RegulonDB

Gene
Name:	uspC
Synonym(s):	ECK1894, G7031, b1895, yecG
Genome position(nucleotides):	1979753 --> 1980181 Genome Browser
Strand:	forward
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	44.99
External database links:

ASAP:	ABE-0006316
ECHOBASE:	EB2704
ECOLIHUB:	uspC
OU-MICROARRAY:	b1895
STRING:	511145.b1895
COLOMBOS:	uspC

Product

Name:

universal stress protein C

Synonym(s):

UspC, YecG

Sequence:

Get amino acid sequence Fasta Format

Cellular location:

cytosol

Molecular weight:

15.633

Isoelectric point:

5.779

Motif(s):

Type	Positions	Sequence
	3 -> 138	YSNILVAVAVTPESQQLLAKAVSIARPVKGHISLITLASDPEMYNQLAAPMLEDLRSVMHEETQSFLDKLIQDAGYPVDKTFIAYGELSEHILEVCHKHHFDLVICGNHNHSFFSRASCSAKRVIASSEVDVLLVP

Classification:

Multifun Terms (GenProtEC)
		5 - cell processes --> 5.5 - adaptations
		5 - cell processes --> 5.6 - protection --> 5.6.1 - radiation
Gene Ontology Terms (GO)
	cellular_component	GO:0005737 - cytoplasm GO:0005829 - cytosol
	molecular_function	GO:0005515 - protein binding GO:0060090 - molecular adaptor activity
	biological_process	GO:0009267 - cellular response to starvation GO:0009651 - response to salt stress GO:0034644 - cellular response to UV

Note(s):

Note(s): ...[more].

Evidence:

[APPHINH] Assay of protein purified to homogeneity from its native host
[IEP] Inferred from expression pattern
[IMP] Inferred from mutant phenotype

Reference(s):

[1] Gustavsson N., et al., 2002
[2] Heermann R., et al., 2009
[3] Kvint K., et al., 2003
[4] Nachin L., et al., 2005
[5] Persson O., et al., 2007

External database links:

ECOCYC:

ECOLIWIKI:

INTERPRO:

INTERPRO:

INTERPRO:

MODBASE:

PANTHER:

PFAM:

PRIDE:

PRODB:

REFSEQ:

SMR:

UNIPROT:

Operon

Name:

uspC

Operon arrangement:

Transcription unit	Promoter
uspC

Elements in the selected gene context region unrelated to any object in RegulonDB

Type	Name	Post Left	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References
promoter	TSS_2232	1979050	forward	nd	[RS-EPT-CBR]	[6]
promoter	TSS_2233	1979233	reverse	nd	[RS-EPT-CBR]	[6]
promoter	uspCp8	1979586	forward	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: high homology. Score: 4.26. P-value: 6.773e-5 Read more >	[ICWHO]	[7]
promoter	uspCp9	1979591	forward	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: high homology. Score: 4.766. P-value: 9.805e-5 Read more >	[ICWHO]	[7]
promoter	uspCp2	1979598	forward	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: poor homology. Score: 2.793. P-value: 6.507e-5 Read more >	[ICWHO]	[7]
promoter	uspCp6	1979619	forward	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: good homology. Score: 3.63. P-value: 9.904e-5 Read more >	[ICWHO]	[7]
promoter	uspCp5	1979658	forward	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: good homology. Score: 3.54. P-value: 7.713e-5 Read more >	[ICWHO]	[7]
promoter	uspCp4	1979668	forward	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: good homology. Score: 3.534. P-value: 9.327e-5 Read more >	[ICWHO]	[7]

Evidence
[RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates
[ICWHO] Inferred computationally without human oversight

Reference(s)
[1] Gustavsson N., Diez A., Nystrom T., 2002, The universal stress protein paralogues of Escherichia coli are co-ordinately regulated and co-operate in the defence against DNA damage., Mol Microbiol 43(1):107-17
[2] Heermann R., Weber A., Mayer B., Ott M., Hauser E., Gabriel G., Pirch T., Jung K., 2009, The universal stress protein UspC scaffolds the KdpD/KdpE signaling cascade of Escherichia coli under salt stress., J Mol Biol 386(1):134-48
[3] Kvint K., Nachin L., Diez A., Nystrom T., 2003, The bacterial universal stress protein: function and regulation., Curr Opin Microbiol 6(2):140-5
[4] Nachin L., Nannmark U., Nystrom T., 2005, Differential roles of the universal stress proteins of Escherichia coli in oxidative stress resistance, adhesion, and motility., J Bacteriol 187(18):6265-72
[5] Persson O., Valadi A., Nystrom T., Farewell A., 2007, Metabolic control of the Escherichia coli universal stress protein response through fructose-6-phosphate., Mol Microbiol 65(4):968-78
[6] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.
[7] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78