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GalS Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
galactopyranose MglB b-methyl-D-galactoside_Ext galET_mRNA glucopyranose GalM GalE galETKM_mRNA galS_mRNA galS galactopyranose_Ext GalS MglC MglC galR_mRNA MglB galET mglBAC_mRNA beta-D-galactose b-methyl-D-galactoside UDP-galactose galETK galE_mRNA galETKM galP GalP galactose-1-P beta-D-galactose galP_mRNA GalT D-glucose 1-phosphate GalR galR MglA MglA alpha-D-galactose galETK_mRNA mglBAC glucopyranose_Ext GalK UDPG GalS galE


Gensor Unit       
Name: GalS
Description: Molecular biology level
Detailed: In the absence or presence of beta-D-galactose, GalS dually regulates the expression of genes required for galactose degradation to UDP-galactose. Under different conditions of galactose availability, GalS remains unmodified or is modified to GalS-beta-D-galactose, binds to its target sites enabling or preventing the expression of its regulated genes.
Less detailed: In the absence or presence of beta-D-galactose, GalS dually regulates the expression of genes needed for galactose degradation to UDP-galactose to respond to different conditions of galactose availability.

Physiology level
Detailed: The presence of beta-D-galactose represses the expression of GalR and genes involved with Galactose uptake. Under this condition, the genes necessary for D-Galactose transport are not expressed. The presence of beta-D-galactose dually regulates the expression of genes required to UDP-D-galactose biosynthesis. Under this condition, the genes necessary for D-galactose conversion to UDP-D-galactose are expressed and not expressed. The absence of D-galactose repress its own expression and the expression of genes necessary for D-galactose and methyl-D-galactoside uptake. Under this condition, the genes necessary for D-galactose and D-methylgalactoside transport are not expressed.
Less detailed: The presence of beta-D-galactose represses the expression of genes needful for D-galactose transport and dually regulates the expression of genes related with D-galactose conversion to UDP-D-galactose. Read more >
Classification:
Groups: Transcription
Carbohydrate transport and metabolism
Cell wall/membrane/envelope biogenesis
Gene Ontology Terms (GO): biological_process GO:0005975 - carbohydrate metabolic process
GO:0046835 - carbohydrate phosphorylation
GO:0034219 - carbohydrate transmembrane transport
GO:0008643 - carbohydrate transport
GO:0006974 - cellular response to DNA damage stimulus
GO:0006935 - chemotaxis
Read more >
cellular_component GO:0043190 - ATP-binding cassette (ABC) transporter complex
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0016021 - integral component of membrane
GO:0005887 - integral component of plasma membrane
GO:0016020 - membrane
GO:0030288 - outer membrane-bounded periplasmic space
Read more >
molecular_function GO:0005524 - ATP binding
GO:0016887 - ATPase activity
GO:0043211 - ATPase-coupled carbohydrate transmembrane transporter activity
GO:0015407 - ATPase-coupled monosaccharide transmembrane transporter activity
GO:0003677 - DNA binding
GO:0003700 - DNA-binding transcription factor activity
GO:0070403 - NAD+ binding
Read more >
Components:
  Function Name Type
  simple_molecule α-D-galactose simple_molecule
  simple_molecule D-glucose 1-phosphate simple_molecule
  protein GalE protein
  protein GalK protein
  protein GalM protein
  protein GalP protein
  protein GalR protein
  protein GalS protein
  complex GalS-beta-D-galactose complex
  protein GalT protein
  protein MglA protein
  complex MglA-MglC-MglB complex
  protein MglB protein
  protein MglC protein
  simple_molecule UDP-galactose simple_molecule
  simple_molecule UDPG simple_molecule
  simple_molecule b-methyl-D-galactoside simple_molecule
  simple_molecule b-methyl-D-galactoside_Ext simple_molecule
  simple_molecule beta-D-galactose simple_molecule
  gene galE gene
  gene galET gene
  gene galETK gene
  gene galETKM gene
  RNA galETKM_mRNA RNA
  RNA galETK_mRNA RNA
  RNA galET_mRNA RNA
  RNA galE_mRNA RNA
  gene galP gene
  RNA galP_mRNA RNA
  gene galR gene
  RNA galR_mRNA RNA
  gene galS gene
  RNA galS_mRNA RNA
  simple_molecule galactopyranose simple_molecule
  simple_molecule galactopyranose_Ext simple_molecule
  simple_molecule galactose-1-P simple_molecule
  simple_molecule glucopyranose simple_molecule
  simple_molecule glucopyranose_Ext simple_molecule
  gene mglBAC gene
  RNA mglBAC_mRNA RNA


Reactions       
Showing 33 reactions
GalS GalS GalS-beta-D-galactose GalS-beta-D-galactose galE galE_mRNA
Name: galE -> galE_mRNA
Description: Transcription of transcription unit galE. Reaction activation by GalS, and GalS-beta-D-galactose. Reaction inhibition by GalS, and GalS-beta-D-galactose.
Type: transcription
Pathway Components: galE - GalS - GalS-beta-D-galactose - GalS - GalS-beta-D-galactose -> galE_mRNA
Components:
Function Name Type
activator GalS protein
inhibitor GalS protein
activator GalS-beta-D-galactose complex
inhibitor GalS-beta-D-galactose complex
reactant galE gene
product galE_mRNA RNA
GalS GalS GalS-beta-D-galactose GalS-beta-D-galactose galET galET_mRNA
Name: galET -> galET_mRNA
Description: Transcription of transcription unit galET. Reaction activation by GalS, and GalS-beta-D-galactose. Reaction inhibition by GalS, and GalS-beta-D-galactose.
Type: transcription
Pathway Components: galET - GalS - GalS-beta-D-galactose - GalS - GalS-beta-D-galactose -> galET_mRNA
Components:
Function Name Type
activator GalS protein
inhibitor GalS protein
activator GalS-beta-D-galactose complex
inhibitor GalS-beta-D-galactose complex
reactant galET gene
product galET_mRNA RNA
GalS GalS GalS-beta-D-galactose GalS-beta-D-galactose galETK galETK_mRNA
Name: galETK -> galETK_mRNA
Description: Transcription of transcription unit galETK. Reaction activation by GalS, and GalS-beta-D-galactose. Reaction inhibition by GalS, and GalS-beta-D-galactose.
Type: transcription
Pathway Components: galETK - GalS - GalS-beta-D-galactose - GalS - GalS-beta-D-galactose -> galETK_mRNA
Components:
Function Name Type
activator GalS protein
inhibitor GalS protein
activator GalS-beta-D-galactose complex
inhibitor GalS-beta-D-galactose complex
reactant galETK gene
product galETK_mRNA RNA
GalS GalS GalS-beta-D-galactose GalS-beta-D-galactose galETKM galETKM_mRNA
Name: galETKM -> galETKM_mRNA
Description: Transcription of transcription unit galETKM. Reaction activation by GalS, and GalS-beta-D-galactose. Reaction inhibition by GalS, and GalS-beta-D-galactose.
Type: transcription
Pathway Components: galETKM - GalS - GalS-beta-D-galactose - GalS - GalS-beta-D-galactose -> galETKM_mRNA
Components:
Function Name Type
activator GalS protein
inhibitor GalS protein
activator GalS-beta-D-galactose complex
inhibitor GalS-beta-D-galactose complex
reactant galETKM gene
product galETKM_mRNA RNA
GalS GalS-beta-D-galactose galP galP_mRNA
Name: galP -> galP_mRNA
Description: Transcription of transcription unit galP. Reaction inhibition by GalS, and GalS-beta-D-galactose.
Type: transcription
Pathway Components: galP - GalS - GalS-beta-D-galactose -> galP_mRNA
Components:
Function Name Type
inhibitor GalS protein
inhibitor GalS-beta-D-galactose complex
reactant galP gene
product galP_mRNA RNA
GalS galS galS_mRNA
Name: galS -> galS_mRNA
Description: Transcription of transcription unit galS. Reaction inhibition by GalS.
Type: transcription
Pathway Components: galS - GalS -> galS_mRNA
Components:
Function Name Type
inhibitor GalS protein
reactant galS gene
product galS_mRNA RNA
GalS mglBAC mglBAC_mRNA
Name: mglBAC -> mglBAC_mRNA
Description: Transcription of transcription unit mglBAC. Reaction inhibition by GalS.
Type: transcription
Pathway Components: mglBAC - GalS -> mglBAC_mRNA
Components:
Function Name Type
inhibitor GalS protein
reactant mglBAC gene
product mglBAC_mRNA RNA
beta-D-galactose + GalS GalS-beta-D-galactose
Name: beta-D-galactose + GalS -> GalS-beta-D-galactose
Description: Reaction transforming beta-D-galactose, GalS into GalS-beta-D-galactose
Type: state transition
Pathway Components: beta-D-galactose + GalS -> GalS-beta-D-galactose
Components:
Function Name Type
reactant GalS protein
product GalS-beta-D-galactose complex
reactant beta-D-galactose simple_molecule
GalS-beta-D-galactose galR galR_mRNA
Name: galR -> galR_mRNA
Description: Transcription of transcription unit galR. Reaction inhibition by GalS-beta-D-galactose.
Type: transcription
Pathway Components: galR - GalS-beta-D-galactose -> galR_mRNA
Components:
Function Name Type
inhibitor GalS-beta-D-galactose complex
reactant galR gene
product galR_mRNA RNA
mglBAC_mRNA MglB
Name: mglBAC_mRNA -> MglB
Description: Translation of MglB
Type: translation
Pathway Components: mglBAC_mRNA -> MglB
Components:
Function Name Type
product MglB protein
reactant mglBAC_mRNA RNA
MglB + MglA + MglC MglA-MglC-MglB
Name: MglB + MglA + MglC -> MglA-MglC-MglB
Description: Reaction transforming MglB, MglA, MglC into MglA-MglC-MglB
Type: state transition
Pathway Components: MglB + MglA + MglC -> MglA-MglC-MglB
Components:
Function Name Type
reactant MglA protein
product MglA-MglC-MglB complex
reactant MglB protein
reactant MglC protein
GalP MglA-MglC-MglB galactopyranose_Ext galactopyranose
Name: galactopyranose_Ext -> galactopyranose
Description: Transport of galactopyranose_Ext through a bacterial membrane, leading to the presence of galactopyranose inside the cell.
Type: transport
Pathway Components: galactopyranose_Ext - GalP - MglA-MglC-MglB -> galactopyranose
Components:
Function Name Type
catalyzer GalP protein
catalyzer MglA-MglC-MglB complex
product galactopyranose simple_molecule
reactant galactopyranose_Ext simple_molecule
MglA-MglC-MglB b-methyl-D-galactoside_Ext b-methyl-D-galactoside
Name: b-methyl-D-galactoside_Ext -> b-methyl-D-galactoside
Description: Transport of b-methyl-D-galactoside_Ext through a bacterial membrane, leading to the presence of b-methyl-D-galactoside inside the cell.
Type: transport
Pathway Components: b-methyl-D-galactoside_Ext - MglA-MglC-MglB -> b-methyl-D-galactoside
Components:
Function Name Type
catalyzer MglA-MglC-MglB complex
product b-methyl-D-galactoside simple_molecule
reactant b-methyl-D-galactoside_Ext simple_molecule
mglBAC_mRNA MglA
Name: mglBAC_mRNA -> MglA
Description: Translation of MglA
Type: translation
Pathway Components: mglBAC_mRNA -> MglA
Components:
Function Name Type
product MglA protein
reactant mglBAC_mRNA RNA
mglBAC_mRNA MglC
Name: mglBAC_mRNA -> MglC
Description: Translation of MglC
Type: translation
Pathway Components: mglBAC_mRNA -> MglC
Components:
Function Name Type
product MglC protein
reactant mglBAC_mRNA RNA
galS_mRNA GalS
Name: galS_mRNA -> GalS
Description: Translation of GalS
Type: translation
Pathway Components: galS_mRNA -> GalS
Components:
Function Name Type
product GalS protein
reactant galS_mRNA RNA
galR_mRNA GalR
Name: galR_mRNA -> GalR
Description: Translation of GalR
Type: translation
Pathway Components: galR_mRNA -> GalR
Components:
Function Name Type
product GalR protein
reactant galR_mRNA RNA
galETKM_mRNA GalE
Name: galETKM_mRNA -> GalE
Description: Translation of GalE
Type: translation
Pathway Components: galETKM_mRNA -> GalE
Components:
Function Name Type
product GalE protein
reactant galETKM_mRNA RNA
GalE UDPG UDP-galactose
Name: UDPG -> UDP-galactose
Description: Reaction transforming UDPG into UDP-galactose
Type: state transition
Pathway Components: UDPG - GalE -> UDP-galactose
Components:
Function Name Type
catalyzer GalE protein
product UDP-galactose simple_molecule
reactant UDPG simple_molecule
galETKM_mRNA GalT
Name: galETKM_mRNA -> GalT
Description: Translation of GalT
Type: translation
Pathway Components: galETKM_mRNA -> GalT
Components:
Function Name Type
product GalT protein
reactant galETKM_mRNA RNA
GalT galactose-1-P + UDPG D-glucose 1-phosphate + UDP-galactose
Name: galactose-1-P + UDPG -> D-glucose 1-phosphate + UDP-galactose
Description: Reaction transforming galactose-1-P, UDPG into D-glucose 1-phosphate, UDP-galactose
Type: state transition
Pathway Components: galactose-1-P + UDPG - GalT -> D-glucose 1-phosphate + UDP-galactose
Components:
Function Name Type
product D-glucose 1-phosphate simple_molecule
catalyzer GalT protein
product UDP-galactose simple_molecule
reactant UDPG simple_molecule
reactant galactose-1-P simple_molecule
galETKM_mRNA GalK
Name: galETKM_mRNA -> GalK
Description: Translation of GalK
Type: translation
Pathway Components: galETKM_mRNA -> GalK
Components:
Function Name Type
product GalK protein
reactant galETKM_mRNA RNA
GalK α-D-galactose galactose-1-P
Name: α-D-galactose -> galactose-1-P
Description: Reaction transforming α-D-galactose into galactose-1-P
Type: state transition
Pathway Components: α-D-galactose - GalK -> galactose-1-P
Components:
Function Name Type
reactant α-D-galactose simple_molecule
catalyzer GalK protein
product galactose-1-P simple_molecule
galETKM_mRNA GalM
Name: galETKM_mRNA -> GalM
Description: Translation of GalM
Type: translation
Pathway Components: galETKM_mRNA -> GalM
Components:
Function Name Type
product GalM protein
reactant galETKM_mRNA RNA
GalM beta-D-galactose α-D-galactose
Name: beta-D-galactose -> α-D-galactose
Description: Reaction transforming beta-D-galactose into α-D-galactose
Type: state transition
Pathway Components: beta-D-galactose - GalM -> α-D-galactose
Components:
Function Name Type
product α-D-galactose simple_molecule
catalyzer GalM protein
reactant beta-D-galactose simple_molecule
galET_mRNA GalE
Name: galET_mRNA -> GalE
Description: Translation of GalE
Type: translation
Pathway Components: galET_mRNA -> GalE
Components:
Function Name Type
product GalE protein
reactant galET_mRNA RNA
galET_mRNA GalT
Name: galET_mRNA -> GalT
Description: Translation of GalT
Type: translation
Pathway Components: galET_mRNA -> GalT
Components:
Function Name Type
product GalT protein
reactant galET_mRNA RNA
galETK_mRNA GalE
Name: galETK_mRNA -> GalE
Description: Translation of GalE
Type: translation
Pathway Components: galETK_mRNA -> GalE
Components:
Function Name Type
product GalE protein
reactant galETK_mRNA RNA
galETK_mRNA GalT
Name: galETK_mRNA -> GalT
Description: Translation of GalT
Type: translation
Pathway Components: galETK_mRNA -> GalT
Components:
Function Name Type
product GalT protein
reactant galETK_mRNA RNA
galETK_mRNA GalK
Name: galETK_mRNA -> GalK
Description: Translation of GalK
Type: translation
Pathway Components: galETK_mRNA -> GalK
Components:
Function Name Type
product GalK protein
reactant galETK_mRNA RNA
galE_mRNA GalE
Name: galE_mRNA -> GalE
Description: Translation of GalE
Type: translation
Pathway Components: galE_mRNA -> GalE
Components:
Function Name Type
product GalE protein
reactant galE_mRNA RNA
galP_mRNA GalP
Name: galP_mRNA -> GalP
Description: Translation of GalP
Type: translation
Pathway Components: galP_mRNA -> GalP
Components:
Function Name Type
product GalP protein
reactant galP_mRNA RNA
GalP glucopyranose_Ext glucopyranose
Name: glucopyranose_Ext -> glucopyranose
Description: Transport of glucopyranose_Ext through a bacterial membrane, leading to the presence of glucopyranose inside the cell.
Type: transport
Pathway Components: glucopyranose_Ext - GalP -> glucopyranose
Components:
Function Name Type
catalyzer GalP protein
product glucopyranose simple_molecule
reactant glucopyranose_Ext simple_molecule
R1 R2 R3 R4 R5 R6 R7 R8 R9 R10 R11 R12 R13 R14 R15 R16 R17 R18 R19 R20 R21 R22 R23 R24 R25 R26 R27 R28 R29 R30 R31 R32 R33



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