RegulonDB RegulonDB 10.9: Gene Form
   

srlA gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

mltB srlE srlA srlB CRP CRP srlAp srlAp TSS_3016 TSS_3016

Gene      
Name: srlA    Texpresso search in the literature
Synonym(s): ECK2697, G8210, b2702, gutA, sbl, srlA-1
Genome position(nucleotides): 2825832 --> 2826395 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
50.18
External database links:  
ASAP:
ABE-0008890
ECHOBASE:
EB0962
ECOLIHUB:
srlA
OU-MICROARRAY:
b2702
STRING:
511145.b2702
COLOMBOS: srlA


Product      
Name: sorbitol-specific PTS enzyme IIC2 component
Synonym(s): Enzyme IIC sorbitol, GutA, Sbl, SrlA, enzyme IIC component of sorbitol PTS
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 20.58
Isoelectric point: 8.609
Motif(s):
 
Type Positions Sequence
6 -> 171 THGAEWFIGLFQKGGEVFTGMVTGILPLLISLLVIMNALINFIGQHRIERFAQRCAGNPVSRYLLLPCIGTFVFCNPMTLSLGRFMPEKYKPSYYAAASYSCHSMNGLFPHINPGELFVYLGIASGLTTLNLPLGPLAVSYLLVGLVTNFFRGWVTDLTTAIFEKK
68 -> 88 YLLLPCIGTFVFCNPMTLSLG
132 -> 152 LTTLNLPLGPLAVSYLLVGLV
1 -> 187 MIETITHGAEWFIGLFQKGGEVFTGMVTGILPLLISLLVIMNALINFIGQHRIERFAQRCAGNPVSRYLLLPCIGTFVFCNPMTLSLGRFMPEKYKPSYYAAASYSCHSMNGLFPHINPGELFVYLGIASGLTTLNLPLGPLAVSYLLVGLVTNFFRGWVTDLTTAIFEKKMGIQLEQKVHLAGATS
29 -> 49 GILPLLISLLVIMNALINFIG

 

Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.1 - carbon utilization --> 1.1.1 - carbon compounds
  4 - transport --> 4.4 - Group Translocators --> 4.4.A - Phosphotransferase Systems (PEP-dependent PTS)
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
biological_process GO:0008643 - carbohydrate transport
GO:0009401 - phosphoenolpyruvate-dependent sugar phosphotransferase system
Note(s): Note(s): ...[more].
Reference(s): [1] Jindal S., et al., 2019
External database links:  
ECOCYC:
G8210-MONOMER
ECOLIWIKI:
b2702
INTERPRO:
IPR004699
PANTHER:
PTHR40399
PFAM:
PF03608
PRIDE:
P56579
PRODB:
PRO_000023983
PROSITE:
PS51107
REFSEQ:
YP_026180
SMR:
P56579
UNIPROT:
P56579


Operon      
Name: srlAEBD-gutM-srlR-gutQ         
Operon arrangement:
Transcription unit        Promoter
srlAEBD-gutM-srlR-gutQ
srlR


Transcriptional Regulation      
Display Regulation             
Activated by: CRP, H-NS, GutM
Repressed by: SrlR


Regulation by small RNA    
  Display Regulation
small RNA spf


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_3016 2825541 reverse nd [RS-EPT-CBR] [2]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates



Reference(s)    

 [1] Jindal S., Yang L., Day PJ., Kell DB., 2019, Involvement of multiple influx and efflux transporters in the accumulation of cationic fluorescent dyes by Escherichia coli., BMC Microbiol 19(1):195

 [2] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.


RegulonDB