RegulonDB

Gene
Name:	mntP
Synonym(s):	ECK1819, G6999, b1821, yebN
Genome position(nucleotides):	1905688 --> 1906254 Genome Browser
Strand:	forward
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	51.68
External database links:

ASAP:	ABE-0006065
ECHOBASE:	EB3768
ECOLIHUB:	yebN
OU-MICROARRAY:	b1821
STRING:	511145.b1821
COLOMBOS:	mntP

Product

Name:

Mn²⁺ exporter

Synonym(s):

MntP, YebN

Sequence:

Get amino acid sequence Fasta Format

Cellular location:

inner membrane

Molecular weight:

20.117

Isoelectric point:

7.746

Motif(s):

Type	Positions	Sequence
	143 -> 163	ATLIMSTLGMMVGRFIGSIIG
	3 -> 23	ITATVLLAFGMSMDAFAASIG
	16 -> 16	D
	35 -> 35	E
	106 -> 128	WLLVTTAIATSLDAMAVGVGLAF

Classification:

Multifun Terms (GenProtEC)
		4 - transport --> 4.9.B - Putative uncharacterized transport protein
		6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)
	cellular_component	GO:0016020 - membrane GO:0005886 - plasma membrane GO:0005887 - integral component of plasma membrane GO:0016021 - integral component of membrane
	molecular_function	GO:0005384 - manganese ion transmembrane transporter activity
	biological_process	GO:0006811 - ion transport GO:0071421 - manganese ion transmembrane transport GO:0010042 - response to manganese ion

Note(s):

Note(s): ...[more].

Reference(s):

[1] Kaur G., et al., 2017
[2] Kaur G., et al., 2014
[3] Price IR., et al., 2015
[4] Yamamoto K., et al., 2011

External database links:

ECOCYC:

ECOLIWIKI:

INTERPRO:

INTERPRO:

PANTHER:

PFAM:

PRIDE:

REFSEQ:

UNIPROT:

Operon

Name:

mntP

Operon arrangement:

Transcription unit	Promoter
mntP	mntPp

Transcriptional Regulation
	Display Regulation
Activated by:	Fur, MntR

RNA cis-regulatory element

Attenuation:	Translational

Elements in the selected gene context region unrelated to any object in RegulonDB

	Type	Name	Post Left	Post Right	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References
	promoter	TSS_2172	1905462		forward	nd	[RS-EPT-CBR]	[5]
	promoter	rlmAp9	1907086		reverse	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: high homology. Score: 4.173. P-value: 5.829e-5 Read more >	[ICWHO]	[6]

Evidence
[RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates
[ICWHO] Inferred computationally without human oversight

Reference(s)
[1] Kaur G., Kumar V., Arora A., Tomar A., Ashish., Sur R., Dutta D., 2017, Affected energy metabolism under manganese stress governs cellular toxicity., Sci Rep 7(1):11645
[2] Kaur G., Sengupta S., Kumar V., Kumari A., Ghosh A., Parrack P., Dutta D., 2014, Novel MntR-independent mechanism of manganese homeostasis in Escherichia coli by the ribosome-associated protein HflX., J Bacteriol 196(14):2587-97
[3] Price IR., Gaballa A., Ding F., Helmann JD., Ke A., 2015, Mn(2+)-sensing mechanisms of yybP-ykoY orphan riboswitches., Mol Cell 57(6):1110-1123
[4] Yamamoto K., Ishihama A., Busby SJ., Grainger DC., 2011, The Escherichia coli K-12 MntR miniregulon includes dps, which encodes the major stationary-phase DNA-binding protein., J Bacteriol 193(6):1477-80
[5] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.
[6] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78