RegulonDB RegulonDB 11.1: Gene Form
   

patZ gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

patZ tapT pssL pssA CRP CRP pssAp pssAp TSS_2895 (cluster) TSS_2895 (cluster) pssAp4 pssAp4 TSS_2894 TSS_2894 TSS_2893 TSS_2893 pkap pkap

Gene      
Name: patZ    Texpresso search in the literature
Synonym(s): ECK2582, G7350, b2584, pka, yfiQ
Genome position(nucleotides): 2719953 --> 2722613
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 54.3
External database links:  
ASAP:
 ABE-0008506
ECHOBASE:
 EB3976
ECOLIHUB:
 yfiQ
OU-MICROARRAY:
 b2584
STRING:
 511145.b2584
COLOMBOS: patZ


Product      
Name: peptidyl-lysine N-acetyltransferase
Synonym(s): PatZ, Pka, YfiQ
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 97.987
Isoelectric point: 6.376
Motif(s):
 
Type Positions Sequence Comment
13 -> 129 KSIAVIGASMKPNRAGYLMMRNLLAGGFNGPVLPVTPAWKAVLGVLAWPDIASLPFTPDLAVLCTNASRNLALLEELGEKGCKTCIILSAPASQHEDLRACALRHNMRLLGPNSLGL
147 -> 280 RGKLAFISQSAAVSNTILDWAQQRKMGFSYFIALGDSLDIDVDELLDYLARDSKTSAILLYLEQLSDARRFVSAARSASRNKPILVIKSGRSPAAQRLLNTTAGMDPAWDAAIQRAGLLRVQDTHELFSAVETL
472 -> 694 QAIAEGATSLDTHEVQPILQAYGMNTLPTWIASDSTEAVHIAEQIGYPVALKLRSPDIPHKSEVQGVMLYLRTANEVQQAANAIFDRVKMAWPQARVHGLLVQSMANRAGAQELRVVVEHDPVFGPLIMLGEGGVEWRPEDQAVVALPPLNMNLARYLVIQGIKSKKIRARSALRPLDVAGLSQLLVQVSNLIVDCPEIQRLDIHPLLASGSEFTALDVTLDI
487 -> 523 QPILQAYGMNTLPTWIASDSTEAVHIAEQIGYPVALK UniProt: ATP-grasp.
506 -> 507 ST UniProt: In Ref. 3; BAA10925..

 
Classification:
Multifun Terms (GenProtEC)  
  2 - information transfer --> 2.3 - protein related --> 2.3.3 - posttranslational modification
  3 - regulation --> 3.1 - type of regulation --> 3.1.3 - posttranscriptional --> 3.1.3.2 - covalent modification, demodification, maturation
Gene Ontology Terms (GO)  
cellular_component GO:0005886 - plasma membrane
GO:0032991 - protein-containing complex
molecular_function GO:0005515 - protein binding
GO:0016740 - transferase activity
GO:0046872 - metal ion binding
GO:0008080 - N-acetyltransferase activity
GO:0016746 - acyltransferase activity
GO:0005524 - ATP binding
GO:0042802 - identical protein binding
GO:0052858 - peptidyl-lysine acetyltransferase activity
GO:0061733 - peptide-lysine-N-acetyltransferase activity
biological_process GO:0006979 - response to oxidative stress
GO:0009408 - response to heat
GO:0018393 - internal peptidyl-lysine acetylation
External database links:  
ALPHAFOLD:
 P76594
DIP:
 DIP-12068N
ECOCYC:
 G7350-MONOMER
ECOLIWIKI:
 b2584
INTERPRO:
 IPR016181
INTERPRO:
 IPR032875
INTERPRO:
 IPR036291
INTERPRO:
 IPR016102
INTERPRO:
 IPR011761
INTERPRO:
 IPR003781
INTERPRO:
 IPR000182
INTERPRO:
 IPR013815
MODBASE:
 P76594
PFAM:
 PF13549
PFAM:
 PF13607
PFAM:
 PF13380
PFAM:
 PF00583
PRIDE:
 P76594
PROSITE:
 PS51186
PROSITE:
 PS50975
REFSEQ:
 NP_417079
SMART:
 SM00881
SMR:
 P76594
UNIPROT:
 P76594


Operon      
Name: tapT-patZ         
Operon arrangement:
Transcription unit        Promoter
patZ
tapT-patZ


Transcriptional Regulation      
Display Regulation             
Activated by: CRP


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_2893 2722287 forward nd [RS-EPT-CBR] [1]
  promoter TSS_2894 2722503 forward nd [RS-EPT-CBR] [1]
  promoter pssAp4 2722578 forward nd [COMP-AINF] [2]
  promoter TSS_2895 (cluster) 2722625 forward nd [RS-EPT-CBR] [1]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

 [COMP-AINF] Inferred computationally without human oversight


Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

 [2] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

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