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NadR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
NadA iminoaspartate NadR NaMN nicotinamide ribose_Ext fumarate diphosphate perhydrol nadB_mRNA nadA-pnuC_mRNA pncB_mRNA nicotinamide ribose niacin quinolinate PnuC oxygen aspartate NadB PRPP DHAP nadA-pnuC nadB PncB pncB


Gensor Unit       
Name: NadR
Classification:
Groups: Coenzyme transport and metabolism
Gene Ontology Terms (GO): biological_process GO:0034628 - 'de novo' NAD biosynthetic process from aspartate
GO:0009435 - NAD biosynthetic process
GO:0034258 - nicotinamide riboside transport
GO:0055114 - oxidation-reduction process
GO:0019363 - pyridine nucleotide biosynthetic process
GO:0019805 - quinolinate biosynthetic process
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cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0016021 - integral component of membrane
GO:0005887 - integral component of plasma membrane
GO:0016020 - membrane
GO:0005886 - plasma membrane
molecular_function GO:0051539 - 4 iron, 4 sulfur cluster binding
GO:0008734 - L-aspartate oxidase activity
GO:0044318 - L-aspartate:fumarate oxidoreductase activity
GO:0050660 - flavin adenine dinucleotide binding
GO:0051536 - iron-sulfur cluster binding
GO:0016874 - ligase activity
GO:0016879 - ligase activity, forming carbon-nitrogen bonds
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Components:
  Function Name Type
  simple_molecule DHAP simple_molecule
  simple_molecule NaMN simple_molecule
  protein NadA protein
  protein NadB protein
  protein NadR protein
  simple_molecule PRPP simple_molecule
  protein PncB protein
  protein PnuC protein
  simple_molecule aspartate simple_molecule
  simple_molecule diphosphate simple_molecule
  simple_molecule fumarate simple_molecule
  simple_molecule iminoaspartate simple_molecule
  gene nadA-pnuC gene
  RNA nadA-pnuC_mRNA RNA
  gene nadB gene
  RNA nadB_mRNA RNA
  simple_molecule niacin simple_molecule
  simple_molecule nicotinamide ribose simple_molecule
  simple_molecule nicotinamide ribose_Ext simple_molecule
  simple_molecule oxygen simple_molecule
  simple_molecule perhydrol simple_molecule
  simple_molecule phosphate simple_molecule
  gene pncB gene
  RNA pncB_mRNA RNA
  simple_molecule quinolinate simple_molecule
  simple_molecule succinate simple_molecule


Reactions       
Showing 12 reactions
NadR nadA-pnuC nadA-pnuC_mRNA
Name: nadA-pnuC -> nadA-pnuC_mRNA
Description: Transcription of transcription unit nadA-pnuC. Reaction inhibition by NadR.
Type: transcription
Pathway Components: nadA-pnuC - NadR -> nadA-pnuC_mRNA
Components:
Function Name Type
inhibitor NadR protein
reactant nadA-pnuC gene
product nadA-pnuC_mRNA RNA
NadR nadB nadB_mRNA
Name: nadB -> nadB_mRNA
Description: Transcription of transcription unit nadB. Reaction inhibition by NadR.
Type: transcription
Pathway Components: nadB - NadR -> nadB_mRNA
Components:
Function Name Type
inhibitor NadR protein
reactant nadB gene
product nadB_mRNA RNA
NadR pncB pncB_mRNA
Name: pncB -> pncB_mRNA
Description: Transcription of transcription unit pncB. Reaction inhibition by NadR.
Type: transcription
Pathway Components: pncB - NadR -> pncB_mRNA
Components:
Function Name Type
inhibitor NadR protein
reactant pncB gene
product pncB_mRNA RNA
pncB_mRNA PncB
Name: pncB_mRNA -> PncB
Description: Translation of PncB
Type: translation
Pathway Components: pncB_mRNA -> PncB
Components:
Function Name Type
product PncB protein
reactant pncB_mRNA RNA
PncB niacin + PRPP diphosphate + phosphate + NaMN
Name: niacin + PRPP -> diphosphate + phosphate + NaMN
Description: Reaction transforming niacin, PRPP into diphosphate, phosphate , NaMN
Type: state transition
Pathway Components: niacin + PRPP - PncB -> diphosphate + phosphate + NaMN
Components:
Function Name Type
product NaMN simple_molecule
reactant PRPP simple_molecule
catalyzer PncB protein
product diphosphate simple_molecule
reactant niacin simple_molecule
product phosphate simple_molecule
nadB_mRNA NadB
Name: nadB_mRNA -> NadB
Description: Translation of NadB
Type: translation
Pathway Components: nadB_mRNA -> NadB
Components:
Function Name Type
product NadB protein
reactant nadB_mRNA RNA
NadB iminoaspartate aspartate + oxygen iminoaspartate + perhydrol
Name: aspartate + oxygen -> iminoaspartate + perhydrol
Description: Reaction transforming aspartate, oxygen into iminoaspartate, perhydrol
Type: state transition
Pathway Components: aspartate + oxygen - NadB - iminoaspartate -> iminoaspartate + perhydrol
Components:
Function Name Type
catalyzer NadB protein
reactant aspartate simple_molecule
inhibitor iminoaspartate simple_molecule
product iminoaspartate simple_molecule
reactant oxygen simple_molecule
product perhydrol simple_molecule
NadB aspartate + fumarate iminoaspartate + succinate
Name: aspartate + fumarate -> iminoaspartate + succinate
Description: Reaction transforming aspartate, fumarate into iminoaspartate, succinate
Type: state transition
Pathway Components: aspartate + fumarate - NadB -> iminoaspartate + succinate
Components:
Function Name Type
catalyzer NadB protein
reactant aspartate simple_molecule
reactant fumarate simple_molecule
product iminoaspartate simple_molecule
product succinate simple_molecule
nadA-pnuC_mRNA NadA
Name: nadA-pnuC_mRNA -> NadA
Description: Translation of NadA
Type: translation
Pathway Components: nadA-pnuC_mRNA -> NadA
Components:
Function Name Type
product NadA protein
reactant nadA-pnuC_mRNA RNA
NadA oxygen iminoaspartate + DHAP quinolinate + phosphate
Name: iminoaspartate + DHAP -> quinolinate + phosphate
Description: Reaction transforming iminoaspartate, DHAP into quinolinate, phosphate
Type: state transition
Pathway Components: iminoaspartate + DHAP - NadA - oxygen -> quinolinate + phosphate
Components:
Function Name Type
reactant DHAP simple_molecule
catalyzer NadA protein
reactant iminoaspartate simple_molecule
inhibitor oxygen simple_molecule
product phosphate simple_molecule
product quinolinate simple_molecule
nadA-pnuC_mRNA PnuC
Name: nadA-pnuC_mRNA -> PnuC
Description: Translation of PnuC
Type: translation
Pathway Components: nadA-pnuC_mRNA -> PnuC
Components:
Function Name Type
product PnuC protein
reactant nadA-pnuC_mRNA RNA
PnuC nicotinamide ribose_Ext nicotinamide ribose
Name: nicotinamide ribose_Ext -> nicotinamide ribose
Description: Transport of nicotinamide ribose_Ext through a bacterial membrane, leading to the presence of nicotinamide ribose inside the cell.
Type: transport
Pathway Components: nicotinamide ribose_Ext - PnuC -> nicotinamide ribose
Components:
Function Name Type
catalyzer PnuC protein
product nicotinamide ribose simple_molecule
reactant nicotinamide ribose_Ext simple_molecule



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