RegulonDB RegulonDB 11.1: Gene Form
   

gatZ gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

gatZ gatY gatA TSS_2432 TSS_2432 TSS_2431 TSS_2431 TSS_2430 TSS_2430 TSS_2429 TSS_2429 TSS_2428 TSS_2428 TSS_2427 TSS_2427 TSS_2426 TSS_2426 TSS_2425 TSS_2425 TSS_2424 TSS_2424 TSS_2423 TSS_2423 TSS_2422 TSS_2422 TSS_2421 (cluster) TSS_2421 (cluster) gatZp gatZp TSS_2419 (cluster) TSS_2419 (cluster) TSS_2418 TSS_2418 TSS_2417 TSS_2417 TSS_2416 TSS_2416 TSS_2415 TSS_2415 TSS_2414 TSS_2414 TSS_2413 TSS_2413 TSS_2412 (cluster) TSS_2412 (cluster) TSS_2411 TSS_2411

Gene      
Name: gatZ    Texpresso search in the literature
Synonym(s): ECK2088, G7128, b2095
Genome position(nucleotides): 2175059 <-- 2176321
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 48.93
External database links:  
ASAP:
 ABE-0006934
ECHOBASE:
 EB2317
ECOLIHUB:
 gatZ
OU-MICROARRAY:
 b2095
STRING:
 511145.b2095
COLOMBOS: gatZ


Product      
Name: putative tagatose-1,6-bisphosphate aldolase 2 chaperone
Synonym(s): GatZ
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol,inner membrane
Molecular weight: 47.109
Isoelectric point: 5.575
Motif(s):
 
Type Positions Sequence Comment
1 -> 418 MKTLIARHKAGEHIGICSVCSAHPLVIEAALAFDRNSTRKVLIEATSNQVNQFGGYTGMTPADFREFVFTIADKVGFARERIILGGDHLGPNCWQQENADAAMEKSVELVKEYVRAGFSKIHLDASMSCAGDPIPLAPETVAERAAVLCFAAESVATDCQREQLSYVIGTEVPVPGGEASAIQSVHITHVEDAANTLRTHQKAFIARGLTEALTRVIAIVVQPGVEFDHSNIIHYQPQEAQPLAQWIENTRMVYEAHSTDYQTRTAYWELVRDHFAILKVGPALTFALREAIFALAQIEQELIAPENRSGCLAVIEEVMLDEPQYWKKYYRTGFNDSLLDIRYSLSDRIRYYWPHSRIKNSVETMMVNLEGVDIPLGMISQYLPKQFERIQSGELSAIPHQLIMDKIYDVLRAYRYGC

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.1 - carbon utilization --> 1.1.1 - carbon compounds
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
GO:0005887 - integral component of plasma membrane
GO:1902494 - catalytic complex
molecular_function GO:0003824 - catalytic activity
GO:0008047 - enzyme activator activity
biological_process GO:0005975 - carbohydrate metabolic process
GO:0009401 - phosphoenolpyruvate-dependent sugar phosphotransferase system
GO:0019402 - galactitol metabolic process
GO:0019404 - galactitol catabolic process
GO:0050790 - regulation of catalytic activity
GO:2001059 - D-tagatose 6-phosphate catabolic process
Note(s): Note(s): ...[more].
Evidence: [EXP-IMP] Inferred from mutant phenotype
Reference(s): [1] Brinkkotter A., et al., 2002
External database links:  
ALPHAFOLD:
 P0C8J8
DIP:
 DIP-48243N
ECOCYC:
 G7128-MONOMER
ECOLIWIKI:
 b2095
INTERPRO:
 IPR013785
INTERPRO:
 IPR012062
INTERPRO:
 IPR023436
PFAM:
 PF08013
PRIDE:
 P0C8J8
REFSEQ:
 NP_416598
SMR:
 P0C8J8
SWISSMODEL:
 P37191
UNIPROT:
 P0C8J8


Operon      
Name: gatYZABCD         
Operon arrangement:
Transcription unit        Promoter
gatZABCD
gatYZABCD


Transcriptional Regulation      
Display Regulation             
Activated by: CRP
Repressed by: ArcA, GatR


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_2411 2174704 reverse nd [RS-EPT-CBR] [2]
  promoter TSS_2412 (cluster) 2174716 reverse nd [RS-EPT-CBR] [2]
  promoter TSS_2413 2174721 reverse nd [RS-EPT-CBR] [2]
  promoter TSS_2414 2175103 reverse nd [RS-EPT-CBR] [2]
  promoter TSS_2415 2175270 reverse nd [RS-EPT-CBR] [2]
  promoter TSS_2416 2175336 reverse nd [RS-EPT-CBR] [2]
  promoter TSS_2417 2176110 reverse nd [RS-EPT-CBR] [2]
  promoter TSS_2418 2176118 reverse nd [RS-EPT-CBR] [2]
  promoter TSS_2419 (cluster) 2176382 reverse nd [RS-EPT-CBR] [2]
  promoter TSS_2421 (cluster) 2176636 reverse nd [RS-EPT-CBR] [2]
  promoter TSS_2422 2176657 reverse nd [RS-EPT-CBR] [2]
  promoter TSS_2423 2176773 reverse nd [RS-EPT-CBR] [2]
  promoter TSS_2424 2176779 reverse nd [RS-EPT-CBR] [2]
  promoter TSS_2425 2176864 reverse nd [RS-EPT-CBR] [2]
  promoter TSS_2426 2177023 reverse nd [RS-EPT-CBR] [2]
  promoter TSS_2427 2177046 reverse nd [RS-EPT-CBR] [2]
  promoter TSS_2428 2177069 reverse nd [RS-EPT-CBR] [2]
  promoter TSS_2429 2177071 reverse nd [RS-EPT-CBR] [2]
  promoter TSS_2430 2177123 reverse nd [RS-EPT-CBR] [2]
  promoter TSS_2431 2177200 reverse nd [RS-EPT-CBR] [2]
  promoter TSS_2432 2177204 reverse nd [RS-EPT-CBR] [2]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates


Reference(s)    

 [1] Brinkkotter A., Shakeri-Garakani A., Lengeler JW., 2002, Two class II D-tagatose-bisphosphate aldolases from enteric bacteria., Arch Microbiol 177(5):410-9

 [2] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

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