RegulonDB RegulonDB

IscR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
nfuA_mRNA ubiquinone SufC SufS ThiI alanine napFDAGHBC NfuA RnlA IscU NapB NapA HyaD ErpA HyaC ubiquinol NapA SufD SufC HyaB [disordered-form [Fe-S] cluster scaffold protein] deoxynucleoside diphosphate reduced Cytochrome C protein NapG ydiU_mRNA SufB NapB HyaF sulfurylated sulfur-carrier protein ThiI ydiU HyaE [2Fe-2S] rnlAB_mRNA guanosine-diphosphate hyaABCDEF RnlB oxidized NrdH glutaredoxin-like protein NrdE rnlAB HyaA NrdF mRNA fragments acceptors HyaB YdiU NrdI cysteine ferri c-type cytochrome Reduced-NapC-proteins NrdF S-sulfanyl-[cysteine desulfurase]-[disordered-form scaffold protein] complex RnlB NapG nrdHIEF nitrite NapH sulfurated sulfur donor NrdH dGDP IscR IscA NapH IscR unsulfurated [sulfur donor] 3-sulfinoalanine SufA cytidine-diphosphate napFDAGHBC_mRNA erpA_mRNA reduced thioredoxin mRNA nfuA selenide NrdE SufB nucleoside diphosphate iscRSUA NapC HyaC Oxidized-NapC-proteins dADP NapD [L-cysteine desulfurase] L-cysteine persulfide sufABCDSE SufE menaquinol thioredoxin disulfide sulfite hyaABCDEF_mRNA [2Fe-2S] SufD A(H2) uridine-diphosphate dUDP selenocysteine YgaN IscS HyaA protein cysteines nitrate erpA sufABCDSE_mRNA vitamin K2 nrdHIEF_mRNA NapF iscRSUA_mRNA RnlA S-sulfanyl-[L-cysteine desulfurase] cystein desulfurase dCDP


Gensor Unit       
Name: IscR
Description: Molecular biology level
Detailed: In the presence of oxygen, IscR negatively regulates the expression of genes required for deoxyribonucleotide and cysteine metabolic process and positively regulates the expression of genes involved in respiratory electron transport chain, nitrate assimilation and mRNA catabolism. Under these conditions, IscR remains unmodified, binds its target sites preventing in some cases and enabling at others the expression of its regulated genes. In the absence of oxygen (or “Under anaerobic conditions”), IscR is modified to IscR-(2Fe-2S)1+, binds its target site preventing its own expression.
Less detailed: In the presence of oxygen, IscR negatively regulates the expression of genes needed for deoxyribonucleotide and cysteine metabolic process and positively regulates the expression of genes involved in respiratory electron transport chain, nitrate assimilation and mRNA catabolism. In the absence of oxygen, IscR negatively regulates its own expression.

Physiology level
Detailed: The presence of (2Fe-2S) cluster bound to IscR inhibits its own expression. Under this condition the gene of IscR is not expressed. When IscR is not bound to a (2Fe-2S)1+ cluster induces the expression of genes involved with reduction of nucleotides to deoxynucleotides, degradation of cysteine to alanine and represses the expression of genes related with electron transference, nitrate reduction to nitrite and mRNA degradation. Under this condition the genes necessary for reduction of nucleotides to deoxynucleotides, degradation of cysteine to alanine are expressed and the genes related with electron transference, nitrate reduction to nitrite and mRNA degradation, are not expressed.
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Classification:
Groups: Posttranslational modification, protein turnover, chaperones
Transcription
Energy production and conversion
Amino acid transport and metabolism
Nucleotide transport and metabolism
Gene Ontology Terms (GO): biological_process GO:0006260 - DNA replication
GO:0090502 - RNA phosphodiester bond hydrolysis, endonucleolytic
GO:0044571 - [2Fe-2S] cluster assembly
GO:0009060 - aerobic respiration
GO:0019645 - anaerobic electron transport chain
GO:0009061 - anaerobic respiration
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cellular_component GO:0044569 - [Ni-Fe] hydrogenase complex
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0009375 - ferredoxin hydrogenase complex
GO:0016021 - integral component of membrane
GO:0005887 - integral component of plasma membrane
GO:0031237 - intrinsic component of periplasmic side of plasma membrane
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molecular_function GO:0051537 - 2 iron, 2 sulfur cluster binding
GO:0051538 - 3 iron, 4 sulfur cluster binding
GO:0051539 - 4 iron, 4 sulfur cluster binding
GO:0005524 - ATP binding
GO:0016887 - ATPase activity
GO:0003677 - DNA binding
GO:0003700 - DNA-binding transcription factor activity
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Components:
  Function Name Type
  simple_molecule 3-sulfinoalanine simple_molecule
  simple_molecule A(H2) simple_molecule
  protein ErpA protein
  protein HyaA protein
  complex HyaA-HyaB-HyaC complex
  protein HyaB protein
  protein HyaC protein
  protein HyaD protein
  protein HyaE protein
  protein HyaF protein
  protein IscA protein
  protein IscR protein
  complex IscR-[2Fe-2S] complex
  protein IscS protein
  protein IscU protein
  protein NapA protein
  protein NapB protein
  complex NapB-NapA complex
  protein NapC protein
  protein NapD protein
  protein NapF protein
  protein NapG protein
  complex NapG-NapH complex
  protein NapH protein
  protein NfuA protein
  protein NrdE protein
  complex NrdE-NrdF complex
  protein NrdF protein
  protein NrdH protein
  protein NrdI protein
  simple_molecule Oxidized-NapC-proteins simple_molecule
  simple_molecule Reduced-NapC-proteins simple_molecule
  protein RnlA protein
  protein RnlB protein
  complex RnlB-RnlA complex
  simple_molecule S-sulfanyl-[L-cysteine desulfurase] simple_molecule
  simple_molecule S-sulfanyl-[cysteine desulfurase]-[disordered-form scaffold protein] complex simple_molecule
  protein SufA protein
  protein SufB protein
  complex SufB-SufC-SufD complex
  protein SufC protein
  protein SufD protein
  protein SufE protein
  protein SufS protein
  simple_molecule ThiI simple_molecule
  protein YdiU protein
  simple_molecule YgaN simple_molecule
  simple_molecule [2Fe-2S] simple_molecule
  simple_molecule [L-cysteine desulfurase] L-cysteine persulfide simple_molecule
  simple_molecule [disordered-form [Fe-S] cluster scaffold protein] simple_molecule
  simple_molecule acceptors simple_molecule
  simple_molecule alanine simple_molecule
  simple_molecule cystein desulfurase simple_molecule
  simple_molecule cysteine simple_molecule
  simple_molecule cytidine-diphosphate simple_molecule
  simple_molecule dADP simple_molecule
  simple_molecule dCDP simple_molecule
  simple_molecule dGDP simple_molecule
  simple_molecule dUDP simple_molecule
  simple_molecule deoxynucleoside diphosphate simple_molecule
  gene erpA gene
  RNA erpA_mRNA RNA
  simple_molecule ferri c-type cytochrome simple_molecule
  simple_molecule guanosine-diphosphate simple_molecule
  gene hyaABCDEF gene
  RNA hyaABCDEF_mRNA RNA
  gene iscRSUA gene
  RNA iscRSUA_mRNA RNA
  simple_molecule mRNA simple_molecule
  simple_molecule mRNA fragments simple_molecule
  simple_molecule menaquinol simple_molecule
  gene napFDAGHBC gene
  RNA napFDAGHBC_mRNA RNA
  gene nfuA gene
  RNA nfuA_mRNA RNA
  simple_molecule nitrate simple_molecule
  simple_molecule nitrite simple_molecule
  gene nrdHIEF gene
  RNA nrdHIEF_mRNA RNA
  simple_molecule nucleoside diphosphate simple_molecule
  simple_molecule oxidized NrdH glutaredoxin-like protein simple_molecule
  simple_molecule protein cysteines simple_molecule
  simple_molecule reduced Cytochrome C protein simple_molecule
  simple_molecule reduced thioredoxin simple_molecule
  gene rnlAB gene
  RNA rnlAB_mRNA RNA
  simple_molecule selenide simple_molecule
  simple_molecule selenocysteine simple_molecule
  gene sufABCDSE gene
  RNA sufABCDSE_mRNA RNA
  simple_molecule sulfite simple_molecule
  simple_molecule sulfurated sulfur donor simple_molecule
  simple_molecule sulfurylated sulfur-carrier protein ThiI simple_molecule
  simple_molecule thioredoxin disulfide simple_molecule
  simple_molecule ubiquinol simple_molecule
  simple_molecule ubiquinone simple_molecule
  simple_molecule unsulfurated [sulfur donor] simple_molecule
  simple_molecule uridine-diphosphate simple_molecule
  simple_molecule vitamin K2 simple_molecule
  gene ydiU gene
  RNA ydiU_mRNA RNA


Reactions       
Showing 65 reactions
IscR nrdHIEF nrdHIEF_mRNA
Name: nrdHIEF -> nrdHIEF_mRNA
Description: Transcription of transcription unit nrdHIEF. Reaction activation by IscR.
Type: transcription
Pathway Components: nrdHIEF - IscR -> nrdHIEF_mRNA
Components:
Function Name Type
activator IscR protein
reactant nrdHIEF gene
product nrdHIEF_mRNA RNA
IscR sufABCDSE sufABCDSE_mRNA
Name: sufABCDSE -> sufABCDSE_mRNA
Description: Transcription of transcription unit sufABCDSE. Reaction activation by IscR.
Type: transcription
Pathway Components: sufABCDSE - IscR -> sufABCDSE_mRNA
Components:
Function Name Type
activator IscR protein
reactant sufABCDSE gene
product sufABCDSE_mRNA RNA
IscR ydiU ydiU_mRNA
Name: ydiU -> ydiU_mRNA
Description: Transcription of transcription unit ydiU. Reaction activation by IscR.
Type: transcription
Pathway Components: ydiU - IscR -> ydiU_mRNA
Components:
Function Name Type
activator IscR protein
reactant ydiU gene
product ydiU_mRNA RNA
IscR erpA erpA_mRNA
Name: erpA -> erpA_mRNA
Description: Transcription of transcription unit erpA. Reaction inhibition by IscR.
Type: transcription
Pathway Components: erpA - IscR -> erpA_mRNA
Components:
Function Name Type
inhibitor IscR protein
reactant erpA gene
product erpA_mRNA RNA
IscR hyaABCDEF hyaABCDEF_mRNA
Name: hyaABCDEF -> hyaABCDEF_mRNA
Description: Transcription of transcription unit hyaABCDEF. Reaction inhibition by IscR.
Type: transcription
Pathway Components: hyaABCDEF - IscR -> hyaABCDEF_mRNA
Components:
Function Name Type
inhibitor IscR protein
reactant hyaABCDEF gene
product hyaABCDEF_mRNA RNA
IscR napFDAGHBC napFDAGHBC_mRNA
Name: napFDAGHBC -> napFDAGHBC_mRNA
Description: Transcription of transcription unit napFDAGHBC. Reaction inhibition by IscR.
Type: transcription
Pathway Components: napFDAGHBC - IscR -> napFDAGHBC_mRNA
Components:
Function Name Type
inhibitor IscR protein
reactant napFDAGHBC gene
product napFDAGHBC_mRNA RNA
IscR nfuA nfuA_mRNA
Name: nfuA -> nfuA_mRNA
Description: Transcription of transcription unit nfuA. Reaction inhibition by IscR.
Type: transcription
Pathway Components: nfuA - IscR -> nfuA_mRNA
Components:
Function Name Type
inhibitor IscR protein
reactant nfuA gene
product nfuA_mRNA RNA
IscR rnlAB rnlAB_mRNA
Name: rnlAB -> rnlAB_mRNA
Description: Transcription of transcription unit rnlAB. Reaction inhibition by IscR.
Type: transcription
Pathway Components: rnlAB - IscR -> rnlAB_mRNA
Components:
Function Name Type
inhibitor IscR protein
reactant rnlAB gene
product rnlAB_mRNA RNA
[2Fe-2S] + IscR IscR-[2Fe-2S]
Name: [2Fe-2S] + IscR -> IscR-[2Fe-2S]
Description: Reaction transforming [2Fe-2S], IscR into IscR-[2Fe-2S]
Type: state transition
Pathway Components: [2Fe-2S] + IscR -> IscR-[2Fe-2S]
Components:
Function Name Type
reactant IscR protein
product IscR-[2Fe-2S] complex
reactant [2Fe-2S] simple_molecule
IscR-[2Fe-2S] iscRSUA iscRSUA_mRNA
Name: iscRSUA -> iscRSUA_mRNA
Description: Transcription of transcription unit iscRSUA. Reaction inhibition by IscR-[2Fe-2S].
Type: transcription
Pathway Components: iscRSUA - IscR-[2Fe-2S] -> iscRSUA_mRNA
Components:
Function Name Type
inhibitor IscR-[2Fe-2S] complex
reactant iscRSUA gene
product iscRSUA_mRNA RNA
nfuA_mRNA NfuA
Name: nfuA_mRNA -> NfuA
Description: Translation of NfuA
Type: translation
Pathway Components: nfuA_mRNA -> NfuA
Components:
Function Name Type
product NfuA protein
reactant nfuA_mRNA RNA
erpA_mRNA ErpA
Name: erpA_mRNA -> ErpA
Description: Translation of ErpA
Type: translation
Pathway Components: erpA_mRNA -> ErpA
Components:
Function Name Type
product ErpA protein
reactant erpA_mRNA RNA
ydiU_mRNA YdiU
Name: ydiU_mRNA -> YdiU
Description: Translation of YdiU
Type: translation
Pathway Components: ydiU_mRNA -> YdiU
Components:
Function Name Type
product YdiU protein
reactant ydiU_mRNA RNA
sufABCDSE_mRNA SufA
Name: sufABCDSE_mRNA -> SufA
Description: Translation of SufA
Type: translation
Pathway Components: sufABCDSE_mRNA -> SufA
Components:
Function Name Type
product SufA protein
reactant sufABCDSE_mRNA RNA
sufABCDSE_mRNA SufB
Name: sufABCDSE_mRNA -> SufB
Description: Translation of SufB
Type: translation
Pathway Components: sufABCDSE_mRNA -> SufB
Components:
Function Name Type
product SufB protein
reactant sufABCDSE_mRNA RNA
SufB + SufD + SufC SufB-SufC-SufD
Name: SufB + SufD + SufC -> SufB-SufC-SufD
Description: Reaction transforming SufB, SufD, SufC into SufB-SufC-SufD
Type: state transition
Pathway Components: SufB + SufD + SufC -> SufB-SufC-SufD
Components:
Function Name Type
reactant SufB protein
product SufB-SufC-SufD complex
reactant SufC protein
reactant SufD protein
sufABCDSE_mRNA SufC
Name: sufABCDSE_mRNA -> SufC
Description: Translation of SufC
Type: translation
Pathway Components: sufABCDSE_mRNA -> SufC
Components:
Function Name Type
product SufC protein
reactant sufABCDSE_mRNA RNA
sufABCDSE_mRNA SufD
Name: sufABCDSE_mRNA -> SufD
Description: Translation of SufD
Type: translation
Pathway Components: sufABCDSE_mRNA -> SufD
Components:
Function Name Type
product SufD protein
reactant sufABCDSE_mRNA RNA
sufABCDSE_mRNA SufS
Name: sufABCDSE_mRNA -> SufS
Description: Translation of SufS
Type: translation
Pathway Components: sufABCDSE_mRNA -> SufS
Components:
Function Name Type
product SufS protein
reactant sufABCDSE_mRNA RNA
IscS SufS unsulfurated [sulfur donor] + cysteine sulfurated sulfur donor + alanine
Name: unsulfurated [sulfur donor] + cysteine -> sulfurated sulfur donor + alanine
Description: Reaction transforming unsulfurated [sulfur donor], cysteine into sulfurated sulfur donor, alanine
Type: state transition
Pathway Components: unsulfurated [sulfur donor] + cysteine - IscS - SufS -> sulfurated sulfur donor + alanine
Components:
Function Name Type
catalyzer IscS protein
catalyzer SufS protein
product alanine simple_molecule
reactant cysteine simple_molecule
product sulfurated sulfur donor simple_molecule
reactant unsulfurated [sulfur donor] simple_molecule
IscS SufS protein cysteines + cysteine Products
Name: protein cysteines + cysteine -> [L-cysteine desulfurase] L-cysteine persulfide + alanine
Description: Reaction transforming protein cysteines, cysteine into [L-cysteine desulfurase] L-cysteine persulfide, alanine
Type: state transition
Pathway Components: protein cysteines + cysteine - IscS - SufS -> [L-cysteine desulfurase] L-cysteine persulfide + alanine
Components:
Function Name Type
catalyzer IscS protein
catalyzer SufS protein
product [L-cysteine desulfurase] L-cysteine persulfide simple_molecule
product alanine simple_molecule
reactant cysteine simple_molecule
reactant protein cysteines simple_molecule
IscS SufS Reactants sulfurated sulfur donor + protein cysteines
Name: [L-cysteine desulfurase] L-cysteine persulfide + unsulfurated [sulfur donor] -> sulfurated sulfur donor + protein cysteines
Description: Reaction transforming [L-cysteine desulfurase] L-cysteine persulfide, unsulfurated [sulfur donor] into sulfurated sulfur donor, protein cysteines
Type: state transition
Pathway Components: [L-cysteine desulfurase] L-cysteine persulfide + unsulfurated [sulfur donor] - IscS - SufS -> sulfurated sulfur donor + protein cysteines
Components:
Function Name Type
catalyzer IscS protein
catalyzer SufS protein
reactant [L-cysteine desulfurase] L-cysteine persulfide simple_molecule
product protein cysteines simple_molecule
product sulfurated sulfur donor simple_molecule
reactant unsulfurated [sulfur donor] simple_molecule
SufS 3-sulfinoalanine alanine + sulfite
Name: 3-sulfinoalanine -> alanine + sulfite
Description: Reaction transforming 3-sulfinoalanine into alanine, sulfite
Type: state transition
Pathway Components: 3-sulfinoalanine - SufS -> alanine + sulfite
Components:
Function Name Type
reactant 3-sulfinoalanine simple_molecule
catalyzer SufS protein
product alanine simple_molecule
product sulfite simple_molecule
SufS selenocysteine + A(H2) acceptors + selenide + alanine
Name: selenocysteine + A(H2) -> acceptors + selenide + alanine
Description: Reaction transforming selenocysteine, A(H2) into acceptors, selenide , alanine
Type: state transition
Pathway Components: selenocysteine + A(H2) - SufS -> acceptors + selenide + alanine
Components:
Function Name Type
reactant A(H2) simple_molecule
catalyzer SufS protein
product acceptors simple_molecule
product alanine simple_molecule
product selenide simple_molecule
reactant selenocysteine simple_molecule
sufABCDSE_mRNA SufE
Name: sufABCDSE_mRNA -> SufE
Description: Translation of SufE
Type: translation
Pathway Components: sufABCDSE_mRNA -> SufE
Components:
Function Name Type
product SufE protein
reactant sufABCDSE_mRNA RNA
rnlAB_mRNA RnlA
Name: rnlAB_mRNA -> RnlA
Description: Translation of RnlA
Type: translation
Pathway Components: rnlAB_mRNA -> RnlA
Components:
Function Name Type
product RnlA protein
reactant rnlAB_mRNA RNA
RnlA mRNA mRNA fragments
Name: mRNA -> mRNA fragments
Description: Reaction transforming mRNA into mRNA fragments
Type: state transition
Pathway Components: mRNA - RnlA -> mRNA fragments
Components:
Function Name Type
catalyzer RnlA protein
reactant mRNA simple_molecule
product mRNA fragments simple_molecule
RnlA + RnlB RnlB-RnlA
Name: RnlA + RnlB -> RnlB-RnlA
Description: Reaction transforming RnlA, RnlB into RnlB-RnlA
Type: state transition
Pathway Components: RnlA + RnlB -> RnlB-RnlA
Components:
Function Name Type
reactant RnlA protein
reactant RnlB protein
product RnlB-RnlA complex
rnlAB_mRNA RnlB
Name: rnlAB_mRNA -> RnlB
Description: Translation of RnlB
Type: translation
Pathway Components: rnlAB_mRNA -> RnlB
Components:
Function Name Type
product RnlB protein
reactant rnlAB_mRNA RNA
iscRSUA_mRNA IscR
Name: iscRSUA_mRNA -> IscR
Description: Translation of IscR
Type: translation
Pathway Components: iscRSUA_mRNA -> IscR
Components:
Function Name Type
product IscR protein
reactant iscRSUA_mRNA RNA
iscRSUA_mRNA IscS
Name: iscRSUA_mRNA -> IscS
Description: Translation of IscS
Type: translation
Pathway Components: iscRSUA_mRNA -> IscS
Components:
Function Name Type
product IscS protein
reactant iscRSUA_mRNA RNA
IscS cystein desulfurase + cysteine S-sulfanyl-[L-cysteine desulfurase] + alanine
Name: cystein desulfurase + cysteine -> S-sulfanyl-[L-cysteine desulfurase] + alanine
Description: Reaction transforming cystein desulfurase, cysteine into S-sulfanyl-[L-cysteine desulfurase], alanine
Type: state transition
Pathway Components: cystein desulfurase + cysteine - IscS -> S-sulfanyl-[L-cysteine desulfurase] + alanine
Components:
Function Name Type
catalyzer IscS protein
product S-sulfanyl-[L-cysteine desulfurase] simple_molecule
product alanine simple_molecule
reactant cystein desulfurase simple_molecule
reactant cysteine simple_molecule
IscS Reactants Products
Name: [L-cysteine desulfurase] L-cysteine persulfide + ThiI -> sulfurylated sulfur-carrier protein ThiI + protein cysteines
Description: Reaction transforming [L-cysteine desulfurase] L-cysteine persulfide, ThiI into sulfurylated sulfur-carrier protein ThiI, protein cysteines
Type: state transition
Pathway Components: [L-cysteine desulfurase] L-cysteine persulfide + ThiI - IscS -> sulfurylated sulfur-carrier protein ThiI + protein cysteines
Components:
Function Name Type
catalyzer IscS protein
reactant ThiI simple_molecule
reactant [L-cysteine desulfurase] L-cysteine persulfide simple_molecule
product protein cysteines simple_molecule
product sulfurylated sulfur-carrier protein ThiI simple_molecule
iscRSUA_mRNA IscU
Name: iscRSUA_mRNA -> IscU
Description: Translation of IscU
Type: translation
Pathway Components: iscRSUA_mRNA -> IscU
Components:
Function Name Type
product IscU protein
reactant iscRSUA_mRNA RNA
IscU Reactants Products
Name: [disordered-form [Fe-S] cluster scaffold protein] + S-sulfanyl-[L-cysteine desulfurase] -> S-sulfanyl-[cysteine desulfurase]-[disordered-form scaffold protein] complex
Description: Reaction transforming [disordered-form [Fe-S] cluster scaffold protein], S-sulfanyl-[L-cysteine desulfurase] into S-sulfanyl-[cysteine desulfurase]-[disordered-form scaffold protein] complex
Type: state transition
Pathway Components: [disordered-form [Fe-S] cluster scaffold protein] + S-sulfanyl-[L-cysteine desulfurase] - IscU -> S-sulfanyl-[cysteine desulfurase]-[disordered-form scaffold protein] complex
Components:
Function Name Type
catalyzer IscU protein
reactant S-sulfanyl-[L-cysteine desulfurase] simple_molecule
product S-sulfanyl-[cysteine desulfurase]-[disordered-form scaffold protein] complex simple_molecule
reactant [disordered-form [Fe-S] cluster scaffold protein] simple_molecule
iscRSUA_mRNA IscA
Name: iscRSUA_mRNA -> IscA
Description: Translation of IscA
Type: translation
Pathway Components: iscRSUA_mRNA -> IscA
Components:
Function Name Type
product IscA protein
reactant iscRSUA_mRNA RNA
hyaABCDEF_mRNA HyaA
Name: hyaABCDEF_mRNA -> HyaA
Description: Translation of HyaA
Type: translation
Pathway Components: hyaABCDEF_mRNA -> HyaA
Components:
Function Name Type
product HyaA protein
reactant hyaABCDEF_mRNA RNA
HyaB + HyaA + HyaC HyaA-HyaB-HyaC
Name: HyaB + HyaA + HyaC -> HyaA-HyaB-HyaC
Description: Reaction transforming HyaB, HyaA, HyaC into HyaA-HyaB-HyaC
Type: state transition
Pathway Components: HyaB + HyaA + HyaC -> HyaA-HyaB-HyaC
Components:
Function Name Type
reactant HyaA protein
product HyaA-HyaB-HyaC complex
reactant HyaB protein
reactant HyaC protein
hyaABCDEF_mRNA HyaB
Name: hyaABCDEF_mRNA -> HyaB
Description: Translation of HyaB
Type: translation
Pathway Components: hyaABCDEF_mRNA -> HyaB
Components:
Function Name Type
product HyaB protein
reactant hyaABCDEF_mRNA RNA
hyaABCDEF_mRNA HyaC
Name: hyaABCDEF_mRNA -> HyaC
Description: Translation of HyaC
Type: translation
Pathway Components: hyaABCDEF_mRNA -> HyaC
Components:
Function Name Type
product HyaC protein
reactant hyaABCDEF_mRNA RNA
hyaABCDEF_mRNA HyaD
Name: hyaABCDEF_mRNA -> HyaD
Description: Translation of HyaD
Type: translation
Pathway Components: hyaABCDEF_mRNA -> HyaD
Components:
Function Name Type
product HyaD protein
reactant hyaABCDEF_mRNA RNA
hyaABCDEF_mRNA HyaE
Name: hyaABCDEF_mRNA -> HyaE
Description: Translation of HyaE
Type: translation
Pathway Components: hyaABCDEF_mRNA -> HyaE
Components:
Function Name Type
product HyaE protein
reactant hyaABCDEF_mRNA RNA
hyaABCDEF_mRNA HyaF
Name: hyaABCDEF_mRNA -> HyaF
Description: Translation of HyaF
Type: translation
Pathway Components: hyaABCDEF_mRNA -> HyaF
Components:
Function Name Type
product HyaF protein
reactant hyaABCDEF_mRNA RNA
napFDAGHBC_mRNA NapF
Name: napFDAGHBC_mRNA -> NapF
Description: Translation of NapF
Type: translation
Pathway Components: napFDAGHBC_mRNA -> NapF
Components:
Function Name Type
product NapF protein
reactant napFDAGHBC_mRNA RNA
napFDAGHBC_mRNA NapD
Name: napFDAGHBC_mRNA -> NapD
Description: Translation of NapD
Type: translation
Pathway Components: napFDAGHBC_mRNA -> NapD
Components:
Function Name Type
product NapD protein
reactant napFDAGHBC_mRNA RNA
napFDAGHBC_mRNA NapA
Name: napFDAGHBC_mRNA -> NapA
Description: Translation of NapA
Type: translation
Pathway Components: napFDAGHBC_mRNA -> NapA
Components:
Function Name Type
product NapA protein
reactant napFDAGHBC_mRNA RNA
NapB + NapA NapB-NapA
Name: NapB + NapA -> NapB-NapA
Description: Reaction transforming NapB, NapA into NapB-NapA
Type: state transition
Pathway Components: NapB + NapA -> NapB-NapA
Components:
Function Name Type
reactant NapA protein
reactant NapB protein
product NapB-NapA complex
NapB-NapA Reduced-NapC-proteins + nitrate Oxidized-NapC-proteins + nitrite
Name: Reduced-NapC-proteins + nitrate -> Oxidized-NapC-proteins + nitrite
Description: Reaction transforming Reduced-NapC-proteins, nitrate into Oxidized-NapC-proteins, nitrite
Type: state transition
Pathway Components: Reduced-NapC-proteins + nitrate - NapB-NapA -> Oxidized-NapC-proteins + nitrite
Components:
Function Name Type
catalyzer NapB-NapA complex
product Oxidized-NapC-proteins simple_molecule
reactant Reduced-NapC-proteins simple_molecule
reactant nitrate simple_molecule
product nitrite simple_molecule
napFDAGHBC_mRNA NapG
Name: napFDAGHBC_mRNA -> NapG
Description: Translation of NapG
Type: translation
Pathway Components: napFDAGHBC_mRNA -> NapG
Components:
Function Name Type
product NapG protein
reactant napFDAGHBC_mRNA RNA
NapG + NapH NapG-NapH
Name: NapG + NapH -> NapG-NapH
Description: Reaction transforming NapG, NapH into NapG-NapH
Type: state transition
Pathway Components: NapG + NapH -> NapG-NapH
Components:
Function Name Type
reactant NapG protein
product NapG-NapH complex
reactant NapH protein
NapG-NapH Oxidized-NapC-proteins + ubiquinol Reduced-NapC-proteins + ubiquinone
Name: Oxidized-NapC-proteins + ubiquinol -> Reduced-NapC-proteins + ubiquinone
Description: Reaction transforming Oxidized-NapC-proteins, ubiquinol into Reduced-NapC-proteins, ubiquinone
Type: state transition
Pathway Components: Oxidized-NapC-proteins + ubiquinol - NapG-NapH -> Reduced-NapC-proteins + ubiquinone
Components:
Function Name Type
catalyzer NapG-NapH complex
reactant Oxidized-NapC-proteins simple_molecule
product Reduced-NapC-proteins simple_molecule
reactant ubiquinol simple_molecule
product ubiquinone simple_molecule
napFDAGHBC_mRNA NapH
Name: napFDAGHBC_mRNA -> NapH
Description: Translation of NapH
Type: translation
Pathway Components: napFDAGHBC_mRNA -> NapH
Components:
Function Name Type
product NapH protein
reactant napFDAGHBC_mRNA RNA
napFDAGHBC_mRNA NapB
Name: napFDAGHBC_mRNA -> NapB
Description: Translation of NapB
Type: translation
Pathway Components: napFDAGHBC_mRNA -> NapB
Components:
Function Name Type
product NapB protein
reactant napFDAGHBC_mRNA RNA
napFDAGHBC_mRNA NapC
Name: napFDAGHBC_mRNA -> NapC
Description: Translation of NapC
Type: translation
Pathway Components: napFDAGHBC_mRNA -> NapC
Components:
Function Name Type
product NapC protein
reactant napFDAGHBC_mRNA RNA
NapC ferri c-type cytochrome + menaquinol reduced Cytochrome C protein + vitamin K2
Name: ferri c-type cytochrome + menaquinol -> reduced Cytochrome C protein + vitamin K2
Description: Reaction transforming ferri c-type cytochrome, menaquinol into reduced Cytochrome C protein, vitamin K2
Type: state transition
Pathway Components: ferri c-type cytochrome + menaquinol - NapC -> reduced Cytochrome C protein + vitamin K2
Components:
Function Name Type
catalyzer NapC protein
reactant ferri c-type cytochrome simple_molecule
reactant menaquinol simple_molecule
product reduced Cytochrome C protein simple_molecule
product vitamin K2 simple_molecule
nrdHIEF_mRNA NrdH
Name: nrdHIEF_mRNA -> NrdH
Description: Translation of NrdH
Type: translation
Pathway Components: nrdHIEF_mRNA -> NrdH
Components:
Function Name Type
product NrdH protein
reactant nrdHIEF_mRNA RNA
nrdHIEF_mRNA NrdI
Name: nrdHIEF_mRNA -> NrdI
Description: Translation of NrdI
Type: translation
Pathway Components: nrdHIEF_mRNA -> NrdI
Components:
Function Name Type
product NrdI protein
reactant nrdHIEF_mRNA RNA
nrdHIEF_mRNA NrdE
Name: nrdHIEF_mRNA -> NrdE
Description: Translation of NrdE
Type: translation
Pathway Components: nrdHIEF_mRNA -> NrdE
Components:
Function Name Type
product NrdE protein
reactant nrdHIEF_mRNA RNA
NrdF + NrdE NrdE-NrdF
Name: NrdF + NrdE -> NrdE-NrdF
Description: Reaction transforming NrdF, NrdE into NrdE-NrdF
Type: state transition
Pathway Components: NrdF + NrdE -> NrdE-NrdF
Components:
Function Name Type
reactant NrdE protein
product NrdE-NrdF complex
reactant NrdF protein
NrdE-NrdF cytidine-diphosphate + YgaN oxidized NrdH glutaredoxin-like protein + dCDP
Name: cytidine-diphosphate + YgaN -> oxidized NrdH glutaredoxin-like protein + dCDP
Description: Reaction transforming cytidine-diphosphate, YgaN into oxidized NrdH glutaredoxin-like protein, dCDP
Type: state transition
Pathway Components: cytidine-diphosphate + YgaN - NrdE-NrdF -> oxidized NrdH glutaredoxin-like protein + dCDP
Components:
Function Name Type
catalyzer NrdE-NrdF complex
reactant YgaN simple_molecule
reactant cytidine-diphosphate simple_molecule
product dCDP simple_molecule
product oxidized NrdH glutaredoxin-like protein simple_molecule
NrdE-NrdF guanosine-diphosphate + YgaN oxidized NrdH glutaredoxin-like protein + dGDP
Name: guanosine-diphosphate + YgaN -> oxidized NrdH glutaredoxin-like protein + dGDP
Description: Reaction transforming guanosine-diphosphate, YgaN into oxidized NrdH glutaredoxin-like protein, dGDP
Type: state transition
Pathway Components: guanosine-diphosphate + YgaN - NrdE-NrdF -> oxidized NrdH glutaredoxin-like protein + dGDP
Components:
Function Name Type
catalyzer NrdE-NrdF complex
reactant YgaN simple_molecule
product dGDP simple_molecule
reactant guanosine-diphosphate simple_molecule
product oxidized NrdH glutaredoxin-like protein simple_molecule
NrdE-NrdF YgaN oxidized NrdH glutaredoxin-like protein + dADP
Name: YgaN -> oxidized NrdH glutaredoxin-like protein + dADP
Description: Reaction transforming YgaN into oxidized NrdH glutaredoxin-like protein, dADP
Type: state transition
Pathway Components: YgaN - NrdE-NrdF -> oxidized NrdH glutaredoxin-like protein + dADP
Components:
Function Name Type
catalyzer NrdE-NrdF complex
reactant YgaN simple_molecule
product dADP simple_molecule
product oxidized NrdH glutaredoxin-like protein simple_molecule
NrdE-NrdF uridine-diphosphate + YgaN oxidized NrdH glutaredoxin-like protein + dUDP
Name: uridine-diphosphate + YgaN -> oxidized NrdH glutaredoxin-like protein + dUDP
Description: Reaction transforming uridine-diphosphate, YgaN into oxidized NrdH glutaredoxin-like protein, dUDP
Type: state transition
Pathway Components: uridine-diphosphate + YgaN - NrdE-NrdF -> oxidized NrdH glutaredoxin-like protein + dUDP
Components:
Function Name Type
catalyzer NrdE-NrdF complex
reactant YgaN simple_molecule
product dUDP simple_molecule
product oxidized NrdH glutaredoxin-like protein simple_molecule
reactant uridine-diphosphate simple_molecule
NrdE-NrdF