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GlpR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
GlpB GlpC GlpR GlpT glycerol glpFKX_mRNA glpD stiborous acid_Ext GlpX DL-glyceraldehyde_Ext glycerol-3-phosphate_Ext urea_Ext menaquinol GlpF GlpA glpFKX glpTQ_mRNA GlpA arsenite glpABC glpD_mRNA GlpR ubiquinone glycine stiborous acid GlpQ ubiquinol DHAP glpABC_mRNA glpTQ polyol GlpK GlpD glycerol-3-P-OR GlpC alcohol glycerol-3-phosphate glycine_Ext glycerol polyol_Ext GlpR glycerol_Ext phosphate glycerol-3-phosphate DL-glyceraldehyde diglycerol phosphate fructose-6-P vitamin K2 urea arsenite_Ext GlpB fructose 1,6-biphosphate glycerol DHAP


Gensor Unit       
Name: GlpR
Description: Molecular biology level
Detailed: In the absence of glycerol-3-phosphate, GlpR negatively regulates the expression of genes required for arsenite, urea, glycine and glycerol transport and metabolism, and glycerol-3-phosphate catabolic process. Under these conditions, GlpR binds its target sites preventing the expression of its regulated genes. In the presence of glycerol-3-phosphate, it is directly transported into cell or generated from glycerol transport and conversion to glycerol-3-phosphate, GlpR is modified to GlpR-glycerol-3-phosphate, unbinds its target sites enabling the expression of its regulated genes.
Less detailed: In the absence of glycerol-3-phosphate, GlpR negatively regulates the expression of genes needed for arsenite, urea, glycine and glycerol transport and metabolism, and glycerol-3-phosphate catabolic process.

Physiology level
Detailed: The presence of glycerol-3-phosphate induces the expression of genes involved with arsenite, urea, glycine and glycerol transport, and glycerol catabolic process. Under these conditions the genes necessary for transport of glycerol and glycerol-3-phosphate, conversion of diglycerol phosphate and glycerol to glycerol-3-phosphate (and DHAP), and the conversion of fructose-1,6-bisphosphate to D-fructose-6-phosphate, a gluconeogenesis intermediary, are expressed.
Less detailed: The presence of glycerol and glycerol-3-phosphate induces the expression of genes needful for transport of glycerol and glycerol-3-phosphate, conversion of diglycerol phosphate and glycerol to glycerol-3-phosphate (and DHAP), and the conversion of fructose-1,6-bisphosphate to D-fructose-6-phosphate, a gluconeogenesis intermediary. Read more >
Classification:
Groups: Lipid transport and metabolism
Carbohydrate transport and metabolism
Energy production and conversion
Amino acid transport and metabolism
Gene Ontology Terms (GO): biological_process GO:0009060 - aerobic respiration
GO:0009061 - anaerobic respiration
GO:0005975 - carbohydrate metabolic process
GO:0006974 - cellular response to DNA damage stimulus
GO:0071288 - cellular response to mercury ion
GO:0016311 - dephosphorylation
Read more >
cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0009331 - glycerol-3-phosphate dehydrogenase complex
GO:0016021 - integral component of membrane
GO:0005887 - integral component of plasma membrane
GO:0016020 - membrane
GO:0042597 - periplasmic space
Read more >
molecular_function GO:0051539 - 4 iron, 4 sulfur cluster binding
GO:0005524 - ATP binding
GO:0071949 - FAD binding
GO:0010181 - FMN binding
GO:0005509 - calcium ion binding
GO:0003824 - catalytic activity
GO:0015267 - channel activity
Read more >
Components:
  Function Name Type
  simple_molecule DHAP simple_molecule
  simple_molecule DL-glyceraldehyde simple_molecule
  simple_molecule DL-glyceraldehyde_Ext simple_molecule
  protein GlpA protein
  complex GlpA-GlpB-GlpC complex
  protein GlpB protein
  protein GlpC protein
  protein GlpD protein
  protein GlpF protein
  protein GlpK protein
  protein GlpQ protein
  protein GlpR protein
  complex GlpR-glycerol complex
  complex GlpR-glycerol-3-phosphate complex
  protein GlpT protein
  protein GlpX protein
  simple_molecule alcohol simple_molecule
  simple_molecule arsenite simple_molecule
  simple_molecule arsenite_Ext simple_molecule
  simple_molecule diglycerol phosphate simple_molecule
  simple_molecule fructose 1,6-biphosphate simple_molecule
  simple_molecule fructose-6-P simple_molecule
  gene glpABC gene
  RNA glpABC_mRNA RNA
  gene glpD gene
  RNA glpD_mRNA RNA
  gene glpFKX gene
  RNA glpFKX_mRNA RNA
  gene glpTQ gene
  RNA glpTQ_mRNA RNA
  simple_molecule glycerol simple_molecule
  simple_molecule glycerol-3-P-OR simple_molecule
  simple_molecule glycerol-3-phosphate simple_molecule
  simple_molecule glycerol-3-phosphate_Ext simple_molecule
  simple_molecule glycerol_Ext simple_molecule
  simple_molecule glycine simple_molecule
  simple_molecule glycine_Ext simple_molecule
  simple_molecule menaquinol simple_molecule
  simple_molecule phosphate simple_molecule
  simple_molecule polyol simple_molecule
  simple_molecule polyol_Ext simple_molecule
  simple_molecule stiborous acid simple_molecule
  simple_molecule stiborous acid_Ext simple_molecule
  simple_molecule ubiquinol simple_molecule
  simple_molecule ubiquinone simple_molecule
  simple_molecule urea simple_molecule
  simple_molecule urea_Ext simple_molecule
  simple_molecule vitamin K2 simple_molecule


Reactions       
Showing 30 reactions
GlpR glpABC glpABC_mRNA
Name: glpABC -> glpABC_mRNA
Description: Transcription of transcription unit glpABC. Reaction inhibition by GlpR.
Type: transcription
Pathway Components: glpABC - GlpR -> glpABC_mRNA
Components:
Function Name Type
inhibitor GlpR protein
reactant glpABC gene
product glpABC_mRNA RNA
GlpR glpD glpD_mRNA
Name: glpD -> glpD_mRNA
Description: Transcription of transcription unit glpD. Reaction inhibition by GlpR.
Type: transcription
Pathway Components: glpD - GlpR -> glpD_mRNA
Components:
Function Name Type
inhibitor GlpR protein
reactant glpD gene
product glpD_mRNA RNA
GlpR glpFKX glpFKX_mRNA
Name: glpFKX -> glpFKX_mRNA
Description: Transcription of transcription unit glpFKX. Reaction inhibition by GlpR.
Type: transcription
Pathway Components: glpFKX - GlpR -> glpFKX_mRNA
Components:
Function Name Type
inhibitor GlpR protein
reactant glpFKX gene
product glpFKX_mRNA RNA
GlpR glpTQ glpTQ_mRNA
Name: glpTQ -> glpTQ_mRNA
Description: Transcription of transcription unit glpTQ. Reaction inhibition by GlpR.
Type: transcription
Pathway Components: glpTQ - GlpR -> glpTQ_mRNA
Components:
Function Name Type
inhibitor GlpR protein
reactant glpTQ gene
product glpTQ_mRNA RNA
glycerol-3-phosphate + GlpR GlpR-glycerol-3-phosphate
Name: glycerol-3-phosphate + GlpR -> GlpR-glycerol-3-phosphate
Description: Reaction transforming glycerol-3-phosphate, GlpR into GlpR-glycerol-3-phosphate
Type: state transition
Pathway Components: glycerol-3-phosphate + GlpR -> GlpR-glycerol-3-phosphate
Components:
Function Name Type
reactant GlpR protein
product GlpR-glycerol-3-phosphate complex
reactant glycerol-3-phosphate simple_molecule
glycerol + GlpR GlpR-glycerol
Name: glycerol + GlpR -> GlpR-glycerol
Description: Reaction transforming glycerol, GlpR into GlpR-glycerol
Type: state transition
Pathway Components: glycerol + GlpR -> GlpR-glycerol
Components:
Function Name Type
reactant GlpR protein
product GlpR-glycerol complex
reactant glycerol simple_molecule
glpFKX_mRNA GlpF
Name: glpFKX_mRNA -> GlpF
Description: Translation of GlpF
Type: translation
Pathway Components: glpFKX_mRNA -> GlpF
Components:
Function Name Type
product GlpF protein
reactant glpFKX_mRNA RNA
GlpF polyol_Ext polyol
Name: polyol_Ext -> polyol
Description: Transport of polyol_Ext through a bacterial membrane, leading to the presence of polyol inside the cell.
Type: transport
Pathway Components: polyol_Ext - GlpF -> polyol
Components:
Function Name Type
catalyzer GlpF protein
product polyol simple_molecule
reactant polyol_Ext simple_molecule
GlpF glycerol_Ext glycerol
Name: glycerol_Ext -> glycerol
Description: Transport of glycerol_Ext through a bacterial membrane, leading to the presence of glycerol inside the cell.
Type: transport
Pathway Components: glycerol_Ext - GlpF -> glycerol
Components:
Function Name Type
catalyzer GlpF protein
product glycerol simple_molecule
reactant glycerol_Ext simple_molecule
GlpF DL-glyceraldehyde_Ext DL-glyceraldehyde
Name: DL-glyceraldehyde_Ext -> DL-glyceraldehyde
Description: Transport of DL-glyceraldehyde_Ext through a bacterial membrane, leading to the presence of DL-glyceraldehyde inside the cell.
Type: transport
Pathway Components: DL-glyceraldehyde_Ext - GlpF -> DL-glyceraldehyde
Components:
Function Name Type
product DL-glyceraldehyde simple_molecule
reactant DL-glyceraldehyde_Ext simple_molecule
catalyzer GlpF protein
GlpF glycine_Ext glycine
Name: glycine_Ext -> glycine
Description: Transport of glycine_Ext through a bacterial membrane, leading to the presence of glycine inside the cell.
Type: transport
Pathway Components: glycine_Ext - GlpF -> glycine
Components:
Function Name Type
catalyzer GlpF protein
product glycine simple_molecule
reactant glycine_Ext simple_molecule
GlpF urea_Ext urea
Name: urea_Ext -> urea
Description: Transport of urea_Ext through a bacterial membrane, leading to the presence of urea inside the cell.
Type: transport
Pathway Components: urea_Ext - GlpF -> urea
Components:
Function Name Type
catalyzer GlpF protein
product urea simple_molecule
reactant urea_Ext simple_molecule
GlpF arsenite_Ext arsenite
Name: arsenite_Ext -> arsenite
Description: Transport of arsenite_Ext through a bacterial membrane, leading to the presence of arsenite inside the cell.
Type: transport
Pathway Components: arsenite_Ext - GlpF -> arsenite
Components:
Function Name Type
catalyzer GlpF protein
product arsenite simple_molecule
reactant arsenite_Ext simple_molecule
GlpF stiborous acid_Ext stiborous acid
Name: stiborous acid_Ext -> stiborous acid
Description: Transport of stiborous acid_Ext through a bacterial membrane, leading to the presence of stiborous acid inside the cell.
Type: transport
Pathway Components: stiborous acid_Ext - GlpF -> stiborous acid
Components:
Function Name Type
catalyzer GlpF protein
product stiborous acid simple_molecule
reactant stiborous acid_Ext simple_molecule
glpFKX_mRNA GlpK
Name: glpFKX_mRNA -> GlpK
Description: Translation of GlpK
Type: translation
Pathway Components: glpFKX_mRNA -> GlpK
Components:
Function Name Type
product GlpK protein
reactant glpFKX_mRNA RNA
GlpK fructose 1,6-biphosphate glycerol-3-phosphate glycerol glycerol-3-phosphate
Name: glycerol -> glycerol-3-phosphate
Description: Reaction transforming glycerol into glycerol-3-phosphate
Type: state transition
Pathway Components: glycerol - GlpK - fructose 1,6-biphosphate - glycerol-3-phosphate -> glycerol-3-phosphate
Components:
Function Name Type
catalyzer GlpK protein
inhibitor fructose 1,6-biphosphate simple_molecule
reactant glycerol simple_molecule
inhibitor glycerol-3-phosphate simple_molecule
product glycerol-3-phosphate simple_molecule
glpFKX_mRNA GlpX
Name: glpFKX_mRNA -> GlpX
Description: Translation of GlpX
Type: translation
Pathway Components: glpFKX_mRNA -> GlpX
Components:
Function Name Type
product GlpX protein
reactant glpFKX_mRNA RNA
GlpX fructose 1,6-biphosphate fructose-6-P + phosphate
Name: fructose 1,6-biphosphate -> fructose-6-P + phosphate
Description: Reaction transforming fructose 1,6-biphosphate into fructose-6-P, phosphate
Type: state transition
Pathway Components: fructose 1,6-biphosphate - GlpX -> fructose-6-P + phosphate
Components:
Function Name Type
catalyzer GlpX protein
reactant fructose 1,6-biphosphate simple_molecule
product fructose-6-P simple_molecule
product phosphate simple_molecule
glpABC_mRNA GlpA
Name: glpABC_mRNA -> GlpA
Description: Translation of GlpA
Type: translation
Pathway Components: glpABC_mRNA -> GlpA
Components:
Function Name Type
product GlpA protein
reactant glpABC_mRNA RNA
GlpC + GlpB + GlpA GlpA-GlpB-GlpC
Name: GlpC + GlpB + GlpA -> GlpA-GlpB-GlpC
Description: Reaction transforming GlpC, GlpB, GlpA into GlpA-GlpB-GlpC
Type: state transition
Pathway Components: GlpC + GlpB + GlpA -> GlpA-GlpB-GlpC
Components:
Function Name Type
reactant GlpA protein
product GlpA-GlpB-GlpC complex
reactant GlpB protein
reactant GlpC protein
GlpA-GlpB-GlpC glycerol-3-phosphate + vitamin K2 menaquinol + DHAP
Name: glycerol-3-phosphate + vitamin K2 -> menaquinol + DHAP
Description: Reaction transforming glycerol-3-phosphate, vitamin K2 into menaquinol, DHAP
Type: state transition
Pathway Components: glycerol-3-phosphate + vitamin K2 - GlpA-GlpB-GlpC -> menaquinol + DHAP
Components:
Function Name Type
product DHAP simple_molecule
catalyzer GlpA-GlpB-GlpC complex
reactant glycerol-3-phosphate simple_molecule
product menaquinol simple_molecule
reactant vitamin K2 simple_molecule
glpABC_mRNA GlpB
Name: glpABC_mRNA -> GlpB
Description: Translation of GlpB
Type: translation
Pathway Components: glpABC_mRNA -> GlpB
Components:
Function Name Type
product GlpB protein
reactant glpABC_mRNA RNA
glpABC_mRNA GlpC
Name: glpABC_mRNA -> GlpC
Description: Translation of GlpC
Type: translation
Pathway Components: glpABC_mRNA -> GlpC
Components:
Function Name Type
product GlpC protein
reactant glpABC_mRNA RNA
glpD_mRNA GlpD
Name: glpD_mRNA -> GlpD
Description: Translation of GlpD
Type: translation
Pathway Components: glpD_mRNA -> GlpD
Components:
Function Name Type
product GlpD protein
reactant glpD_mRNA RNA
DHAP GlpD glycerol-3-phosphate + ubiquinone ubiquinol + DHAP
Name: glycerol-3-phosphate + ubiquinone -> ubiquinol + DHAP
Description: Reaction transforming glycerol-3-phosphate, ubiquinone into ubiquinol, DHAP
Type: state transition
Pathway Components: glycerol-3-phosphate + ubiquinone - GlpD - DHAP -> ubiquinol + DHAP
Components:
Function Name Type
inhibitor DHAP simple_molecule
product DHAP simple_molecule
catalyzer GlpD protein
reactant glycerol-3-phosphate simple_molecule
product ubiquinol simple_molecule
reactant ubiquinone simple_molecule
glpTQ_mRNA GlpT
Name: glpTQ_mRNA -> GlpT
Description: Translation of GlpT
Type: translation
Pathway Components: glpTQ_mRNA -> GlpT
Components:
Function Name Type
product GlpT protein
reactant glpTQ_mRNA RNA
GlpT glycerol-3-phosphate_Ext glycerol-3-phosphate
Name: glycerol-3-phosphate_Ext -> glycerol-3-phosphate
Description: Transport of glycerol-3-phosphate_Ext through a bacterial membrane, leading to the presence of glycerol-3-phosphate inside the cell.
Type: transport
Pathway Components: glycerol-3-phosphate_Ext - GlpT -> glycerol-3-phosphate
Components:
Function Name Type
catalyzer GlpT protein
product glycerol-3-phosphate simple_molecule
reactant glycerol-3-phosphate_Ext simple_molecule
glpTQ_mRNA GlpQ
Name: glpTQ_mRNA -> GlpQ
Description: Translation of GlpQ
Type: translation
Pathway Components: glpTQ_mRNA -> GlpQ
Components:
Function Name Type
product GlpQ protein
reactant glpTQ_mRNA RNA
GlpQ glycerol-3-P-OR glycerol-3-phosphate + alcohol
Name: glycerol-3-P-OR -> glycerol-3-phosphate + alcohol
Description: Reaction transforming glycerol-3-P-OR into glycerol-3-phosphate, alcohol
Type: state transition
Pathway Components: glycerol-3-P-OR - GlpQ -> glycerol-3-phosphate + alcohol
Components:
Function Name Type
catalyzer GlpQ protein
product alcohol simple_molecule
reactant glycerol-3-P-OR simple_molecule
product glycerol-3-phosphate simple_molecule
GlpQ diglycerol phosphate glycerol-3-phosphate + glycerol
Name: diglycerol phosphate -> glycerol-3-phosphate + glycerol
Description: Reaction transforming diglycerol phosphate into glycerol-3-phosphate, glycerol
Type: state transition
Pathway Components: diglycerol phosphate - GlpQ -> glycerol-3-phosphate + glycerol
Components:
Function Name Type
catalyzer GlpQ protein
reactant diglycerol phosphate simple_molecule
product glycerol simple_molecule
product glycerol-3-phosphate simple_molecule



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