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RcnR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
RcnR RcnR rcnAB nickel_Ext RcnA rcnAB_mRNA cobalt ion rcnR_mRNA nickel RcnB nickel cobalt ion RcnR cobalt ion_Ext rcnR


Gensor Unit       
Name: RcnR
Description: Molecular biology level
Detailed: In the absence of cobalt and nickel, RcnR negatively regulates the expression of genes required for their efflux system; under this condition, RcnR repress its own expression and the expression of its regulated genes. In the presence of cobalt or nickel, RcnR is modified to RcnR-Co or RcnR-Ni, unbinds its target sites enabling the expression of its regulated genes.
Less detailed: In the absence of cobalt or nickel, RcnR negatively regulates the expression of genes needed for detoxification of cobalt and nickel.

Physiology level
Detailed: The presence of cobalt or nickel induces the expression of genes involved with detoxification of cobalt and nickel. Under this condition the genes necessary for efflux of cobalt and nickel are expressed.
Less detailed: The presence of cobalt or nickel induces the expression of genes needfurl for an efflux of cobalt and nickel.
Classification:
Groups: Inorganic ion transport and metabolism
Transcription
Gene Ontology Terms (GO): biological_process GO:0006974 - cellular response to DNA damage stimulus
GO:0006824 - cobalt ion transport
GO:0006811 - ion transport
GO:0045892 - negative regulation of transcription, DNA-templated
GO:0035784 - nickel cation homeostasis
GO:0035444 - nickel cation transmembrane transport
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cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0016021 - integral component of membrane
GO:0005887 - integral component of plasma membrane
GO:0016020 - membrane
GO:0030288 - outer membrane-bounded periplasmic space
GO:0042597 - periplasmic space
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molecular_function GO:0003677 - DNA binding
GO:0046583 - cation efflux transmembrane transporter activity
GO:0005507 - copper ion binding
GO:0046872 - metal ion binding
GO:0015099 - nickel cation transmembrane transporter activity
Components:
  Function Name Type
  protein RcnA protein
  protein RcnB protein
  protein RcnR protein
  complex RcnR-cobalt ion complex
  complex RcnR-nickel complex
  simple_molecule cobalt ion simple_molecule
  simple_molecule cobalt ion_Ext simple_molecule
  simple_molecule nickel simple_molecule
  simple_molecule nickel_Ext simple_molecule
  gene rcnAB gene
  RNA rcnAB_mRNA RNA
  gene rcnR gene
  RNA rcnR_mRNA RNA


Reactions       
Showing 9 reactions
RcnR rcnAB rcnAB_mRNA
Name: rcnAB -> rcnAB_mRNA
Description: Transcription of transcription unit rcnAB. Reaction inhibition by RcnR.
Type: transcription
Pathway Components: rcnAB - RcnR -> rcnAB_mRNA
Components:
Function Name Type
inhibitor RcnR protein
reactant rcnAB gene
product rcnAB_mRNA RNA
RcnR rcnR rcnR_mRNA
Name: rcnR -> rcnR_mRNA
Description: Transcription of transcription unit rcnR. Reaction inhibition by RcnR.
Type: transcription
Pathway Components: rcnR - RcnR -> rcnR_mRNA
Components:
Function Name Type
inhibitor RcnR protein
reactant rcnR gene
product rcnR_mRNA RNA
cobalt ion + RcnR RcnR-cobalt ion
Name: cobalt ion + RcnR -> RcnR-cobalt ion
Description: Reaction transforming cobalt ion, RcnR into RcnR-cobalt ion
Type: state transition
Pathway Components: cobalt ion + RcnR -> RcnR-cobalt ion
Components:
Function Name Type
reactant RcnR protein
product RcnR-cobalt ion complex
reactant cobalt ion simple_molecule
nickel + RcnR RcnR-nickel
Name: nickel + RcnR -> RcnR-nickel
Description: Reaction transforming nickel, RcnR into RcnR-nickel
Type: state transition
Pathway Components: nickel + RcnR -> RcnR-nickel
Components:
Function Name Type
reactant RcnR protein
product RcnR-nickel complex
reactant nickel simple_molecule
rcnR_mRNA RcnR
Name: rcnR_mRNA -> RcnR
Description: Translation of RcnR
Type: translation
Pathway Components: rcnR_mRNA -> RcnR
Components:
Function Name Type
product RcnR protein
reactant rcnR_mRNA RNA
rcnAB_mRNA RcnA
Name: rcnAB_mRNA -> RcnA
Description: Translation of RcnA
Type: translation
Pathway Components: rcnAB_mRNA -> RcnA
Components:
Function Name Type
product RcnA protein
reactant rcnAB_mRNA RNA
RcnA cobalt ion_Ext cobalt ion
Name: cobalt ion_Ext -> cobalt ion
Description: Transport of cobalt ion_Ext through a bacterial membrane, leading to the presence of cobalt ion inside the cell.
Type: transport
Pathway Components: cobalt ion_Ext - RcnA -> cobalt ion
Components:
Function Name Type
catalyzer RcnA protein
product cobalt ion simple_molecule
reactant cobalt ion_Ext simple_molecule
RcnA nickel_Ext nickel
Name: nickel_Ext -> nickel
Description: Transport of nickel_Ext through a bacterial membrane, leading to the presence of nickel inside the cell.
Type: transport
Pathway Components: nickel_Ext - RcnA -> nickel
Components:
Function Name Type
catalyzer RcnA protein
product nickel simple_molecule
reactant nickel_Ext simple_molecule
rcnAB_mRNA RcnB
Name: rcnAB_mRNA -> RcnB
Description: Translation of RcnB
Type: translation
Pathway Components: rcnAB_mRNA -> RcnB
Components:
Function Name Type
product RcnB protein
reactant rcnAB_mRNA RNA



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