RegulonDB RegulonDB 11.2: Gene Form
   

aaeA gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

aaeB aaeA aaeX anti-anti-terminator anti-terminator aaeBp3 aaeBp3 aaeBp8 aaeBp8 aaeBp7 aaeBp7 yhcOp3 yhcOp3

Gene      
Name: aaeA    Texpresso search in the literature
Synonym(s): ECK3230, G7686, b3241, yhcQ
Genome position(nucleotides): 3388194 <-- 3389126
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 53.59
External database links:  
ASAP:
 ABE-0010631
ECHOBASE:
 EB2674
ECOLIHUB:
 aaeA
OU-MICROARRAY:
 b3241
STRING:
 511145.b3241
COLOMBOS: aaeA


Product      
Name: aromatic carboxylic acid efflux pump membrane fusion protein
Synonym(s): AaeA, YhcQ
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 34.775
Isoelectric point: 9.75
Motif(s):
 
Type Positions Sequence Comment
12 -> 32 AITVVLVILAFIAIFNAWVYY UniProt: Helical.
47 -> 94 VVAIAPDVSGLITQVNVHDNQLVKKGQILFTIDQPRYQKALEEAQADV
156 -> 269 VIRAPADGWVTNLNVYTGEFITRGSTAVALVKQNSFYVLAYMEETKLEGVRPGYRAEITPLGSNKVLKGTVDSVAAGVTNASSTRDDKGMATIDSNLEWVRLAQRVPVRIRLDN

 
Classification:
Multifun Terms (GenProtEC)  
  4 - transport
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0022857 - transmembrane transporter activity
biological_process GO:0046942 - carboxylic acid transport
GO:0055085 - transmembrane transport
Reference(s): [1] Lynch SV., et al., 2007
External database links:  
ALPHAFOLD:
 P46482
DIP:
 DIP-12289N
ECOCYC:
 G7686-MONOMER
ECOLIWIKI:
 b3241
INTERPRO:
 IPR039562
INTERPRO:
 IPR022871
INTERPRO:
 IPR006143
MODBASE:
 P46482
PFAM:
 PF13437
PFAM:
 PF13533
PRIDE:
 P46482
PRODB:
 PRO_000022021
REFSEQ:
 NP_417708
SMR:
 P46482
UNIPROT:
 P46482


Operon      
Name: aaeXAB         
Operon arrangement:
Transcription unit        Promoter
aaeXAB


Transcriptional Regulation      
Display Regulation             
Activated by: CRP, AaeR


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter yhcOp3 3386303 reverse nd [COMP-AINF] [2]
  promoter aaeBp7 3388236 reverse nd [COMP-AINF] [2]
  promoter aaeBp8 3388258 reverse nd [COMP-AINF] [2]
  promoter aaeBp3 3388263 reverse nd [COMP-AINF] [2]


Evidence    

 [COMP-AINF] Inferred computationally without human oversight


Reference(s)    

 [1] Lynch SV., Dixon L., Benoit MR., Brodie EL., Keyhan M., Hu P., Ackerley DF., Andersen GL., Matin A., 2007, Role of the rapA gene in controlling antibiotic resistance of Escherichia coli biofilms., Antimicrob Agents Chemother 51(10):3650-8

 [2] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

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