RegulonDB RegulonDB 10.10: Gene Form
   

thiD gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

yegX thiD thiM rcnR Cis-reg; riboswitch terminator terminator thiMp thiMp thiDp3 thiDp3 yegXp6 yegXp6 yegXp1 yegXp1

Gene      
Name: thiD    Texpresso search in the literature
Synonym(s): ECK2096, G7135, b2103, thiA, thiJ, thiN
Genome position(nucleotides): 2183716 <-- 2184516 Genome Browser
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 55.43
External database links:  
ASAP:
 ABE-0006958
ECHOBASE:
 EB3821
ECOLIHUB:
 thiD
OU-MICROARRAY:
 b2103
STRING:
 511145.b2103
COLOMBOS: thiD


Product      
Name: bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase
Synonym(s): ThiA, ThiD, ThiJ, ThiN
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 28.634
Isoelectric point: 6.084
Motif(s):
 
Type Positions Sequence
13 -> 260 DPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPVH

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.5 - biosynthesis of building blocks --> 1.5.3 - cofactors, small molecule carriers --> 1.5.3.8 - thiamin
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
molecular_function GO:0016740 - transferase activity
GO:0016301 - kinase activity
GO:0000166 - nucleotide binding
GO:0005524 - ATP binding
GO:0008902 - hydroxymethylpyrimidine kinase activity
GO:0008972 - phosphomethylpyrimidine kinase activity
biological_process GO:0009228 - thiamine biosynthetic process
GO:0016310 - phosphorylation
GO:0009229 - thiamine diphosphate biosynthetic process
Note(s): Note(s): ...[more].
External database links:  
DIP:
 DIP-6867N
ECOCYC:
 HMP-P-KIN-MONOMER
ECOLIWIKI:
 b2103
INTERPRO:
 IPR013749
INTERPRO:
 IPR029056
INTERPRO:
 IPR004399
MODBASE:
 P76422
PFAM:
 PF08543
PRIDE:
 P76422
PRODB:
 PRO_000024053
REFSEQ:
 NP_416606
SMR:
 P76422
SWISSMODEL:
 P76422
UNIPROT:
 P76422


Operon      
Name: thiMD         
Operon arrangement:
Transcription unit        Promoter
thiMD


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter yegXp1 2183801 reverse nd [ICWHO] [1]
  promoter yegXp6 2183820 reverse nd [ICWHO] [1]
  promoter thiDp3 2184673 reverse nd [ICWHO] [1]


Evidence    

 [ICWHO] Inferred computationally without human oversight


Reference(s)    

 [1] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

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