RegulonDB RegulonDB

GalR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
beta-D-galactose UDP-galactose galE_mRNA D-glucose 1-phosphate MglA GalR mglBAC_mRNA galactose-1-P galactopyranose galR_mRNA galETK_mRNA MglA GalS b-methyl-D-galactoside glucopyranose beta-D-galactose galE MglC GalM galS GalE galR mglBAC galETKM galETK galactopyranose_Ext galS_mRNA galP MglB galET_mRNA GalP b-methyl-D-galactoside_Ext galETKM_mRNA GalT glucopyranose_Ext MglB MglC alpha-D-galactose galP_mRNA GalK GalR galET UDPG


Gensor Unit       
Name: GalR
Description: Molecular biology level
Detailed: In the presence of galactose, GalR negatively regulates its own expression and the expression of genes required for galactose transport and regulation of transcription by galactose, and dually regulates the expression of genes required for galactose catabolic process via UDP-galactose. Under these conditions, GalR is modified to GalR-galactose, binds its target sites preventing its own expression and the expression of its regulated genes. In the absence of galactose, GalR binds its target sites preventing the expression of genes necessary for galactose and methylgalactoside transport and regulation of transcription by galactose.
Less detailed: GalR dually regulates the expression of genes required for galactose transport, galactose catabolic process via UDP-galactose and regulation of transcription by galactose in the presence of diverse levels of galactose.

Physiology level
Detailed: The presence of galactose inhibits the expression of genes involved with galactose transport and regulation of transcription by galactose and dually regulates the expression of the genes required for catabolism of galactose. Under these conditions, the genes necessary for the transport are not expressed and those genes necessary for the conversion of galactose to UDP-galactose are dually expressed.
Less detailed: The presence of galactose inhibits the expression of genes needful for galactose transport and regulation of transcription by galactose and dually regulates the expression of the genes required for catabolism of galactose. Read more >
Classification:
Groups: Transcription
Carbohydrate transport and metabolism
Cell wall/membrane/envelope biogenesis
Gene Ontology Terms (GO): biological_process GO:0005975 - carbohydrate metabolic process
GO:0046835 - carbohydrate phosphorylation
GO:0034219 - carbohydrate transmembrane transport
GO:0008643 - carbohydrate transport
GO:0006974 - cellular response to DNA damage stimulus
GO:0006935 - chemotaxis
Read more >
cellular_component GO:0043190 - ATP-binding cassette (ABC) transporter complex
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0016021 - integral component of membrane
GO:0005887 - integral component of plasma membrane
GO:0016020 - membrane
GO:0030288 - outer membrane-bounded periplasmic space
Read more >
molecular_function GO:0005524 - ATP binding
GO:0016887 - ATPase activity
GO:0043211 - ATPase-coupled carbohydrate transmembrane transporter activity
GO:0015407 - ATPase-coupled monosaccharide transmembrane transporter activity
GO:0003677 - DNA binding
GO:0003700 - DNA-binding transcription factor activity
GO:0070403 - NAD+ binding
Read more >
Components:
  Function Name Type
  simple_molecule α-D-galactose simple_molecule
  simple_molecule D-glucose 1-phosphate simple_molecule
  protein GalE protein
  protein GalK protein
  protein GalM protein
  protein GalP protein
  protein GalR protein
  complex GalR-beta-D-galactose complex
  protein GalS protein
  protein GalT protein
  protein MglA protein
  complex MglA-MglC-MglB complex
  protein MglB protein
  protein MglC protein
  simple_molecule UDP-galactose simple_molecule
  simple_molecule UDPG simple_molecule
  simple_molecule b-methyl-D-galactoside simple_molecule
  simple_molecule b-methyl-D-galactoside_Ext simple_molecule
  simple_molecule beta-D-galactose simple_molecule
  gene galE gene
  gene galET gene
  gene galETK gene
  gene galETKM gene
  RNA galETKM_mRNA RNA
  RNA galETK_mRNA RNA
  RNA galET_mRNA RNA
  RNA galE_mRNA RNA
  gene galP gene
  RNA galP_mRNA RNA
  gene galR gene
  RNA galR_mRNA RNA
  gene galS gene
  RNA galS_mRNA RNA
  simple_molecule galactopyranose simple_molecule
  simple_molecule galactopyranose_Ext simple_molecule
  simple_molecule galactose-1-P simple_molecule
  simple_molecule glucopyranose simple_molecule
  simple_molecule glucopyranose_Ext simple_molecule
  gene mglBAC gene
  RNA mglBAC_mRNA RNA


Reactions       
Showing 33 reactions
GalR GalR GalR-beta-D-galactose GalR-beta-D-galactose galE galE_mRNA
Name: galE -> galE_mRNA
Description: Transcription of transcription unit galE. Reaction activation by GalR, and GalR-beta-D-galactose. Reaction inhibition by GalR, and GalR-beta-D-galactose.
Type: transcription
Pathway Components: galE - GalR - GalR-beta-D-galactose - GalR - GalR-beta-D-galactose -> galE_mRNA
Components:
Function Name Type
activator GalR protein
inhibitor GalR protein
activator GalR-beta-D-galactose complex
inhibitor GalR-beta-D-galactose complex
reactant galE gene
product galE_mRNA RNA
GalR GalR GalR-beta-D-galactose GalR-beta-D-galactose galET galET_mRNA
Name: galET -> galET_mRNA
Description: Transcription of transcription unit galET. Reaction activation by GalR, and GalR-beta-D-galactose. Reaction inhibition by GalR, and GalR-beta-D-galactose.
Type: transcription
Pathway Components: galET - GalR - GalR-beta-D-galactose - GalR - GalR-beta-D-galactose -> galET_mRNA
Components:
Function Name Type
activator GalR protein
inhibitor GalR protein
activator GalR-beta-D-galactose complex
inhibitor GalR-beta-D-galactose complex
reactant galET gene
product galET_mRNA RNA
GalR GalR GalR-beta-D-galactose GalR-beta-D-galactose galETK galETK_mRNA
Name: galETK -> galETK_mRNA
Description: Transcription of transcription unit galETK. Reaction activation by GalR, and GalR-beta-D-galactose. Reaction inhibition by GalR, and GalR-beta-D-galactose.
Type: transcription
Pathway Components: galETK - GalR - GalR-beta-D-galactose - GalR - GalR-beta-D-galactose -> galETK_mRNA
Components:
Function Name Type
activator GalR protein
inhibitor GalR protein
activator GalR-beta-D-galactose complex
inhibitor GalR-beta-D-galactose complex
reactant galETK gene
product galETK_mRNA RNA
GalR GalR GalR-beta-D-galactose GalR-beta-D-galactose galETKM galETKM_mRNA
Name: galETKM -> galETKM_mRNA
Description: Transcription of transcription unit galETKM. Reaction activation by GalR, and GalR-beta-D-galactose. Reaction inhibition by GalR, and GalR-beta-D-galactose.
Type: transcription
Pathway Components: galETKM - GalR - GalR-beta-D-galactose - GalR - GalR-beta-D-galactose -> galETKM_mRNA
Components:
Function Name Type
activator GalR protein
inhibitor GalR protein
activator GalR-beta-D-galactose complex
inhibitor GalR-beta-D-galactose complex
reactant galETKM gene
product galETKM_mRNA RNA
GalR GalR-beta-D-galactose galP galP_mRNA
Name: galP -> galP_mRNA
Description: Transcription of transcription unit galP. Reaction inhibition by GalR, and GalR-beta-D-galactose.
Type: transcription
Pathway Components: galP - GalR - GalR-beta-D-galactose -> galP_mRNA
Components:
Function Name Type
inhibitor GalR protein
inhibitor GalR-beta-D-galactose complex
reactant galP gene
product galP_mRNA RNA
GalR galS galS_mRNA
Name: galS -> galS_mRNA
Description: Transcription of transcription unit galS. Reaction inhibition by GalR.
Type: transcription
Pathway Components: galS - GalR -> galS_mRNA
Components:
Function Name Type
inhibitor GalR protein
reactant galS gene
product galS_mRNA RNA
GalR mglBAC mglBAC_mRNA
Name: mglBAC -> mglBAC_mRNA
Description: Transcription of transcription unit mglBAC. Reaction inhibition by GalR.
Type: transcription
Pathway Components: mglBAC - GalR -> mglBAC_mRNA
Components:
Function Name Type
inhibitor GalR protein
reactant mglBAC gene
product mglBAC_mRNA RNA
beta-D-galactose + GalR GalR-beta-D-galactose
Name: beta-D-galactose + GalR -> GalR-beta-D-galactose
Description: Reaction transforming beta-D-galactose, GalR into GalR-beta-D-galactose
Type: state transition
Pathway Components: beta-D-galactose + GalR -> GalR-beta-D-galactose
Components:
Function Name Type
reactant GalR protein
product GalR-beta-D-galactose complex
reactant beta-D-galactose simple_molecule
GalR-beta-D-galactose galR galR_mRNA
Name: galR -> galR_mRNA
Description: Transcription of transcription unit galR. Reaction inhibition by GalR-beta-D-galactose.
Type: transcription
Pathway Components: galR - GalR-beta-D-galactose -> galR_mRNA
Components:
Function Name Type
inhibitor GalR-beta-D-galactose complex
reactant galR gene
product galR_mRNA RNA
galR_mRNA GalR
Name: galR_mRNA -> GalR
Description: Translation of GalR
Type: translation
Pathway Components: galR_mRNA -> GalR
Components:
Function Name Type
product GalR protein
reactant galR_mRNA RNA
galETKM_mRNA GalE
Name: galETKM_mRNA -> GalE
Description: Translation of GalE
Type: translation
Pathway Components: galETKM_mRNA -> GalE
Components:
Function Name Type
product GalE protein
reactant galETKM_mRNA RNA
GalE UDPG UDP-galactose
Name: UDPG -> UDP-galactose
Description: Reaction transforming UDPG into UDP-galactose
Type: state transition
Pathway Components: UDPG - GalE -> UDP-galactose
Components:
Function Name Type
catalyzer GalE protein
product UDP-galactose simple_molecule
reactant UDPG simple_molecule
galETKM_mRNA GalT
Name: galETKM_mRNA -> GalT
Description: Translation of GalT
Type: translation
Pathway Components: galETKM_mRNA -> GalT
Components:
Function Name Type
product GalT protein
reactant galETKM_mRNA RNA
GalT galactose-1-P + UDPG D-glucose 1-phosphate + UDP-galactose
Name: galactose-1-P + UDPG -> D-glucose 1-phosphate + UDP-galactose
Description: Reaction transforming galactose-1-P, UDPG into D-glucose 1-phosphate, UDP-galactose
Type: state transition
Pathway Components: galactose-1-P + UDPG - GalT -> D-glucose 1-phosphate + UDP-galactose
Components:
Function Name Type
product D-glucose 1-phosphate simple_molecule
catalyzer GalT protein
product UDP-galactose simple_molecule
reactant UDPG simple_molecule
reactant galactose-1-P simple_molecule
galETKM_mRNA GalK
Name: galETKM_mRNA -> GalK
Description: Translation of GalK
Type: translation
Pathway Components: galETKM_mRNA -> GalK
Components:
Function Name Type
product GalK protein
reactant galETKM_mRNA RNA
GalK α-D-galactose galactose-1-P
Name: α-D-galactose -> galactose-1-P
Description: Reaction transforming α-D-galactose into galactose-1-P
Type: state transition
Pathway Components: α-D-galactose - GalK -> galactose-1-P
Components:
Function Name Type
reactant α-D-galactose simple_molecule
catalyzer GalK protein
product galactose-1-P simple_molecule
galETKM_mRNA GalM
Name: galETKM_mRNA -> GalM
Description: Translation of GalM
Type: translation
Pathway Components: galETKM_mRNA -> GalM
Components:
Function Name Type
product GalM protein
reactant galETKM_mRNA RNA
GalM beta-D-galactose α-D-galactose
Name: beta-D-galactose -> α-D-galactose
Description: Reaction transforming beta-D-galactose into α-D-galactose
Type: state transition
Pathway Components: beta-D-galactose - GalM -> α-D-galactose
Components:
Function Name Type
product α-D-galactose simple_molecule
catalyzer GalM protein
reactant beta-D-galactose simple_molecule
galETK_mRNA GalE
Name: galETK_mRNA -> GalE
Description: Translation of GalE
Type: translation
Pathway Components: galETK_mRNA -> GalE
Components:
Function Name Type
product GalE protein
reactant galETK_mRNA RNA
galETK_mRNA GalT
Name: galETK_mRNA -> GalT
Description: Translation of GalT
Type: translation
Pathway Components: galETK_mRNA -> GalT
Components:
Function Name Type
product GalT protein
reactant galETK_mRNA RNA
galETK_mRNA GalK
Name: galETK_mRNA -> GalK
Description: Translation of GalK
Type: translation
Pathway Components: galETK_mRNA -> GalK
Components:
Function Name Type
product GalK protein
reactant galETK_mRNA RNA
galET_mRNA GalE
Name: galET_mRNA -> GalE
Description: Translation of GalE
Type: translation
Pathway Components: galET_mRNA -> GalE
Components:
Function Name Type
product GalE protein
reactant galET_mRNA RNA
galET_mRNA GalT
Name: galET_mRNA -> GalT
Description: Translation of GalT
Type: translation
Pathway Components: galET_mRNA -> GalT
Components:
Function Name Type
product GalT protein
reactant galET_mRNA RNA
mglBAC_mRNA MglB
Name: mglBAC_mRNA -> MglB
Description: Translation of MglB
Type: translation
Pathway Components: mglBAC_mRNA -> MglB
Components:
Function Name Type
product MglB protein
reactant mglBAC_mRNA RNA
MglB + MglA + MglC MglA-MglC-MglB
Name: MglB + MglA + MglC -> MglA-MglC-MglB
Description: Reaction transforming MglB, MglA, MglC into MglA-MglC-MglB
Type: state transition
Pathway Components: MglB + MglA + MglC -> MglA-MglC-MglB
Components:
Function Name Type
reactant MglA protein
product MglA-MglC-MglB complex
reactant MglB protein
reactant MglC protein
GalP MglA-MglC-MglB galactopyranose_Ext galactopyranose
Name: galactopyranose_Ext -> galactopyranose
Description: Transport of galactopyranose_Ext through a bacterial membrane, leading to the presence of galactopyranose inside the cell.
Type: transport
Pathway Components: galactopyranose_Ext - GalP - MglA-MglC-MglB -> galactopyranose
Components:
Function Name Type
catalyzer GalP protein
catalyzer MglA-MglC-MglB complex
product galactopyranose simple_molecule
reactant galactopyranose_Ext simple_molecule
MglA-MglC-MglB b-methyl-D-galactoside_Ext b-methyl-D-galactoside
Name: b-methyl-D-galactoside_Ext -> b-methyl-D-galactoside
Description: Transport of b-methyl-D-galactoside_Ext through a bacterial membrane, leading to the presence of b-methyl-D-galactoside inside the cell.
Type: transport
Pathway Components: b-methyl-D-galactoside_Ext - MglA-MglC-MglB -> b-methyl-D-galactoside
Components:
Function Name Type
catalyzer MglA-MglC-MglB complex
product b-methyl-D-galactoside simple_molecule
reactant b-methyl-D-galactoside_Ext simple_molecule
mglBAC_mRNA MglA
Name: mglBAC_mRNA -> MglA
Description: Translation of MglA
Type: translation
Pathway Components: mglBAC_mRNA -> MglA
Components:
Function Name Type
product MglA protein
reactant mglBAC_mRNA RNA
mglBAC_mRNA MglC
Name: mglBAC_mRNA -> MglC
Description: Translation of MglC
Type: translation
Pathway Components: mglBAC_mRNA -> MglC
Components:
Function Name Type
product MglC protein
reactant mglBAC_mRNA RNA
galS_mRNA GalS
Name: galS_mRNA -> GalS
Description: Translation of GalS
Type: translation
Pathway Components: galS_mRNA -> GalS
Components:
Function Name Type
product GalS protein
reactant galS_mRNA RNA
galP_mRNA GalP
Name: galP_mRNA -> GalP
Description: Translation of GalP
Type: translation
Pathway Components: galP_mRNA -> GalP
Components:
Function Name Type
product GalP protein
reactant galP_mRNA RNA
GalP glucopyranose_Ext glucopyranose
Name: glucopyranose_Ext -> glucopyranose
Description: Transport of glucopyranose_Ext through a bacterial membrane, leading to the presence of glucopyranose inside the cell.
Type: transport
Pathway Components: glucopyranose_Ext - GalP -> glucopyranose
Components:
Function Name Type
catalyzer GalP protein
product glucopyranose simple_molecule
reactant glucopyranose_Ext simple_molecule
galE_mRNA GalE
Name: galE_mRNA -> GalE
Description: Translation of GalE
Type: translation
Pathway Components: galE_mRNA -> GalE
Components:
Function Name Type
product GalE protein
reactant galE_mRNA RNA



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