RegulonDB RegulonDB 10.9: Gene Form
   

nanK gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

nanT yhcG nanK nanE yhcH yhcHp2 yhcHp2

Gene      
Name: nanK    Texpresso search in the literature
Synonym(s): ECK3211, G7676, b3222, yhcI
Genome position(nucleotides): 3369475 <-- 3370350 Genome Browser
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
58.45
External database links:  
ASAP:
ABE-0010571
ECHOBASE:
EB2666
ECOLIHUB:
nanK
OU-MICROARRAY:
b3222
STRING:
511145.b3222
COLOMBOS: nanK


Product      
Name: N-acetylmannosamine kinase
Synonym(s): NanK, YhcI
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 29.644
Isoelectric point: 5.97
Motif(s):
 
Type Positions Sequence
138 -> 138 V
4 -> 288 LAIDIGGTKLAAALIGADGQIRDRRELPTPASQTPEALRDALSALVSPLQAHAQRVAIASTGIIRDGSLLALNPHNLGGLLHFPLVKTLEQLTNLPTIAINDAQAAAWAEFQALDGDITDMVFITVSTGVGGGVVSGCKLLTGPGGLAGHIGHTLADPHGPVCGCGRTGCVEAIASGRGIAAAAQGELAGADAKTIFTRAGQGDEQAQQLIHRSARTLARLIADIKATTDCQCVVVGGSVGLAEGYLALVETYLAQEPAAFHVDLLAAHYRHDAGLLGAALLAQG
5 -> 12 AIDIGGTK
84 -> 84 L
132 -> 139 GVGGGVVS

 

Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.7 - central intermediary metabolism --> 1.7.12 - amino sugar conversions
Gene Ontology Terms (GO)  
cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
molecular_function GO:0016740 - transferase activity
GO:0046872 - metal ion binding
GO:0016301 - kinase activity
GO:0000166 - nucleotide binding
GO:0005524 - ATP binding
GO:0008270 - zinc ion binding
GO:0009384 - N-acylmannosamine kinase activity
biological_process GO:0005975 - carbohydrate metabolic process
GO:0006974 - cellular response to DNA damage stimulus
GO:0016310 - phosphorylation
GO:0006051 - N-acetylmannosamine metabolic process
GO:0046835 - carbohydrate phosphorylation
GO:0019262 - N-acetylneuraminate catabolic process
Note(s): Note(s): ...[more].
External database links:  
DIP:
DIP-12282N
ECOCYC:
NANK-MONOMER
ECOLIWIKI:
b3222
INTERPRO:
IPR000600
INTERPRO:
IPR023945
INTERPRO:
IPR043129
MODBASE:
P45425
PANTHER:
PTHR18964
PDB:
2AA4
PFAM:
PF00480
PRIDE:
P45425
PRODB:
PRO_000023342
PROSITE:
PS01125
REFSEQ:
NP_417689
SMR:
P45425
UNIPROT:
P45425


Operon      
Name: nanATEK-yhcH         
Operon arrangement:
Transcription unit        Promoter
nanA
nanATEK-yhcH


Transcriptional Regulation      
Display Regulation             
Activated by: CRP
Repressed by: NanR, Fis


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter yhcHp2 3369562 reverse Similarity to the consensus
Read more >
[ICWHO] [1]


Evidence    

 [ICWHO] Inferred computationally without human oversight



Reference(s)    

 [1] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78


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