RegulonDB RegulonDB 11.0: Gene Form
   

letB gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

letB rsmF letA msrC TSS_2183 TSS_2183 TSS_2182 TSS_2182 TSS_2181 TSS_2181 yebSp6 yebSp6 TSS_2180 TSS_2180 TSS_2179 TSS_2179 yebSp5 yebSp5

Gene      
Name: letB    Texpresso search in the literature
Synonym(s): ECK1833, G7007, b1834, yebT
Genome position(nucleotides): 1917510 --> 1920143
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 53.64
External database links:  
ASAP:
 ABE-0006101
ECHOBASE:
 EB3776
ECOLIHUB:
 yebT
OU-MICROARRAY:
 b1834
STRING:
 511145.b1834
COLOMBOS: letB


Product      
Name: lipophilic envelope spanning tunnel
Synonym(s): LetB, YebT
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane,periplasmic space
Molecular weight: 94.97
Isoelectric point: 5.919
Motif(s):
 
Type Positions Sequence Comment
20 -> 40 ISPFWLLPFIALMIASWLIWD UniProt: Helical.
46 -> 137 GNTVTIDFMSADGIVPGRTPVRYQGVEVGTVQDISLSDDLRKIEVKVSIKSDMKDALREETQFWLVTPKASLAGVSGLDALVGGNYIGMMPG
163 -> 220 IHLQAPDLGSLNSGSLVYFRKIPVGKVYDYAINPNKQGVVIDVLIERRFTDLVKKGSR
280 -> 351 GVIIKLELPSGAGLTADSTPLMYQGLEVGQLTKLDLNPGGKVTGEMTVDPSVVTLLRENTRIELRNPKLSLS UniProt: MCE/MlaD 3; Sequence Annotation Type: region of interest.
394 -> 455 TLTLTAPESYGIDAGQPLILHGVQVGQVIDRKLTSKGVTFTVAIEPQHRELVKGDSKFVVNS UniProt: MCE/MlaD 4; Sequence Annotation Type: region of interest.

 
Classification:
Multifun Terms (GenProtEC)  
  4 - transport
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0030288 - outer membrane-bounded periplasmic space
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0042802 - identical protein binding
biological_process GO:0120009 - intermembrane lipid transfer
External database links:  
ALPHAFOLD:
 P76272
DIP:
 DIP-11815N
ECOCYC:
 G7007-MONOMER
ECOLIWIKI:
 b1834
INTERPRO:
 IPR003399
PDB:
 6V0F
PDB:
 6VCI
PDB:
 6V0J
PDB:
 6V0I
PDB:
 6V0H
PDB:
 6KZ3
PDB:
 6KZ4
PDB:
 6V0C
PDB:
 6V0D
PDB:
 6V0E
PDB:
 6V0G
PFAM:
 PF02470
PRIDE:
 P76272
REFSEQ:
 NP_416348
SMR:
 P76272
UNIPROT:
 P76272


Operon      
Name: letAB         
Operon arrangement:
Transcription unit        Promoter
letAB


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter yebSp5 1916119 forward nd [ICWHO] [1]
  promoter TSS_2179 1916143 forward nd [RS-EPT-CBR] [2]
  promoter TSS_2180 1916164 reverse nd [RS-EPT-CBR] [2]
  promoter yebSp6 1916181 forward nd [ICWHO] [1]
  promoter TSS_2181 1916234 forward nd [RS-EPT-CBR] [2]
  promoter TSS_2182 1918414 forward nd [RS-EPT-CBR] [2]
  promoter TSS_2183 1920196 forward nd [RS-EPT-CBR] [2]


Evidence    

 [ICWHO] Inferred computationally without human oversight

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates


Reference(s)    

 [1] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

 [2] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

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