RegulonDB RegulonDB 10.9: Gene Form
   

mscM gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

mscM psd yjeO yjeN TSS_5001 TSS_5001 TSS_5000 TSS_5000 TSS_4999 TSS_4999

Gene      
Name: mscM    Texpresso search in the literature
Synonym(s): ECK4155, G7840, b4159, yjeP
Genome position(nucleotides): 4386047 <-- 4389370 Genome Browser
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
55.75
External database links:  
ASAP:
ABE-0013621
ECHOBASE:
EB2371
ECOLIHUB:
yjeP
OU-MICROARRAY:
b4159
STRING:
511145.b4159
COLOMBOS: mscM


Product      
Name: miniconductance mechanosensitive channel MscM
Synonym(s): MscM, YjeP
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 123.967
Isoelectric point: 7.0
Motif(s):
 
Type Positions Sequence
20 -> 1107 ATAPDSKQITQELEQAKAAKPAQPEVVEALQSALNALEERKGSLERIKQYQQVIDNYPKLSATLRAQLNNMRDEPRSVSPGMSTDALNQEILQVSSQLLDKSRQAQQEQERAREIADSLNQLPQQQTDARRQLNEIERRLGTLTGNTPLNQAQNFALQSDSARLKALVDELELAQLSANNRQELARLRSELAEKESQQLDAYLQALRNQLNSQRQLEAERALESTELLAENSADLPKDIVAQFKINRELSAALNQQAQRMDLVASQQRQAASQTLQVRQALNTLREQSQWLGSSNLLGEALRAQVARLPEMPKPQQLDTEMAQLRVQRLRYEDLLNKQPLLRQIHQADGQPLTAEQNRILEAQLRTQRELLNSLLQGGDTLLLELTKLKVSNGQLEDALKEVNEATHRYLFWTSDVRPMTIAWPLEIAQDLRRLISLDTFSQLGKASVMMLTSKETILPLFGALILVGCSIYSRRYFTRFLERSAAKVGKVTQDHFWLTLRTLFWSILVASPLPVLWMTLGYGLREAWPYPLAVAIGDGVTATVPLLWVVMICATFARPNGLFIAHFGWPRERVSRGMRYYLMSIGLIVPLIMALMMFDNLDDREFSGSLGRLCFILICGALAVVTLSLKKAGIPLYLNKEGSGDNITNHMLWNMMIGAPLVAILASAVGYLATAQALLARLETSVAIWFLLLVVYHVIRRWMLIQRRRLAFDRAKHRRAEMLAQRARGEEEAHHHSSPEGAIEVDESEVDLDAISAQSLRLVRSILMLIALLSVIVLWSEIHSAFGFLENISLWDVTSTVQGVESLEPITLGAVLIAILVFIITTQLVRNLPALLELAILQHLDLTPGTGYAITTITKYLLMLIGGLVGFSMIGIEWSKLQWLVAALGVGLGFGLQEIFANFISGLIILFEKPIRIGDTVTIRDLTGSVTKINTRATTISDWDRKEIIVPNKAFITEQFINWSLSDSVTRVVLTIPAPADANSEEVTEILLTAARRCSLVIDNPAPEVFLVDLQQGIQIFELRIYAAEMGHRMPLRHEIHQLILAGFHAHGIDMPFPPFQMRLESLNGKQTGRTLTSAGKGRQAGSL
551 -> 571 LAVAIGDGVTATVPLLWVVMI
478 -> 814 PLFGALILVGCSIYSRRYFTRFLERSAAKVGKVTQDHFWLTLRTLFWSILVASPLPVLWMTLGYGLREAWPYPLAVAIGDGVTATVPLLWVVMICATFARPNGLFIAHFGWPRERVSRGMRYYLMSIGLIVPLIMALMMFDNLDDREFSGSLGRLCFILICGALAVVTLSLKKAGIPLYLNKEGSGDNITNHMLWNMMIGAPLVAILASAVGYLATAQALLARLETSVAIWFLLLVVYHVIRRWMLIQRRRLAFDRAKHRRAEMLAQRARGEEEAHHHSSPEGAIEVDESEVDLDAISAQSLRLVRSILMLIALLSVIVLWSEIHSAFGFLENISLW
785 -> 805 ILMLIALLSVIVLWSEIHSAF
467 -> 487 VMMLTSKETILPLFGALILVG

 

Classification:
Multifun Terms (GenProtEC)  
  4 - transport --> 4.1 - Channel-type Transporters
  5 - cell processes --> 5.5 - adaptations --> 5.5.1 - osmotic pressure
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0008381 - mechanosensitive ion channel activity
biological_process GO:0006811 - ion transport
GO:0055085 - transmembrane transport
GO:0071470 - cellular response to osmotic stress
External database links:  
ECOCYC:
G7840-MONOMER
ECOLIWIKI:
b4159
ECOO157CYC:
YJEP-MONOMER
INTERPRO:
IPR011066
INTERPRO:
IPR023408
INTERPRO:
IPR024393
INTERPRO:
IPR025692
INTERPRO:
IPR010920
INTERPRO:
IPR006686
INTERPRO:
IPR006685
INTERPRO:
IPR011014
MODBASE:
P39285
PFAM:
PF00924
PFAM:
PF12794
PFAM:
PF12795
PRIDE:
P39285
PROSITE:
PS01246
REFSEQ:
NP_418583
SMR:
P39285
UNIPROT:
P39285


Operon      
Name: psd-mscM         
Operon arrangement:
Transcription unit        Promoter
psd-mscM


Transcriptional Regulation      
Display Regulation             
Repressed by: CpxR


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_4999 4386346 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_5000 4386996 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_5001 4389996 reverse nd [RS-EPT-CBR] [1]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates



Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.


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