RegulonDB RegulonDB 10.9: Gene Form
   

glcA gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

yghJ glcB glcA C0719 anti-anti-terminator anti-terminator terminator TSS_3299 TSS_3299 glcAp10 glcAp10 glcAp12 glcAp12 yghJp6 yghJp6 yghJp7 yghJp7 yghJp5 yghJp5 TSS_3298 TSS_3298

Gene      
Name: glcA    Texpresso search in the literature
Synonym(s): ECK2969, G7542, b2975, yghK
Genome position(nucleotides): 3119597 <-- 3121279 Genome Browser
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
53.48
External database links:  
ASAP:
ABE-0009763
ECHOBASE:
EB2818
ECOLIHUB:
glcA
OU-MICROARRAY:
b2975
STRING:
511145.b2975
COLOMBOS: glcA


Product      
Name: glycolate/lactate:H+ symporter GlcA
Synonym(s): GlcA, YghK
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 58.92
Isoelectric point: 9.663
Motif(s):
 
Type Positions Sequence
159 -> 179 LCLIANTAPVAFGALGVPILV
226 -> 246 AALVAGGSFAVTQFFTSNYIG
440 -> 460 ALVLAGTGVMFPFFSPFLGWL
538 -> 558 IFASVIGIITLLQAYVFTGML
70 -> 90 GYGFIYGLWPIAWIIVAAVFL

 

Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.1 - carbon utilization --> 1.1.1 - carbon compounds
  4 - transport --> 4.2 - Electrochemical potential driven transporters --> 4.2.A - Porters (Uni-, Sym- and Antiporters)
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0015295 - solute:proton symporter activity
GO:0015129 - lactate transmembrane transporter activity
GO:0043879 - glycolate transmembrane transporter activity
biological_process GO:0015727 - lactate transport
GO:0035873 - lactate transmembrane transport
GO:1902600 - proton transmembrane transport
Note(s): Note(s): ...[more].
External database links:  
DIP:
DIP-12206N
ECOCYC:
B2975-MONOMER
ECOLIWIKI:
b2975
INTERPRO:
IPR003804
PANTHER:
PTHR30003
PFAM:
PF02652
PRIDE:
Q46839
PRODB:
PRO_000022771
REFSEQ:
NP_417449
UNIPROT:
Q46839


Operon      
Name: glcDEFGBA         
Operon arrangement:
Transcription unit        Promoter
glcDEFGBA
glcBA


Transcriptional Regulation      
Display Regulation             
Activated by: GlcC, IHF
Repressed by: ArcA, PdhR


RNA cis-regulatory element    
Attenuation: Transcriptional


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_3298 3115931 reverse nd [RS-EPT-CBR] [1]
  promoter yghJp5 3119259 reverse Similarity to the consensus
Read more >
[ICWHO] [2]
  promoter yghJp7 3119266 reverse Similarity to the consensus
Read more >
[ICWHO] [2]
  promoter yghJp6 3119320 reverse Similarity to the consensus
Read more >
[ICWHO] [2]
  promoter glcAp12 3121321 reverse Similarity to the consensus
Read more >
[ICWHO] [2]
  promoter glcAp10 3121364 reverse Similarity to the consensus
Read more >
[ICWHO] [2]
  promoter TSS_3299 3121581 reverse nd [RS-EPT-CBR] [1]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

 [ICWHO] Inferred computationally without human oversight



Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

 [2] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78


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