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MntR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
Cadmium mntP_mRNA mntH_mRNA Mn(II) rybA-mntS Fe+2 mntH Dps dps Fe+2_Ext dps_mRNA Mn(II)_Ext mntP MntR MntH MntP MntR MntS Mn(II) MntR rybA-mntS_mRNA Cadmium RNA:RybA


Gensor Unit       
Name: MntR
Description: Molecular biology level
Detailed: In the presence of Mn(II), MntR positively regulates the expression of genes required for manganese transport and negatively regulates the expression of genes required for iron transport. Under these conditions, MntR is modified to MntR-Mn(II), binds its target sites preventing the expression of some of its regulated genes and enabling the expression of others. (Conversely,) in the absence of Mn(II), MntR unbinds its target sites enabling in some cases and preventing in others the expression of its regulated genes.
Less detailed: In the presence of Mn(II), MntR positively regulates the expression of genes needed for manganese and iron transport.

Physiology level
Detailed: The presence of Mn(II) induces the expression of genes involved with manganese transport. Under these conditions the genes necessary for transport of Mn(II) and Fe+2 into cell are expressed.
Less detailed: The presence of Mn(II) induces the expression of genes needful for manganese and iron transport into the cell.
Classification:
Groups: Inorganic ion transport and metabolism
Gene Ontology Terms (GO): biological_process GO:0070574 - cadmium ion transmembrane transport
GO:0015691 - cadmium ion transport
GO:0006879 - cellular iron ion homeostasis
GO:0030026 - cellular manganese ion homeostasis
GO:0071287 - cellular response to manganese ion
GO:0034599 - cellular response to oxidative stress
Read more >
cellular_component GO:0005737 - cytoplasm
GO:0016021 - integral component of membrane
GO:0005887 - integral component of plasma membrane
GO:0016020 - membrane
GO:0009295 - nucleoid
GO:0005886 - plasma membrane
molecular_function GO:0003677 - DNA binding
GO:0015086 - cadmium ion transmembrane transporter activity
GO:0008199 - ferric iron binding
GO:0042802 - identical protein binding
GO:0005384 - manganese ion transmembrane transporter activity
GO:0046872 - metal ion binding
GO:0046873 - metal ion transmembrane transporter activity
Read more >
Components:
  Function Name Type
  simple_molecule Cadmium simple_molecule
  protein Dps protein
  simple_molecule Fe+2 simple_molecule
  simple_molecule Fe+2_Ext simple_molecule
  simple_molecule Mn(II) simple_molecule
  simple_molecule Mn(II)_Ext simple_molecule
  protein MntH protein
  protein MntP protein
  protein MntR protein
  complex MntR-Cadmium complex
  complex MntR-Mn(II) complex
  protein MntS protein
  protein RNA:RybA protein
  gene dps gene
  RNA dps_mRNA RNA
  gene mntH gene
  RNA mntH_mRNA RNA
  gene mntP gene
  RNA mntP_mRNA RNA
  gene rybA-mntS gene
  RNA rybA-mntS_mRNA RNA


Reactions       
Showing 13 reactions
Mn(II) + MntR MntR-Mn(II)
Name: Mn(II) + MntR -> MntR-Mn(II)
Description: Reaction transforming Mn(II), MntR into MntR-Mn(II)
Type: state transition
Pathway Components: Mn(II) + MntR -> MntR-Mn(II)
Components:
Function Name Type
reactant Mn(II) simple_molecule
reactant MntR protein
product MntR-Mn(II) complex
MntR-Mn(II) mntP mntP_mRNA
Name: mntP -> mntP_mRNA
Description: Transcription of transcription unit mntP. Reaction activation by MntR-Mn(II).
Type: transcription
Pathway Components: mntP - MntR-Mn(II) -> mntP_mRNA
Components:
Function Name Type
activator MntR-Mn(II) complex
reactant mntP gene
product mntP_mRNA RNA
MntR-Mn(II) dps dps_mRNA
Name: dps -> dps_mRNA
Description: Transcription of transcription unit dps. Reaction inhibition by MntR-Mn(II).
Type: transcription
Pathway Components: dps - MntR-Mn(II) -> dps_mRNA
Components:
Function Name Type
inhibitor MntR-Mn(II) complex
reactant dps gene
product dps_mRNA RNA
MntR-Mn(II) mntH mntH_mRNA
Name: mntH -> mntH_mRNA
Description: Transcription of transcription unit mntH. Reaction inhibition by MntR-Mn(II).
Type: transcription
Pathway Components: mntH - MntR-Mn(II) -> mntH_mRNA
Components:
Function Name Type
inhibitor MntR-Mn(II) complex
reactant mntH gene
product mntH_mRNA RNA
MntR-Mn(II) rybA-mntS rybA-mntS_mRNA
Name: rybA-mntS -> rybA-mntS_mRNA
Description: Transcription of transcription unit rybA-mntS. Reaction inhibition by MntR-Mn(II).
Type: transcription
Pathway Components: rybA-mntS - MntR-Mn(II) -> rybA-mntS_mRNA
Components:
Function Name Type
inhibitor MntR-Mn(II) complex
reactant rybA-mntS gene
product rybA-mntS_mRNA RNA
Cadmium + MntR MntR-Cadmium
Name: Cadmium + MntR -> MntR-Cadmium
Description: Reaction transforming Cadmium, MntR into MntR-Cadmium
Type: state transition
Pathway Components: Cadmium + MntR -> MntR-Cadmium
Components:
Function Name Type
reactant Cadmium simple_molecule
reactant MntR protein
product MntR-Cadmium complex
mntH_mRNA MntH
Name: mntH_mRNA -> MntH
Description: Translation of MntH
Type: translation
Pathway Components: mntH_mRNA -> MntH
Components:
Function Name Type
product MntH protein
reactant mntH_mRNA RNA
MntH Fe+2_Ext Fe+2
Name: Fe+2_Ext -> Fe+2
Description: Transport of Fe+2_Ext through a bacterial membrane, leading to the presence of Fe+2 inside the cell.
Type: transport
Pathway Components: Fe+2_Ext - MntH -> Fe+2
Components:
Function Name Type
product Fe+2 simple_molecule
reactant Fe+2_Ext simple_molecule
catalyzer MntH protein
MntH MntP Mn(II)_Ext Mn(II)
Name: Mn(II)_Ext -> Mn(II)
Description: Transport of Mn(II)_Ext through a bacterial membrane, leading to the presence of Mn(II) inside the cell.
Type: transport
Pathway Components: Mn(II)_Ext - MntH - MntP -> Mn(II)
Components:
Function Name Type
product Mn(II) simple_molecule
reactant Mn(II)_Ext simple_molecule
catalyzer MntH protein
catalyzer MntP protein
mntP_mRNA MntP
Name: mntP_mRNA -> MntP
Description: Translation of MntP
Type: translation
Pathway Components: mntP_mRNA -> MntP
Components:
Function Name Type
product MntP protein
reactant mntP_mRNA RNA
dps_mRNA Dps
Name: dps_mRNA -> Dps
Description: Translation of Dps
Type: translation
Pathway Components: dps_mRNA -> Dps
Components:
Function Name Type
product Dps protein
reactant dps_mRNA RNA
rybA-mntS_mRNA RNA:RybA
Name: rybA-mntS_mRNA -> RNA:RybA
Description: Translation of RNA:RybA
Type: translation
Pathway Components: rybA-mntS_mRNA -> RNA:RybA
Components:
Function Name Type
product RNA:RybA protein
reactant rybA-mntS_mRNA RNA
rybA-mntS_mRNA MntS
Name: rybA-mntS_mRNA -> MntS
Description: Translation of MntS
Type: translation
Pathway Components: rybA-mntS_mRNA -> MntS
Components:
Function Name Type
product MntS protein
reactant rybA-mntS_mRNA RNA



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