RegulonDB RegulonDB 11.1: Gene Form
   

hyfD gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

hyfD hyfC hyfE

Gene      
Name: hyfD    Texpresso search in the literature
Synonym(s): ECK2480, G7301, b2484
Genome position(nucleotides): 2604811 --> 2606250
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 55.35
Reference(s): [1] Andrews SC., et al., 1997
External database links:  
ASAP:
 ABE-0008185
ECHOBASE:
 EB3964
ECOLIHUB:
 hyfD
OU-MICROARRAY:
 b2484
STRING:
 511145.b2484
COLOMBOS: hyfD


Product      
Name: hydrogenase 4 component D
Synonym(s): HyfD
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 51.755
Isoelectric point: 9.151
Motif(s):
 
Type Positions Sequence Comment
3 -> 23 NLALTTLLLPFIGALVVSFSP UniProt: Helical.
30 -> 50 WGVLFAALTTLCMLSLISAFY UniProt: Helical.
55 -> 75 VAVTLTLVNVGDVALFGLVID UniProt: Helical.
70 -> 116 FGLVIDRVSTLILFVVVFLGLLVTIYSTGYLTDKNREHPHNGTNRYY
80 -> 100 LILFVVVFLGLLVTIYSTGYL UniProt: Helical.

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.3 - energy metabolism, carbon --> 1.3.7 - anaerobic respiration
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
GO:0009326 - formate dehydrogenase complex
GO:0044569 - [Ni-Fe] hydrogenase complex
molecular_function GO:0016491 - oxidoreductase activity
GO:0003954 - NADH dehydrogenase activity
GO:0008137 - NADH dehydrogenase (ubiquinone) activity
biological_process GO:0006007 - glucose catabolic process
GO:0009061 - anaerobic respiration
GO:0015990 - electron transport coupled proton transport
GO:0019645 - anaerobic electron transport chain
GO:0042773 - ATP synthesis coupled electron transport
GO:0015944 - formate oxidation
Note(s): Note(s): ...[more].
Reference(s): [1] Andrews SC., et al., 1997
External database links:  
ALPHAFOLD:
 P77416
ECOCYC:
 MONOMER0-141
ECOLIWIKI:
 b2484
INTERPRO:
 IPR001516
INTERPRO:
 IPR001750
PFAM:
 PF00361
PFAM:
 PF00662
PRIDE:
 P77416
PRODB:
 PRO_000022966
REFSEQ:
 NP_416979
UNIPROT:
 P77416


Operon      
Name: hyfABCDEFGHIJR-focB         
Operon arrangement:
Transcription unit        Promoter
hyfABCDEFGHIJR-focB


Transcriptional Regulation      
Display Regulation             
Activated by: FhlA, CRP, HyfR
Repressed by: FNR


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References


Reference(s)    

 [1] Andrews SC., Berks BC., McClay J., Ambler A., Quail MA., Golby P., Guest JR., 1997, A 12-cistron Escherichia coli operon (hyf) encoding a putative proton-translocating formate hydrogenlyase system., Microbiology 143 ( Pt 11):3633-47

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