RegulonDB RegulonDB 11.0: Gene Form
   

mdtB gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

mdtB mdtC mdtA sibB ibsB BaeR CpxR CpxR mdtAp mdtAp

Gene      
Name: mdtB    Texpresso search in the literature
Synonym(s): ECK2071, G7114, b2075, yegN
Genome position(nucleotides): 2155263 --> 2158385
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 56.61
External database links:  
ASAP:
 ABE-0006874
ECHOBASE:
 EB3810
ECOLIHUB:
 mdtB
OU-MICROARRAY:
 b2075
STRING:
 511145.b2075
COLOMBOS: mdtB


Product      
Name: multidrug efflux pump RND permease subunit MdtB
Synonym(s): MdtB, YegN
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 112.077
Isoelectric point: 5.092
Motif(s):
 
Type Positions Sequence Comment
13 -> 1022 SRLFIMRPVATTLLMVAILLAGIIGYRALPVSALPEVDYPTIQVVTLYPGASPDVMTSAVTAPLERQFGQMSGLKQMSSQSSGGASVITLQFQLTLPLDVAEQEVQAAINAATNLLPSDLPNPPVYSKVNPADPPIMTLAVTSTAMPMTQVEDMVETRVAQKISQISGVGLVTLSGGQRPAVRVKLNAQAIAALGLTSETVRTAITGANVNSAKGSLDGPSRAVTLSANDQMQSAEEYRQLIIAYQNGAPIRLGDVATVEQGAENSWLGAWANKEQAIVMNVQRQPGANIISTADSIRQMLPQLTESLPKSVKVTVLSDRTTNIRASVDDTQFELMMAIALVVMIIYLFLRNIPATIIPGVAVPLSLIGTFAVMVFLDFSINNLTLMALTIATGFVVDDAIVVIENISRYIEKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAITLAVAILISAVVSLTLTPMMCARMLSQESLRKQNRFSRASEKMFDRIIAAYGRGLAKVLNHPWLTLSVALSTLLLSVLLWVFIPKGFFPVQDNGIIQGTLQAPQSSSFANMAQRQRQVADVILQDPAVQSLTSFVGVDGTNPSLNSARLQINLKPLDERDDRVQKVIARLQTAVDKVPGVDLFLQPTQDLTIDTQVSRTQYQFTLQATSLDALSTWVPQLMEKLQQLPQLSDVSSDWQDKGLVAYVNVDRDSASRLGISMADVDNALYNAFGQRLISTIYTQANQYRVVLEHNTENTPGLAALDTIRLTSSDGGVVPLSSIAKIEQRFAPLSINHLDQFPVTTISFNVPDNYSLGDAVQAIMDTEKTLNLPVDITTQFQGSTLAFQSALGSTVWLIVAAVVAMYIVLGILYESFIHPITILSTLPTAGVGALLALLIAGSELDVIAIIGIILLIGIVKKNAIMMIDFALAAEREQGMSPREAIYQACLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGIGMVGGLIVSQVLTLFTTPVIYLLF
15 -> 37 LFIMRPVATTLLMVAILLAGIIG UniProt: Helical.
345 -> 362 FELMMAIALVVMIIYLFL UniProt: Helical.
367 -> 389 ATIIPGVAVPLSLIGTFAVMVFL UniProt: Helical.
396 -> 418 LTLMALTIATGFVVDDAIVVIEN UniProt: Helical.

 
Classification:
Multifun Terms (GenProtEC)  
  4 - transport --> 4.2 - Electrochemical potential driven transporters --> 4.2.A - Porters (Uni-, Sym- and Antiporters)
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0098567 - periplasmic side of plasma membrane
GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
GO:1990281 - efflux pump complex
molecular_function GO:0015125 - bile acid transmembrane transporter activity
GO:0005515 - protein binding
GO:0022857 - transmembrane transporter activity
GO:0015299 - solute:proton antiporter activity
GO:0042910 - xenobiotic transmembrane transporter activity
biological_process GO:0140330 - xenobiotic detoxification by transmembrane export across the cell outer membrane
GO:0055085 - transmembrane transport
GO:0042908 - xenobiotic transport
GO:1902600 - proton transmembrane transport
GO:0015721 - bile acid and bile salt transport
Note(s): Note(s): ...[more].
Reference(s): [1] Jindal S., et al., 2019
[2] Nishino K., et al., 2001
External database links:  
ALPHAFOLD:
 P76398
DIP:
 DIP-11884N
ECOCYC:
 B2075-MONOMER
ECOLIWIKI:
 b2075
INTERPRO:
 IPR022831
INTERPRO:
 IPR001036
INTERPRO:
 IPR027463
MODBASE:
 P76398
PANTHER:
 PTHR32063
PFAM:
 PF00873
PRIDE:
 P76398
PRINTS:
 PR00702
PRODB:
 PRO_000023183
REFSEQ:
 NP_416579
SMR:
 P76398
UNIPROT:
 P76398


Operon      
Name: mdtABCD-baeSR         
Operon arrangement:
Transcription unit        Promoter
mdtABCD-baeSR
baeSR


Transcriptional Regulation      
Display Regulation             
Activated by: BaeR, CpxR


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References


Reference(s)    

 [1] Jindal S., Yang L., Day PJ., Kell DB., 2019, Involvement of multiple influx and efflux transporters in the accumulation of cationic fluorescent dyes by Escherichia coli., BMC Microbiol 19(1):195

 [2] Nishino K., Yamaguchi A., 2001, Analysis of a complete library of putative drug transporter genes in Escherichia coli., J Bacteriol 183(20):5803-12

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