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MprA Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
caprate_Ext EmrB acriflavine drug MprA 2,4-DNP AcrA AcrB mprA-emrAB TolC acriflavine_Ext hexane AcrB nmpC_mRNA enterobactin chenodiol_Ext CCCP TolC AcrD enterobactin_Ext EmrB nmpC EmrA NmpC 2,4-DNP CCCP acrAB_mRNA AcrA mprA-emrAB_mRNA AcrA AcrD chenodiol Carbonyl cyanide p-(trifluoro-methoxy)phenylhydrazone acrAB TolC caprate EmrA hexane_Ext MprA Carbonyl cyanide p-(trifluoro-methoxy)phenylhydrazone TolC drug_Ext MprA MprA


Gensor Unit       
Name: MprA
Classification:
Groups: Transcription
Carbohydrate transport and metabolism
Defense mechanisms
Cell wall/membrane/envelope biogenesis
Gene Ontology Terms (GO): biological_process GO:0015895 - alkane transport
GO:0015721 - bile acid and bile salt transport
GO:0046618 - drug export
GO:0006855 - drug transmembrane transport
GO:0042930 - enterobactin transport
GO:0015908 - fatty acid transport
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cellular_component GO:0009279 - cell outer membrane
GO:0005829 - cytosol
GO:1990281 - efflux pump complex
GO:0016021 - integral component of membrane
GO:0005887 - integral component of plasma membrane
GO:0031237 - intrinsic component of periplasmic side of plasma membrane
GO:0031226 - intrinsic component of plasma membrane
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molecular_function GO:0003677 - DNA binding
GO:0003700 - DNA-binding transcription factor activity
GO:0015567 - alkane transmembrane transporter activity
GO:0015125 - bile acid transmembrane transporter activity
GO:0015562 - efflux transmembrane transporter activity
GO:0042931 - enterobactin transmembrane transporter activity
GO:0042802 - identical protein binding
Read more >
Components:
  Function Name Type
  simple_molecule 2,4-DNP simple_molecule
  protein AcrA protein
  complex AcrA-TolC-AcrB complex
  protein AcrB protein
  protein AcrD protein
  complex AcrD-AcrA-TolC complex
  simple_molecule CCCP simple_molecule
  simple_molecule Carbonyl cyanide p-(trifluoro-methoxy)phenylhydrazone simple_molecule
  protein EmrA protein
  complex EmrA-EmrB-TolC complex
  protein EmrB protein
  protein MprA protein
  complex MprA-2,4-DNP complex
  complex MprA-CCCP complex
  complex MprA-Carbonyl cyanide p-(trifluoro-methoxy)phenylhydrazone complex
  protein NmpC protein
  protein TolC protein
  gene acrAB gene
  RNA acrAB_mRNA RNA
  simple_molecule acriflavine simple_molecule
  simple_molecule acriflavine_Ext simple_molecule
  simple_molecule caprate simple_molecule
  simple_molecule caprate_Ext simple_molecule
  simple_molecule chenodiol simple_molecule
  simple_molecule chenodiol_Ext simple_molecule
  simple_molecule drug simple_molecule
  simple_molecule drug_Ext simple_molecule
  simple_molecule enterobactin simple_molecule
  simple_molecule enterobactin_Ext simple_molecule
  simple_molecule hexane simple_molecule
  simple_molecule hexane_Ext simple_molecule
  gene mprA-emrAB gene
  RNA mprA-emrAB_mRNA RNA
  gene nmpC gene
  RNA nmpC_mRNA RNA


Reactions       
Showing 21 reactions
MprA acrAB acrAB_mRNA
Name: acrAB -> acrAB_mRNA
Description: Transcription of transcription unit acrAB. Reaction inhibition by MprA.
Type: transcription
Pathway Components: acrAB - MprA -> acrAB_mRNA
Components:
Function Name Type
inhibitor MprA protein
reactant acrAB gene
product acrAB_mRNA RNA
MprA mprA-emrAB mprA-emrAB_mRNA
Name: mprA-emrAB -> mprA-emrAB_mRNA
Description: Transcription of transcription unit mprA-emrAB. Reaction inhibition by MprA.
Type: transcription
Pathway Components: mprA-emrAB - MprA -> mprA-emrAB_mRNA
Components:
Function Name Type
inhibitor MprA protein
reactant mprA-emrAB gene
product mprA-emrAB_mRNA RNA
MprA nmpC nmpC_mRNA
Name: nmpC -> nmpC_mRNA
Description: Transcription of transcription unit nmpC. Reaction inhibition by MprA.
Type: transcription
Pathway Components: nmpC - MprA -> nmpC_mRNA
Components:
Function Name Type
inhibitor MprA protein
reactant nmpC gene
product nmpC_mRNA RNA
2,4-DNP + MprA MprA-2,4-DNP
Name: 2,4-DNP + MprA -> MprA-2,4-DNP
Description: Reaction transforming 2,4-DNP, MprA into MprA-2,4-DNP
Type: state transition
Pathway Components: 2,4-DNP + MprA -> MprA-2,4-DNP
Components:
Function Name Type
reactant 2,4-DNP simple_molecule
reactant MprA protein
product MprA-2,4-DNP complex
CCCP + MprA MprA-CCCP
Name: CCCP + MprA -> MprA-CCCP
Description: Reaction transforming CCCP, MprA into MprA-CCCP
Type: state transition
Pathway Components: CCCP + MprA -> MprA-CCCP
Components:
Function Name Type
reactant CCCP simple_molecule
reactant MprA protein
product MprA-CCCP complex
TF + effector TF - effector Complex
Name: Carbonyl cyanide p-(trifluoro-methoxy)phenylhydrazone + MprA -> MprA-Carbonyl cyanide p-(trifluoro-methoxy)phenylhydrazone
Description: Reaction transforming Carbonyl cyanide p-(trifluoro-methoxy)phenylhydrazone, MprA into MprA-Carbonyl cyanide p-(trifluoro-methoxy)phenylhydrazone
Type: state transition
Pathway Components: Carbonyl cyanide p-(trifluoro-methoxy)phenylhydrazone + MprA -> MprA-Carbonyl cyanide p-(trifluoro-methoxy)phenylhydrazone
Components:
Function Name Type
reactant Carbonyl cyanide p-(trifluoro-methoxy)phenylhydrazone simple_molecule
reactant MprA protein
product MprA-Carbonyl cyanide p-(trifluoro-methoxy)phenylhydrazone complex
acrAB_mRNA AcrA
Name: acrAB_mRNA -> AcrA
Description: Translation of AcrA
Type: translation
Pathway Components: acrAB_mRNA -> AcrA
Components:
Function Name Type
product AcrA protein
reactant acrAB_mRNA RNA
AcrD + TolC + AcrA AcrD-AcrA-TolC
Name: AcrD + TolC + AcrA -> AcrD-AcrA-TolC
Description: Reaction transforming AcrD, TolC, AcrA into AcrD-AcrA-TolC
Type: state transition
Pathway Components: AcrD + TolC + AcrA -> AcrD-AcrA-TolC
Components:
Function Name Type
reactant AcrA protein
reactant AcrD protein
product AcrD-AcrA-TolC complex
reactant TolC protein
AcrA-TolC-AcrB AcrD-AcrA-TolC EmrA-EmrB-TolC drug_Ext drug
Name: drug_Ext -> drug
Description: Transport of drug_Ext through a bacterial membrane, leading to the presence of drug inside the cell.
Type: transport
Pathway Components: drug_Ext - AcrA-TolC-AcrB - AcrD-AcrA-TolC - EmrA-EmrB-TolC -> drug
Components:
Function Name Type
catalyzer AcrA-TolC-AcrB complex
catalyzer AcrD-AcrA-TolC complex
catalyzer EmrA-EmrB-TolC complex
product drug simple_molecule
reactant drug_Ext simple_molecule
AcrB + TolC + AcrA AcrA-TolC-AcrB
Name: AcrB + TolC + AcrA -> AcrA-TolC-AcrB
Description: Reaction transforming AcrB, TolC, AcrA into AcrA-TolC-AcrB
Type: state transition
Pathway Components: AcrB + TolC + AcrA -> AcrA-TolC-AcrB
Components:
Function Name Type
reactant AcrA protein
product AcrA-TolC-AcrB complex
reactant AcrB protein
reactant TolC protein
AcrA-TolC-AcrB acriflavine_Ext acriflavine
Name: acriflavine_Ext -> acriflavine
Description: Transport of acriflavine_Ext through a bacterial membrane, leading to the presence of acriflavine inside the cell.
Type: transport
Pathway Components: acriflavine_Ext - AcrA-TolC-AcrB -> acriflavine
Components:
Function Name Type
catalyzer AcrA-TolC-AcrB complex
product acriflavine simple_molecule
reactant acriflavine_Ext simple_molecule
AcrA-TolC-AcrB chenodiol_Ext chenodiol
Name: chenodiol_Ext -> chenodiol
Description: Transport of chenodiol_Ext through a bacterial membrane, leading to the presence of chenodiol inside the cell.
Type: transport
Pathway Components: chenodiol_Ext - AcrA-TolC-AcrB -> chenodiol
Components:
Function Name Type
catalyzer AcrA-TolC-AcrB complex
product chenodiol simple_molecule
reactant chenodiol_Ext simple_molecule
AcrA-TolC-AcrB caprate_Ext caprate
Name: caprate_Ext -> caprate
Description: Transport of caprate_Ext through a bacterial membrane, leading to the presence of caprate inside the cell.
Type: transport
Pathway Components: caprate_Ext - AcrA-TolC-AcrB -> caprate
Components:
Function Name Type
catalyzer AcrA-TolC-AcrB complex
product caprate simple_molecule
reactant caprate_Ext simple_molecule
AcrA-TolC-AcrB hexane_Ext hexane
Name: hexane_Ext -> hexane
Description: Transport of hexane_Ext through a bacterial membrane, leading to the presence of hexane inside the cell.
Type: transport
Pathway Components: hexane_Ext - AcrA-TolC-AcrB -> hexane
Components:
Function Name Type
catalyzer AcrA-TolC-AcrB complex
product hexane simple_molecule
reactant hexane_Ext simple_molecule
AcrA-TolC-AcrB enterobactin_Ext enterobactin
Name: enterobactin_Ext -> enterobactin
Description: Transport of enterobactin_Ext through a bacterial membrane, leading to the presence of enterobactin inside the cell.
Type: transport
Pathway Components: enterobactin_Ext - AcrA-TolC-AcrB -> enterobactin
Components:
Function Name Type
catalyzer AcrA-TolC-AcrB complex
product enterobactin simple_molecule
reactant enterobactin_Ext simple_molecule
acrAB_mRNA AcrB
Name: acrAB_mRNA -> AcrB
Description: Translation of AcrB
Type: translation
Pathway Components: acrAB_mRNA -> AcrB
Components:
Function Name Type
product AcrB protein
reactant acrAB_mRNA RNA
mprA-emrAB_mRNA MprA
Name: mprA-emrAB_mRNA -> MprA
Description: Translation of MprA
Type: translation
Pathway Components: mprA-emrAB_mRNA -> MprA
Components:
Function Name Type
product MprA protein
reactant mprA-emrAB_mRNA RNA
mprA-emrAB_mRNA EmrA
Name: mprA-emrAB_mRNA -> EmrA
Description: Translation of EmrA
Type: translation
Pathway Components: mprA-emrAB_mRNA -> EmrA
Components:
Function Name Type
product EmrA protein
reactant mprA-emrAB_mRNA RNA
EmrB + TolC + EmrA EmrA-EmrB-TolC
Name: EmrB + TolC + EmrA -> EmrA-EmrB-TolC
Description: Reaction transforming EmrB, TolC, EmrA into EmrA-EmrB-TolC
Type: state transition
Pathway Components: EmrB + TolC + EmrA -> EmrA-EmrB-TolC
Components:
Function Name Type
reactant EmrA protein
product EmrA-EmrB-TolC complex
reactant EmrB protein
reactant TolC protein
mprA-emrAB_mRNA EmrB
Name: mprA-emrAB_mRNA -> EmrB
Description: Translation of EmrB
Type: translation
Pathway Components: mprA-emrAB_mRNA -> EmrB
Components:
Function Name Type
product EmrB protein
reactant mprA-emrAB_mRNA RNA
nmpC_mRNA NmpC
Name: nmpC_mRNA -> NmpC
Description: Translation of NmpC
Type: translation
Pathway Components: nmpC_mRNA -> NmpC
Components:
Function Name Type
product NmpC protein
reactant nmpC_mRNA RNA



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