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TyrR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
folA_mRNA AroF indole YaiA indole_Ext erythrose-4P THF polyglutamate tryptophan aroP leucine phosphate tyrR tyrosine AroG tyrB aroG TyrR phenylalanine_Ext mtr shikimate aroF-tyrA_mRNA aromatic amino acid mtr_mRNA 7,8-dihydrofolate prephenate FolA P-enol-pyruvate tyrR_mRNA TyrB shikimate-5-P tyrB_mRNA AroM tyrosine ketoleucine aroL-yaiA-aroM_mRNA tryptophan TyrR chorismate phenylalanine TyrR L-glutamate aromatic oxo-acid ketoglutarate TyrA tryptophan_Ext AroL phenylpyruvate tyrP_mRNA tyrP aroP_mRNA folA hydroxyphenylpyruvate CO2 Mtr DAHP aroG_mRNA tyrosine_Ext TyrR TyrP phenylalanine aroL-yaiA-aroM AroP aroF-tyrA shikimate chorismate ketoglutarate leucine L-glutamate phenylalanine


Gensor Unit       
Name: TyrR
Description: Molecular biology level
Detailed: In the presence of tryptophan, TrpR negatively regulates the expression of genes required for tryptophan transport and biosynthetic process. Under these conditions, TrpR is modified to TrpR-tryptophan, binds its target sites preventing its own expression and the expression of its regulated genes. In the absence of effector, TrpR unbinds its target sites enabling the expression of its regulated genes.
Less detailed: In the presence of tryptophan, TrpR negatively regulates the expression of genes needed for tryptophan transport and biosynthetic process.

Physiology level
Detailed: The presence of tryptophan inhibits the expression of genes involved with tryptophan transport and biosynthetic process. Under these conditions the genes necessary for transport and synthesis of tryptophan from serine and conversion of erythrose-4P to chorismate, a precursor of tryptophan, are not expressed.
Less detailed: The presence of tryptophan inhibits the expression of genes needful for transport and synthesis of tryptophan from serine and conversion of erythrose-4P to chorismate, a precursor of tryptophan.
Classification:
Groups: Transcription
Amino acid transport and metabolism
Coenzyme transport and metabolism
Gene Ontology Terms (GO): biological_process GO:0009257 - 10-formyltetrahydrofolate biosynthetic process
GO:0009094 - L-phenylalanine biosynthetic process
GO:0033585 - L-phenylalanine biosynthetic process from chorismate via phenylpyruvate
GO:0003333 - amino acid transmembrane transport
GO:0006865 - amino acid transport
GO:0009073 - aromatic amino acid family biosynthetic process
Read more >
cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0016021 - integral component of membrane
GO:0005887 - integral component of plasma membrane
GO:0016020 - membrane
GO:0005886 - plasma membrane
molecular_function GO:0003849 - 3-deoxy-7-phosphoheptulonate synthase activity
GO:0005524 - ATP binding
GO:0003677 - DNA binding
GO:0050048 - L-leucine:2-oxoglutarate aminotransferase activity
GO:0015192 - L-phenylalanine transmembrane transporter activity
GO:0080130 - L-phenylalanine:2-oxoglutarate aminotransferase activity
GO:0015196 - L-tryptophan transmembrane transporter activity
Read more >
Components:
  Function Name Type
  simple_molecule 7,8-dihydrofolate simple_molecule
  protein AroF protein
  protein AroG protein
  protein AroL protein
  protein AroM protein
  protein AroP protein
  simple_molecule CO2 simple_molecule
  simple_molecule DAHP simple_molecule
  protein FolA protein
  simple_molecule L-glutamate simple_molecule
  protein Mtr protein
  simple_molecule P-enol-pyruvate simple_molecule
  simple_molecule THF polyglutamate simple_molecule
  protein TyrA protein
  protein TyrB protein
  protein TyrP protein
  protein TyrR protein
  complex TyrR-phenylalanine complex
  complex TyrR-tryptophan complex
  complex TyrR-tyrosine complex
  protein YaiA protein
  gene aroF-tyrA gene
  RNA aroF-tyrA_mRNA RNA
  gene aroG gene
  RNA aroG_mRNA RNA
  gene aroL-yaiA-aroM gene
  RNA aroL-yaiA-aroM_mRNA RNA
  gene aroP gene
  RNA aroP_mRNA RNA
  simple_molecule aromatic amino acid simple_molecule
  simple_molecule aromatic oxo-acid simple_molecule
  simple_molecule chorismate simple_molecule
  simple_molecule erythrose-4P simple_molecule
  gene folA gene
  RNA folA_mRNA RNA
  simple_molecule hydroxyphenylpyruvate simple_molecule
  simple_molecule indole simple_molecule
  simple_molecule indole_Ext simple_molecule
  simple_molecule ketoglutarate simple_molecule
  simple_molecule ketoleucine simple_molecule
  simple_molecule leucine simple_molecule
  gene mtr gene
  RNA mtr_mRNA RNA
  simple_molecule phenylalanine simple_molecule
  simple_molecule phenylalanine_Ext simple_molecule
  simple_molecule phenylpyruvate simple_molecule
  simple_molecule phosphate simple_molecule
  simple_molecule prephenate simple_molecule
  simple_molecule shikimate simple_molecule
  simple_molecule shikimate-5-P simple_molecule
  simple_molecule tryptophan simple_molecule
  simple_molecule tryptophan_Ext simple_molecule
  gene tyrB gene
  RNA tyrB_mRNA RNA
  gene tyrP gene
  RNA tyrP_mRNA RNA
  gene tyrR gene
  RNA tyrR_mRNA RNA
  simple_molecule tyrosine simple_molecule
  simple_molecule tyrosine_Ext simple_molecule


Reactions       
Showing 42 reactions
phenylalanine + TyrR TyrR-phenylalanine
Name: phenylalanine + TyrR -> TyrR-phenylalanine
Description: Reaction transforming phenylalanine, TyrR into TyrR-phenylalanine
Type: state transition
Pathway Components: phenylalanine + TyrR -> TyrR-phenylalanine
Components:
Function Name Type
reactant TyrR protein
product TyrR-phenylalanine complex
reactant phenylalanine simple_molecule
TyrR TyrR TyrR-phenylalanine TyrR-phenylalanine TyrR-tyrosine tyrP tyrP_mRNA
Name: tyrP -> tyrP_mRNA
Description: Transcription of transcription unit tyrP. Reaction activation by TyrR, and TyrR-phenylalanine. Reaction inhibition by TyrR, TyrR-phenylalanine, and TyrR-tyrosine.
Type: transcription
Pathway Components: tyrP - TyrR - TyrR-phenylalanine - TyrR-tyrosine - TyrR - TyrR-phenylalanine -> tyrP_mRNA
Components:
Function Name Type
activator TyrR protein
inhibitor TyrR protein
activator TyrR-phenylalanine complex
inhibitor TyrR-phenylalanine complex
inhibitor TyrR-tyrosine complex
reactant tyrP gene
product tyrP_mRNA RNA
TyrR-phenylalanine aroG aroG_mRNA
Name: aroG -> aroG_mRNA
Description: Transcription of transcription unit aroG. Reaction inhibition by TyrR-phenylalanine.
Type: transcription
Pathway Components: aroG - TyrR-phenylalanine -> aroG_mRNA
Components:
Function Name Type
inhibitor TyrR-phenylalanine complex
reactant aroG gene
product aroG_mRNA RNA
tyrosine + TyrR TyrR-tyrosine
Name: tyrosine + TyrR -> TyrR-tyrosine
Description: Reaction transforming tyrosine, TyrR into TyrR-tyrosine
Type: state transition
Pathway Components: tyrosine + TyrR -> TyrR-tyrosine
Components:
Function Name Type
reactant TyrR protein
product TyrR-tyrosine complex
reactant tyrosine simple_molecule
TyrR-tyrosine folA folA_mRNA
Name: folA -> folA_mRNA
Description: Transcription of transcription unit folA. Reaction activation by TyrR-tyrosine.
Type: transcription
Pathway Components: folA - TyrR-tyrosine -> folA_mRNA
Components:
Function Name Type
activator TyrR-tyrosine complex
reactant folA gene
product folA_mRNA RNA
TyrR tyrR tyrR_mRNA
Name: tyrR -> tyrR_mRNA
Description: Transcription of transcription unit tyrR. Reaction inhibition by TyrR.
Type: transcription
Pathway Components: tyrR - TyrR -> tyrR_mRNA
Components:
Function Name Type
inhibitor TyrR protein
reactant tyrR gene
product tyrR_mRNA RNA
TyrR-tyrosine mtr mtr_mRNA
Name: mtr -> mtr_mRNA
Description: Transcription of transcription unit mtr. Reaction activation by TyrR-tyrosine.
Type: transcription
Pathway Components: mtr - TyrR-tyrosine -> mtr_mRNA
Components:
Function Name Type
activator TyrR-tyrosine complex
reactant mtr gene
product mtr_mRNA RNA
TyrR-tyrosine aroF-tyrA aroF-tyrA_mRNA
Name: aroF-tyrA -> aroF-tyrA_mRNA
Description: Transcription of transcription unit aroF-tyrA. Reaction inhibition by TyrR-tyrosine.
Type: transcription
Pathway Components: aroF-tyrA - TyrR-tyrosine -> aroF-tyrA_mRNA
Components:
Function Name Type
inhibitor TyrR-tyrosine complex
reactant aroF-tyrA gene
product aroF-tyrA_mRNA RNA
TyrR-tyrosine aroL-yaiA-aroM aroL-yaiA-aroM_mRNA
Name: aroL-yaiA-aroM -> aroL-yaiA-aroM_mRNA
Description: Transcription of transcription unit aroL-yaiA-aroM. Reaction inhibition by TyrR-tyrosine.
Type: transcription
Pathway Components: aroL-yaiA-aroM - TyrR-tyrosine -> aroL-yaiA-aroM_mRNA
Components:
Function Name Type
inhibitor TyrR-tyrosine complex
reactant aroL-yaiA-aroM gene
product aroL-yaiA-aroM_mRNA RNA
TyrR-tyrosine aroP aroP_mRNA
Name: aroP -> aroP_mRNA
Description: Transcription of transcription unit aroP. Reaction inhibition by TyrR-tyrosine.
Type: transcription
Pathway Components: aroP - TyrR-tyrosine -> aroP_mRNA
Components:
Function Name Type
inhibitor TyrR-tyrosine complex
reactant aroP gene
product aroP_mRNA RNA
TyrR-tyrosine tyrB tyrB_mRNA
Name: tyrB -> tyrB_mRNA
Description: Transcription of transcription unit tyrB. Reaction inhibition by TyrR-tyrosine.
Type: transcription
Pathway Components: tyrB - TyrR-tyrosine -> tyrB_mRNA
Components:
Function Name Type
inhibitor TyrR-tyrosine complex
reactant tyrB gene
product tyrB_mRNA RNA
tryptophan + TyrR TyrR-tryptophan
Name: tryptophan + TyrR -> TyrR-tryptophan
Description: Reaction transforming tryptophan, TyrR into TyrR-tryptophan
Type: state transition
Pathway Components: tryptophan + TyrR -> TyrR-tryptophan
Components:
Function Name Type
reactant TyrR protein
product TyrR-tryptophan complex
reactant tryptophan simple_molecule
aroL-yaiA-aroM_mRNA AroL
Name: aroL-yaiA-aroM_mRNA -> AroL
Description: Translation of AroL
Type: translation
Pathway Components: aroL-yaiA-aroM_mRNA -> AroL
Components:
Function Name Type
product AroL protein
reactant aroL-yaiA-aroM_mRNA RNA
AroL shikimate shikimate-5-P
Name: shikimate -> shikimate-5-P
Description: Reaction transforming shikimate into shikimate-5-P
Type: state transition
Pathway Components: shikimate - AroL -> shikimate-5-P
Components:
Function Name Type
catalyzer AroL protein
reactant shikimate simple_molecule
product shikimate-5-P simple_molecule
aroL-yaiA-aroM_mRNA YaiA
Name: aroL-yaiA-aroM_mRNA -> YaiA
Description: Translation of YaiA
Type: translation
Pathway Components: aroL-yaiA-aroM_mRNA -> YaiA
Components:
Function Name Type
product YaiA protein
reactant aroL-yaiA-aroM_mRNA RNA
aroL-yaiA-aroM_mRNA AroM
Name: aroL-yaiA-aroM_mRNA -> AroM
Description: Translation of AroM
Type: translation
Pathway Components: aroL-yaiA-aroM_mRNA -> AroM
Components:
Function Name Type
product AroM protein
reactant aroL-yaiA-aroM_mRNA RNA
tyrR_mRNA TyrR
Name: tyrR_mRNA -> TyrR
Description: Translation of TyrR
Type: translation
Pathway Components: tyrR_mRNA -> TyrR
Components:
Function Name Type
product TyrR protein
reactant tyrR_mRNA RNA
aroG_mRNA AroG
Name: aroG_mRNA -> AroG
Description: Translation of AroG
Type: translation
Pathway Components: aroG_mRNA -> AroG
Components:
Function Name Type
product AroG protein
reactant aroG_mRNA RNA
AroF AroG DAHP phenylalanine tryptophan tyrosine P-enol-pyruvate + erythrose-4P phosphate + DAHP
Name: P-enol-pyruvate + erythrose-4P -> phosphate + DAHP
Description: Reaction transforming P-enol-pyruvate, erythrose-4P into phosphate, DAHP
Type: state transition
Pathway Components: P-enol-pyruvate + erythrose-4P - AroF - AroG - DAHP - phenylalanine - tryptophan - tyrosine -> phosphate + DAHP
Components: Show/Hide Components Table
folA_mRNA FolA
Name: folA_mRNA -> FolA
Description: Translation of FolA
Type: translation
Pathway Components: folA_mRNA -> FolA
Components:
Function Name Type
product FolA protein
reactant folA_mRNA RNA
FolA 7,8-dihydrofolate THF polyglutamate
Name: 7,8-dihydrofolate -> THF polyglutamate
Description: Reaction transforming 7,8-dihydrofolate into THF polyglutamate
Type: state transition
Pathway Components: 7,8-dihydrofolate - FolA -> THF polyglutamate
Components:
Function Name Type
reactant 7,8-dihydrofolate simple_molecule
catalyzer FolA protein
product THF polyglutamate simple_molecule
aroF-tyrA_mRNA AroF
Name: aroF-tyrA_mRNA -> AroF
Description: Translation of AroF
Type: translation
Pathway Components: aroF-tyrA_mRNA -> AroF
Components:
Function Name Type
product AroF protein
reactant aroF-tyrA_mRNA RNA
aroF-tyrA_mRNA TyrA
Name: aroF-tyrA_mRNA -> TyrA
Description: Translation of TyrA
Type: translation
Pathway Components: aroF-tyrA_mRNA -> TyrA
Components:
Function Name Type
product TyrA protein
reactant aroF-tyrA_mRNA RNA
TyrA phenylalanine prephenate tyrosine chorismate prephenate
Name: chorismate -> prephenate
Description: Reaction transforming chorismate into prephenate
Type: state transition
Pathway Components: chorismate - TyrA - phenylalanine - prephenate - tyrosine -> prephenate
Components:
Function Name Type
catalyzer TyrA protein
reactant chorismate simple_molecule
inhibitor phenylalanine simple_molecule
inhibitor prephenate simple_molecule
product prephenate simple_molecule
inhibitor tyrosine simple_molecule
TyrA tyrosine prephenate hydroxyphenylpyruvate + CO2
Name: prephenate -> hydroxyphenylpyruvate + CO2
Description: Reaction transforming prephenate into hydroxyphenylpyruvate, CO2
Type: state transition
Pathway Components: prephenate - TyrA - tyrosine -> hydroxyphenylpyruvate + CO2
Components:
Function Name Type
product CO2 simple_molecule
catalyzer TyrA protein
product hydroxyphenylpyruvate simple_molecule
reactant prephenate simple_molecule
inhibitor tyrosine simple_molecule
mtr_mRNA Mtr
Name: mtr_mRNA -> Mtr
Description: Translation of Mtr
Type: translation
Pathway Components: mtr_mRNA -> Mtr
Components:
Function Name Type
product Mtr protein
reactant mtr_mRNA RNA
Mtr indole_Ext indole
Name: indole_Ext -> indole
Description: Transport of indole_Ext through a bacterial membrane, leading to the presence of indole inside the cell.
Type: transport
Pathway Components: indole_Ext - Mtr -> indole
Components:
Function Name Type
catalyzer Mtr protein
product indole simple_molecule
reactant indole_Ext simple_molecule
AroP Mtr tryptophan_Ext tryptophan
Name: tryptophan_Ext -> tryptophan
Description: Transport of tryptophan_Ext through a bacterial membrane, leading to the presence of tryptophan inside the cell.
Type: transport
Pathway Components: tryptophan_Ext - AroP - Mtr -> tryptophan
Components:
Function Name Type
catalyzer AroP protein
catalyzer Mtr protein
product tryptophan simple_molecule
reactant tryptophan_Ext simple_molecule
tyrP_mRNA TyrP
Name: tyrP_mRNA -> TyrP
Description: Translation of TyrP
Type: translation
Pathway Components: tyrP_mRNA -> TyrP
Components:
Function Name Type
product TyrP protein
reactant tyrP_mRNA RNA
AroP TyrP tyrosine_Ext tyrosine
Name: tyrosine_Ext -> tyrosine
Description: Transport of tyrosine_Ext through a bacterial membrane, leading to the presence of tyrosine inside the cell.
Type: transport
Pathway Components: tyrosine_Ext - AroP - TyrP -> tyrosine
Components:
Function Name Type
catalyzer AroP protein
catalyzer TyrP protein
product tyrosine simple_molecule
reactant tyrosine_Ext simple_molecule
aroP_mRNA AroP
Name: aroP_mRNA -> AroP
Description: Translation of AroP
Type: translation
Pathway Components: aroP_mRNA -> AroP
Components:
Function Name Type
product AroP protein
reactant aroP_mRNA RNA
AroP phenylalanine_Ext phenylalanine
Name: phenylalanine_Ext -> phenylalanine
Description: Transport of phenylalanine_Ext through a bacterial membrane, leading to the presence of phenylalanine inside the cell.
Type: transport
Pathway Components: phenylalanine_Ext - AroP -> phenylalanine
Components:
Function Name Type
catalyzer AroP protein
product phenylalanine simple_molecule
reactant phenylalanine_Ext simple_molecule
tyrB_mRNA TyrB
Name: tyrB_mRNA -> TyrB
Description: Translation of TyrB
Type: translation
Pathway Components: tyrB_mRNA -> TyrB
Components:
Function Name Type
product TyrB protein
reactant tyrB_mRNA RNA
TyrB aromatic amino acid + ketoglutarate aromatic oxo-acid + L-glutamate
Name: aromatic amino acid + ketoglutarate -> aromatic oxo-acid + L-glutamate
Description: Reaction transforming aromatic amino acid, ketoglutarate into aromatic oxo-acid, L-glutamate
Type: state transition
Pathway Components: aromatic amino acid + ketoglutarate - TyrB -> aromatic oxo-acid + L-glutamate
Components:
Function Name Type
product L-glutamate simple_molecule
catalyzer TyrB protein
reactant aromatic amino acid simple_molecule
product aromatic oxo-acid simple_molecule
reactant ketoglutarate simple_molecule
TyrB leucine tyrosine ketoglutarate + leucine L-glutamate + ketoleucine
Name: ketoglutarate + leucine -> L-glutamate + ketoleucine
Description: Reaction transforming ketoglutarate, leucine into L-glutamate, ketoleucine
Type: state transition
Pathway Components: ketoglutarate + leucine - TyrB - leucine - tyrosine -> L-glutamate + ketoleucine
Components:
Function Name Type
product L-glutamate simple_molecule
catalyzer TyrB protein
reactant ketoglutarate simple_molecule
product ketoleucine simple_molecule
inhibitor leucine simple_molecule
reactant leucine simple_molecule
inhibitor tyrosine simple_molecule
TyrB leucine tyrosine ketoglutarate + tyrosine hydroxyphenylpyruvate + L-glutamate
Name: ketoglutarate + tyrosine -> hydroxyphenylpyruvate + L-glutamate
Description: Reaction transforming ketoglutarate, tyrosine into hydroxyphenylpyruvate, L-glutamate
Type: state transition
Pathway Components: ketoglutarate + tyrosine - TyrB - leucine - tyrosine -> hydroxyphenylpyruvate + L-glutamate
Components:
Function Name Type
product L-glutamate simple_molecule
catalyzer TyrB protein
product hydroxyphenylpyruvate simple_molecule
reactant ketoglutarate simple_molecule
inhibitor leucine simple_molecule
inhibitor tyrosine simple_molecule
reactant tyrosine simple_molecule
TyrB leucine tyrosine phenylpyruvate + L-glutamate phenylalanine + ketoglutarate
Name: phenylpyruvate + L-glutamate -> phenylalanine + ketoglutarate
Description: Reaction transforming phenylpyruvate, L-glutamate into phenylalanine, ketoglutarate
Type: state transition
Pathway Components: phenylpyruvate + L-glutamate - TyrB - leucine - tyrosine -> phenylalanine + ketoglutarate
Components:
Function Name Type
reactant L-glutamate simple_molecule
catalyzer TyrB protein
product ketoglutarate simple_molecule
inhibitor leucine simple_molecule
product phenylalanine simple_molecule
reactant phenylpyruvate simple_molecule
inhibitor tyrosine simple_molecule
shikimate-5-P chorismate
Name: shikimate-5-P -> chorismate
Description: Transformation of shikimate-5-P into chorismate by one or more reactions not shown.
Type: complementary pathway reaction
Pathway Components: shikimate-5-P / 2.5.1.19-RXN / CHORISMATE-SYNTHASE-RXN / chorismate
Components:
Function Name Type
product chorismate simple_molecule
reactant shikimate-5-P simple_molecule
DAHP shikimate
Name: DAHP -> shikimate
Description: Transformation of DAHP into shikimate by one or more reactions not shown.
Type: complementary pathway reaction
Pathway Components: DAHP / 3-DEHYDROQUINATE-SYNTHASE-RXN / 3-DEHYDROQUINATE-DEHYDRATASE-RXN / SHIKIMATE-5-DEHYDROGENASE-RXN / shikimate
Components:
Function Name Type
reactant DAHP simple_molecule
product shikimate simple_molecule
shikimate-5-P 7,8-dihydrofolate
Name: shikimate-5-P -> 7,8-dihydrofolate
Description: Transformation of shikimate-5-P into 7,8-dihydrofolate by one or more reactions not shown.
Type: complementary pathway reaction
Pathway Components: shikimate-5-P / 2.5.1.19-RXN / CHORISMATE-SYNTHASE-RXN / PABASYN-RXN / ADCLY-RXN / H2PTEROATESYNTH-RXN / DIHYDROFOLATESYNTH-RXN / 7,8-dihydrofolate
Components:
Function Name Type
product 7,8-dihydrofolate simple_molecule
reactant shikimate-5-P simple_molecule
prephenate phenylpyruvate
Name: prephenate -> phenylpyruvate
Description: Transformation of prephenate into phenylpyruvate by one or more reactions not shown.
Type: complementary pathway reaction
Pathway Components: prephenate / PREPHENATEDEHYDRAT-RXN / phenylpyruvate
Components:
Function Name Type
product phenylpyruvate simple_molecule
reactant prephenate simple_molecule
shikimate-5-P indole
Name: shikimate-5-P -> indole
Description: Transformation of shikimate-5-P into indole by one or more reactions not shown.
Type: complementary pathway reaction
Pathway Components: shikimate-5-P / 2.5.1.19-RXN / CHORISMATE-SYNTHASE-RXN / ANTHRANSYN-RXN / PRTRANS-RXN / PRAISOM-RXN / IGPSYN-RXN / RXN0-2381 / indole
Components:
Function Name Type
product indole simple_molecule
reactant shikimate-5-P simple_molecule
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