RegulonDB

Gene
Name:	kdgR
Synonym(s):	ECK1826, G7003, b1827, yebP
Genome position(nucleotides):	1909308 <-- 1910099 Genome Browser
Strand:	reverse
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	49.75
External database links:

ASAP:	ABE-0006081
ECHOBASE:	EB3772
ECOLIHUB:	kdgR
OU-MICROARRAY:	b1827
STRING:	511145.b1827
COLOMBOS:	kdgR

Product

Name:

DNA-binding transcriptional repressor KdgR

Synonym(s):

KdgR, YebP

Sequence:

Get amino acid sequence Fasta Format

Regulator Family:

IclR

Cellular location:

cytosol

Molecular weight:

30.029

Isoelectric point:

5.258

Motif(s):

Type	Positions	Sequence
	34 -> 53	ITELSQRVMMSKSTVYRFLQ
	89 -> 258	LIRSADIQMRELSRLTKETIHLGALDEDSIVYIHKIDSMYNLRMYSRIGRRNPLYSTAIGKVLLAWRDRDEVKQILEGVEYKRSTERTITSTEALLPVLDQVREQGYGEDNEEQEEGLRCIAVPVFDRFGVVIAGLSISFPTLRFSEERLQEYVAMLHTAARKISAQMGY
	15 -> 65	SVLKVFGILQALGEEREIGITELSQRVMMSKSTVYRFLQTMKTLGYVAQEG
	13 -> 74	VSSVLKVFGILQALGEEREIGITELSQRVMMSKSTVYRFLQTMKTLGYVAQEGESEKYSLTL
	129 -> 254	NLRMYSRIGRRNPLYSTAIGKVLLAWRDRDEVKQILEGVEYKRSTERTITSTEALLPVLDQVREQGYGEDNEEQEEGLRCIAVPVFDRFGVVIAGLSISFPTLRFSEERLQEYVAMLHTAARKISA

Classification:

Multifun Terms (GenProtEC)
		2 - information transfer --> 2.2 - RNA related --> 2.2.2 - Transcription related
		3 - regulation --> 3.1 - type of regulation --> 3.1.2 - transcriptional level --> 3.1.2.3 - repressor
		3 - regulation --> 3.3 - genetic unit regulated --> 3.3.1 - operon
Gene Ontology Terms (GO)
	cellular_component	GO:0005737 - cytoplasm GO:0005829 - cytosol
	molecular_function	GO:0003677 - DNA binding GO:0005515 - protein binding GO:0003700 - DNA-binding transcription factor activity
	biological_process	GO:0006355 - regulation of transcription, DNA-templated GO:0045892 - negative regulation of transcription, DNA-templated

Note(s):

Note(s): ...[more].

Evidence:

[IEP] Inferred from expression pattern
[IMP] Inferred from mutant phenotype

Reference(s):

[1] Murray EL., et al., 2005
[2] Nishino K., et al., 2001
[3] Pouyssegur J., et al., 1974

External database links:

DIP:

ECOCYC:

ECOLIWIKI:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

MODBASE:

PDB:

PFAM:

PFAM:

PRIDE:

PRODB:

PROSITE:

PROSITE:

REFSEQ:

SMART:

SMR:

UNIPROT:

Elements in the selected gene context region unrelated to any object in RegulonDB

Type	Name	Post Left	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References
promoter	kdgRp8	1910125	reverse	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: good homology. Score: 4.245. P-value: 4.450e-5 Read more >	[ICWHO]	[4]
promoter	kdgRp9	1910140	reverse	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: high homology. Score: 5.976. P-value: 6.144e-6 Read more >	[ICWHO]	[4]
promoter	yebQp4	1910157	forward	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: high homology. Score: 4.838. P-value: 3.136e-5 Read more >	[ICWHO]	[4]
promoter	yebQp5	1910159	forward	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: high homology. Score: 5.033. P-value: 6.023e-6 Read more >	[ICWHO]	[4]
promoter	kdgRp1	1910253	reverse	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: poor homology. Score: -0.5. P-value: 1.832e-6 Read more >	[ICWHO]	[4]

Reference(s)
[1] Murray EL., Conway T., 2005, Multiple regulators control expression of the Entner-Doudoroff aldolase (Eda) of Escherichia coli., J Bacteriol 187(3):991-1000
[2] Nishino K., Yamaguchi A., 2001, Analysis of a complete library of putative drug transporter genes in Escherichia coli., J Bacteriol 183(20):5803-12
[3] Pouyssegur J., Stoeber F., 1974, Genetic control of the 2-keto-3-deoxy-d-gluconate metabolism in Escherichia coli K-12: kdg regulon., J Bacteriol 117(2):641-51
[4] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78