RegulonDB

Gene
Name:	malH
Synonym(s):	ECK4664, G0-17082, b4807
Genome position(nucleotides):	4242531 <-- 4242633
Strand:	reverse
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	46.6
Reference(s):	[1] Iosub IA., et al., 2021

Product

Name:

small regulatory RNA MalH

Synonym(s):

MalH

Type:

small RNA

Classification:

Multifun Terms (GenProtEC)
Multifun Terms (GenProtEC)		3 - regulation --> 3.1 - type of regulation --> 3.1.3 - posttranscriptional --> 3.1.3.6 - antisense RNA
Gene Ontology Terms (GO)
	molecular_function	GO:0005515 - protein binding GO:0003729 - mRNA binding
	biological_process	GO:0070928 - regulation of mRNA stability, ncRNA-mediated

Note(s):

Note(s): ...[more].

Evidence:

[EXP-IMP] Inferred from mutant phenotype

Reference(s):

[1] Iosub IA., et al., 2021
[2] Iosub IA., et al., 2020

External database links:

ECOCYC:

Operon

Name:

malEFGH

Operon arrangement:

Transcription unit	Promoter
malEFGH	malEp

Elements in the selected gene context region unrelated to any object in RegulonDB

Type	Name	Post Left	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References
promoter	xylEp8	4242260	reverse	nd	[COMP-AINF]	[3]
promoter	xylEp1	4242270	reverse	nd	[COMP-AINF]	[3]
promoter	TSS_4872	4242704	reverse	nd	[RS-EPT-CBR]	[4]
promoter	TSS_4873	4242731	reverse	nd	[RS-EPT-CBR]	[4]
promoter	TSS_4874	4242830	reverse	nd	[RS-EPT-CBR]	[4]

Evidence
[COMP-AINF] Inferred computationally without human oversight
[RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

Reference(s)
[1] Iosub IA., Marchioretto M., van Nues RW., McKellar S., Viero G., Granneman S., 2021, The mRNA derived MalH sRNA contributes to alternative carbon source utilization by tuning maltoporin expression in E. coli., RNA Biol 18(6):914-931
[2] Iosub IA., van Nues RW., McKellar SW., Nieken KJ., Marchioretto M., Sy B., Tree JJ., Viero G., Granneman S., 2020, Hfq CLASH uncovers sRNA-target interaction networks linked to nutrient availability adaptation., Elife 9
[3] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78
[4] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.