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HipB Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
hipBA HipA HipA MazE ppGpp MazF 2E-decenoyl-CoA relA-mazEF_mRNA MazE hipBA_mRNA fadH_mRNA FadH HipB pppGpp MazF RelA fadH trans-delta2, cis-delta4-decadienoyl-CoA guanosine-triphosphate guanosine-diphosphate HipB relA-mazEF


Gensor Unit       
Name: HipB
Description: Molecular biology level
Detailed: HipB negatively regulates the expression of genes required for dormancy process, biofilm formation and antibiotic tolerance. HipB binds its target site preventing its own expression and the expression of HipA.
Less detailed: HipB negatively regulates the expression of genes needed for dormancy process.
Classification:
Groups: Lipid transport and metabolism
Transcription
Signal transduction mechanisms
Defense mechanisms
Gene Ontology Terms (GO): biological_process GO:0090502 - RNA phosphodiester bond hydrolysis, endonucleolytic
GO:0051607 - defense response to virus
GO:0022611 - dormancy process
GO:0006635 - fatty acid beta-oxidation
GO:0033543 - fatty acid beta-oxidation, unsaturated, even number, reductase/isomerase pathway
GO:0015970 - guanosine tetraphosphate biosynthetic process
Read more >
cellular_component GO:0005618 - cell wall
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0032993 - protein-DNA complex
GO:0032991 - protein-containing complex
molecular_function GO:0008670 - 2,4-dienoyl-CoA reductase (NADPH) activity
GO:0051539 - 4 iron, 4 sulfur cluster binding
GO:0005524 - ATP binding
GO:0003677 - DNA binding
GO:0001217 - DNA-binding transcription repressor activity
GO:0071949 - FAD binding
GO:0010181 - FMN binding
Read more >
Components:
  Function Name Type
  simple_molecule 2E-decenoyl-CoA simple_molecule
  protein FadH protein
  protein HipA protein
  protein HipB protein
  complex HipB-HipA complex
  protein MazE protein
  protein MazF protein
  complex MazF-MazE complex
  protein RelA protein
  gene fadH gene
  RNA fadH_mRNA RNA
  simple_molecule guanosine-diphosphate simple_molecule
  simple_molecule guanosine-triphosphate simple_molecule
  gene hipBA gene
  RNA hipBA_mRNA RNA
  simple_molecule ppGpp simple_molecule
  simple_molecule pppGpp simple_molecule
  gene relA-mazEF gene
  RNA relA-mazEF_mRNA RNA
  simple_molecule trans-Δ2, cis-Δ4-decadienoyl-CoA simple_molecule


Reactions       
Showing 15 reactions
HipB fadH fadH_mRNA
Name: fadH -> fadH_mRNA
Description: Transcription of transcription unit fadH. Reaction inhibition by HipB.
Type: transcription
Pathway Components: fadH - HipB -> fadH_mRNA
Components:
Function Name Type
inhibitor HipB protein
reactant fadH gene
product fadH_mRNA RNA
HipB hipBA hipBA_mRNA
Name: hipBA -> hipBA_mRNA
Description: Transcription of transcription unit hipBA. Reaction inhibition by HipB.
Type: transcription
Pathway Components: hipBA - HipB -> hipBA_mRNA
Components:
Function Name Type
inhibitor HipB protein
reactant hipBA gene
product hipBA_mRNA RNA
HipB relA-mazEF relA-mazEF_mRNA
Name: relA-mazEF -> relA-mazEF_mRNA
Description: Transcription of transcription unit relA-mazEF. Reaction inhibition by HipB.
Type: transcription
Pathway Components: relA-mazEF - HipB -> relA-mazEF_mRNA
Components:
Function Name Type
inhibitor HipB protein
reactant relA-mazEF gene
product relA-mazEF_mRNA RNA
hipBA_mRNA HipB
Name: hipBA_mRNA -> HipB
Description: Translation of HipB
Type: translation
Pathway Components: hipBA_mRNA -> HipB
Components:
Function Name Type
product HipB protein
reactant hipBA_mRNA RNA
HipA + HipB HipB-HipA
Name: HipA + HipB -> HipB-HipA
Description: Reaction transforming HipA, HipB into HipB-HipA
Type: state transition
Pathway Components: HipA + HipB -> HipB-HipA
Components:
Function Name Type
reactant HipA protein
reactant HipB protein
product HipB-HipA complex
HipA hipBA_mRNA HipA
Name: hipBA_mRNA -> HipA
Description: Translation of HipA
Type: translation
Pathway Components: hipBA_mRNA - HipA -> HipA
Components:
Function Name Type
catalyzer HipA protein
product HipA protein
reactant hipBA_mRNA RNA
relA-mazEF_mRNA RelA
Name: relA-mazEF_mRNA -> RelA
Description: Translation of RelA
Type: translation
Pathway Components: relA-mazEF_mRNA -> RelA
Components:
Function Name Type
product RelA protein
reactant relA-mazEF_mRNA RNA
RelA ppGpp guanosine-diphosphate ppGpp
Name: guanosine-diphosphate -> ppGpp
Description: Reaction transforming guanosine-diphosphate into ppGpp
Type: state transition
Pathway Components: guanosine-diphosphate - RelA - ppGpp -> ppGpp
Components:
Function Name Type
catalyzer RelA protein
reactant guanosine-diphosphate simple_molecule
inhibitor ppGpp simple_molecule
product ppGpp simple_molecule
RelA guanosine-triphosphate pppGpp
Name: guanosine-triphosphate -> pppGpp
Description: Reaction transforming guanosine-triphosphate into pppGpp
Type: state transition
Pathway Components: guanosine-triphosphate - RelA -> pppGpp
Components:
Function Name Type
catalyzer RelA protein
reactant guanosine-triphosphate simple_molecule
product pppGpp simple_molecule
relA-mazEF_mRNA MazE
Name: relA-mazEF_mRNA -> MazE
Description: Translation of MazE
Type: translation
Pathway Components: relA-mazEF_mRNA -> MazE
Components:
Function Name Type
product MazE protein
reactant relA-mazEF_mRNA RNA
MazF + MazE MazF-MazE
Name: MazF + MazE -> MazF-MazE
Description: Reaction transforming MazF, MazE into MazF-MazE
Type: state transition
Pathway Components: MazF + MazE -> MazF-MazE
Components:
Function Name Type
reactant MazE protein
reactant MazF protein
product MazF-MazE complex
relA-mazEF_mRNA MazF
Name: relA-mazEF_mRNA -> MazF
Description: Translation of MazF
Type: translation
Pathway Components: relA-mazEF_mRNA -> MazF
Components:
Function Name Type
product MazF protein
reactant relA-mazEF_mRNA RNA
fadH_mRNA FadH
Name: fadH_mRNA -> FadH
Description: Translation of FadH
Type: translation
Pathway Components: fadH_mRNA -> FadH
Components:
Function Name Type
product FadH protein
reactant fadH_mRNA RNA
FadH trans-Δ2, cis-Δ4-decadienoyl-CoA trans-Δ2, cis-Δ4-decadienoyl-CoA 2E-decenoyl-CoA
Name: trans-Δ2, cis-Δ4-decadienoyl-CoA -> 2E-decenoyl-CoA
Description: Reaction transforming trans-Δ2, cis-Δ4-decadienoyl-CoA into 2E-decenoyl-CoA
Type: state transition
Pathway Components: trans-Δ2, cis-Δ4-decadienoyl-CoA - FadH - trans-Δ2, cis-Δ4-decadienoyl-CoA -> 2E-decenoyl-CoA
Components:
Function Name Type
product 2E-decenoyl-CoA simple_molecule
catalyzer FadH protein
inhibitor trans-Δ2, cis-Δ4-decadienoyl-CoA simple_molecule
reactant trans-Δ2, cis-Δ4-decadienoyl-CoA simple_molecule
pppGpp guanosine-diphosphate
Name: pppGpp -> guanosine-diphosphate
Description: Transformation of pppGpp into guanosine-diphosphate by one or more reactions not shown.
Type: complementary pathway reaction
Pathway Components: pppGpp / PPPGPPHYDRO-RXN / PPGPPSYN-RXN / guanosine-diphosphate
Components:
Function Name Type
product guanosine-diphosphate simple_molecule
reactant pppGpp simple_molecule



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