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HypT Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
iron dicitrate metNIQ oxygen_Ext methionine FecC methionine_Ext succinyl-homoserine aspartate Methionine S-oxide fecABCDE FecB ExbB fecABCDE_mRNA cydAB_mRNA acetyl-DL-methionine_Ext succinate FecR 3',5'-ADP ammonium MetQ methionine-R-sulfoxide_Ext cydAB MetI metBL_mRNA FecR (2Z)-2-aminobut-2-enoate aspartate-semialdehyde TonB ExbB metNIQ_mRNA cysteine FecD iron dicitrate_Ext Met-oxidized PAPS MetL reduced thioredoxin MetN FecE CydX ExbD FecE Methionine S-oxide_Ext CysH TonB cystathionine MetN FecA MetB HypT CydX thioredoxin disulfide CydB acetyl-DL-methionine MetQ homo-ser aspartyl-4-P HypT CydB ubiquinone FecA methionine-(S)-S-oxide_Ext methionine-R-sulfoxide CydA 2-oxobutyrate FecC This Gensor Unit is not yet available ExbD CydA ubiquinol_Ext This Gensor Unit is not yet available methionine-(S)-S-oxide sulfite MetI FecA metBL Met-oxidized FecD FecB


Gensor Unit       
Name: HypT
Classification:
Groups: Inorganic ion transport and metabolism
Energy production and conversion
Amino acid transport and metabolism
Gene Ontology Terms (GO): biological_process GO:0048473 - D-methionine transport
GO:1902475 - L-alpha-amino acid transmembrane transport
GO:0019646 - aerobic electron transport chain
GO:0006865 - amino acid transport
GO:0009067 - aspartate family amino acid biosynthetic process
GO:0008652 - cellular amino acid biosynthetic process
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cellular_component GO:0055052 - ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
GO:0009276 - Gram-negative-bacterium-type cell wall
GO:0046658 - anchored component of plasma membrane
GO:0009279 - cell outer membrane
GO:0070069 - cytochrome complex
GO:0005737 - cytoplasm
GO:0005829 - cytosol
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molecular_function GO:0005524 - ATP binding
GO:0016887 - ATPase activity
GO:0042626 - ATPase-coupled transmembrane transporter activity
GO:0048474 - D-methionine transmembrane transporter activity
GO:0015191 - L-methionine transmembrane transporter activity
GO:0050661 - NADP binding
GO:0004072 - aspartate kinase activity
Read more >
Components:
  Function Name Type
  simple_molecule (2Z)-2-aminobut-2-enoate simple_molecule
  simple_molecule 2-oxobutyrate simple_molecule
  simple_molecule 3',5'-ADP simple_molecule
  protein CydA protein
  complex CydA-CydB-CydX complex
  protein CydB protein
  protein CydX protein
  protein CysH protein
  protein ExbB protein
  protein ExbD protein
  protein FecA protein
  complex FecA-ExbD-ExbB-TonB complex
  complex FecA-FecR complex
  protein FecB protein
  protein FecC protein
  protein FecD protein
  protein FecE protein
  complex FecE-FecC-FecD-FecB complex
  protein FecR protein
  protein HypT protein
  complex HypT-Met-oxidized complex
  simple_molecule Met-oxidized simple_molecule
  protein MetB protein
  protein MetI protein
  protein MetL protein
  protein MetN protein
  complex MetN-MetI-MetQ complex
  protein MetQ protein
  simple_molecule Methionine S-oxide simple_molecule
  simple_molecule Methionine S-oxide_Ext simple_molecule
  simple_molecule PAPS simple_molecule
  protein TonB protein
  simple_molecule acetyl-DL-methionine simple_molecule
  simple_molecule acetyl-DL-methionine_Ext simple_molecule
  simple_molecule ammonium simple_molecule
  simple_molecule aspartate simple_molecule
  simple_molecule aspartate-semialdehyde simple_molecule
  simple_molecule aspartyl-4-P simple_molecule
  gene cydAB gene
  RNA cydAB_mRNA RNA
  gene cysH gene
  RNA cysH_mRNA RNA
  simple_molecule cystathionine simple_molecule
  simple_molecule cysteine simple_molecule
  gene fecABCDE gene
  RNA fecABCDE_mRNA RNA
  simple_molecule homo-ser simple_molecule
  simple_molecule iron dicitrate simple_molecule
  simple_molecule iron dicitrate_Ext simple_molecule
  gene metBL gene
  RNA metBL_mRNA RNA
  gene metNIQ gene
  RNA metNIQ_mRNA RNA
  simple_molecule methionine simple_molecule
  simple_molecule methionine-(S)-S-oxide simple_molecule
  simple_molecule methionine-(S)-S-oxide_Ext simple_molecule
  simple_molecule methionine-R-sulfoxide simple_molecule
  simple_molecule methionine-R-sulfoxide_Ext simple_molecule
  simple_molecule methionine_Ext simple_molecule
  simple_molecule oxygen_Ext simple_molecule
  simple_molecule reduced thioredoxin simple_molecule
  simple_molecule succinate simple_molecule
  simple_molecule succinyl-homoserine simple_molecule
  simple_molecule sulfite simple_molecule
  simple_molecule thioredoxin disulfide simple_molecule
  simple_molecule ubiquinol_Ext simple_molecule
  simple_molecule ubiquinone simple_molecule


Reactions       
Showing 39 reactions
Met-oxidized + HypT HypT-Met-oxidized
Name: Met-oxidized + HypT -> HypT-Met-oxidized
Description: Reaction transforming Met-oxidized, HypT into HypT-Met-oxidized
Type: state transition
Pathway Components: Met-oxidized + HypT -> HypT-Met-oxidized
Components:
Function Name Type
reactant HypT protein
product HypT-Met-oxidized complex
reactant Met-oxidized simple_molecule
HypT-Met-oxidized cydAB cydAB_mRNA
Name: cydAB -> cydAB_mRNA
Description: Transcription of transcription unit cydAB. Reaction activation by HypT-Met-oxidized.
Type: transcription
Pathway Components: cydAB - HypT-Met-oxidized -> cydAB_mRNA
Components:
Function Name Type
activator HypT-Met-oxidized complex
reactant cydAB gene
product cydAB_mRNA RNA
HypT-Met-oxidized cysH cysH_mRNA
Name: cysH -> cysH_mRNA
Description: Transcription of transcription unit cysH. Reaction activation by HypT-Met-oxidized.
Type: transcription
Pathway Components: cysH - HypT-Met-oxidized -> cysH_mRNA
Components:
Function Name Type
activator HypT-Met-oxidized complex
reactant cysH gene
product cysH_mRNA RNA
HypT-Met-oxidized metBL metBL_mRNA
Name: metBL -> metBL_mRNA
Description: Transcription of transcription unit metBL. Reaction activation by HypT-Met-oxidized.
Type: transcription
Pathway Components: metBL - HypT-Met-oxidized -> metBL_mRNA
Components:
Function Name Type
activator HypT-Met-oxidized complex
reactant metBL gene
product metBL_mRNA RNA
HypT-Met-oxidized metNIQ metNIQ_mRNA
Name: metNIQ -> metNIQ_mRNA
Description: Transcription of transcription unit metNIQ. Reaction activation by HypT-Met-oxidized.
Type: transcription
Pathway Components: metNIQ - HypT-Met-oxidized -> metNIQ_mRNA
Components:
Function Name Type
activator HypT-Met-oxidized complex
reactant metNIQ gene
product metNIQ_mRNA RNA
HypT-Met-oxidized fecABCDE fecABCDE_mRNA
Name: fecABCDE -> fecABCDE_mRNA
Description: Transcription of transcription unit fecABCDE. Reaction inhibition by HypT-Met-oxidized.
Type: transcription
Pathway Components: fecABCDE - HypT-Met-oxidized -> fecABCDE_mRNA
Components:
Function Name Type
inhibitor HypT-Met-oxidized complex
reactant fecABCDE gene
product fecABCDE_mRNA RNA
cydAB_mRNA CydA
Name: cydAB_mRNA -> CydA
Description: Translation of CydA
Type: translation
Pathway Components: cydAB_mRNA -> CydA
Components:
Function Name Type
product CydA protein
reactant cydAB_mRNA RNA
CydX + CydB + CydA CydA-CydB-CydX
Name: CydX + CydB + CydA -> CydA-CydB-CydX
Description: Reaction transforming CydX, CydB, CydA into CydA-CydB-CydX
Type: state transition
Pathway Components: CydX + CydB + CydA -> CydA-CydB-CydX
Components:
Function Name Type
reactant CydA protein
product CydA-CydB-CydX complex
reactant CydB protein
reactant CydX protein
CydA-CydB-CydX ubiquinol_Ext + oxygen_Ext ubiquinone
Name: ubiquinol_Ext + oxygen_Ext -> ubiquinone
Description: Transport of ubiquinol_Ext, oxygen_Ext through a bacterial membrane, leading to the presence of ubiquinone inside the cell.
Type: transport
Pathway Components: ubiquinol_Ext + oxygen_Ext - CydA-CydB-CydX -> ubiquinone
Components:
Function Name Type
catalyzer CydA-CydB-CydX complex
reactant oxygen_Ext simple_molecule
reactant ubiquinol_Ext simple_molecule
product ubiquinone simple_molecule
cydAB_mRNA CydB
Name: cydAB_mRNA -> CydB
Description: Translation of CydB
Type: translation
Pathway Components: cydAB_mRNA -> CydB
Components:
Function Name Type
product CydB protein
reactant cydAB_mRNA RNA
fecABCDE_mRNA FecA
Name: fecABCDE_mRNA -> FecA
Description: Translation of FecA
Type: translation
Pathway Components: fecABCDE_mRNA -> FecA
Components:
Function Name Type
product FecA protein
reactant fecABCDE_mRNA RNA
FecA + FecR FecA-FecR
Name: FecA + FecR -> FecA-FecR
Description: Reaction transforming FecA, FecR into FecA-FecR
Type: state transition
Pathway Components: FecA + FecR -> FecA-FecR
Components:
Function Name Type
reactant FecA protein
product FecA-FecR complex
reactant FecR protein
ExbB + ExbD + FecA + TonB FecA-ExbD-ExbB-TonB
Name: ExbB + ExbD + FecA + TonB -> FecA-ExbD-ExbB-TonB
Description: Reaction transforming ExbB, ExbD, FecA, TonB into FecA-ExbD-ExbB-TonB
Type: state transition
Pathway Components: ExbB + ExbD + FecA + TonB -> FecA-ExbD-ExbB-TonB
Components:
Function Name Type
reactant ExbB protein
reactant ExbD protein
reactant FecA protein
product FecA-ExbD-ExbB-TonB complex
reactant TonB protein
FecA-ExbD-ExbB-TonB FecE-FecC-FecD-FecB iron dicitrate_Ext iron dicitrate
Name: iron dicitrate_Ext -> iron dicitrate
Description: Transport of iron dicitrate_Ext through a bacterial membrane, leading to the presence of iron dicitrate inside the cell.
Type: transport
Pathway Components: iron dicitrate_Ext - FecA-ExbD-ExbB-TonB - FecE-FecC-FecD-FecB -> iron dicitrate
Components:
Function Name Type
catalyzer FecA-ExbD-ExbB-TonB complex
catalyzer FecE-FecC-FecD-FecB complex
product iron dicitrate simple_molecule
reactant iron dicitrate_Ext simple_molecule
fecABCDE_mRNA FecB
Name: fecABCDE_mRNA -> FecB
Description: Translation of FecB
Type: translation
Pathway Components: fecABCDE_mRNA -> FecB
Components:
Function Name Type
product FecB protein
reactant fecABCDE_mRNA RNA
FecC + FecB + FecD + FecE FecE-FecC-FecD-FecB
Name: FecC + FecB + FecD + FecE -> FecE-FecC-FecD-FecB
Description: Reaction transforming FecC, FecB, FecD, FecE into FecE-FecC-FecD-FecB
Type: state transition
Pathway Components: FecC + FecB + FecD + FecE -> FecE-FecC-FecD-FecB
Components:
Function Name Type
reactant FecB protein
reactant FecC protein
reactant FecD protein
reactant FecE protein
product FecE-FecC-FecD-FecB complex
fecABCDE_mRNA FecC
Name: fecABCDE_mRNA -> FecC
Description: Translation of FecC
Type: translation
Pathway Components: fecABCDE_mRNA -> FecC
Components:
Function Name Type
product FecC protein
reactant fecABCDE_mRNA RNA
fecABCDE_mRNA FecD
Name: fecABCDE_mRNA -> FecD
Description: Translation of FecD
Type: translation
Pathway Components: fecABCDE_mRNA -> FecD
Components:
Function Name Type
product FecD protein
reactant fecABCDE_mRNA RNA
fecABCDE_mRNA FecE
Name: fecABCDE_mRNA -> FecE
Description: Translation of FecE
Type: translation
Pathway Components: fecABCDE_mRNA -> FecE
Components:
Function Name Type
product FecE protein
reactant fecABCDE_mRNA RNA
cysH_mRNA CysH
Name: cysH_mRNA -> CysH
Description: Translation of CysH
Type: translation
Pathway Components: cysH_mRNA -> CysH
Components:
Function Name Type
product CysH protein
reactant cysH_mRNA RNA
3',5'-ADP CysH reduced thioredoxin + PAPS Products
Name: reduced thioredoxin + PAPS -> thioredoxin disulfide + 3',5'-ADP + sulfite
Description: Reaction transforming reduced thioredoxin, PAPS into thioredoxin disulfide, 3',5'-ADP , sulfite
Type: state transition
Pathway Components: reduced thioredoxin + PAPS - CysH - 3',5'-ADP -> thioredoxin disulfide + 3',5'-ADP + sulfite
Components:
Function Name Type
inhibitor 3',5'-ADP simple_molecule
product 3',5'-ADP simple_molecule
catalyzer CysH protein
reactant PAPS simple_molecule
reactant reduced thioredoxin simple_molecule
product sulfite simple_molecule
product thioredoxin disulfide simple_molecule
metNIQ_mRNA MetN
Name: metNIQ_mRNA -> MetN
Description: Translation of MetN
Type: translation
Pathway Components: metNIQ_mRNA -> MetN
Components:
Function Name Type
product MetN protein
reactant metNIQ_mRNA RNA
MetN + MetI + MetQ MetN-MetI-MetQ
Name: MetN + MetI + MetQ -> MetN-MetI-MetQ
Description: Reaction transforming MetN, MetI, MetQ into MetN-MetI-MetQ
Type: state transition
Pathway Components: MetN + MetI + MetQ -> MetN-MetI-MetQ
Components:
Function Name Type
reactant MetI protein
reactant MetN protein
product MetN-MetI-MetQ complex
reactant MetQ protein
MetN-MetI-MetQ methionine_Ext methionine
Name: methionine_Ext -> methionine
Description: Transport of methionine_Ext through a bacterial membrane, leading to the presence of methionine inside the cell.
Type: transport
Pathway Components: methionine_Ext - MetN-MetI-MetQ -> methionine
Components:
Function Name Type
catalyzer MetN-MetI-MetQ complex
product methionine simple_molecule
reactant methionine_Ext simple_molecule
MetN-MetI-MetQ Methionine S-oxide_Ext Methionine S-oxide
Name: Methionine S-oxide_Ext -> Methionine S-oxide
Description: Transport of Methionine S-oxide_Ext through a bacterial membrane, leading to the presence of Methionine S-oxide inside the cell.
Type: transport
Pathway Components: Methionine S-oxide_Ext - MetN-MetI-MetQ -> Methionine S-oxide
Components:
Function Name Type
catalyzer MetN-MetI-MetQ complex
product Methionine S-oxide simple_molecule
reactant Methionine S-oxide_Ext simple_molecule
MetN-MetI-MetQ methionine-R-sulfoxide_Ext methionine-R-sulfoxide
Name: methionine-R-sulfoxide_Ext -> methionine-R-sulfoxide
Description: Transport of methionine-R-sulfoxide_Ext through a bacterial membrane, leading to the presence of methionine-R-sulfoxide inside the cell.
Type: transport
Pathway Components: methionine-R-sulfoxide_Ext - MetN-MetI-MetQ -> methionine-R-sulfoxide
Components:
Function Name Type
catalyzer MetN-MetI-MetQ complex
product methionine-R-sulfoxide simple_molecule
reactant methionine-R-sulfoxide_Ext simple_molecule
MetN-MetI-MetQ methionine-(S)-S-oxide_Ext methionine-(S)-S-oxide
Name: methionine-(S)-S-oxide_Ext -> methionine-(S)-S-oxide
Description: Transport of methionine-(S)-S-oxide_Ext through a bacterial membrane, leading to the presence of methionine-(S)-S-oxide inside the cell.
Type: transport
Pathway Components: methionine-(S)-S-oxide_Ext - MetN-MetI-MetQ -> methionine-(S)-S-oxide
Components:
Function Name Type
catalyzer MetN-MetI-MetQ complex
product methionine-(S)-S-oxide simple_molecule
reactant methionine-(S)-S-oxide_Ext simple_molecule
MetN-MetI-MetQ acetyl-DL-methionine_Ext acetyl-DL-methionine
Name: acetyl-DL-methionine_Ext -> acetyl-DL-methionine
Description: Transport of acetyl-DL-methionine_Ext through a bacterial membrane, leading to the presence of acetyl-DL-methionine inside the cell.
Type: transport
Pathway Components: acetyl-DL-methionine_Ext - MetN-MetI-MetQ -> acetyl-DL-methionine
Components:
Function Name Type
catalyzer MetN-MetI-MetQ complex
product acetyl-DL-methionine simple_molecule
reactant acetyl-DL-methionine_Ext simple_molecule
metNIQ_mRNA MetI
Name: metNIQ_mRNA -> MetI
Description: Translation of MetI
Type: translation
Pathway Components: metNIQ_mRNA -> MetI
Components:
Function Name Type
product MetI protein
reactant metNIQ_mRNA RNA
metNIQ_mRNA MetQ
Name: metNIQ_mRNA -> MetQ
Description: Translation of MetQ
Type: translation
Pathway Components: metNIQ_mRNA -> MetQ
Components:
Function Name Type
product MetQ protein
reactant metNIQ_mRNA RNA
metBL_mRNA MetB
Name: metBL_mRNA -> MetB
Description: Translation of MetB
Type: translation
Pathway Components: metBL_mRNA -> MetB
Components:
Function Name Type
product MetB protein
reactant metBL_mRNA RNA
MetB succinyl-homoserine + cysteine cystathionine + succinate
Name: succinyl-homoserine + cysteine -> cystathionine + succinate
Description: Reaction transforming succinyl-homoserine, cysteine into cystathionine, succinate
Type: state transition
Pathway Components: succinyl-homoserine + cysteine - MetB -> cystathionine + succinate
Components:
Function Name Type
catalyzer MetB protein
product cystathionine simple_molecule
reactant cysteine simple_molecule
product succinate simple_molecule
reactant succinyl-homoserine simple_molecule
MetB succinyl-homoserine 2-oxobutyrate + succinate + ammonium
Name: succinyl-homoserine -> 2-oxobutyrate + succinate + ammonium
Description: Reaction transforming succinyl-homoserine into 2-oxobutyrate, succinate , ammonium
Type: state transition
Pathway Components: succinyl-homoserine - MetB -> 2-oxobutyrate + succinate + ammonium
Components:
Function Name Type
product 2-oxobutyrate simple_molecule
catalyzer MetB protein
product ammonium simple_molecule
product succinate simple_molecule
reactant succinyl-homoserine simple_molecule
MetB succinyl-homoserine (2Z)-2-aminobut-2-enoate + succinate
Name: succinyl-homoserine -> (2Z)-2-aminobut-2-enoate + succinate
Description: Reaction transforming succinyl-homoserine into (2Z)-2-aminobut-2-enoate, succinate
Type: state transition
Pathway Components: succinyl-homoserine - MetB -> (2Z)-2-aminobut-2-enoate + succinate
Components:
Function Name Type
product (2Z)-2-aminobut-2-enoate simple_molecule
catalyzer MetB protein
product succinate simple_molecule
reactant succinyl-homoserine simple_molecule
metBL_mRNA MetL
Name: metBL_mRNA -> MetL
Description: Translation of MetL
Type: translation
Pathway Components: metBL_mRNA -> MetL
Components:
Function Name Type
product MetL protein
reactant metBL_mRNA RNA
MetL homo-ser aspartate aspartyl-4-P
Name: aspartate -> aspartyl-4-P
Description: Reaction transforming aspartate into aspartyl-4-P
Type: state transition
Pathway Components: aspartate - MetL - homo-ser -> aspartyl-4-P
Components:
Function Name Type
catalyzer MetL protein
reactant aspartate simple_molecule
product aspartyl-4-P simple_molecule
inhibitor homo-ser simple_molecule
MetL aspartate-semialdehyde homo-ser
Name: aspartate-semialdehyde -> homo-ser
Description: Reaction transforming aspartate-semialdehyde into homo-ser
Type: state transition
Pathway Components: aspartate-semialdehyde - MetL -> homo-ser
Components:
Function Name Type
catalyzer MetL protein
reactant aspartate-semialdehyde simple_molecule
product homo-ser simple_molecule
homo-ser succinyl-homoserine
Name: homo-ser -> succinyl-homoserine
Description: Transformation of homo-ser into succinyl-homoserine by one or more reactions not shown.
Type: complementary pathway reaction
Pathway Components: homo-ser / HOMSUCTRAN-RXN / succinyl-homoserine
Components:
Function Name Type
reactant homo-ser simple_molecule
product succinyl-homoserine simple_molecule
aspartyl-4-P aspartate-semialdehyde
Name: aspartyl-4-P -> aspartate-semialdehyde
Description: Transformation of aspartyl-4-P into aspartate-semialdehyde by one or more reactions not shown.
Type: complementary pathway reaction
Pathway Components: aspartyl-4-P / ASPARTATE-SEMIALDEHYDE-DEHYDROGENASE-RXN / aspartate-semialdehyde
Components:
Function Name Type
product aspartate-semialdehyde simple_molecule
reactant aspartyl-4-P simple_molecule



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