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NanR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
fimB N-acetylneuraminate NanS nanATEK-yhcH_mRNA nanATEK-yhcH NanR nanCM_mRNA NanM NanK YjhB N-acetylneuraminate NanC NanA alpha-Neu5Ac nanCM N-acetyl-beta-D-mannosamine NanR N-acetylneuraminate_Ext nanA N-acetyl-alpha-D-glucosamine 6-phosphate fimB_mRNA nanCMS nanCMS_mRNA This Gensor Unit is not yet available beta-Neu5Ac FimB NanT pyruvate YhcH YjhC NanE ManNAc-6-P beta-Neu5Ac_Ext nanA_mRNA This Gensor Unit is not yet available


Gensor Unit       
Name: NanR
Description: Molecular biology level
Detailed: In the absence of N-acetylneuraminate, NanR positively regulates the expression of a gene required for regulation of pilus assembly and negatively regulates the expression of the genes required for N-acetylneuraminate (NANA) transport and catabolic process. Under these conditions, NanR remains unmodified, binds its target sites enabling in some cases and preventing in other cases the expression of its regulated genes. (In the presence of N-acetylneuraminate, NanR unbinds its target sites preventing some genes expression and enabling other genes expression.
Less detailed: In the absence of N-acetylneuraminate, NanR positively regulates the expression of genes needed for regulation of pilus assembly and negatively regulates the expression of genes needed for N-acetylneuraminate transport and catabolic process.

Physiology level
Detailed: The presence of N-acetylneuraminate inhbits the expression of genes involved with regulation of pilus assembly and induces the expression of genes necessary for N-acetylneuraminate transport and catabolic process. Under these conditions the genes necessary for N-acetylneuraminate transport and its conversion to N-acetyl-D-glucosamine-6-phosphate, and conversion of N-acetyl-alfa-neuraminate to N-acetyl-beta-neuraminate are expressed.
Less detailed: The presence of N-acetylneuraminate induces the expression of genes needful for N-acetylneuraminate transport and its conversion to N-acetyl-D-glucosamine-6-phosphate, and conversion of N-acetyl-alfa-neuraminate to N-acetyl-beta-neuraminate. Read more >
Classification:
Groups: General function prediction only
Transcription
Carbohydrate transport and metabolism
Replication, recombination and repair
Amino acid transport and metabolism
Cell wall/membrane/envelope biogenesis
Gene Ontology Terms (GO): biological_process GO:0015074 - DNA integration
GO:0006310 - DNA recombination
GO:0006053 - N-acetylmannosamine catabolic process
GO:0006051 - N-acetylmannosamine metabolic process
GO:0019262 - N-acetylneuraminate catabolic process
GO:0005975 - carbohydrate metabolic process
Read more >
cellular_component GO:0009279 - cell outer membrane
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0045203 - integral component of cell outer membrane
GO:0016021 - integral component of membrane
GO:0005887 - integral component of plasma membrane
GO:0016020 - membrane
Read more >
molecular_function GO:0005524 - ATP binding
GO:0003677 - DNA binding
GO:0008747 - N-acetylneuraminate lyase activity
GO:0047465 - N-acylglucosamine-6-phosphate 2-epimerase activity
GO:0009384 - N-acylmannosamine kinase activity
GO:0015144 - carbohydrate transmembrane transporter activity
GO:0005351 - carbohydrate:proton symporter activity
Read more >
Components:
  Function Name Type
  simple_molecule α-Neu5Ac simple_molecule
  protein FimB protein
  simple_molecule ManNAc-6-P simple_molecule
  simple_molecule N-acetyl-α-D-glucosamine 6-phosphate simple_molecule
  simple_molecule N-acetyl-beta-D-mannosamine simple_molecule
  simple_molecule N-acetylneuraminate simple_molecule
  simple_molecule N-acetylneuraminate_Ext simple_molecule
  protein NanA protein
  protein NanC protein
  protein NanE protein
  protein NanK protein
  protein NanM protein
  protein NanR protein
  complex NanR-N-acetylneuraminate complex
  protein NanS protein
  protein NanT protein
  protein YhcH protein
  protein YjhB protein
  protein YjhC protein
  simple_molecule beta-Neu5Ac simple_molecule
  simple_molecule beta-Neu5Ac_Ext simple_molecule
  gene fimB gene
  RNA fimB_mRNA RNA
  gene nanA gene
  gene nanATEK-yhcH gene
  RNA nanATEK-yhcH_mRNA RNA
  RNA nanA_mRNA RNA
  gene nanCM gene
  gene nanCMS gene
  RNA nanCMS_mRNA RNA
  RNA nanCM_mRNA RNA
  simple_molecule pyruvate simple_molecule
  gene yjhBC gene
  RNA yjhBC_mRNA RNA


Reactions       
Showing 28 reactions
NanR fimB fimB_mRNA
Name: fimB -> fimB_mRNA
Description: Transcription of transcription unit fimB. Reaction activation by NanR.
Type: transcription
Pathway Components: fimB - NanR -> fimB_mRNA
Components:
Function Name Type
activator NanR protein
reactant fimB gene
product fimB_mRNA RNA
NanR nanA nanA_mRNA
Name: nanA -> nanA_mRNA
Description: Transcription of transcription unit nanA. Reaction inhibition by NanR.
Type: transcription
Pathway Components: nanA - NanR -> nanA_mRNA
Components:
Function Name Type
inhibitor NanR protein
reactant nanA gene
product nanA_mRNA RNA
NanR nanATEK-yhcH nanATEK-yhcH_mRNA
Name: nanATEK-yhcH -> nanATEK-yhcH_mRNA
Description: Transcription of transcription unit nanATEK-yhcH. Reaction inhibition by NanR.
Type: transcription
Pathway Components: nanATEK-yhcH - NanR -> nanATEK-yhcH_mRNA
Components:
Function Name Type
inhibitor NanR protein
reactant nanATEK-yhcH gene
product nanATEK-yhcH_mRNA RNA
NanR nanCM nanCM_mRNA
Name: nanCM -> nanCM_mRNA
Description: Transcription of transcription unit nanCM. Reaction inhibition by NanR.
Type: transcription
Pathway Components: nanCM - NanR -> nanCM_mRNA
Components:
Function Name Type
inhibitor NanR protein
reactant nanCM gene
product nanCM_mRNA RNA
NanR nanCMS nanCMS_mRNA
Name: nanCMS -> nanCMS_mRNA
Description: Transcription of transcription unit nanCMS. Reaction inhibition by NanR.
Type: transcription
Pathway Components: nanCMS - NanR -> nanCMS_mRNA
Components:
Function Name Type
inhibitor NanR protein
reactant nanCMS gene
product nanCMS_mRNA RNA
NanR yjhBC yjhBC_mRNA
Name: yjhBC -> yjhBC_mRNA
Description: Transcription of transcription unit yjhBC. Reaction inhibition by NanR.
Type: transcription
Pathway Components: yjhBC - NanR -> yjhBC_mRNA
Components:
Function Name Type
inhibitor NanR protein
reactant yjhBC gene
product yjhBC_mRNA RNA
N-acetylneuraminate + NanR NanR-N-acetylneuraminate
Name: N-acetylneuraminate + NanR -> NanR-N-acetylneuraminate
Description: Reaction transforming N-acetylneuraminate, NanR into NanR-N-acetylneuraminate
Type: state transition
Pathway Components: N-acetylneuraminate + NanR -> NanR-N-acetylneuraminate
Components:
Function Name Type
reactant N-acetylneuraminate simple_molecule
reactant NanR protein
product NanR-N-acetylneuraminate complex
nanCMS_mRNA NanC
Name: nanCMS_mRNA -> NanC
Description: Translation of NanC
Type: translation
Pathway Components: nanCMS_mRNA -> NanC
Components:
Function Name Type
product NanC protein
reactant nanCMS_mRNA RNA
NanC NanT N-acetylneuraminate_Ext N-acetylneuraminate
Name: N-acetylneuraminate_Ext -> N-acetylneuraminate
Description: Transport of N-acetylneuraminate_Ext through a bacterial membrane, leading to the presence of N-acetylneuraminate inside the cell.
Type: transport
Pathway Components: N-acetylneuraminate_Ext - NanC - NanT -> N-acetylneuraminate
Components:
Function Name Type
product N-acetylneuraminate simple_molecule
reactant N-acetylneuraminate_Ext simple_molecule
catalyzer NanC protein
catalyzer NanT protein
NanC NanT beta-Neu5Ac_Ext beta-Neu5Ac
Name: beta-Neu5Ac_Ext -> beta-Neu5Ac
Description: Transport of beta-Neu5Ac_Ext through a bacterial membrane, leading to the presence of beta-Neu5Ac inside the cell.
Type: transport
Pathway Components: beta-Neu5Ac_Ext - NanC - NanT -> beta-Neu5Ac
Components:
Function Name Type
catalyzer NanC protein
catalyzer NanT protein
product beta-Neu5Ac simple_molecule
reactant beta-Neu5Ac_Ext simple_molecule
nanCMS_mRNA NanM
Name: nanCMS_mRNA -> NanM
Description: Translation of NanM
Type: translation
Pathway Components: nanCMS_mRNA -> NanM
Components:
Function Name Type
product NanM protein
reactant nanCMS_mRNA RNA
NanM α-Neu5Ac beta-Neu5Ac
Name: α-Neu5Ac -> beta-Neu5Ac
Description: Reaction transforming α-Neu5Ac into beta-Neu5Ac
Type: state transition
Pathway Components: α-Neu5Ac - NanM -> beta-Neu5Ac
Components:
Function Name Type
reactant α-Neu5Ac simple_molecule
catalyzer NanM protein
product beta-Neu5Ac simple_molecule
nanCMS_mRNA NanS
Name: nanCMS_mRNA -> NanS
Description: Translation of NanS
Type: translation
Pathway Components: nanCMS_mRNA -> NanS
Components:
Function Name Type
product NanS protein
reactant nanCMS_mRNA RNA
nanA_mRNA NanA
Name: nanA_mRNA -> NanA
Description: Translation of NanA
Type: translation
Pathway Components: nanA_mRNA -> NanA
Components:
Function Name Type
product NanA protein
reactant nanA_mRNA RNA
NanA pyruvate N-acetylneuraminate N-acetyl-beta-D-mannosamine + pyruvate
Name: N-acetylneuraminate -> N-acetyl-beta-D-mannosamine + pyruvate
Description: Reaction transforming N-acetylneuraminate into N-acetyl-beta-D-mannosamine, pyruvate
Type: state transition
Pathway Components: N-acetylneuraminate - NanA - pyruvate -> N-acetyl-beta-D-mannosamine + pyruvate
Components:
Function Name Type
product N-acetyl-beta-D-mannosamine simple_molecule
reactant N-acetylneuraminate simple_molecule
catalyzer NanA protein
inhibitor pyruvate simple_molecule
product pyruvate simple_molecule
NanA pyruvate beta-Neu5Ac N-acetyl-beta-D-mannosamine + pyruvate
Name: beta-Neu5Ac -> N-acetyl-beta-D-mannosamine + pyruvate
Description: Reaction transforming beta-Neu5Ac into N-acetyl-beta-D-mannosamine, pyruvate
Type: state transition
Pathway Components: beta-Neu5Ac - NanA - pyruvate -> N-acetyl-beta-D-mannosamine + pyruvate
Components:
Function Name Type
product N-acetyl-beta-D-mannosamine simple_molecule
catalyzer NanA protein
reactant beta-Neu5Ac simple_molecule
inhibitor pyruvate simple_molecule
product pyruvate simple_molecule
fimB_mRNA FimB
Name: fimB_mRNA -> FimB
Description: Translation of FimB
Type: translation
Pathway Components: fimB_mRNA -> FimB
Components:
Function Name Type
product FimB protein
reactant fimB_mRNA RNA
yjhBC_mRNA YjhB
Name: yjhBC_mRNA -> YjhB
Description: Translation of YjhB
Type: translation
Pathway Components: yjhBC_mRNA -> YjhB
Components:
Function Name Type
product YjhB protein
reactant yjhBC_mRNA RNA
yjhBC_mRNA YjhC
Name: yjhBC_mRNA -> YjhC
Description: Translation of YjhC
Type: translation
Pathway Components: yjhBC_mRNA -> YjhC
Components:
Function Name Type
product YjhC protein
reactant yjhBC_mRNA RNA
nanCM_mRNA NanC
Name: nanCM_mRNA -> NanC
Description: Translation of NanC
Type: translation
Pathway Components: nanCM_mRNA -> NanC
Components:
Function Name Type
product NanC protein
reactant nanCM_mRNA RNA
nanCM_mRNA NanM
Name: nanCM_mRNA -> NanM
Description: Translation of NanM
Type: translation
Pathway Components: nanCM_mRNA -> NanM
Components:
Function Name Type
product NanM protein
reactant nanCM_mRNA RNA
nanATEK-yhcH_mRNA NanA
Name: nanATEK-yhcH_mRNA -> NanA
Description: Translation of NanA
Type: translation
Pathway Components: nanATEK-yhcH_mRNA -> NanA
Components:
Function Name Type
product NanA protein
reactant nanATEK-yhcH_mRNA RNA
nanATEK-yhcH_mRNA NanT
Name: nanATEK-yhcH_mRNA -> NanT
Description: Translation of NanT
Type: translation
Pathway Components: nanATEK-yhcH_mRNA -> NanT
Components:
Function Name Type
product NanT protein
reactant nanATEK-yhcH_mRNA RNA
nanATEK-yhcH_mRNA NanE
Name: nanATEK-yhcH_mRNA -> NanE
Description: Translation of NanE
Type: translation
Pathway Components: nanATEK-yhcH_mRNA -> NanE
Components:
Function Name Type
product NanE protein
reactant nanATEK-yhcH_mRNA RNA
NanE ManNAc-6-P N-acetyl-α-D-glucosamine 6-phosphate
Name: ManNAc-6-P -> N-acetyl-α-D-glucosamine 6-phosphate
Description: Reaction transforming ManNAc-6-P into N-acetyl-α-D-glucosamine 6-phosphate
Type: state transition
Pathway Components: ManNAc-6-P - NanE -> N-acetyl-α-D-glucosamine 6-phosphate
Components:
Function Name Type
reactant ManNAc-6-P simple_molecule
product N-acetyl-α-D-glucosamine 6-phosphate simple_molecule
catalyzer NanE protein
nanATEK-yhcH_mRNA NanK
Name: nanATEK-yhcH_mRNA -> NanK
Description: Translation of NanK
Type: translation
Pathway Components: nanATEK-yhcH_mRNA -> NanK
Components:
Function Name Type
product NanK protein
reactant nanATEK-yhcH_mRNA RNA
NanK N-acetyl-beta-D-mannosamine ManNAc-6-P
Name: N-acetyl-beta-D-mannosamine -> ManNAc-6-P
Description: Reaction transforming N-acetyl-beta-D-mannosamine into ManNAc-6-P
Type: state transition
Pathway Components: N-acetyl-beta-D-mannosamine - NanK -> ManNAc-6-P
Components:
Function Name Type
product ManNAc-6-P simple_molecule
reactant N-acetyl-beta-D-mannosamine simple_molecule
catalyzer NanK protein
nanATEK-yhcH_mRNA YhcH
Name: nanATEK-yhcH_mRNA -> YhcH
Description: Translation of YhcH
Type: translation
Pathway Components: nanATEK-yhcH_mRNA -> YhcH
Components:
Function Name Type
product YhcH protein
reactant nanATEK-yhcH_mRNA RNA



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