RegulonDB RegulonDB 10.9: Gene Form
   

dsrA gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

yedP yodD dsrA dgcQ DksA-ppGpp DksA-ppGpp terminator dsrAp dsrAp

Gene      
Name: dsrA    Texpresso search in the literature
Synonym(s): ECK1952, G7047, b1954
Genome position(nucleotides): 2025223 <-- 2025313 Genome Browser
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
41.76
External database links:  
ASAP:
ABE-0006490
ECHOBASE:
EB4281
ECOLIHUB:
dsrA
OU-MICROARRAY:
b1954
COLOMBOS: dsrA


Product      
Name: small regulatory RNA DsrA
Synonym(s): DsrA, DsrA small regulatory RNA; riboregulator of RpoS and H-NS production
Type: small RNA
Classification:
Multifun Terms (GenProtEC)  
  2 - information transfer --> 2.2 - RNA related --> 2.2.7 - antisense RNA
  2 - information transfer --> 2.3 - protein related --> 2.3.2 - translation
  3 - regulation --> 3.1 - type of regulation --> 3.1.3 - posttranscriptional --> 3.1.3.6 - antisense RNA
  6 - cell structure --> 6.3 - surface antigens (ECA, O antigen of LPS)
Gene Ontology Terms (GO)  
biological_process GO:1900191 - negative regulation of single-species biofilm formation
GO:1902201 - negative regulation of bacterial-type flagellum-dependent cell motility
Note(s): Note(s): ...[more].
Evidence: [IMP] Inferred from mutant phenotype
Reference(s): [1] Chen S., et al., 2002
[2] Malecka EM., et al., 2015
[3] Mihailovic MK., et al., 2018
[4] Peterman N., et al., 2014
External database links:  
ECOCYC:
DSRA-RNA
ECOLIWIKI:
b1954


Operon      
Name: dsrA         
Operon arrangement:
Transcription unit        Promoter
dsrA


Transcriptional Regulation      
Display Regulation             
Repressed by: LeuO


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References


Reference(s)    

 [1] Chen S., Lesnik EA., Hall TA., Sampath R., Griffey RH., Ecker DJ., Blyn LB., 2002, A bioinformatics based approach to discover small RNA genes in the Escherichia coli genome., Biosystems 65(2-3):157-77

 [2] Malecka EM., Strozecka J., Sobanska D., Olejniczak M., 2015, Structure of bacterial regulatory RNAs determines their performance in competition for the chaperone protein Hfq., Biochemistry 54(5):1157-70

 [3] Mihailovic MK., Vazquez-Anderson J., Li Y., Fry V., Vimalathas P., Herrera D., Lease RA., Powell WB., Contreras LM., 2018, High-throughput in vivo mapping of RNA accessible interfaces to identify functional sRNA binding sites., Nat Commun 9(1):4084

 [4] Peterman N., Lavi-Itzkovitz A., Levine E., 2014, Large-scale mapping of sequence-function relations in small regulatory RNAs reveals plasticity and modularity., Nucleic Acids Res 42(19):12177-88


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