RegulonDB RegulonDB 11.2: Gene Form
   

aaeB gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

aaeB aaeA yhcO anti-anti-terminator anti-terminator terminator aaeBp3 aaeBp3 aaeBp8 aaeBp8 aaeBp7 aaeBp7 yhcOp3 yhcOp3 yhcOp1 yhcOp1 TSS_3574 TSS_3574

Gene      
Name: aaeB    Texpresso search in the literature
Synonym(s): ECK3229, G7685, b3240, yhcP
Genome position(nucleotides): 3386221 <-- 3388188
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 52.59
External database links:  
ASAP:
 ABE-0010629
ECHOBASE:
 EB2673
ECOLIHUB:
 aaeB
OU-MICROARRAY:
 b3240
STRING:
 511145.b3240
COLOMBOS: aaeB


Product      
Name: aromatic carboxylic acid efflux pump subunit AaeB
Synonym(s): AaeB, YhcP
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 73.591
Isoelectric point: 9.545
Motif(s):
 
Type Positions Sequence Comment
11 -> 652 IRFAVKLATAIVLALFVGFHFQLETPRWAVLTAAIVAAGTAFAAGGEPYSGAIRYRGFLRIIGTFIGCIAGLVIIIAMIRAPLLMILVCCIWAGFCTWISSLVRIENSYAWGLAGYTALIIVITIQPEPLLTPQFAVERCSEIVIGIVCAIMADLLFSPRSIKQEVDRELESLLVAQYQLMQLCIKHGDGEVVDKAWGDLVRRTTALQGMRSNLNMESSRWARANRRLKAINTLSLTLITQSCETYLIQNTRPELITDTFREFFDTPVETAQDVHKQLKRLRRVIAWTGERETPVTIYSWVAAATRYQLLKRGVISNTKINATEEEILQGEPEVKVESAERHHAMVNFWRTTLSCILGTLFWLWTGWTSGSGAMVMIAVVTSLAMRLPNPRMVAIDFIYGTLAALPLGLLYFLVIIPNTQQSMLLLCISLAVLGFFLGIEVQKRRLGSMGALASTINIIVLDNPMTFHFSQFLDSALGQIVGCVLAFTVILLVRDKSRDRTGRVLLNQFVSAAVSAMTTNVARRKENHLPALYQQLFLLMNKFPGDLPKFRLALTMIIAHQRLRDAPIPVNEDLSAFHRQMRRTADHVISARSDDKRRRYFGQLLEELEIYQEKLRIWQAPPQVTEPVNRLAGMLHKYQHAL
13 -> 33 FAVKLATAIVLALFVGFHFQL UniProt: Helical.
38 -> 58 WAVLTAAIVAAGTAFAAGGEP UniProt: Helical.
69 -> 89 LRIIGTFIGCIAGLVIIIAMI UniProt: Helical.
93 -> 113 LLMILVCCIWAGFCTWISSLV UniProt: Helical.

 
Classification:
Multifun Terms (GenProtEC)  
  4 - transport
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0022857 - transmembrane transporter activity
biological_process GO:0046942 - carboxylic acid transport
GO:0055085 - transmembrane transport
External database links:  
ALPHAFOLD:
 P46481
ECOCYC:
 G7685-MONOMER
ECOLIWIKI:
 b3240
INTERPRO:
 IPR006726
INTERPRO:
 IPR023706
PANTHER:
 PTHR30509:SF10
PFAM:
 PF04632
PRIDE:
 P46481
PRODB:
 PRO_000022022
REFSEQ:
 NP_417707
UNIPROT:
 P46481


Operon      
Name: aaeXAB         
Operon arrangement:
Transcription unit        Promoter
aaeXAB


Transcriptional Regulation      
Display Regulation             
Activated by: CRP, AaeR


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_3574 3386169 reverse nd [RS-EPT-CBR] [1]
  promoter yhcOp1 3386210 reverse nd [COMP-AINF] [2]
  promoter yhcOp3 3386303 reverse nd [COMP-AINF] [2]
  promoter aaeBp7 3388236 reverse nd [COMP-AINF] [2]
  promoter aaeBp8 3388258 reverse nd [COMP-AINF] [2]
  promoter aaeBp3 3388263 reverse nd [COMP-AINF] [2]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

 [COMP-AINF] Inferred computationally without human oversight


Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

 [2] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

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