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HcaR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
HcaR 2,3-DHP HcaR oxygen HcaE cis-3-(3-carboxyethenyl)-3,5-cyclohexadiene-1,2-diol HcaB HcaF HcaD hydrocinnamate hcaR_mRNA hcaR 3-(5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate HcaD 2,3-dihydroxycinnamic acid HcaF HcaC hydrocinnamate hcaEFCBD HcaE HcaC hcaEFCBD_mRNA cinnamate


Gensor Unit       
Name: HcaR
Classification:
Groups: Lipid transport and metabolism
Inorganic ion transport and metabolism
Secondary metabolites biosynthesis, transport and catabolism
Transcription
Gene Ontology Terms (GO): biological_process GO:0019380 - 3-phenylpropionate catabolic process
GO:0019439 - aromatic compound catabolic process
GO:0006725 - cellular aromatic compound metabolic process
GO:0045892 - negative regulation of transcription, DNA-templated
GO:0055114 - oxidation-reduction process
GO:0045893 - positive regulation of transcription, DNA-templated
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cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
molecular_function GO:0051537 - 2 iron, 2 sulfur cluster binding
GO:0008695 - 3-phenylpropionate dioxygenase activity
GO:0003677 - DNA binding
GO:0003700 - DNA-binding transcription factor activity
GO:0003824 - catalytic activity
GO:0051213 - dioxygenase activity
GO:0008860 - ferredoxin-NAD+ reductase activity
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Components:
  Function Name Type
  simple_molecule 2,3-DHP simple_molecule
  simple_molecule 2,3-dihydroxycinnamic acid simple_molecule
  simple_molecule 3-(5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate simple_molecule
  protein HcaB protein
  protein HcaC protein
  complex HcaC-HcaD-HcaF-HcaE complex
  protein HcaD protein
  protein HcaE protein
  protein HcaF protein
  protein HcaR protein
  complex HcaR-hydrocinnamate complex
  simple_molecule cinnamate simple_molecule
  simple_molecule cis-3-(3-carboxyethenyl)-3,5-cyclohexadiene-1,2-diol simple_molecule
  gene hcaEFCBD gene
  RNA hcaEFCBD_mRNA RNA
  gene hcaR gene
  RNA hcaR_mRNA RNA
  simple_molecule hydrocinnamate simple_molecule
  simple_molecule oxygen simple_molecule


Reactions       
Showing 14 reactions
HcaR hcaR hcaR_mRNA
Name: hcaR -> hcaR_mRNA
Description: Transcription of transcription unit hcaR. Reaction inhibition by HcaR.
Type: transcription
Pathway Components: hcaR - HcaR -> hcaR_mRNA
Components:
Function Name Type
inhibitor HcaR protein
reactant hcaR gene
product hcaR_mRNA RNA
hydrocinnamate + HcaR HcaR-hydrocinnamate
Name: hydrocinnamate + HcaR -> HcaR-hydrocinnamate
Description: Reaction transforming hydrocinnamate, HcaR into HcaR-hydrocinnamate
Type: state transition
Pathway Components: hydrocinnamate + HcaR -> HcaR-hydrocinnamate
Components:
Function Name Type
reactant HcaR protein
product HcaR-hydrocinnamate complex
reactant hydrocinnamate simple_molecule
HcaR-hydrocinnamate hcaEFCBD hcaEFCBD_mRNA
Name: hcaEFCBD -> hcaEFCBD_mRNA
Description: Transcription of transcription unit hcaEFCBD. Reaction activation by HcaR-hydrocinnamate.
Type: transcription
Pathway Components: hcaEFCBD - HcaR-hydrocinnamate -> hcaEFCBD_mRNA
Components:
Function Name Type
activator HcaR-hydrocinnamate complex
reactant hcaEFCBD gene
product hcaEFCBD_mRNA RNA
hcaEFCBD_mRNA HcaE
Name: hcaEFCBD_mRNA -> HcaE
Description: Translation of HcaE
Type: translation
Pathway Components: hcaEFCBD_mRNA -> HcaE
Components:
Function Name Type
product HcaE protein
reactant hcaEFCBD_mRNA RNA
HcaF + HcaC + HcaD + HcaE HcaC-HcaD-HcaF-HcaE
Name: HcaF + HcaC + HcaD + HcaE -> HcaC-HcaD-HcaF-HcaE
Description: Reaction transforming HcaF, HcaC, HcaD, HcaE into HcaC-HcaD-HcaF-HcaE
Type: state transition
Pathway Components: HcaF + HcaC + HcaD + HcaE -> HcaC-HcaD-HcaF-HcaE
Components:
Function Name Type
reactant HcaC protein
product HcaC-HcaD-HcaF-HcaE complex
reactant HcaD protein
reactant HcaE protein
reactant HcaF protein
HcaC-HcaD-HcaF-HcaE cinnamate + oxygen Products
Name: cinnamate + oxygen -> cis-3-(3-carboxyethenyl)-3,5-cyclohexadiene-1,2-diol
Description: Reaction transforming cinnamate, oxygen into cis-3-(3-carboxyethenyl)-3,5-cyclohexadiene-1,2-diol
Type: state transition
Pathway Components: cinnamate + oxygen - HcaC-HcaD-HcaF-HcaE -> cis-3-(3-carboxyethenyl)-3,5-cyclohexadiene-1,2-diol
Components:
Function Name Type
catalyzer HcaC-HcaD-HcaF-HcaE complex
reactant cinnamate simple_molecule
product cis-3-(3-carboxyethenyl)-3,5-cyclohexadiene-1,2-diol simple_molecule
reactant oxygen simple_molecule
HcaC-HcaD-HcaF-HcaE hydrocinnamate + oxygen Products
Name: hydrocinnamate + oxygen -> 3-(5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate
Description: Reaction transforming hydrocinnamate, oxygen into 3-(5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate
Type: state transition
Pathway Components: hydrocinnamate + oxygen - HcaC-HcaD-HcaF-HcaE -> 3-(5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate
Components:
Function Name Type
product 3-(5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate simple_molecule
catalyzer HcaC-HcaD-HcaF-HcaE complex
reactant hydrocinnamate simple_molecule
reactant oxygen simple_molecule
hcaEFCBD_mRNA HcaF
Name: hcaEFCBD_mRNA -> HcaF
Description: Translation of HcaF
Type: translation
Pathway Components: hcaEFCBD_mRNA -> HcaF
Components:
Function Name Type
product HcaF protein
reactant hcaEFCBD_mRNA RNA
hcaEFCBD_mRNA HcaC
Name: hcaEFCBD_mRNA -> HcaC
Description: Translation of HcaC
Type: translation
Pathway Components: hcaEFCBD_mRNA -> HcaC
Components:
Function Name Type
product HcaC protein
reactant hcaEFCBD_mRNA RNA
hcaEFCBD_mRNA HcaB
Name: hcaEFCBD_mRNA -> HcaB
Description: Translation of HcaB
Type: translation
Pathway Components: hcaEFCBD_mRNA -> HcaB
Components:
Function Name Type
product HcaB protein
reactant hcaEFCBD_mRNA RNA
HcaB Reactants 2,3-dihydroxycinnamic acid
Name: cis-3-(3-carboxyethenyl)-3,5-cyclohexadiene-1,2-diol -> 2,3-dihydroxycinnamic acid
Description: Reaction transforming cis-3-(3-carboxyethenyl)-3,5-cyclohexadiene-1,2-diol into 2,3-dihydroxycinnamic acid
Type: state transition
Pathway Components: cis-3-(3-carboxyethenyl)-3,5-cyclohexadiene-1,2-diol - HcaB -> 2,3-dihydroxycinnamic acid
Components:
Function Name Type
product 2,3-dihydroxycinnamic acid simple_molecule
catalyzer HcaB protein
reactant cis-3-(3-carboxyethenyl)-3,5-cyclohexadiene-1,2-diol simple_molecule
HcaB Reactants 2,3-DHP
Name: 3-(5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate -> 2,3-DHP
Description: Reaction transforming 3-(5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate into 2,3-DHP
Type: state transition
Pathway Components: 3-(5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate - HcaB -> 2,3-DHP
Components:
Function Name Type
product 2,3-DHP simple_molecule
reactant 3-(5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate simple_molecule
catalyzer HcaB protein
hcaEFCBD_mRNA HcaD
Name: hcaEFCBD_mRNA -> HcaD
Description: Translation of HcaD
Type: translation
Pathway Components: hcaEFCBD_mRNA -> HcaD
Components:
Function Name Type
product HcaD protein
reactant hcaEFCBD_mRNA RNA
hcaR_mRNA HcaR
Name: hcaR_mRNA -> HcaR
Description: Translation of HcaR
Type: translation
Pathway Components: hcaR_mRNA -> HcaR
Components:
Function Name Type
product HcaR protein
reactant hcaR_mRNA RNA



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