RegulonDB RegulonDB 10.8: Gene Form
   

mdtB gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

mdtB mdtC mdtA sibB ibsB BaeR CpxR CpxR SibB mdtAp mdtAp

Gene      
Name: mdtB    Texpresso search in the literature
Synonym(s): ECK2071, G7114, b2075, yegN
Genome position(nucleotides): 2155263 --> 2158385 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 56.61
External database links:  
ASAP:
 ABE-0006874
ECHOBASE:
 EB3810
OU-MICROARRAY:
 b2075
PortEco:
 mdtB
STRING:
 511145.b2075
COLOMBOS: mdtB


Product      
Name: multidrug efflux pump RND permease subunit MdtB
Synonym(s): MdtB, YegN
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 112.077
Isoelectric point: 5.092
Motif(s):
 
Type Positions Sequence
15 -> 37 LFIMRPVATTLLMVAILLAGIIG
396 -> 418 LTLMALTIATGFVVDDAIVVIEN
909 -> 931 LLIAGSELDVIAIIGIILLIGIV
968 -> 990 ILMTTLAALLGALPLMLSTGVGA
13 -> 1022 SRLFIMRPVATTLLMVAILLAGIIGYRALPVSALPEVDYPTIQVVTLYPGASPDVMTSAVTAPLERQFGQMSGLKQMSSQSSGGASVITLQFQLTLPLDVAEQEVQAAINAATNLLPSDLPNPPVYSKVNPADPPIMTLAVTSTAMPMTQVEDMVETRVAQKISQISGVGLVTLSGGQRPAVRVKLNAQAIAALGLTSETVRTAITGANVNSAKGSLDGPSRAVTLSANDQMQSAEEYRQLIIAYQNGAPIRLGDVATVEQGAENSWLGAWANKEQAIVMNVQRQPGANIISTADSIRQMLPQLTESLPKSVKVTVLSDRTTNIRASVDDTQFELMMAIALVVMIIYLFLRNIPATIIPGVAVPLSLIGTFAVMVFLDFSINNLTLMALTIATGFVVDDAIVVIENISRYIEKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAITLAVAILISAVVSLTLTPMMCARMLSQESLRKQNRFSRASEKMFDRIIAAYGRGLAKVLNHPWLTLSVALSTLLLSVLLWVFIPKGFFPVQDNGIIQGTLQAPQSSSFANMAQRQRQVADVILQDPAVQSLTSFVGVDGTNPSLNSARLQINLKPLDERDDRVQKVIARLQTAVDKVPGVDLFLQPTQDLTIDTQVSRTQYQFTLQATSLDALSTWVPQLMEKLQQLPQLSDVSSDWQDKGLVAYVNVDRDSASRLGISMADVDNALYNAFGQRLISTIYTQANQYRVVLEHNTENTPGLAALDTIRLTSSDGGVVPLSSIAKIEQRFAPLSINHLDQFPVTTISFNVPDNYSLGDAVQAIMDTEKTLNLPVDITTQFQGSTLAFQSALGSTVWLIVAAVVAMYIVLGILYESFIHPITILSTLPTAGVGALLALLIAGSELDVIAIIGIILLIGIVKKNAIMMIDFALAAEREQGMSPREAIYQACLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGIGMVGGLIVSQVLTLFTTPVIYLLF

 
Classification:
Multifun Terms (GenProtEC)  
  4 - transport --> 4.2 - Electrochemical potential driven transporters --> 4.2.A - Porters (Uni-, Sym- and Antiporters)
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
GO:1990281 - efflux pump complex
molecular_function GO:0015125 - bile acid transmembrane transporter activity
GO:0005515 - protein binding
GO:0022857 - transmembrane transporter activity
GO:0015299 - solute:proton antiporter activity
biological_process GO:0055085 - transmembrane transport
GO:0042908 - xenobiotic transport
GO:0015721 - bile acid and bile salt transport
Note(s): Note(s): ...[more].
Reference(s): [1] Jindal S., et al., 2019
[2] Nishino K., et al., 2001
External database links:  
DIP:
 DIP-11884N
ECOCYC:
 B2075-MONOMER
ECOLIWIKI:
 b2075
INTERPRO:
 IPR001036
INTERPRO:
 IPR027463
INTERPRO:
 IPR022831
MINT:
 MINT-1301811
MODBASE:
 P76398
PANTHER:
 PTHR32063
PFAM:
 PF00873
PRIDE:
 P76398
PRINTS:
 PR00702
PRODB:
 PRO_000023183
REFSEQ:
 NP_416579
SMR:
 P76398
UNIPROT:
 P76398


Operon      
Name: mdtABCD-baeSR         
Operon arrangement:
Transcription unit        Promoter
mdtABCD-baeSR
baeSR


Transcriptional Regulation      
Display Regulation             
Activated by: BaeR, CpxR


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  srna SibB 2153681 2153737 reverse unknow. nd nd


Reference(s)    

 [1] Jindal S., Yang L., Day PJ., Kell DB., 2019, Involvement of multiple influx and efflux transporters in the accumulation of cationic fluorescent dyes by Escherichia coli., BMC Microbiol 19(1):195

 [2] Nishino K., Yamaguchi A., 2001, Analysis of a complete library of putative drug transporter genes in Escherichia coli., J Bacteriol 183(20):5803-12

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