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UxuR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
exuR_mRNA uxuR 2-keto-3-deoxygluconate lgoR gluconate exuR LgoR D-glucoronoside uidABC UxuR glucuronide UidA uidABC_mRNA aldehydo-D-glucuronate UxuR gntP_mRNA GntP UidB uxuR_mRNA fructuronate_Ext alpha-D-galacturonate UxuB uxuAB_mRNA uxuAB glucopyranuronate fructuronate lgoR_mRNA UxuR gntP mannonate fructuronate D-glucoronoside_Ext alpha-D-galacturonate UxuR gluconate_Ext alcohol alpha-D-glucuronate UxuA UidC ExuR alpha-D-glucuronate


Gensor Unit       
Name: UxuR
Description: Molecular biology level
Detailed: In the absence of fructuronate, UxuR negatively regulates the expression of genes required for gluconate and glucuronoside transport and catabolic processes. Under these conditions, UxuR remains unmodified, binds its target sites preventing its own expression and the expression of its regulated genes. In the presence of fructuronate, UxuR is modified to UxuR-fructuronate, unbinds its target sites enabling its own expression and the expression of its regulated genes.
Less detailed: In the absence of fructuronate, UxuR negatively regulates the expression of genes needed for gluconate and glucuronoside transport and catabolic processes.

Physiology level
Detailed: The presence of fructuronate induces the expression of genes involved with gluconate and glucuronoside transport and catabolic processes. Under these conditions the genes necessary for fructuronate, D-gluconate and glucuronide transport into cell, and conversion of D-gluconate to 2-dehydro-3-deoxy-D-gluconate are expressed.
Less detailed: The presence of fructuronate induces the expression of genes needful for fructuronate, D-gluconate and glucuronide transport and conversion of D-gluconate to 2-dehydro-3-deoxy-D-gluconate.
Classification:
Groups: Transcription
Carbohydrate transport and metabolism
Gene Ontology Terms (GO): biological_process GO:0046177 - D-gluconate catabolic process
GO:0019521 - D-gluconate metabolic process
GO:0042840 - D-glucuronate catabolic process
GO:0005975 - carbohydrate metabolic process
GO:0008643 - carbohydrate transport
GO:0006974 - cellular response to DNA damage stimulus
Read more >
cellular_component GO:0009279 - cell outer membrane
GO:0005829 - cytosol
GO:0016021 - integral component of membrane
GO:0005887 - integral component of plasma membrane
GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0046930 - pore complex
Read more >
molecular_function GO:0003677 - DNA binding
GO:0003700 - DNA-binding transcription factor activity
GO:0004566 - beta-glucuronidase activity
GO:0005351 - carbohydrate:proton symporter activity
GO:0003824 - catalytic activity
GO:0008198 - ferrous iron binding
GO:0008866 - fructuronate reductase activity
Read more >
Components:
  Function Name Type
  simple_molecule α-D-galacturonate simple_molecule
  simple_molecule α-D-glucuronate simple_molecule
  simple_molecule 2-keto-3-deoxygluconate simple_molecule
  simple_molecule D-glucoronoside simple_molecule
  simple_molecule D-glucoronoside_Ext simple_molecule
  protein ExuR protein
  protein GntP protein
  protein LgoR protein
  protein UidA protein
  protein UidB protein
  protein UidC protein
  protein UxuA protein
  protein UxuB protein
  protein UxuR protein
  complex UxuR-α-D-galacturonate complex
  complex UxuR-α-D-glucuronate complex
  complex UxuR-fructuronate complex
  simple_molecule alcohol simple_molecule
  simple_molecule aldehydo-D-glucuronate simple_molecule
  gene exuR gene
  RNA exuR_mRNA RNA
  simple_molecule fructuronate simple_molecule
  simple_molecule fructuronate_Ext simple_molecule
  simple_molecule gluconate simple_molecule
  simple_molecule gluconate_Ext simple_molecule
  simple_molecule glucopyranuronate simple_molecule
  simple_molecule glucuronide simple_molecule
  gene gntP gene
  RNA gntP_mRNA RNA
  gene lgoR gene
  RNA lgoR_mRNA RNA
  simple_molecule mannonate simple_molecule
  gene uidABC gene
  RNA uidABC_mRNA RNA
  gene uxuAB gene
  RNA uxuAB_mRNA RNA
  gene uxuR gene
  RNA uxuR_mRNA RNA


Reactions       
Showing 26 reactions
UxuR exuR exuR_mRNA
Name: exuR -> exuR_mRNA
Description: Transcription of transcription unit exuR. Reaction inhibition by UxuR.
Type: transcription
Pathway Components: exuR - UxuR -> exuR_mRNA
Components:
Function Name Type
inhibitor UxuR protein
reactant exuR gene
product exuR_mRNA RNA
UxuR gntP gntP_mRNA
Name: gntP -> gntP_mRNA
Description: Transcription of transcription unit gntP. Reaction inhibition by UxuR.
Type: transcription
Pathway Components: gntP - UxuR -> gntP_mRNA
Components:
Function Name Type
inhibitor UxuR protein
reactant gntP gene
product gntP_mRNA RNA
UxuR lgoR lgoR_mRNA
Name: lgoR -> lgoR_mRNA
Description: Transcription of transcription unit lgoR. Reaction inhibition by UxuR.
Type: transcription
Pathway Components: lgoR - UxuR -> lgoR_mRNA
Components:
Function Name Type
inhibitor UxuR protein
reactant lgoR gene
product lgoR_mRNA RNA
UxuR uidABC uidABC_mRNA
Name: uidABC -> uidABC_mRNA
Description: Transcription of transcription unit uidABC. Reaction inhibition by UxuR.
Type: transcription
Pathway Components: uidABC - UxuR -> uidABC_mRNA
Components:
Function Name Type
inhibitor UxuR protein
reactant uidABC gene
product uidABC_mRNA RNA
UxuR uxuAB uxuAB_mRNA
Name: uxuAB -> uxuAB_mRNA
Description: Transcription of transcription unit uxuAB. Reaction inhibition by UxuR.
Type: transcription
Pathway Components: uxuAB - UxuR -> uxuAB_mRNA
Components:
Function Name Type
inhibitor UxuR protein
reactant uxuAB gene
product uxuAB_mRNA RNA
UxuR uxuR uxuR_mRNA
Name: uxuR -> uxuR_mRNA
Description: Transcription of transcription unit uxuR. Reaction inhibition by UxuR.
Type: transcription
Pathway Components: uxuR - UxuR -> uxuR_mRNA
Components:
Function Name Type
inhibitor UxuR protein
reactant uxuR gene
product uxuR_mRNA RNA
α-D-galacturonate + UxuR UxuR-α-D-galacturonate
Name: α-D-galacturonate + UxuR -> UxuR-α-D-galacturonate
Description: Reaction transforming α-D-galacturonate, UxuR into UxuR-α-D-galacturonate
Type: state transition
Pathway Components: α-D-galacturonate + UxuR -> UxuR-α-D-galacturonate
Components:
Function Name Type
reactant α-D-galacturonate simple_molecule
reactant UxuR protein
product UxuR-α-D-galacturonate complex
α-D-glucuronate + UxuR UxuR-α-D-glucuronate
Name: α-D-glucuronate + UxuR -> UxuR-α-D-glucuronate
Description: Reaction transforming α-D-glucuronate, UxuR into UxuR-α-D-glucuronate
Type: state transition
Pathway Components: α-D-glucuronate + UxuR -> UxuR-α-D-glucuronate
Components:
Function Name Type
reactant α-D-glucuronate simple_molecule
reactant UxuR protein
product UxuR-α-D-glucuronate complex
fructuronate + UxuR UxuR-fructuronate
Name: fructuronate + UxuR -> UxuR-fructuronate
Description: Reaction transforming fructuronate, UxuR into UxuR-fructuronate
Type: state transition
Pathway Components: fructuronate + UxuR -> UxuR-fructuronate
Components:
Function Name Type
reactant UxuR protein
product UxuR-fructuronate complex
reactant fructuronate simple_molecule
uidABC_mRNA UidA
Name: uidABC_mRNA -> UidA
Description: Translation of UidA
Type: translation
Pathway Components: uidABC_mRNA -> UidA
Components:
Function Name Type
product UidA protein
reactant uidABC_mRNA RNA
UidA glucuronide glucopyranuronate + alcohol
Name: glucuronide -> glucopyranuronate + alcohol
Description: Reaction transforming glucuronide into glucopyranuronate, alcohol
Type: state transition
Pathway Components: glucuronide - UidA -> glucopyranuronate + alcohol
Components:
Function Name Type
catalyzer UidA protein
product alcohol simple_molecule
product glucopyranuronate simple_molecule
reactant glucuronide simple_molecule
uidABC_mRNA UidB
Name: uidABC_mRNA -> UidB
Description: Translation of UidB
Type: translation
Pathway Components: uidABC_mRNA -> UidB
Components:
Function Name Type
product UidB protein
reactant uidABC_mRNA RNA
UidB D-glucoronoside_Ext D-glucoronoside
Name: D-glucoronoside_Ext -> D-glucoronoside
Description: Transport of D-glucoronoside_Ext through a bacterial membrane, leading to the presence of D-glucoronoside inside the cell.
Type: transport
Pathway Components: D-glucoronoside_Ext - UidB -> D-glucoronoside
Components:
Function Name Type
product D-glucoronoside simple_molecule
reactant D-glucoronoside_Ext simple_molecule
catalyzer UidB protein
uidABC_mRNA UidC
Name: uidABC_mRNA -> UidC
Description: Translation of UidC
Type: translation
Pathway Components: uidABC_mRNA -> UidC
Components:
Function Name Type
product UidC protein
reactant uidABC_mRNA RNA
lgoR_mRNA LgoR
Name: lgoR_mRNA -> LgoR
Description: Translation of LgoR
Type: translation
Pathway Components: lgoR_mRNA -> LgoR
Components:
Function Name Type
product LgoR protein
reactant lgoR_mRNA RNA
gntP_mRNA GntP
Name: gntP_mRNA -> GntP
Description: Translation of GntP
Type: translation
Pathway Components: gntP_mRNA -> GntP
Components:
Function Name Type
product GntP protein
reactant gntP_mRNA RNA
GntP fructuronate_Ext fructuronate
Name: fructuronate_Ext -> fructuronate
Description: Transport of fructuronate_Ext through a bacterial membrane, leading to the presence of fructuronate inside the cell.
Type: transport
Pathway Components: fructuronate_Ext - GntP -> fructuronate
Components:
Function Name Type
catalyzer GntP protein
product fructuronate simple_molecule
reactant fructuronate_Ext simple_molecule
GntP gluconate_Ext gluconate
Name: gluconate_Ext -> gluconate
Description: Transport of gluconate_Ext through a bacterial membrane, leading to the presence of gluconate inside the cell.
Type: transport
Pathway Components: gluconate_Ext - GntP -> gluconate
Components:
Function Name Type
catalyzer GntP protein
product gluconate simple_molecule
reactant gluconate_Ext simple_molecule
uxuAB_mRNA UxuA
Name: uxuAB_mRNA -> UxuA
Description: Translation of UxuA
Type: translation
Pathway Components: uxuAB_mRNA -> UxuA
Components:
Function Name Type
product UxuA protein
reactant uxuAB_mRNA RNA
UxuA gluconate mannonate 2-keto-3-deoxygluconate
Name: mannonate -> 2-keto-3-deoxygluconate
Description: Reaction transforming mannonate into 2-keto-3-deoxygluconate
Type: state transition
Pathway Components: mannonate - UxuA - gluconate -> 2-keto-3-deoxygluconate
Components:
Function Name Type
product 2-keto-3-deoxygluconate simple_molecule
catalyzer UxuA protein
inhibitor gluconate simple_molecule
reactant mannonate simple_molecule
uxuAB_mRNA UxuB
Name: uxuAB_mRNA -> UxuB
Description: Translation of UxuB
Type: translation
Pathway Components: uxuAB_mRNA -> UxuB
Components:
Function Name Type
product UxuB protein
reactant uxuAB_mRNA RNA
UxuB mannonate fructuronate
Name: mannonate -> fructuronate
Description: Reaction transforming mannonate into fructuronate
Type: state transition
Pathway Components: mannonate - UxuB -> fructuronate
Components:
Function Name Type
catalyzer UxuB protein
product fructuronate simple_molecule
reactant mannonate simple_molecule
uxuR_mRNA UxuR
Name: uxuR_mRNA -> UxuR
Description: Translation of UxuR
Type: translation
Pathway Components: uxuR_mRNA -> UxuR
Components:
Function Name Type
product UxuR protein
reactant uxuR_mRNA RNA
exuR_mRNA ExuR
Name: exuR_mRNA -> ExuR
Description: Translation of ExuR
Type: translation
Pathway Components: exuR_mRNA -> ExuR
Components:
Function Name Type
product ExuR protein
reactant exuR_mRNA RNA
glucopyranuronate fructuronate
Name: glucopyranuronate -> fructuronate
Description: Transformation of glucopyranuronate into fructuronate by one or more reactions not shown.
Type: complementary pathway reaction
Pathway Components: glucopyranuronate / RXN-14693 / GLUCUROISOM-RXN / fructuronate
Components:
Function Name Type
product fructuronate simple_molecule
reactant glucopyranuronate simple_molecule
glucopyranuronate aldehydo-D-glucuronate
Name: glucopyranuronate -> aldehydo-D-glucuronate
Description: Transformation of glucopyranuronate into aldehydo-D-glucuronate by one or more reactions not shown.
Type: complementary pathway reaction
Pathway Components: glucopyranuronate / RXN-14693 / aldehydo-D-glucuronate
Components:
Function Name Type
product aldehydo-D-glucuronate simple_molecule
reactant glucopyranuronate simple_molecule



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