RegulonDB RegulonDB 10.9: Gene Form
   

tatA gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

ubiB tatB tatA esrE ubiJ terminator anti-terminator anti-anti-terminator TSS_4511 TSS_4511 TSS_4510 (cluster) TSS_4510 (cluster) tatAp1 tatAp1 TSS_4508 TSS_4508

Gene      
Name: tatA    Texpresso search in the literature
Synonym(s): ECK3830, G7806, b3836, mttA1, yigT
Genome position(nucleotides): 4021945 --> 4022214 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
45.56
External database links:  
ASAP:
ABE-0012541
ECHOBASE:
EB1444
ECOLIHUB:
tatA
OU-MICROARRAY:
b3836
STRING:
511145.b3836
COLOMBOS: tatA


Product      
Name: twin arginine protein translocation system - TatA protein
Synonym(s): MttA1, TatA, YigT
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane,cytosol
Molecular weight: 9.664
Isoelectric point: 5.855
Motif(s):
 
Type Positions Sequence
24 -> 43 KLGSIGSDLGASIKGFKKAM
1 -> 21 MGGISIWQLLIIAVIVVLLFG
8 -> 8 Q
20 -> 23 FGTK
39 -> 39 F

 

Classification:
Multifun Terms (GenProtEC)  
  4 - transport --> 4.2 - Electrochemical potential driven transporters
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
GO:0033281 - TAT protein transport complex
molecular_function GO:0005515 - protein binding
GO:0008320 - protein transmembrane transporter activity
GO:0042802 - identical protein binding
GO:0009977 - proton motive force dependent protein transmembrane transporter activity
biological_process GO:0015031 - protein transport
GO:0065002 - intracellular protein transmembrane transport
GO:0043953 - protein transport by the Tat complex
Note(s): Note(s): ...[more].
Reference(s): [1] Chan CS., et al., 2011
[2] Lange C., et al., 2007
External database links:  
DIP:
DIP-10958N
DISPROT:
DP00834
ECOCYC:
TATA
ECOLIWIKI:
b3836
INTERPRO:
IPR006312
INTERPRO:
IPR003369
MINT:
P69428
PDB:
2MN7
PDB:
2MN6
PDB:
2LZS
PDB:
2LZR
PFAM:
PF02416
PRIDE:
P69428
PRODB:
PRO_000024028
REFSEQ:
NP_418280
SMR:
P69428
UNIPROT:
P69428


Operon      
Name: tatABCD         
Operon arrangement:
Transcription unit        Promoter
tatABC
tatD


RNA cis-regulatory element    
Attenuation: Transcriptional


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_4508 4021218 forward nd [RS-EPT-CBR] [3]
  promoter TSS_4510 (cluster) 4021912 forward For this promoter, there
Read more >
[RS-EPT-CBR] [3]
  promoter TSS_4511 4022711 forward nd [RS-EPT-CBR] [3]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates



Reference(s)    

 [1] Chan CS., Haney EF., Vogel HJ., Turner RJ., 2011, Towards understanding the Tat translocation mechanism through structural and biophysical studies of the amphipathic region of TatA from Escherichia coli., Biochim Biophys Acta 1808(9):2289-96

 [2] Lange C., Muller SD., Walther TH., Burck J., Ulrich AS., 2007, Structure analysis of the protein translocating channel TatA in membranes using a multi-construct approach., Biochim Biophys Acta 1768(10):2627-34

 [3] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.


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