1]
  promoter dmlAp4 1881712 forward nd [COMP-AINF] [1]


Evidence    

 [COMP-AINF] Inferred computationally without human oversight


Reference(s)    

 [1] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

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