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PepA Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
amino acids pepA_mRNA pepA CarB carbonate PepA carbamoyl-P L-glutamate cysteine ammonium phosphate Cys-Gly peptide with an N-terminal X-L-proline CarA CarB carAB peptide with an N-terminal L-proline CarA carAB_mRNA glutamine glycine


Gensor Unit       
Name: PepA
Classification:
Groups: Amino acid transport and metabolism
Gene Ontology Terms (GO): biological_process GO:0044205 - 'de novo' UMP biosynthetic process
GO:0006207 - 'de novo' pyrimidine nucleobase biosynthetic process
GO:0006526 - arginine biosynthetic process
GO:0008652 - cellular amino acid biosynthetic process
GO:0006541 - glutamine metabolic process
GO:0006807 - nitrogen compound metabolic process
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cellular_component GO:0005951 - carbamoyl-phosphate synthase complex
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005622 - intracellular anatomical structure
molecular_function GO:0005524 - ATP binding
GO:0003677 - DNA binding
GO:0016597 - amino acid binding
GO:0004177 - aminopeptidase activity
GO:0004087 - carbamoyl-phosphate synthase (ammonia) activity
GO:0004088 - carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GO:0003824 - catalytic activity
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Components:
  Function Name Type
  protein CarA protein
  protein CarB protein
  complex CarB-CarA complex
  simple_molecule Cys-Gly simple_molecule
  simple_molecule L-glutamate simple_molecule
  protein PepA protein
  simple_molecule amino acids simple_molecule
  simple_molecule ammonium simple_molecule
  gene carAB gene
  RNA carAB_mRNA RNA
  simple_molecule carbamoyl-P simple_molecule
  simple_molecule carbonate simple_molecule
  simple_molecule cysteine simple_molecule
  simple_molecule glutamine simple_molecule
  simple_molecule glycine simple_molecule
  gene pepA gene
  RNA pepA_mRNA RNA
  simple_molecule peptide with an N-terminal L-proline simple_molecule
  simple_molecule peptide with an N-terminal X-L-proline simple_molecule
  simple_molecule phosphate simple_molecule


Reactions       
Showing 11 reactions
PepA carAB carAB_mRNA
Name: carAB -> carAB_mRNA
Description: Transcription of transcription unit carAB. Reaction inhibition by PepA.
Type: transcription
Pathway Components: carAB - PepA -> carAB_mRNA
Components:
Function Name Type
inhibitor PepA protein
reactant carAB gene
product carAB_mRNA RNA
PepA pepA pepA_mRNA
Name: pepA -> pepA_mRNA
Description: Transcription of transcription unit pepA. Reaction inhibition by PepA.
Type: transcription
Pathway Components: pepA - PepA -> pepA_mRNA
Components:
Function Name Type
inhibitor PepA protein
reactant pepA gene
product pepA_mRNA RNA
carAB_mRNA CarA
Name: carAB_mRNA -> CarA
Description: Translation of CarA
Type: translation
Pathway Components: carAB_mRNA -> CarA
Components:
Function Name Type
product CarA protein
reactant carAB_mRNA RNA
CarB + CarA CarB-CarA
Name: CarB + CarA -> CarB-CarA
Description: Reaction transforming CarB, CarA into CarB-CarA
Type: state transition
Pathway Components: CarB + CarA -> CarB-CarA
Components:
Function Name Type
reactant CarA protein
reactant CarB protein
product CarB-CarA complex
CarB-CarA ammonium glutamine + carbonate L-glutamate + carbamoyl-P + phosphate
Name: glutamine + carbonate -> L-glutamate + carbamoyl-P + phosphate
Description: Reaction transforming glutamine, carbonate into L-glutamate, carbamoyl-P , phosphate
Type: state transition
Pathway Components: glutamine + carbonate - CarB-CarA - ammonium -> L-glutamate + carbamoyl-P + phosphate
Components:
Function Name Type
catalyzer CarB-CarA complex
product L-glutamate simple_molecule
inhibitor ammonium simple_molecule
product carbamoyl-P simple_molecule
reactant carbonate simple_molecule
reactant glutamine simple_molecule
product phosphate simple_molecule
CarB-CarA glutamine L-glutamate + ammonium
Name: glutamine -> L-glutamate + ammonium
Description: Reaction transforming glutamine into L-glutamate, ammonium
Type: state transition
Pathway Components: glutamine - CarB-CarA -> L-glutamate + ammonium
Components:
Function Name Type
catalyzer CarB-CarA complex
product L-glutamate simple_molecule
product ammonium simple_molecule
reactant glutamine simple_molecule
CarB-CarA carbonate + ammonium carbamoyl-P + phosphate
Name: carbonate + ammonium -> carbamoyl-P + phosphate
Description: Reaction transforming carbonate, ammonium into carbamoyl-P, phosphate
Type: state transition
Pathway Components: carbonate + ammonium - CarB-CarA -> carbamoyl-P + phosphate
Components:
Function Name Type
catalyzer CarB-CarA complex
reactant ammonium simple_molecule
product carbamoyl-P simple_molecule
reactant carbonate simple_molecule
product phosphate simple_molecule
carAB_mRNA CarB
Name: carAB_mRNA -> CarB
Description: Translation of CarB
Type: translation
Pathway Components: carAB_mRNA -> CarB
Components:
Function Name Type
product CarB protein
reactant carAB_mRNA RNA
pepA_mRNA PepA
Name: pepA_mRNA -> PepA
Description: Translation of PepA
Type: translation
Pathway Components: pepA_mRNA -> PepA
Components:
Function Name Type
product PepA protein
reactant pepA_mRNA RNA
PepA carbonate peptide with an N-terminal X-L-proline Products
Name: peptide with an N-terminal X-L-proline -> peptide with an N-terminal L-proline + amino acids
Description: Reaction transforming peptide with an N-terminal X-L-proline into peptide with an N-terminal L-proline, amino acids
Type: state transition
Pathway Components: peptide with an N-terminal X-L-proline - PepA - carbonate -> peptide with an N-terminal L-proline + amino acids
Components:
Function Name Type
catalyzer PepA protein
product amino acids simple_molecule
inhibitor carbonate simple_molecule
product peptide with an N-terminal L-proline simple_molecule
reactant peptide with an N-terminal X-L-proline simple_molecule
PepA Cys-Gly cysteine + glycine
Name: Cys-Gly -> cysteine + glycine
Description: Reaction transforming Cys-Gly into cysteine, glycine
Type: state transition
Pathway Components: Cys-Gly - PepA -> cysteine + glycine
Components:
Function Name Type
reactant Cys-Gly simple_molecule
catalyzer PepA protein
product cysteine simple_molecule
product glycine simple_molecule
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