RegulonDB RegulonDB 11.1: Gene Form

malH gene in Escherichia coli K-12 genome

Gene local context to scale (view description)

malF xylE malG malH CRP XylR XylR TSS_4874 TSS_4874 TSS_4873 TSS_4873 TSS_4872 TSS_4872 xylEp xylEp xylEp1 xylEp1 xylEp8 xylEp8

Name: malH    Texpresso search in the literature
Synonym(s): ECK4664, G0-17082, b4807
Genome position(nucleotides): 4242531 <-- 4242633
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
Reference(s): [1] Iosub IA., et al., 2021

Name: small regulatory RNA MalH
Synonym(s): MalH
Type: small RNA
Multifun Terms (GenProtEC)  
  3 - regulation --> 3.1 - type of regulation --> 3.1.3 - posttranscriptional --> - antisense RNA
Gene Ontology Terms (GO)  
molecular_function GO:0005515 - protein binding
GO:0003729 - mRNA binding
biological_process GO:0070928 - regulation of mRNA stability, ncRNA-mediated
Note(s): Note(s): ...[more].
Evidence: [EXP-IMP] Inferred from mutant phenotype
Reference(s): [1] Iosub IA., et al., 2021
[2] Iosub IA., et al., 2020
External database links:  

Name: malEFGH         
Operon arrangement:
Transcription unit        Promoter

Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter xylEp8 4242260 reverse nd [COMP-AINF] [3]
  promoter xylEp1 4242270 reverse nd [COMP-AINF] [3]
  promoter TSS_4872 4242704 reverse nd [RS-EPT-CBR] [4]
  promoter TSS_4873 4242731 reverse nd [RS-EPT-CBR] [4]
  promoter TSS_4874 4242830 reverse nd [RS-EPT-CBR] [4]


 [COMP-AINF] Inferred computationally without human oversight

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates


 [1] Iosub IA., Marchioretto M., van Nues RW., McKellar S., Viero G., Granneman S., 2021, The mRNA derived MalH sRNA contributes to alternative carbon source utilization by tuning maltoporin expression in E. coli., RNA Biol 18(6):914-931

 [2] Iosub IA., van Nues RW., McKellar SW., Nieken KJ., Marchioretto M., Sy B., Tree JJ., Viero G., Granneman S., 2020, Hfq CLASH uncovers sRNA-target interaction networks linked to nutrient availability adaptation., Elife 9

 [3] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

 [4] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.