RegulonDB RegulonDB 11.1: Gene Form
   

yhiM gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

yhiJ yhiL yhiN yhiM GadE yhiMp11 yhiMp11 yhiMp9 yhiMp9 yhiMp yhiMp yhiMp10 yhiMp10 yhiJp6 yhiJp6

Gene      
Name: yhiM    Texpresso search in the literature
Synonym(s): ECK3476, EG12228, b3491
Genome position(nucleotides): 3634841 --> 3635893
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 47.1
External database links:  
ASAP:
 ABE-0011400
ECHOBASE:
 EB2140
ECOLIHUB:
 yhiM
STRING:
 511145.b3491
COLOMBOS: yhiM


Product      
Name: inner membrane protein YhiM
Synonym(s): YhiM, inner membrane protein with a role in acid resistance
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 37.657
Isoelectric point: 7.966
Motif(s):
 
Type Positions Sequence Comment
1 -> 347 MNIYIGWLFKLIPLIMGLICIALGGFVLESSGQSEYFVAGHVLISLAAICLALFTTAFIIISQLTRGVNTFYNTLFPIIGYAGSIITMIWGWALLAGNDVMADEFVAGHVIFGVGMIAACVSTVAASSGHFLLIPKNAAGSKSDGTPVQAYSSLIGNCLIAVPVLLTLLGFIWSITLLRSADITPHYVAGHVLLGLTAICACLIGLVATIVHQTRNTFSTKEHWLWCYWVIFLGSITVLQGIYVLVSSDASARLAPGIILICLGMICYSIFSKVWLLALVWRRTCSLANRIPMIPVFTCLFCLFLASFLAEMAQTDMGYFIPSRVLVGLGAVCFTLFSIVSILEAGS
3 -> 23 IYIGWLFKLIPLIMGLICIAL UniProt: Helical.
42 -> 62 VLISLAAICLALFTTAFIIIS UniProt: Helical.
75 -> 95 LFPIIGYAGSIITMIWGWALL UniProt: Helical.
105 -> 125 FVAGHVIFGVGMIAACVSTVA UniProt: Helical.

 
Classification:
Multifun Terms (GenProtEC)  
  5 - cell processes --> 5.5 - adaptations --> 5.5.4 - pH
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
biological_process GO:0071468 - cellular response to acidic pH
Note(s): Note(s): ...[more].
Evidence: [EXP-IEP] Inferred from expression pattern
[EXP-IMP] Inferred from mutant phenotype
Reference(s): [1] Altuvia S., et al., 1997
[2] Nguyen TM., et al., 2012
[3] Tucker DL., et al., 2002
External database links:  
ALPHAFOLD:
 P37630
ECOCYC:
 MONOMER0-2489
ECOLIWIKI:
 b3491
INTERPRO:
 IPR021240
PFAM:
 PF10951
PRIDE:
 P37630
REFSEQ:
 NP_417948
UNIPROT:
 P37630


Operon      
Name: yhiM         
Operon arrangement:
Transcription unit        Promoter
yhiM


Transcriptional Regulation      
Display Regulation             
Activated by: GadE-RcsB, GadE
Repressed by: H-NS


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter yhiJp6 3632595 reverse nd [COMP-AINF] [4]
  promoter yhiMp10 3634635 forward nd [COMP-AINF] [4]
  promoter yhiMp9 3634783 forward nd [COMP-AINF] [4]
  promoter yhiMp11 3634817 forward nd [COMP-AINF] [4]


Evidence    

 [COMP-AINF] Inferred computationally without human oversight


Reference(s)    

 [1] Altuvia S., Weinstein-Fischer D., Zhang A., Postow L., Storz G., 1997, A small, stable RNA induced by oxidative stress: role as a pleiotropic regulator and antimutator., Cell 90(1):43-53

 [2] Nguyen TM., Sparks-Thissen RL., 2012, The inner membrane protein, YhiM, is necessary for Escherichia coli (E. coli) survival in acidic conditions., Arch Microbiol 194(7):637-41

 [3] Tucker DL., Tucker N., Conway T., 2002, Gene expression profiling of the pH response in Escherichia coli., J Bacteriol 184(23):6551-8

 [4] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

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