RegulonDB RegulonDB

HU Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
indole_Ext phosphorylated phosphoglucomutase SeqA GalT GalM indole D-glucose 1-phosphate seqA-pgm tyrP micF_mRNA mtr tyrosine_Ext HU GalE galETK micF phosphoglucomutase galETK_mRNA galETKM galE galET_mRNA galE_mRNA Pgm mtr_mRNA alpha-glucose 1,6-bisphosphate seqA-pgm_mRNA galactose-1-P UDP-galactose tryptophan GalK RNA:MicF glucose-6-P tryptophan_Ext tyrosine beta-D-galactose TyrP galET UDPG tyrP_mRNA alpha-D-galactose galETKM_mRNA Mtr


Gensor Unit       
Name: HU
Classification:
Groups: Carbohydrate transport and metabolism
Replication, recombination and repair
Amino acid transport and metabolism
Cell wall/membrane/envelope biogenesis
Gene Ontology Terms (GO): biological_process GO:0003333 - amino acid transmembrane transport
GO:0006865 - amino acid transport
GO:0015801 - aromatic amino acid transport
GO:0005975 - carbohydrate metabolic process
GO:0046835 - carbohydrate phosphorylation
GO:0071474 - cellular hyperosmotic response
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cellular_component GO:1990097 - SeqA-DNA complex
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0016021 - integral component of membrane
GO:0005887 - integral component of plasma membrane
GO:0016020 - membrane
GO:0005886 - plasma membrane
Read more >
molecular_function GO:0005524 - ATP binding
GO:0003677 - DNA binding
GO:0003688 - DNA replication origin binding
GO:0070403 - NAD+ binding
GO:0003978 - UDP-glucose 4-epimerase activity
GO:0008108 - UDP-glucose:hexose-1-phosphate uridylyltransferase activity
GO:0022804 - active transmembrane transporter activity
Read more >
Components:
  Function Name Type
  simple_molecule α-D-galactose simple_molecule
  simple_molecule α-glucose 1,6-bisphosphate simple_molecule
  simple_molecule D-glucose 1-phosphate simple_molecule
  protein GalE protein
  protein GalK protein
  protein GalM protein
  protein GalT protein
  protein HU protein
  protein Mtr protein
  protein Pgm protein
  protein RNA:MicF protein
  protein SeqA protein
  protein TyrP protein
  simple_molecule UDP-galactose simple_molecule
  simple_molecule UDPG simple_molecule
  simple_molecule beta-D-galactose simple_molecule
  gene galE gene
  gene galET gene
  gene galETK gene
  gene galETKM gene
  RNA galETKM_mRNA RNA
  RNA galETK_mRNA RNA
  RNA galET_mRNA RNA
  RNA galE_mRNA RNA
  simple_molecule galactose-1-P simple_molecule
  simple_molecule glucose-6-P simple_molecule
  simple_molecule indole simple_molecule
  simple_molecule indole_Ext simple_molecule
  gene micF gene
  RNA micF_mRNA RNA
  gene mtr gene
  RNA mtr_mRNA RNA
  simple_molecule phosphoglucomutase simple_molecule
  simple_molecule phosphorylated phosphoglucomutase simple_molecule
  gene seqA-pgm gene
  RNA seqA-pgm_mRNA RNA
  simple_molecule tryptophan simple_molecule
  simple_molecule tryptophan_Ext simple_molecule
  gene tyrP gene
  RNA tyrP_mRNA RNA
  simple_molecule tyrosine simple_molecule
  simple_molecule tyrosine_Ext simple_molecule


Reactions       
Showing 33 reactions
HU micF micF_mRNA
Name: micF -> micF_mRNA
Description: Transcription of transcription unit micF. Reaction activation by HU.
Type: transcription
Pathway Components: micF - HU -> micF_mRNA
Components:
Function Name Type
activator HU protein
reactant micF gene
product micF_mRNA RNA
HU galE galE_mRNA
Name: galE -> galE_mRNA
Description: Transcription of transcription unit galE. Reaction inhibition by HU.
Type: transcription
Pathway Components: galE - HU -> galE_mRNA
Components:
Function Name Type
inhibitor HU protein
reactant galE gene
product galE_mRNA RNA
HU galET galET_mRNA
Name: galET -> galET_mRNA
Description: Transcription of transcription unit galET. Reaction inhibition by HU.
Type: transcription
Pathway Components: galET - HU -> galET_mRNA
Components:
Function Name Type
inhibitor HU protein
reactant galET gene
product galET_mRNA RNA
HU galETK galETK_mRNA
Name: galETK -> galETK_mRNA
Description: Transcription of transcription unit galETK. Reaction inhibition by HU.
Type: transcription
Pathway Components: galETK - HU -> galETK_mRNA
Components:
Function Name Type
inhibitor HU protein
reactant galETK gene
product galETK_mRNA RNA
HU galETKM galETKM_mRNA
Name: galETKM -> galETKM_mRNA
Description: Transcription of transcription unit galETKM. Reaction inhibition by HU.
Type: transcription
Pathway Components: galETKM - HU -> galETKM_mRNA
Components:
Function Name Type
inhibitor HU protein
reactant galETKM gene
product galETKM_mRNA RNA
HU mtr mtr_mRNA
Name: mtr -> mtr_mRNA
Description: Transcription of transcription unit mtr. Reaction inhibition by HU.
Type: transcription
Pathway Components: mtr - HU -> mtr_mRNA
Components:
Function Name Type
inhibitor HU protein
reactant mtr gene
product mtr_mRNA RNA
HU seqA-pgm seqA-pgm_mRNA
Name: seqA-pgm -> seqA-pgm_mRNA
Description: Transcription of transcription unit seqA-pgm. Reaction inhibition by HU.
Type: transcription
Pathway Components: seqA-pgm - HU -> seqA-pgm_mRNA
Components:
Function Name Type
inhibitor HU protein
reactant seqA-pgm gene
product seqA-pgm_mRNA RNA
HU tyrP tyrP_mRNA
Name: tyrP -> tyrP_mRNA
Description: Transcription of transcription unit tyrP. Reaction inhibition by HU.
Type: transcription
Pathway Components: tyrP - HU -> tyrP_mRNA
Components:
Function Name Type
inhibitor HU protein
reactant tyrP gene
product tyrP_mRNA RNA
tyrP_mRNA TyrP
Name: tyrP_mRNA -> TyrP
Description: Translation of TyrP
Type: translation
Pathway Components: tyrP_mRNA -> TyrP
Components:
Function Name Type
product TyrP protein
reactant tyrP_mRNA RNA
TyrP tyrosine_Ext tyrosine
Name: tyrosine_Ext -> tyrosine
Description: Transport of tyrosine_Ext through a bacterial membrane, leading to the presence of tyrosine inside the cell.
Type: transport
Pathway Components: tyrosine_Ext - TyrP -> tyrosine
Components:
Function Name Type
catalyzer TyrP protein
product tyrosine simple_molecule
reactant tyrosine_Ext simple_molecule
seqA-pgm_mRNA SeqA
Name: seqA-pgm_mRNA -> SeqA
Description: Translation of SeqA
Type: translation
Pathway Components: seqA-pgm_mRNA -> SeqA
Components:
Function Name Type
product SeqA protein
reactant seqA-pgm_mRNA RNA
seqA-pgm_mRNA Pgm
Name: seqA-pgm_mRNA -> Pgm
Description: Translation of Pgm
Type: translation
Pathway Components: seqA-pgm_mRNA -> Pgm
Components:
Function Name Type
product Pgm protein
reactant seqA-pgm_mRNA RNA
α-glucose 1,6-bisphosphate D-glucose 1-phosphate Pgm D-glucose 1-phosphate glucose-6-P
Name: D-glucose 1-phosphate -> glucose-6-P
Description: Reaction transforming D-glucose 1-phosphate into glucose-6-P
Type: state transition
Pathway Components: D-glucose 1-phosphate - Pgm - D-glucose 1-phosphate - α-glucose 1,6-bisphosphate -> glucose-6-P
Components:
Function Name Type
inhibitor α-glucose 1,6-bisphosphate simple_molecule
inhibitor D-glucose 1-phosphate simple_molecule
reactant D-glucose 1-phosphate simple_molecule
catalyzer Pgm protein
product glucose-6-P simple_molecule
Pgm Reactants Products
Name: phosphorylated phosphoglucomutase + D-glucose 1-phosphate -> α-glucose 1,6-bisphosphate + phosphoglucomutase
Description: Reaction transforming phosphorylated phosphoglucomutase, D-glucose 1-phosphate into α-glucose 1,6-bisphosphate, phosphoglucomutase
Type: state transition
Pathway Components: phosphorylated phosphoglucomutase + D-glucose 1-phosphate - Pgm -> α-glucose 1,6-bisphosphate + phosphoglucomutase
Components:
Function Name Type
product α-glucose 1,6-bisphosphate simple_molecule
reactant D-glucose 1-phosphate simple_molecule
catalyzer Pgm protein
product phosphoglucomutase simple_molecule
reactant phosphorylated phosphoglucomutase simple_molecule
Pgm Reactants phosphorylated phosphoglucomutase + glucose-6-P
Name: α-glucose 1,6-bisphosphate + phosphoglucomutase -> phosphorylated phosphoglucomutase + glucose-6-P
Description: Reaction transforming α-glucose 1,6-bisphosphate, phosphoglucomutase into phosphorylated phosphoglucomutase, glucose-6-P
Type: state transition
Pathway Components: α-glucose 1,6-bisphosphate + phosphoglucomutase - Pgm -> phosphorylated phosphoglucomutase + glucose-6-P
Components:
Function Name Type
reactant α-glucose 1,6-bisphosphate simple_molecule
catalyzer Pgm protein
product glucose-6-P simple_molecule
reactant phosphoglucomutase simple_molecule
product phosphorylated phosphoglucomutase simple_molecule
mtr_mRNA Mtr
Name: mtr_mRNA -> Mtr
Description: Translation of Mtr
Type: translation
Pathway Components: mtr_mRNA -> Mtr
Components:
Function Name Type
product Mtr protein
reactant mtr_mRNA RNA
Mtr indole_Ext indole
Name: indole_Ext -> indole
Description: Transport of indole_Ext through a bacterial membrane, leading to the presence of indole inside the cell.
Type: transport
Pathway Components: indole_Ext - Mtr -> indole
Components:
Function Name Type
catalyzer Mtr protein
product indole simple_molecule
reactant indole_Ext simple_molecule
Mtr tryptophan_Ext tryptophan
Name: tryptophan_Ext -> tryptophan
Description: Transport of tryptophan_Ext through a bacterial membrane, leading to the presence of tryptophan inside the cell.
Type: transport
Pathway Components: tryptophan_Ext - Mtr -> tryptophan
Components:
Function Name Type
catalyzer Mtr protein
product tryptophan simple_molecule
reactant tryptophan_Ext simple_molecule
galE_mRNA GalE
Name: galE_mRNA -> GalE
Description: Translation of GalE
Type: translation
Pathway Components: galE_mRNA -> GalE
Components:
Function Name Type
product GalE protein
reactant galE_mRNA RNA
GalE UDPG UDP-galactose
Name: UDPG -> UDP-galactose
Description: Reaction transforming UDPG into UDP-galactose
Type: state transition
Pathway Components: UDPG - GalE -> UDP-galactose
Components:
Function Name Type
catalyzer GalE protein
product UDP-galactose simple_molecule
reactant UDPG simple_molecule
galET_mRNA GalE
Name: galET_mRNA -> GalE
Description: Translation of GalE
Type: translation
Pathway Components: galET_mRNA -> GalE
Components:
Function Name Type
product GalE protein
reactant galET_mRNA RNA
galET_mRNA GalT
Name: galET_mRNA -> GalT
Description: Translation of GalT
Type: translation
Pathway Components: galET_mRNA -> GalT
Components:
Function Name Type
product GalT protein
reactant galET_mRNA RNA
GalT galactose-1-P + UDPG D-glucose 1-phosphate + UDP-galactose
Name: galactose-1-P + UDPG -> D-glucose 1-phosphate + UDP-galactose
Description: Reaction transforming galactose-1-P, UDPG into D-glucose 1-phosphate, UDP-galactose
Type: state transition
Pathway Components: galactose-1-P + UDPG - GalT -> D-glucose 1-phosphate + UDP-galactose
Components:
Function Name Type
product D-glucose 1-phosphate simple_molecule
catalyzer GalT protein
product UDP-galactose simple_molecule
reactant UDPG simple_molecule
reactant galactose-1-P simple_molecule
galETK_mRNA GalE
Name: galETK_mRNA -> GalE
Description: Translation of GalE
Type: translation
Pathway Components: galETK_mRNA -> GalE
Components:
Function Name Type
product GalE protein
reactant galETK_mRNA RNA
galETK_mRNA GalT
Name: galETK_mRNA -> GalT
Description: Translation of GalT
Type: translation
Pathway Components: galETK_mRNA -> GalT
Components:
Function Name Type
product GalT protein
reactant galETK_mRNA RNA
galETK_mRNA GalK
Name: galETK_mRNA -> GalK
Description: Translation of GalK
Type: translation
Pathway Components: galETK_mRNA -> GalK
Components:
Function Name Type
product GalK protein
reactant galETK_mRNA RNA
GalK α-D-galactose galactose-1-P
Name: α-D-galactose -> galactose-1-P
Description: Reaction transforming α-D-galactose into galactose-1-P
Type: state transition
Pathway Components: α-D-galactose - GalK -> galactose-1-P
Components:
Function Name Type
reactant α-D-galactose simple_molecule
catalyzer GalK protein
product galactose-1-P simple_molecule
galETKM_mRNA GalE
Name: galETKM_mRNA -> GalE
Description: Translation of GalE
Type: translation
Pathway Components: galETKM_mRNA -> GalE
Components:
Function Name Type
product GalE protein
reactant galETKM_mRNA RNA
galETKM_mRNA GalT
Name: galETKM_mRNA -> GalT
Description: Translation of GalT
Type: translation
Pathway Components: galETKM_mRNA -> GalT
Components:
Function Name Type
product GalT protein
reactant galETKM_mRNA RNA
galETKM_mRNA GalK
Name: galETKM_mRNA -> GalK
Description: Translation of GalK
Type: translation
Pathway Components: galETKM_mRNA -> GalK
Components:
Function Name Type
product GalK protein
reactant galETKM_mRNA RNA
galETKM_mRNA GalM
Name: galETKM_mRNA -> GalM
Description: Translation of GalM
Type: translation
Pathway Components: galETKM_mRNA -> GalM
Components:
Function Name Type
product GalM protein
reactant galETKM_mRNA RNA
GalM beta-D-galactose α-D-galactose
Name: beta-D-galactose -> α-D-galactose
Description: Reaction transforming beta-D-galactose into α-D-galactose
Type: state transition
Pathway Components: beta-D-galactose - GalM -> α-D-galactose
Components:
Function Name Type
product α-D-galactose simple_molecule
catalyzer GalM protein
reactant beta-D-galactose simple_molecule
micF_mRNA RNA:MicF
Name: micF_mRNA -> RNA:MicF
Description: Translation of RNA:MicF
Type: translation
Pathway Components: micF_mRNA -> RNA:MicF
Components:
Function Name Type
product RNA:MicF protein
reactant micF_mRNA RNA



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