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MhpR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
succinate MhpR coenzyme A ethanal MhpR oxygen 3-coumarate mhpABCDFE (2Z)-2-hydroxypenta-2,4-dienoate 2-hydroxy-6-oxononatrienedioate MhpE 3HPP MhpR fumarate (2Z,4E)-2-hydroxy-6-ketononadienedioic acid 2,3-DHP 3HPP acetyl-CoA MhpA MhpC MhpB mhpABCDFE_mRNA MhpD 2,3-dihydroxycinnamic acid MhpF 2,3-DHP pyruvate 2-oxo-4-hydroxyvalerate


Gensor Unit       
Name: MhpR
Description: Molecular biology level
Detailed: In the presence of aromatic compounds, MhpR positively regulates the expression of genes required for phenylpropanoid catabolic process. Under this condition, MhpR is modified to MhpR-3-(3-hydroxyphenyl) propionate, binds its target sites enabling the expression of its regulated genes.
Less detailed: In the presence of aromatic compounds, such as 3-(3-hydroxyphenyl)propionate, MhpR positively regulates the expression of genes needed for phenylpropanoid catabolic process.

Physiology level
Detailed: The presence of 3-(3-hydroxyphenyl)propionate induces the expression of genes involved with assimilation of aromatic compounds. Under this condition the genes necessary for conversion of 3-(3-hydroxyphenyl)propionate to acetaldehyde are expressed (or induced).
Less detailed: The presence of 3-(3-hydroxyphenyl)propionate induces the expression of genes needful for the conversion of aromatic compounds to acetaldehyde as precursor of acetyl-CoA.
Classification:
Groups: Secondary metabolites biosynthesis, transport and catabolism
Amino acid transport and metabolism
Coenzyme transport and metabolism
Gene Ontology Terms (GO): biological_process GO:0019622 - 3-(3-hydroxy)phenylpropionate catabolic process
GO:0019380 - 3-phenylpropionate catabolic process
GO:0019439 - aromatic compound catabolic process
GO:0006725 - cellular aromatic compound metabolic process
GO:0008152 - metabolic process
GO:0055114 - oxidation-reduction process
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cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
molecular_function GO:0052823 - 2-hydroxy-6-oxonona-2,4,7-trienedioate hydrolase activity
GO:0018771 - 2-hydroxy-6-oxonona-2,4-dienedioate hydrolase activity
GO:0008684 - 2-oxopent-4-enoate hydratase activity
GO:0008688 - 3-(3-hydroxyphenyl)propionate hydroxylase activity
GO:0047070 - 3-carboxyethylcatechol 2,3-dioxygenase activity
GO:0008701 - 4-hydroxy-2-oxovalerate aldolase activity
GO:0071949 - FAD binding
Read more >
Components:
  Function Name Type
  simple_molecule (2Z)-2-hydroxypenta-2,4-dienoate simple_molecule
  simple_molecule (2Z,4E)-2-hydroxy-6-ketononadienedioic acid simple_molecule
  simple_molecule 2,3-DHP simple_molecule
  simple_molecule 2,3-dihydroxycinnamic acid simple_molecule
  simple_molecule 2-hydroxy-6-oxononatrienedioate simple_molecule
  simple_molecule 2-oxo-4-hydroxyvalerate simple_molecule
  simple_molecule 3-coumarate simple_molecule
  simple_molecule 3HPP simple_molecule
  protein MhpA protein
  protein MhpB protein
  protein MhpC protein
  protein MhpD protein
  protein MhpE protein
  protein MhpF protein
  protein MhpR protein
  complex MhpR-2,3-DHP complex
  complex MhpR-3HPP complex
  simple_molecule acetyl-CoA simple_molecule
  simple_molecule coenzyme A simple_molecule
  simple_molecule ethanal simple_molecule
  simple_molecule fumarate simple_molecule
  gene mhpABCDFE gene
  RNA mhpABCDFE_mRNA RNA
  simple_molecule oxygen simple_molecule
  simple_molecule pyruvate simple_molecule
  simple_molecule succinate simple_molecule


Reactions       
Showing 18 reactions
3HPP + MhpR MhpR-3HPP
Name: 3HPP + MhpR -> MhpR-3HPP
Description: Reaction transforming 3HPP, MhpR into MhpR-3HPP
Type: state transition
Pathway Components: 3HPP + MhpR -> MhpR-3HPP
Components:
Function Name Type
reactant 3HPP simple_molecule
reactant MhpR protein
product MhpR-3HPP complex
MhpR-3HPP mhpABCDFE mhpABCDFE_mRNA
Name: mhpABCDFE -> mhpABCDFE_mRNA
Description: Transcription of transcription unit mhpABCDFE. Reaction activation by MhpR-3HPP.
Type: transcription
Pathway Components: mhpABCDFE - MhpR-3HPP -> mhpABCDFE_mRNA
Components:
Function Name Type
activator MhpR-3HPP complex
reactant mhpABCDFE gene
product mhpABCDFE_mRNA RNA
2,3-DHP + MhpR MhpR-2,3-DHP
Name: 2,3-DHP + MhpR -> MhpR-2,3-DHP
Description: Reaction transforming 2,3-DHP, MhpR into MhpR-2,3-DHP
Type: state transition
Pathway Components: 2,3-DHP + MhpR -> MhpR-2,3-DHP
Components:
Function Name Type
reactant 2,3-DHP simple_molecule
reactant MhpR protein
product MhpR-2,3-DHP complex
mhpABCDFE_mRNA MhpA
Name: mhpABCDFE_mRNA -> MhpA
Description: Translation of MhpA
Type: translation
Pathway Components: mhpABCDFE_mRNA -> MhpA
Components:
Function Name Type
product MhpA protein
reactant mhpABCDFE_mRNA RNA
MhpA oxygen + 3HPP 2,3-DHP
Name: oxygen + 3HPP -> 2,3-DHP
Description: Reaction transforming oxygen, 3HPP into 2,3-DHP
Type: state transition
Pathway Components: oxygen + 3HPP - MhpA -> 2,3-DHP
Components:
Function Name Type
product 2,3-DHP simple_molecule
reactant 3HPP simple_molecule
catalyzer MhpA protein
reactant oxygen simple_molecule
MhpA 3-coumarate + oxygen 2,3-dihydroxycinnamic acid
Name: 3-coumarate + oxygen -> 2,3-dihydroxycinnamic acid
Description: Reaction transforming 3-coumarate, oxygen into 2,3-dihydroxycinnamic acid
Type: state transition
Pathway Components: 3-coumarate + oxygen - MhpA -> 2,3-dihydroxycinnamic acid
Components:
Function Name Type
product 2,3-dihydroxycinnamic acid simple_molecule
reactant 3-coumarate simple_molecule
catalyzer MhpA protein
reactant oxygen simple_molecule
mhpABCDFE_mRNA MhpB
Name: mhpABCDFE_mRNA -> MhpB
Description: Translation of MhpB
Type: translation
Pathway Components: mhpABCDFE_mRNA -> MhpB
Components:
Function Name Type
product MhpB protein
reactant mhpABCDFE_mRNA RNA
MhpB 2,3-DHP + oxygen (2Z,4E)-2-hydroxy-6-ketononadienedioic acid
Name: 2,3-DHP + oxygen -> (2Z,4E)-2-hydroxy-6-ketononadienedioic acid
Description: Reaction transforming 2,3-DHP, oxygen into (2Z,4E)-2-hydroxy-6-ketononadienedioic acid
Type: state transition
Pathway Components: 2,3-DHP + oxygen - MhpB -> (2Z,4E)-2-hydroxy-6-ketononadienedioic acid
Components:
Function Name Type
product (2Z,4E)-2-hydroxy-6-ketononadienedioic acid simple_molecule
reactant 2,3-DHP simple_molecule
catalyzer MhpB protein
reactant oxygen simple_molecule
MhpB 2,3-dihydroxycinnamic acid + oxygen 2-hydroxy-6-oxononatrienedioate
Name: 2,3-dihydroxycinnamic acid + oxygen -> 2-hydroxy-6-oxononatrienedioate
Description: Reaction transforming 2,3-dihydroxycinnamic acid, oxygen into 2-hydroxy-6-oxononatrienedioate
Type: state transition
Pathway Components: 2,3-dihydroxycinnamic acid + oxygen - MhpB -> 2-hydroxy-6-oxononatrienedioate
Components:
Function Name Type
reactant 2,3-dihydroxycinnamic acid simple_molecule
product 2-hydroxy-6-oxononatrienedioate simple_molecule
catalyzer MhpB protein
reactant oxygen simple_molecule
mhpABCDFE_mRNA MhpC
Name: mhpABCDFE_mRNA -> MhpC
Description: Translation of MhpC
Type: translation
Pathway Components: mhpABCDFE_mRNA -> MhpC
Components:
Function Name Type
product MhpC protein
reactant mhpABCDFE_mRNA RNA
MhpC (2Z,4E)-2-hydroxy-6-ketononadienedioic acid (2Z)-2-hydroxypenta-2,4-dienoate + succinate
Name: (2Z,4E)-2-hydroxy-6-ketononadienedioic acid -> (2Z)-2-hydroxypenta-2,4-dienoate + succinate
Description: Reaction transforming (2Z,4E)-2-hydroxy-6-ketononadienedioic acid into (2Z)-2-hydroxypenta-2,4-dienoate, succinate
Type: state transition
Pathway Components: (2Z,4E)-2-hydroxy-6-ketononadienedioic acid - MhpC -> (2Z)-2-hydroxypenta-2,4-dienoate + succinate
Components:
Function Name Type
product (2Z)-2-hydroxypenta-2,4-dienoate simple_molecule
reactant (2Z,4E)-2-hydroxy-6-ketononadienedioic acid simple_molecule
catalyzer MhpC protein
product succinate simple_molecule
MhpC 2-hydroxy-6-oxononatrienedioate (2Z)-2-hydroxypenta-2,4-dienoate + fumarate
Name: 2-hydroxy-6-oxononatrienedioate -> (2Z)-2-hydroxypenta-2,4-dienoate + fumarate
Description: Reaction transforming 2-hydroxy-6-oxononatrienedioate into (2Z)-2-hydroxypenta-2,4-dienoate, fumarate
Type: state transition
Pathway Components: 2-hydroxy-6-oxononatrienedioate - MhpC -> (2Z)-2-hydroxypenta-2,4-dienoate + fumarate
Components:
Function Name Type
product (2Z)-2-hydroxypenta-2,4-dienoate simple_molecule
reactant 2-hydroxy-6-oxononatrienedioate simple_molecule
catalyzer MhpC protein
product fumarate simple_molecule
mhpABCDFE_mRNA MhpD
Name: mhpABCDFE_mRNA -> MhpD
Description: Translation of MhpD
Type: translation
Pathway Components: mhpABCDFE_mRNA -> MhpD
Components:
Function Name Type
product MhpD protein
reactant mhpABCDFE_mRNA RNA
MhpD (2Z)-2-hydroxypenta-2,4-dienoate 2-oxo-4-hydroxyvalerate
Name: (2Z)-2-hydroxypenta-2,4-dienoate -> 2-oxo-4-hydroxyvalerate
Description: Reaction transforming (2Z)-2-hydroxypenta-2,4-dienoate into 2-oxo-4-hydroxyvalerate
Type: state transition
Pathway Components: (2Z)-2-hydroxypenta-2,4-dienoate - MhpD -> 2-oxo-4-hydroxyvalerate
Components:
Function Name Type
reactant (2Z)-2-hydroxypenta-2,4-dienoate simple_molecule
product 2-oxo-4-hydroxyvalerate simple_molecule
catalyzer MhpD protein
mhpABCDFE_mRNA MhpF
Name: mhpABCDFE_mRNA -> MhpF
Description: Translation of MhpF
Type: translation
Pathway Components: mhpABCDFE_mRNA -> MhpF
Components:
Function Name Type
product MhpF protein
reactant mhpABCDFE_mRNA RNA
MhpF coenzyme A + ethanal acetyl-CoA
Name: coenzyme A + ethanal -> acetyl-CoA
Description: Reaction transforming coenzyme A, ethanal into acetyl-CoA
Type: state transition
Pathway Components: coenzyme A + ethanal - MhpF -> acetyl-CoA
Components:
Function Name Type
catalyzer MhpF protein
product acetyl-CoA simple_molecule
reactant coenzyme A simple_molecule
reactant ethanal simple_molecule
mhpABCDFE_mRNA MhpE
Name: mhpABCDFE_mRNA -> MhpE
Description: Translation of MhpE
Type: translation
Pathway Components: mhpABCDFE_mRNA -> MhpE
Components:
Function Name Type
product MhpE protein
reactant mhpABCDFE_mRNA RNA
MhpE 2-oxo-4-hydroxyvalerate pyruvate + ethanal
Name: 2-oxo-4-hydroxyvalerate -> pyruvate + ethanal
Description: Reaction transforming 2-oxo-4-hydroxyvalerate into pyruvate, ethanal
Type: state transition
Pathway Components: 2-oxo-4-hydroxyvalerate - MhpE -> pyruvate + ethanal
Components:
Function Name Type
reactant 2-oxo-4-hydroxyvalerate simple_molecule
catalyzer MhpE protein
product ethanal simple_molecule
product pyruvate simple_molecule



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