RegulonDB RegulonDB 11.1: Gene Form
   

glaH gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

ygaQ lhgD glaH unknown ileY Nac GlaR GlaR CRP ppGpp anti-anti-terminator anti-terminator terminator gabDp1 gabDp1 gabDp gabDp gabDp2 gabDp2 csiDp csiDp

Gene      
Name: glaH    Texpresso search in the literature
Synonym(s): ECK2653, G7394, b2659, csi-12, csiD, ygaT
Genome position(nucleotides): 2788985 --> 2789962
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 54.29
Reference(s): [1] Marschall C., et al., 1998
External database links:  
ASAP:
 ABE-0008754
ECHOBASE:
 EB3295
ECOLIHUB:
 csiD
OU-MICROARRAY:
 b2659
STRING:
 511145.b2659
COLOMBOS: glaH


Product      
Name: glutarate dioxygenase GlaH
Synonym(s): CsiD, GlaH, YgaT
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 37.36
Isoelectric point: 6.135
Motif(s):
 
Type Positions Sequence Comment
21 -> 314 FTLTPSAQSPRLLELTFTEQTTKQFLEQVAEWPVQALEYKSFLRFRVAKILDDLCANQLQPLLLKTLLNRAEGALLINAVGVDDVKQADEMVKLATAVAHLIGRSNFDAMSGQYYARFVVKNVDNSDSYLRQPHRVMELHNDGTYVEEITDYVLMMKIDEQNMQGGNSLLLHLDDWEHLDNYFRHPLARRPMRFAAPPSKNVSKDVFHPVFDVDQQGRPVMRYIDQFVQPKDFEEGVWLSELSDAIETSKGILSVPVPVGKFLLINNLFWLHGRDRFTPHPDLRRELMRQRGYF
152 -> 153 QP UniProt: In Ref. 1; AAD10865..
212 -> 213 MR UniProt: In Ref. 1; AAD10865..
310 -> 311 QR UniProt: In Ref. 1; AAD10865..

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.1 - carbon utilization --> 1.1.3 - amino acids
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
GO:0032991 - protein-containing complex
molecular_function GO:0050498 - oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with 2-oxoglutarate as one donor, and the other dehydrogenated
GO:0106343 - glutarate dioxygenase activity
GO:0046872 - metal ion binding
GO:0016491 - oxidoreductase activity
GO:0005506 - iron ion binding
GO:0008198 - ferrous iron binding
GO:0051213 - dioxygenase activity
GO:0042802 - identical protein binding
biological_process GO:0019477 - L-lysine catabolic process
GO:0090549 - response to carbon starvation
External database links:  
ALPHAFOLD:
 P76621
ECOCYC:
 G7394-MONOMER
ECOLIWIKI:
 b2659
INTERPRO:
 IPR015038
INTERPRO:
 IPR042098
MODBASE:
 P76621
PDB:
 1JR7
PDB:
 6HL8
PDB:
 6GPE
PFAM:
 PF08943
PRIDE:
 P76621
PRODB:
 PRO_000022337
REFSEQ:
 NP_417145
SMR:
 P76621
UNIPROT:
 P76621


Operon      
Name: glaH-lhgD-gabDTP         
Operon arrangement:
Transcription unit        Promoter
csiD-ygaF-gabDTP
gabDTP
gabDTP
gabDTP


Transcriptional Regulation      
Display Regulation             
Activated by: CRP, H-NS, Lrp
Repressed by: GlaR


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References


Reference(s)    

 [1] Marschall C., Labrousse V., Kreimer M., Weichart D., Kolb A., Hengge-Aronis R., 1998, Molecular analysis of the regulation of csiD, a carbon starvation-inducible gene in Escherichia coli that is exclusively dependent on sigma s and requires activation by cAMP-CRP., J Mol Biol 276(2):339-53

RegulonDB