RegulonDB RegulonDB 11.1: Gene Form
   

znuC gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

ruvB znuA znuB znuC Zur OxyR znuAp znuAp znuCp znuCp yebAp5 yebAp5 yebAp6 yebAp6 yebAp1 yebAp1

Gene      
Name: znuC    Texpresso search in the literature
Synonym(s): ECK1859, G7018, b1858, yebM
Genome position(nucleotides): 1942662 --> 1943417
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 49.21
External database links:  
ASAP:
 ABE-0006198
ECHOBASE:
 EB2931
ECOLIHUB:
 znuC
OU-MICROARRAY:
 b1858
STRING:
 511145.b1858
COLOMBOS: znuC


Product      
Name: Zn2+ ABC transporter ATP binding subunit
Synonym(s): YebM, ZnuC
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 27.867
Isoelectric point: 9.794
Motif(s):
 
Type Positions Sequence Comment
5 -> 220 VSLENVSVSFGQRRVLSDVSLELKPGKILTLLGPNGAGKSTLVRVVLGLVTPDEGVIKRNGKLRIGYVPQKLYLDTTLPLTVNRFLRLRPGTHKEDILPALKRVQAGHLINAPMQKLSGGETQRVLLARALLNRPQLLVLDEPTQGVDVNGQVALYDLIDQLRRELDCGVLMVSHDLHLVMAKTDEVLCLNHHICCSGTPEVVSLHPEFISMFGPR UniProt: ABC transporter.
20 -> 149 LSDVSLELKPGKILTLLGPNGAGKSTLVRVVLGLVTPDEGVIKRNGKLRIGYVPQKLYLDTTLPLTVNRFLRLRPGTHKEDILPALKRVQAGHLINAPMQKLSGGETQRVLLARALLNRPQLLVLDEPTQ
37 -> 44 GPNGAGKS UniProt: ATP.
80 -> 83 TTLP UniProt: In Ref. 1; U38702..
121 -> 124 LSGG

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.5 - biosynthesis of building blocks --> 1.5.3 - cofactors, small molecule carriers --> 1.5.3.12 - heme, porphyrine
  4 - transport --> 4.3 - Primary Active Transporters --> 4.3.A - Pyrophosphate Bond (ATP; GTP; P2) Hydrolysis-driven Active Transporters --> 4.3.A.1 - The ATP-binding Cassette (ABC) Superfamily + ABC-type Uptake Permeases --> 4.3.A.1.a - ABC superfamily ATP binding cytoplasmic component
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0043190 - ATP-binding cassette (ABC) transporter complex
GO:0055052 - ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
molecular_function GO:0042626 - ATPase-coupled transmembrane transporter activity
GO:0000166 - nucleotide binding
GO:0005524 - ATP binding
GO:0015633 - ABC-type zinc transporter activity
biological_process GO:0071578 - zinc ion import across plasma membrane
GO:0006811 - ion transport
GO:0006829 - zinc ion transport
GO:0055069 - zinc ion homeostasis
GO:0010043 - response to zinc ion
Note(s): Note(s): ...[more].
External database links:  
ALPHAFOLD:
 P0A9X1
DIP:
 DIP-48234N
ECOCYC:
 ZNUC-MONOMER
ECOLIWIKI:
 b1858
INTERPRO:
 IPR017882
INTERPRO:
 IPR027417
INTERPRO:
 IPR003593
INTERPRO:
 IPR003439
MODBASE:
 P0A9X1
PFAM:
 PF00005
PRIDE:
 P0A9X1
PRODB:
 PRO_000024254
PROSITE:
 PS51298
PROSITE:
 PS50893
REFSEQ:
 NP_416372
SMART:
 SM00382
SMR:
 P0A9X1
UNIPROT:
 P0A9X1


Operon      
Name: znuCB         
Operon arrangement:
Transcription unit        Promoter
znuCB


Transcriptional Regulation      
Display Regulation             
Activated by: OxyR
Repressed by: Zur


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter yebAp1 1941683 reverse nd [COMP-AINF] [1]
  promoter yebAp6 1941721 reverse nd [COMP-AINF] [1]
  promoter yebAp5 1941833 reverse nd [COMP-AINF] [1]


Evidence    

 [COMP-AINF] Inferred computationally without human oversight


Reference(s)    

 [1] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

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