RegulonDB RegulonDB

LeuO Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
LeuA LeuC beta-D-cellobiose-6'-p bglGFB CasC yjjQ-bglJ_mRNA CasB RcsB CasE beta-D-glucose-6-P bglGFB_mRNA leuO LeuO Ursin_Ext BglF crRNA 2-isopropyl-3-oxosuccinate Cas2 CasD hydroquinol leuL dsrA BglB leuLABCD_mRNA LeuC LeuL bglG casABCDE12 CasE salicin_Ext acetyl-CoA cadC alpha-isopropylmalate RcsB dsrA_mRNA RNA:DsrA LeuD leuLABCD glucopyranose_Ext methyl beta-D-glucoside 6-phosphate CadC leuO_mRNA yjjQ-bglJ saligenin 2-isopropylmaleate PtsH HPr - phosphorylated_Ext BglJ bglG_mRNA arbutin-6P CasB casABCDE12_mRNA LeuD CasC CasA 3-isopropylmalate cadC_mRNA b-methyl-D-glucoside_Ext Cas2 BglG pre-crRNA LeuB Cas1 CasD glucopyranose salicin-6-p coenzyme A 2-ketovaline leuL_mRNA YjjQ Cas1 CasA glucose-6-P BglJ PtsH


Gensor Unit       
Name: LeuO
Classification:
Groups: Transcription
Carbohydrate transport and metabolism
Energy production and conversion
Signal transduction mechanisms
Amino acid transport and metabolism
Defense mechanisms
Gene Ontology Terms (GO): biological_process GO:0006281 - DNA repair
GO:0090502 - RNA phosphodiester bond hydrolysis, endonucleolytic
GO:0006396 - RNA processing
GO:0009082 - branched-chain amino acid biosynthetic process
GO:0005975 - carbohydrate metabolic process
GO:0034219 - carbohydrate transmembrane transport
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cellular_component GO:0009316 - 3-isopropylmalate dehydratase complex
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0016021 - integral component of membrane
GO:0005622 - intracellular anatomical structure
GO:0016020 - membrane
GO:0005886 - plasma membrane
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molecular_function GO:0003852 - 2-isopropylmalate synthase activity
GO:0003861 - 3-isopropylmalate dehydratase activity
GO:0003862 - 3-isopropylmalate dehydrogenase activity
GO:0051539 - 4 iron, 4 sulfur cluster binding
GO:0017108 - 5'-flap endonuclease activity
GO:0008706 - 6-phospho-beta-glucosidase activity
GO:0003677 - DNA binding
Read more >
Components:
  Function Name Type
  simple_molecule α-isopropylmalate simple_molecule
  simple_molecule 2-isopropyl-3-oxosuccinate simple_molecule
  simple_molecule 2-isopropylmaleate simple_molecule
  simple_molecule 2-ketovaline simple_molecule
  simple_molecule 3-isopropylmalate simple_molecule
  protein BglB protein
  protein BglF protein
  protein BglG protein
  protein BglJ protein
  complex BglJ-RcsB complex
  protein CadC protein
  protein Cas1 protein
  protein Cas2 protein
  complex Cas2-Cas1 complex
  protein CasA protein
  complex CasA-CasB-CasC-CasD-CasE complex
  protein CasB protein
  protein CasC protein
  protein CasD protein
  protein CasE protein
  simple_molecule HPr - phosphorylated_Ext simple_molecule
  protein LeuA protein
  protein LeuB protein
  protein LeuC protein
  complex LeuC-LeuD complex
  protein LeuD protein
  protein LeuL protein
  protein LeuO protein
  simple_molecule PtsH simple_molecule
  protein RNA:DsrA protein
  protein RcsB protein
  simple_molecule Ursin_Ext simple_molecule
  protein YjjQ protein
  simple_molecule acetyl-CoA simple_molecule
  simple_molecule arbutin-6P simple_molecule
  simple_molecule b-methyl-D-glucoside_Ext simple_molecule
  simple_molecule beta-D-cellobiose-6'-p simple_molecule
  simple_molecule beta-D-glucose-6-P simple_molecule
  gene bglG gene
  gene bglGFB gene
  RNA bglGFB_mRNA RNA
  RNA bglG_mRNA RNA
  gene cadC gene
  RNA cadC_mRNA RNA
  gene casABCDE12 gene
  RNA casABCDE12_mRNA RNA
  simple_molecule coenzyme A simple_molecule
  simple_molecule crRNA simple_molecule
  gene dsrA gene
  RNA dsrA_mRNA RNA
  simple_molecule glucopyranose simple_molecule
  simple_molecule glucopyranose_Ext simple_molecule
  simple_molecule glucose-6-P simple_molecule
  simple_molecule hydroquinol simple_molecule
  gene leuL gene
  gene leuLABCD gene
  RNA leuLABCD_mRNA RNA
  RNA leuL_mRNA RNA
  gene leuO gene
  RNA leuO_mRNA RNA
  simple_molecule methyl beta-D-glucoside 6-phosphate simple_molecule
  simple_molecule pre-crRNA simple_molecule
  simple_molecule salicin-6-p simple_molecule
  simple_molecule salicin_Ext simple_molecule
  simple_molecule saligenin simple_molecule
  gene yjjQ-bglJ gene
  RNA yjjQ-bglJ_mRNA RNA


Reactions       
Showing 48 reactions
LeuO bglG bglG_mRNA
Name: bglG -> bglG_mRNA
Description: Transcription of transcription unit bglG. Reaction activation by LeuO.
Type: transcription
Pathway Components: bglG - LeuO -> bglG_mRNA
Components:
Function Name Type
activator LeuO protein
reactant bglG gene
product bglG_mRNA RNA
LeuO bglGFB bglGFB_mRNA
Name: bglGFB -> bglGFB_mRNA
Description: Transcription of transcription unit bglGFB. Reaction activation by LeuO.
Type: transcription
Pathway Components: bglGFB - LeuO -> bglGFB_mRNA
Components:
Function Name Type
activator LeuO protein
reactant bglGFB gene
product bglGFB_mRNA RNA
LeuO casABCDE12 casABCDE12_mRNA
Name: casABCDE12 -> casABCDE12_mRNA
Description: Transcription of transcription unit casABCDE12. Reaction activation by LeuO.
Type: transcription
Pathway Components: casABCDE12 - LeuO -> casABCDE12_mRNA
Components:
Function Name Type
activator LeuO protein
reactant casABCDE12 gene
product casABCDE12_mRNA RNA
LeuO leuL leuL_mRNA
Name: leuL -> leuL_mRNA
Description: Transcription of transcription unit leuL. Reaction activation by LeuO.
Type: transcription
Pathway Components: leuL - LeuO -> leuL_mRNA
Components:
Function Name Type
activator LeuO protein
reactant leuL gene
product leuL_mRNA RNA
LeuO leuLABCD leuLABCD_mRNA
Name: leuLABCD -> leuLABCD_mRNA
Description: Transcription of transcription unit leuLABCD. Reaction activation by LeuO.
Type: transcription
Pathway Components: leuLABCD - LeuO -> leuLABCD_mRNA
Components:
Function Name Type
activator LeuO protein
reactant leuLABCD gene
product leuLABCD_mRNA RNA
LeuO LeuO leuO leuO_mRNA
Name: leuO -> leuO_mRNA
Description: Transcription of transcription unit leuO. Reaction activation by LeuO. Reaction inhibition by LeuO.
Type: transcription
Pathway Components: leuO - LeuO - LeuO -> leuO_mRNA
Components:
Function Name Type
activator LeuO protein
inhibitor LeuO protein
reactant leuO gene
product leuO_mRNA RNA
LeuO yjjQ-bglJ yjjQ-bglJ_mRNA
Name: yjjQ-bglJ -> yjjQ-bglJ_mRNA
Description: Transcription of transcription unit yjjQ-bglJ. Reaction activation by LeuO.
Type: transcription
Pathway Components: yjjQ-bglJ - LeuO -> yjjQ-bglJ_mRNA
Components:
Function Name Type
activator LeuO protein
reactant yjjQ-bglJ gene
product yjjQ-bglJ_mRNA RNA
LeuO cadC cadC_mRNA
Name: cadC -> cadC_mRNA
Description: Transcription of transcription unit cadC. Reaction inhibition by LeuO.
Type: transcription
Pathway Components: cadC - LeuO -> cadC_mRNA
Components:
Function Name Type
inhibitor LeuO protein
reactant cadC gene
product cadC_mRNA RNA
LeuO dsrA dsrA_mRNA
Name: dsrA -> dsrA_mRNA
Description: Transcription of transcription unit dsrA. Reaction inhibition by LeuO.
Type: transcription
Pathway Components: dsrA - LeuO -> dsrA_mRNA
Components:
Function Name Type
inhibitor LeuO protein
reactant dsrA gene
product dsrA_mRNA RNA
leuLABCD_mRNA LeuL
Name: leuLABCD_mRNA -> LeuL
Description: Translation of LeuL
Type: translation
Pathway Components: leuLABCD_mRNA -> LeuL
Components:
Function Name Type
product LeuL protein
reactant leuLABCD_mRNA RNA
leuLABCD_mRNA LeuA
Name: leuLABCD_mRNA -> LeuA
Description: Translation of LeuA
Type: translation
Pathway Components: leuLABCD_mRNA -> LeuA
Components:
Function Name Type
product LeuA protein
reactant leuLABCD_mRNA RNA
LeuA 2-ketovaline + acetyl-CoA α-isopropylmalate + coenzyme A
Name: 2-ketovaline + acetyl-CoA -> α-isopropylmalate + coenzyme A
Description: Reaction transforming 2-ketovaline, acetyl-CoA into α-isopropylmalate, coenzyme A
Type: state transition
Pathway Components: 2-ketovaline + acetyl-CoA - LeuA -> α-isopropylmalate + coenzyme A
Components:
Function Name Type
product α-isopropylmalate simple_molecule
reactant 2-ketovaline simple_molecule
catalyzer LeuA protein
reactant acetyl-CoA simple_molecule
product coenzyme A simple_molecule
leuLABCD_mRNA LeuB
Name: leuLABCD_mRNA -> LeuB
Description: Translation of LeuB
Type: translation
Pathway Components: leuLABCD_mRNA -> LeuB
Components:
Function Name Type
product LeuB protein
reactant leuLABCD_mRNA RNA
LeuB 3-isopropylmalate 2-isopropyl-3-oxosuccinate
Name: 3-isopropylmalate -> 2-isopropyl-3-oxosuccinate
Description: Reaction transforming 3-isopropylmalate into 2-isopropyl-3-oxosuccinate
Type: state transition
Pathway Components: 3-isopropylmalate - LeuB -> 2-isopropyl-3-oxosuccinate
Components:
Function Name Type
product 2-isopropyl-3-oxosuccinate simple_molecule
reactant 3-isopropylmalate simple_molecule
catalyzer LeuB protein
leuLABCD_mRNA LeuC
Name: leuLABCD_mRNA -> LeuC
Description: Translation of LeuC
Type: translation
Pathway Components: leuLABCD_mRNA -> LeuC
Components:
Function Name Type
product LeuC protein
reactant leuLABCD_mRNA RNA
LeuD + LeuC LeuC-LeuD
Name: LeuD + LeuC -> LeuC-LeuD
Description: Reaction transforming LeuD, LeuC into LeuC-LeuD
Type: state transition
Pathway Components: LeuD + LeuC -> LeuC-LeuD
Components:
Function Name Type
reactant LeuC protein
product LeuC-LeuD complex
reactant LeuD protein
LeuC-LeuD 3-isopropylmalate α-isopropylmalate
Name: 3-isopropylmalate -> α-isopropylmalate
Description: Reaction transforming 3-isopropylmalate into α-isopropylmalate
Type: state transition
Pathway Components: 3-isopropylmalate - LeuC-LeuD -> α-isopropylmalate
Components:
Function Name Type
product α-isopropylmalate simple_molecule
reactant 3-isopropylmalate simple_molecule
catalyzer LeuC-LeuD complex
LeuC-LeuD 3-isopropylmalate 2-isopropylmaleate
Name: 3-isopropylmalate -> 2-isopropylmaleate
Description: Reaction transforming 3-isopropylmalate into 2-isopropylmaleate
Type: state transition
Pathway Components: 3-isopropylmalate - LeuC-LeuD -> 2-isopropylmaleate
Components:
Function Name Type
product 2-isopropylmaleate simple_molecule
reactant 3-isopropylmalate simple_molecule
catalyzer LeuC-LeuD complex
LeuC-LeuD 2-isopropylmaleate α-isopropylmalate
Name: 2-isopropylmaleate -> α-isopropylmalate
Description: Reaction transforming 2-isopropylmaleate into α-isopropylmalate
Type: state transition
Pathway Components: 2-isopropylmaleate - LeuC-LeuD -> α-isopropylmalate
Components:
Function Name Type
product α-isopropylmalate simple_molecule
reactant 2-isopropylmaleate simple_molecule
catalyzer LeuC-LeuD complex
leuLABCD_mRNA LeuD
Name: leuLABCD_mRNA -> LeuD
Description: Translation of LeuD
Type: translation
Pathway Components: leuLABCD_mRNA -> LeuD
Components:
Function Name Type
product LeuD protein
reactant leuLABCD_mRNA RNA
bglG_mRNA BglG
Name: bglG_mRNA -> BglG
Description: Translation of BglG
Type: translation
Pathway Components: bglG_mRNA -> BglG
Components:
Function Name Type
product BglG protein
reactant bglG_mRNA RNA
casABCDE12_mRNA CasA
Name: casABCDE12_mRNA -> CasA
Description: Translation of CasA
Type: translation
Pathway Components: casABCDE12_mRNA -> CasA
Components:
Function Name Type
product CasA protein
reactant casABCDE12_mRNA RNA
CasB + CasA + CasD + CasE + CasC CasA-CasB-CasC-CasD-CasE
Name: CasB + CasA + CasD + CasE + CasC -> CasA-CasB-CasC-CasD-CasE
Description: Reaction transforming CasB, CasA, CasD, CasE, CasC into CasA-CasB-CasC-CasD-CasE
Type: state transition
Pathway Components: CasB + CasA + CasD + CasE + CasC -> CasA-CasB-CasC-CasD-CasE
Components:
Function Name Type
reactant CasA protein
product CasA-CasB-CasC-CasD-CasE complex
reactant CasB protein
reactant CasC protein
reactant CasD protein
reactant CasE protein
CasA-CasB-CasC-CasD-CasE pre-crRNA crRNA
Name: pre-crRNA -> crRNA
Description: Reaction transforming pre-crRNA into crRNA
Type: state transition
Pathway Components: pre-crRNA - CasA-CasB-CasC-CasD-CasE -> crRNA
Components:
Function Name Type
catalyzer CasA-CasB-CasC-CasD-CasE complex
product crRNA simple_molecule
reactant pre-crRNA simple_molecule
casABCDE12_mRNA CasB
Name: casABCDE12_mRNA -> CasB
Description: Translation of CasB
Type: translation
Pathway Components: casABCDE12_mRNA -> CasB
Components:
Function Name Type
product CasB protein
reactant casABCDE12_mRNA RNA
casABCDE12_mRNA CasC
Name: casABCDE12_mRNA -> CasC
Description: Translation of CasC
Type: translation
Pathway Components: casABCDE12_mRNA -> CasC
Components:
Function Name Type
product CasC protein
reactant casABCDE12_mRNA RNA
casABCDE12_mRNA CasD
Name: casABCDE12_mRNA -> CasD
Description: Translation of CasD
Type: translation
Pathway Components: casABCDE12_mRNA -> CasD
Components:
Function Name Type
product CasD protein
reactant casABCDE12_mRNA RNA
casABCDE12_mRNA CasE
Name: casABCDE12_mRNA -> CasE
Description: Translation of CasE
Type: translation
Pathway Components: casABCDE12_mRNA -> CasE
Components:
Function Name Type
product CasE protein
reactant casABCDE12_mRNA RNA
casABCDE12_mRNA Cas1
Name: casABCDE12_mRNA -> Cas1
Description: Translation of Cas1
Type: translation
Pathway Components: casABCDE12_mRNA -> Cas1
Components:
Function Name Type
product Cas1 protein
reactant casABCDE12_mRNA RNA
Cas2 + Cas1 Cas2-Cas1
Name: Cas2 + Cas1 -> Cas2-Cas1
Description: Reaction transforming Cas2, Cas1 into Cas2-Cas1
Type: state transition
Pathway Components: Cas2 + Cas1 -> Cas2-Cas1
Components:
Function Name Type
reactant Cas1 protein
reactant Cas2 protein
product Cas2-Cas1 complex
casABCDE12_mRNA Cas2
Name: casABCDE12_mRNA -> Cas2
Description: Translation of Cas2
Type: translation
Pathway Components: casABCDE12_mRNA -> Cas2
Components:
Function Name Type
product Cas2 protein
reactant casABCDE12_mRNA RNA
yjjQ-bglJ_mRNA YjjQ
Name: yjjQ-bglJ_mRNA -> YjjQ
Description: Translation of YjjQ
Type: translation
Pathway Components: yjjQ-bglJ_mRNA -> YjjQ
Components:
Function Name Type
product YjjQ protein
reactant yjjQ-bglJ_mRNA RNA
yjjQ-bglJ_mRNA BglJ
Name: yjjQ-bglJ_mRNA -> BglJ
Description: Translation of BglJ
Type: translation
Pathway Components: yjjQ-bglJ_mRNA -> BglJ
Components:
Function Name Type
product BglJ protein
reactant yjjQ-bglJ_mRNA RNA
BglJ + RcsB BglJ-RcsB
Name: BglJ + RcsB -> BglJ-RcsB
Description: Reaction transforming BglJ, RcsB into BglJ-RcsB
Type: state transition
Pathway Components: BglJ + RcsB -> BglJ-RcsB
Components:
Function Name Type
reactant BglJ protein
product BglJ-RcsB complex
reactant RcsB protein
bglGFB_mRNA BglG
Name: bglGFB_mRNA -> BglG
Description: Translation of BglG
Type: translation
Pathway Components: bglGFB_mRNA -> BglG
Components:
Function Name Type
product BglG protein
reactant bglGFB_mRNA RNA
bglGFB_mRNA BglF
Name: bglGFB_mRNA -> BglF
Description: Translation of BglF
Type: translation
Pathway Components: bglGFB_mRNA -> BglF
Components:
Function Name Type
product BglF protein
reactant bglGFB_mRNA RNA
BglF Reactants methyl beta-D-glucoside 6-phosphate + PtsH
Name: b-methyl-D-glucoside_Ext + HPr - phosphorylated_Ext -> methyl beta-D-glucoside 6-phosphate + PtsH
Description: Transport of b-methyl-D-glucoside_Ext, HPr - phosphorylated_Ext through a bacterial membrane, leading to the presence of methyl beta-D-glucoside 6-phosphate, PtsH inside the cell.
Type: transport
Pathway Components: b-methyl-D-glucoside_Ext + HPr - phosphorylated_Ext - BglF -> methyl beta-D-glucoside 6-phosphate + PtsH
Components:
Function Name Type
catalyzer BglF protein
reactant HPr - phosphorylated_Ext simple_molecule
product PtsH simple_molecule
reactant b-methyl-D-glucoside_Ext simple_molecule
product methyl beta-D-glucoside 6-phosphate simple_molecule
BglF HPr - phosphorylated_Ext + Ursin_Ext arbutin-6P + PtsH
Name: HPr - phosphorylated_Ext + Ursin_Ext -> arbutin-6P + PtsH
Description: Transport of HPr - phosphorylated_Ext, Ursin_Ext through a bacterial membrane, leading to the presence of arbutin-6P, PtsH inside the cell.
Type: transport
Pathway Components: HPr - phosphorylated_Ext + Ursin_Ext - BglF -> arbutin-6P + PtsH
Components:
Function Name Type
catalyzer BglF protein
reactant HPr - phosphorylated_Ext simple_molecule
product PtsH simple_molecule
reactant Ursin_Ext simple_molecule
product arbutin-6P simple_molecule
BglF HPr - phosphorylated_Ext + salicin_Ext salicin-6-p + PtsH
Name: HPr - phosphorylated_Ext + salicin_Ext -> salicin-6-p + PtsH
Description: Transport of HPr - phosphorylated_Ext, salicin_Ext through a bacterial membrane, leading to the presence of salicin-6-p, PtsH inside the cell.
Type: transport
Pathway Components: HPr - phosphorylated_Ext + salicin_Ext - BglF -> salicin-6-p + PtsH
Components:
Function Name Type
catalyzer BglF protein
reactant HPr - phosphorylated_Ext simple_molecule
product PtsH simple_molecule
product salicin-6-p simple_molecule
reactant salicin_Ext simple_molecule
BglF HPr - phosphorylated_Ext + glucopyranose_Ext glucose-6-P + PtsH
Name: HPr - phosphorylated_Ext + glucopyranose_Ext -> glucose-6-P + PtsH
Description: Transport of HPr - phosphorylated_Ext, glucopyranose_Ext through a bacterial membrane, leading to the presence of glucose-6-P, PtsH inside the cell.
Type: transport
Pathway Components: HPr - phosphorylated_Ext + glucopyranose_Ext - BglF -> glucose-6-P + PtsH
Components:
Function Name Type
catalyzer BglF protein
reactant HPr - phosphorylated_Ext simple_molecule
product PtsH simple_molecule
reactant glucopyranose_Ext simple_molecule
product glucose-6-P simple_molecule
bglGFB_mRNA BglB
Name: bglGFB_mRNA -> BglB
Description: Translation of BglB
Type: translation
Pathway Components: bglGFB_mRNA -> BglB
Components:
Function Name Type
product BglB protein
reactant bglGFB_mRNA RNA
BglB salicin-6-p beta-D-glucose-6-P + saligenin
Name: salicin-6-p -> beta-D-glucose-6-P + saligenin
Description: Reaction transforming salicin-6-p into beta-D-glucose-6-P, saligenin
Type: state transition
Pathway Components: salicin-6-p - BglB -> beta-D-glucose-6-P + saligenin
Components:
Function Name Type
catalyzer BglB protein
product beta-D-glucose-6-P simple_molecule
reactant salicin-6-p simple_molecule
product saligenin simple_molecule
BglB arbutin-6P beta-D-glucose-6-P + hydroquinol
Name: arbutin-6P -> beta-D-glucose-6-P + hydroquinol
Description: Reaction transforming arbutin-6P into beta-D-glucose-6-P, hydroquinol
Type: state transition
Pathway Components: arbutin-6P - BglB -> beta-D-glucose-6-P + hydroquinol
Components:
Function Name Type
catalyzer BglB protein
reactant arbutin-6P simple_molecule
product beta-D-glucose-6-P simple_molecule
product hydroquinol simple_molecule
BglB beta-D-cellobiose-6'-p glucopyranose + glucose-6-P
Name: beta-D-cellobiose-6'-p -> glucopyranose + glucose-6-P
Description: Reaction transforming beta-D-cellobiose-6'-p into glucopyranose, glucose-6-P
Type: state transition
Pathway Components: beta-D-cellobiose-6'-p - BglB -> glucopyranose + glucose-6-P
Components:
Function Name Type
catalyzer BglB protein
reactant beta-D-cellobiose-6'-p simple_molecule
product glucopyranose simple_molecule
product glucose-6-P simple_molecule
cadC_mRNA CadC
Name: cadC_mRNA -> CadC
Description: Translation of CadC
Type: translation
Pathway Components: cadC_mRNA -> CadC
Components:
Function Name Type
product CadC protein
reactant cadC_mRNA RNA
dsrA_mRNA RNA:DsrA
Name: dsrA_mRNA -> RNA:DsrA
Description: Translation of RNA:DsrA
Type: translation
Pathway Components: dsrA_mRNA -> RNA:DsrA
Components:
Function Name Type
product RNA:DsrA protein
reactant dsrA_mRNA RNA
leuL_mRNA LeuL
Name: leuL_mRNA -> LeuL
Description: Translation of LeuL
Type: translation
Pathway Components: leuL_mRNA -> LeuL
Components:
Function Name Type
product LeuL protein
reactant leuL_mRNA RNA
leuO_mRNA LeuO
Name: leuO_mRNA -> LeuO
Description: Translation of LeuO
Type: translation
Pathway Components: leuO_mRNA -> LeuO
Components:
Function Name Type
product LeuO protein
reactant leuO_mRNA RNA
R1 R2 R3 R4 R5 R6 R7 R8 R9 R10 R11 R12 R13 R14 R15 R16 R17 R18 R19 R20 R21 R22 R23 R24 R25 R26 R27 R28 R29 R30 R31 R32 R33 R34 R35 R36 R37 R38 R39 R40 R41 R42 R43 R44 R45 R46 R47 R48



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