RegulonDB RegulonDB 10.9: Gene Form
   

exoX gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

ptrB exoX yebE yobB ptrBp ptrBp TSS_2187 (cluster) TSS_2187 (cluster)

Gene      
Name: exoX    Texpresso search in the literature
Synonym(s): ECK1845, G7016, b1844, yobC
Genome position(nucleotides): 1926120 --> 1926782 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
51.89
External database links:  
ASAP:
ABE-0006131
ECHOBASE:
EB3785
ECOLIHUB:
exoX
OU-MICROARRAY:
b1844
STRING:
511145.b1844
COLOMBOS: exoX


Product      
Name: exonuclease X
Synonym(s): ExoX, YobC
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 25.133
Isoelectric point: 7.658
Motif(s):
 
Type Positions Sequence
4 -> 147 IIDTETCGLQGGIVEIASVDVIDGKIVNPMSHLVRPDRPISPQAMAIHRITEAMVADKPWIEDVIPHYYGSEWYVAHNASFDRRVLPEMPGEWICTMKLARRLWPGIKYSNMALYKTRKLNVQTPPGLHHHRALYDCYITAALL

 

Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.2 - degradation of macromolecules --> 1.2.2 - DNA
  2 - information transfer --> 2.1 - DNA related --> 2.1.4 - DNA repair
  2 - information transfer --> 2.1 - DNA related --> 2.1.5 - DNA degradation
  5 - cell processes --> 5.6 - protection --> 5.6.1 - radiation
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
GO:0044776 - DNA polymerase III, core complex
molecular_function GO:0003676 - nucleic acid binding
GO:0004518 - nuclease activity
GO:0004527 - exonuclease activity
GO:0016787 - hydrolase activity
GO:0008408 - 3'-5' exonuclease activity
biological_process GO:0006281 - DNA repair
GO:0006974 - cellular response to DNA damage stimulus
GO:0045004 - DNA replication proofreading
GO:0006298 - mismatch repair
GO:0090305 - nucleic acid phosphodiester bond hydrolysis
Note(s): Note(s): ...[more].
Evidence: [APPH] Assay of protein purified to homogeneity
[IGI] Inferred from genetic interaction
Reference(s): [1] Burdett V., et al., 2001
[2] Feschenko VV., et al., 2003
[3] Viswanathan M., et al., 2001
[4] Viswanathan M., et al., 1999
External database links:  
ECOCYC:
G7016-MONOMER
ECOLIWIKI:
b1844
INTERPRO:
IPR013520
INTERPRO:
IPR012337
INTERPRO:
IPR036397
MODBASE:
P0AEK0
PDB:
4FZZ
PDB:
4FZY
PDB:
4FZX
PFAM:
PF00929
PRIDE:
P0AEK0
PRODB:
PRO_000022556
REFSEQ:
NP_416358
SMART:
SM00479
SMR:
P0AEK0
UNIPROT:
P0AEK0


Operon      
Name: yobB-exoX         
Operon arrangement:
Transcription unit        Promoter
yobB-exoX


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_2187 (cluster) 1926096 forward For this promoter, there
Read more >
[RS-EPT-CBR] [5]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates



Reference(s)    

 [1] Burdett V., Baitinger C., Viswanathan M., Lovett ST., Modrich P., 2001, In vivo requirement for RecJ, ExoVII, ExoI, and ExoX in methyl-directed mismatch repair., Proc Natl Acad Sci U S A 98(12):6765-70

 [2] Feschenko VV., Rajman LA., Lovett ST., 2003, Stabilization of perfect and imperfect tandem repeats by single-strand DNA exonucleases., Proc Natl Acad Sci U S A 100(3):1134-9

 [3] Viswanathan M., Burdett V., Baitinger C., Modrich P., Lovett ST., 2001, Redundant exonuclease involvement in Escherichia coli methyl-directed mismatch repair., J Biol Chem 276(33):31053-8

 [4] Viswanathan M., Lovett ST., 1999, Exonuclease X of Escherichia coli. A novel 3'-5' DNase and Dnaq superfamily member involved in DNA repair., J Biol Chem 274(42):30094-100

 [5] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.


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