RegulonDB RegulonDB 11.1: Gene Form
   

mgrB gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

yebO yobH mgrB PhoP terminator yobHp4 yobHp4 mgrBp mgrBp

Gene      
Name: mgrB    Texpresso search in the literature
Synonym(s): ECK1824, G7002, b1826, yobG
Genome position(nucleotides): 1908623 <-- 1908766
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 46.53
Reference(s): [1] Kato A., et al., 1999
External database links:  
ASAP:
 ABE-0006078
ECHOBASE:
 EB4126
ECOLIHUB:
 mgrB
OU-MICROARRAY:
 b1826
STRING:
 511145.b1826
COLOMBOS: mgrB


Product      
Name: PhoQ kinase inhibitor
Synonym(s): MgrB, YobG
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol,inner membrane
Molecular weight: 5.552
Isoelectric point: 8.039
Motif(s):
 
Type Positions Sequence Comment
2 -> 24 KKFRWVVLVVVVLACLLLWAQVF
19 -> 47 LWAQVFNMMCDQDVQFFSGICAINQFIPW

 
Classification:
Multifun Terms (GenProtEC)  
  5 - cell processes --> 5.5 - adaptations --> 5.5.4 - pH
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0005515 - protein binding
biological_process GO:0010447 - response to acidic pH
GO:0044092 - negative regulation of molecular function
GO:0071286 - cellular response to magnesium ion
GO:0070298 - negative regulation of phosphorelay signal transduction system
Note(s): Note(s): ...[more].
Evidence: [EXP-IMP] Inferred from mutant phenotype
Reference(s): [2] Chang Y., et al., 2021
[3] Duval M., et al., 2017
[4] Hamdallah I., et al., 2018
[5] Hobbs EC., et al., 2010
[6] Lippa AM., et al., 2009
[7] Lippa AM., et al., 2012
[8] Miyashiro T., et al., 2007
[9] Patel V., et al., 2021
[10] Rao SD., et al., 2021
External database links:  
ALPHAFOLD:
 P64512
ECOCYC:
 G7002-MONOMER
ECOLIWIKI:
 b1826
INTERPRO:
 IPR020907
PFAM:
 PF13998
PRIDE:
 P64512
PRODB:
 PRO_000023225
REFSEQ:
 NP_416340
SMR:
 P64512
UNIPROT:
 P64512


Operon      
Name: mgrB         
Operon arrangement:
Transcription unit        Promoter
mgrB


Transcriptional Regulation      
Display Regulation             
Activated by: PhoP


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter yobHp4 1908900 forward nd [COMP-AINF] [11]


Evidence    

 [COMP-AINF] Inferred computationally without human oversight


Reference(s)    

 [1] Kato A., Tanabe H., Utsumi R., 1999, Molecular characterization of the PhoP-PhoQ two-component system in Escherichia coli K-12: identification of extracellular Mg2+-responsive promoters., J Bacteriol 181(17):5516-20

 [2] Chang Y., Carroll BL., Liu J., 2021, Structural basis of bacterial flagellar motor rotation and switching., Trends Microbiol 29(11):1024-1033

 [3] Duval M., Cossart P., 2017, Small bacterial and phagic proteins: an updated view on a rapidly moving field., Curr Opin Microbiol 39:81-88

 [4] Hamdallah I., Torok N., Bischof KM., Majdalani N., Chadalavada S., Mdluli N., Creamer KE., Clark M., Holdener C., Basting PJ., Gottesman S., Slonczewski JL., 2018, Experimental Evolution of Escherichia coli K-12 at High pH and with RpoS Induction., Appl Environ Microbiol 84(15)

 [5] Hobbs EC., Astarita JL., Storz G., 2010, Small RNAs and small proteins involved in resistance to cell envelope stress and acid shock in Escherichia coli: analysis of a bar-coded mutant collection., J Bacteriol 192(1):59-67

 [6] Lippa AM., Goulian M., 2009, Feedback inhibition in the PhoQ/PhoP signaling system by a membrane peptide., PLoS Genet 5(12):e1000788

 [7] Lippa AM., Goulian M., 2012, Perturbation of the oxidizing environment of the periplasm stimulates the PhoQ/PhoP system in Escherichia coli., J Bacteriol 194(6):1457-63

 [8] Miyashiro T., Goulian M., 2007, Stimulus-dependent differential regulation in the Escherichia coli PhoQ PhoP system., Proc Natl Acad Sci U S A 104(41):16305-10

 [9] Patel V., Matange N., 2021, Adaptation and compensation in a bacterial gene regulatory network evolving under antibiotic selection., Elife 10

 [10] Rao SD., Igoshin OA., 2021, Overlaid positive and negative feedback loops shape dynamical properties of PhoPQ two-component system., PLoS Comput Biol 17(1):e1008130

 [11] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

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