RegulonDB RegulonDB 10.9: Gene Form
   

wcaA gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

wzc wcaA wcaB wcaC terminator

Gene      
Name: wcaA    Texpresso search in the literature
Synonym(s): ECK2053, G7104, b2059
Genome position(nucleotides): 2132558 <-- 2133397 Genome Browser
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
51.55
External database links:  
ASAP:
ABE-0006816
ECHOBASE:
EB3339
ECOLIHUB:
wcaA
OU-MICROARRAY:
b2059
STRING:
511145.b2059
COLOMBOS: wcaA


Product      
Name: colanic acid biosynthesis glucuronosyltransferase WcaA
Synonym(s): WcaA
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 33.035
Isoelectric point: 9.531
Motif(s):
 
Type Positions Sequence
8 -> 159 SIYMPTWNRQQLAIRAIKSVLRQDYSNWEMIIVDDCSTSWEQLQQYVTALNDPRITYIHNDINSGACAVRNQAIMLAQGEYITGIDDDDEWTPNRLSVFLAHKQQLVTHAFLYANDYVCQGEVYSQPASLPLYPKSPYSRRLFYKRNIIGNQ

 

Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.6 - biosynthesis of macromolecules (cellular constituents) --> 1.6.2 - colanic acid (M antigen)
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
molecular_function GO:0016757 - transferase activity, transferring glycosyl groups
GO:0016740 - transferase activity
GO:0015020 - glucuronosyltransferase activity
biological_process GO:0009103 - lipopolysaccharide biosynthetic process
GO:0009242 - colanic acid biosynthetic process
GO:0045228 - slime layer polysaccharide biosynthetic process
Note(s): Note(s): ...[more].
Evidence: [HIFS] Human inference of function from sequence
Reference(s): [1] Hersch SJ., et al., 2020
[2] Stevenson G., et al., 1996
External database links:  
CAZY:
GT2
ECOCYC:
G7104-MONOMER
ECOLIWIKI:
b2059
INTERPRO:
IPR001173
INTERPRO:
IPR024009
INTERPRO:
IPR029044
MODBASE:
P77414
PFAM:
PF00535
PRIDE:
P77414
REFSEQ:
NP_416563
SMR:
P77414
UNIPROT:
P77414


Operon      
Name: wza-wzb-wzc-wcaAB         
Operon arrangement:
Transcription unit        Promoter
wzbc
wza-wzb-wzc-wcaAB


Transcriptional Regulation      
Display Regulation             
Activated by: RcsAB


RNA cis-regulatory element    
Attenuation: Translational


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References


Reference(s)    

 [1] Hersch SJ., Watanabe N., Stietz MS., Manera K., Kamal F., Burkinshaw B., Lam L., Pun A., Li M., Savchenko A., Dong TG., 2020, Envelope stress responses defend against type six secretion system attacks independently of immunity proteins., Nat Microbiol 5(5):706-714

 [2] Stevenson G., Andrianopoulos K., Hobbs M., Reeves PR., 1996, Organization of the Escherichia coli K-12 gene cluster responsible for production of the extracellular polysaccharide colanic acid., J Bacteriol 178(16):4885-93


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