RegulonDB RegulonDB

Zur Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
YkgM Zinc_Ext zinT YkgO ZinT Zinc ZnuB ZnuC znuCB_mRNA Zinc znuA Zur ykgMO ZnuA Zur ykgMO_mRNA znuA_mRNA znuCB zinT_mRNA ZnuC ZnuB ZnuA


Gensor Unit       
Name: Zur
Description: Molecular biology level
Detailed: In the presence of zinc, Zur negatively regulates the expression of genes required for zinc import and response to zinc starvation. Under these condition, Zur is modified to Zur-zinc, binds its target sites preventing the expression of its regulated genes. In the absence of zinc, Zur unbinds its target sites enabling the expression of its regulated genes.
Less detailed: In the presence of zinc, Zur negatively regulates the expression of genes needed for zinc import and response to zinc starvation.

Physiology level
Detailed: The presence of zinc inhibits the expression of genes involved with zinc import and zinc starvation. Under these conditions, the genes necessary for import of zinc are not expressed.
Less detailed: The presence of zinc inhibits the expression of genes needful for import of zinc.
Classification:
Groups: Inorganic ion transport and metabolism
Translation, ribosomal structure and biogenesis
Gene Ontology Terms (GO): biological_process GO:0007155 - cell adhesion
GO:0034224 - cellular response to zinc ion starvation
GO:0006811 - ion transport
GO:0030001 - metal ion transport
GO:0046686 - response to cadmium ion
GO:0010043 - response to zinc ion
Read more >
cellular_component GO:0043190 - ATP-binding cassette (ABC) transporter complex
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0016021 - integral component of membrane
GO:0005887 - integral component of plasma membrane
GO:0005622 - intracellular anatomical structure
GO:0016020 - membrane
Read more >
molecular_function GO:0005524 - ATP binding
GO:0016887 - ATPase activity
GO:0042626 - ATPase-coupled transmembrane transporter activity
GO:0015633 - ATPase-coupled zinc transmembrane transporter activity
GO:0046870 - cadmium ion binding
GO:0000006 - high-affinity zinc transmembrane transporter activity
GO:0016787 - hydrolase activity
Read more >
Components:
  Function Name Type
  protein YkgM protein
  protein YkgO protein
  protein ZinT protein
  simple_molecule Zinc simple_molecule
  simple_molecule Zinc_Ext simple_molecule
  protein ZnuA protein
  protein ZnuB protein
  protein ZnuC protein
  complex ZnuC-ZnuB-ZnuA complex
  protein Zur protein
  complex Zur-Zinc complex
  gene ykgMO gene
  RNA ykgMO_mRNA RNA
  gene zinT gene
  RNA zinT_mRNA RNA
  gene znuA gene
  RNA znuA_mRNA RNA
  gene znuCB gene
  RNA znuCB_mRNA RNA


Reactions       
Showing 13 reactions
Zinc + Zur Zur-Zinc
Name: Zinc + Zur -> Zur-Zinc
Description: Reaction transforming Zinc, Zur into Zur-Zinc
Type: state transition
Pathway Components: Zinc + Zur -> Zur-Zinc
Components:
Function Name Type
reactant Zinc simple_molecule
reactant Zur protein
product Zur-Zinc complex
Zur-Zinc ykgMO ykgMO_mRNA
Name: ykgMO -> ykgMO_mRNA
Description: Transcription of transcription unit ykgMO. Reaction inhibition by Zur-Zinc.
Type: transcription
Pathway Components: ykgMO - Zur-Zinc -> ykgMO_mRNA
Components:
Function Name Type
inhibitor Zur-Zinc complex
reactant ykgMO gene
product ykgMO_mRNA RNA
Zur-Zinc zinT zinT_mRNA
Name: zinT -> zinT_mRNA
Description: Transcription of transcription unit zinT. Reaction inhibition by Zur-Zinc.
Type: transcription
Pathway Components: zinT - Zur-Zinc -> zinT_mRNA
Components:
Function Name Type
inhibitor Zur-Zinc complex
reactant zinT gene
product zinT_mRNA RNA
Zur-Zinc znuA znuA_mRNA
Name: znuA -> znuA_mRNA
Description: Transcription of transcription unit znuA. Reaction inhibition by Zur-Zinc.
Type: transcription
Pathway Components: znuA - Zur-Zinc -> znuA_mRNA
Components:
Function Name Type
inhibitor Zur-Zinc complex
reactant znuA gene
product znuA_mRNA RNA
Zur-Zinc znuCB znuCB_mRNA
Name: znuCB -> znuCB_mRNA
Description: Transcription of transcription unit znuCB. Reaction inhibition by Zur-Zinc.
Type: transcription
Pathway Components: znuCB - Zur-Zinc -> znuCB_mRNA
Components:
Function Name Type
inhibitor Zur-Zinc complex
reactant znuCB gene
product znuCB_mRNA RNA
znuCB_mRNA ZnuC
Name: znuCB_mRNA -> ZnuC
Description: Translation of ZnuC
Type: translation
Pathway Components: znuCB_mRNA -> ZnuC
Components:
Function Name Type
product ZnuC protein
reactant znuCB_mRNA RNA
ZnuC + ZnuA + ZnuB ZnuC-ZnuB-ZnuA
Name: ZnuC + ZnuA + ZnuB -> ZnuC-ZnuB-ZnuA
Description: Reaction transforming ZnuC, ZnuA, ZnuB into ZnuC-ZnuB-ZnuA
Type: state transition
Pathway Components: ZnuC + ZnuA + ZnuB -> ZnuC-ZnuB-ZnuA
Components:
Function Name Type
reactant ZnuA protein
reactant ZnuB protein
reactant ZnuC protein
product ZnuC-ZnuB-ZnuA complex
ZnuC-ZnuB-ZnuA Zinc_Ext Zinc
Name: Zinc_Ext -> Zinc
Description: Transport of Zinc_Ext through a bacterial membrane, leading to the presence of Zinc inside the cell.
Type: transport
Pathway Components: Zinc_Ext - ZnuC-ZnuB-ZnuA -> Zinc
Components:
Function Name Type
product Zinc simple_molecule
reactant Zinc_Ext simple_molecule
catalyzer ZnuC-ZnuB-ZnuA complex
znuCB_mRNA ZnuB
Name: znuCB_mRNA -> ZnuB
Description: Translation of ZnuB
Type: translation
Pathway Components: znuCB_mRNA -> ZnuB
Components:
Function Name Type
product ZnuB protein
reactant znuCB_mRNA RNA
zinT_mRNA ZinT
Name: zinT_mRNA -> ZinT
Description: Translation of ZinT
Type: translation
Pathway Components: zinT_mRNA -> ZinT
Components:
Function Name Type
product ZinT protein
reactant zinT_mRNA RNA
ykgMO_mRNA YkgM
Name: ykgMO_mRNA -> YkgM
Description: Translation of YkgM
Type: translation
Pathway Components: ykgMO_mRNA -> YkgM
Components:
Function Name Type
product YkgM protein
reactant ykgMO_mRNA RNA
ykgMO_mRNA YkgO
Name: ykgMO_mRNA -> YkgO
Description: Translation of YkgO
Type: translation
Pathway Components: ykgMO_mRNA -> YkgO
Components:
Function Name Type
product YkgO protein
reactant ykgMO_mRNA RNA
znuA_mRNA ZnuA
Name: znuA_mRNA -> ZnuA
Description: Translation of ZnuA
Type: translation
Pathway Components: znuA_mRNA -> ZnuA
Components:
Function Name Type
product ZnuA protein
reactant znuA_mRNA RNA



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