RegulonDB RegulonDB

GalS Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
galactopyranose MglB b-methyl-D-galactoside_Ext galET_mRNA glucopyranose GalM GalE galETKM_mRNA galS_mRNA galS galactopyranose_Ext GalS MglC MglC galR_mRNA MglB galET mglBAC_mRNA beta-D-galactose b-methyl-D-galactoside UDP-galactose galETK galE_mRNA galETKM galP GalP galactose-1-P beta-D-galactose galP_mRNA GalT D-glucose 1-phosphate GalR galR MglA MglA alpha-D-galactose galETK_mRNA mglBAC glucopyranose_Ext GalK UDPG GalS galE


Gensor Unit       
Name: GalS
Description: Molecular biology level
Detailed: In the absence or presence of beta-D-galactose, GalS dually regulates the expression of genes required for galactose degradation to UDP-galactose. Under different conditions of galactose availability, GalS remains unmodified or is modified to GalS-beta-D-galactose, binds to its target sites enabling or preventing the expression of its regulated genes.
Less detailed: In the absence or presence of beta-D-galactose, GalS dually regulates the expression of genes needed for galactose degradation to UDP-galactose to respond to different conditions of galactose availability.

Physiology level
Detailed: The presence of beta-D-galactose represses the expression of GalR and genes involved with Galactose uptake. Under this condition, the genes necessary for D-Galactose transport are not expressed. The presence of beta-D-galactose dually regulates the expression of genes required to UDP-D-galactose biosynthesis. Under this condition, the genes necessary for D-galactose conversion to UDP-D-galactose are expressed and not expressed. The absence of D-galactose repress its own expression and the expression of genes necessary for D-galactose and methyl-D-galactoside uptake. Under this condition, the genes necessary for D-galactose and D-methylgalactoside transport are not expressed.
Less detailed: The presence of beta-D-galactose represses the expression of genes needful for D-galactose transport and dually regulates the expression of genes related with D-galactose conversion to UDP-D-galactose. Read more >
Classification:
Groups: Transcription
Carbohydrate transport and metabolism
Cell wall/membrane/envelope biogenesis
Gene Ontology Terms (GO): biological_process GO:0005975 - carbohydrate metabolic process
GO:0046835 - carbohydrate phosphorylation
GO:0034219 - carbohydrate transmembrane transport
GO:0008643 - carbohydrate transport
GO:0006974 - cellular response to DNA damage stimulus
GO:0006935 - chemotaxis
Read more >
cellular_component GO:0043190 - ATP-binding cassette (ABC) transporter complex
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0016021 - integral component of membrane
GO:0005887 - integral component of plasma membrane
GO:0016020 - membrane
GO:0030288 - outer membrane-bounded periplasmic space
Read more >
molecular_function GO:0005524 - ATP binding
GO:0016887 - ATPase activity
GO:0043211 - ATPase-coupled carbohydrate transmembrane transporter activity
GO:0015407 - ATPase-coupled monosaccharide transmembrane transporter activity
GO:0003677 - DNA binding
GO:0003700 - DNA-binding transcription factor activity
GO:0070403 - NAD+ binding
Read more >
Components:
  Function Name Type
  simple_molecule α-D-galactose simple_molecule
  simple_molecule D-glucose 1-phosphate simple_molecule
  protein GalE protein
  protein GalK protein
  protein GalM protein
  protein GalP protein
  protein GalR protein
  protein GalS protein
  complex GalS-beta-D-galactose complex
  protein GalT protein
  protein MglA protein
  complex MglA-MglC-MglB complex
  protein MglB protein
  protein MglC protein
  simple_molecule UDP-galactose simple_molecule
  simple_molecule UDPG simple_molecule
  simple_molecule b-methyl-D-galactoside simple_molecule
  simple_molecule b-methyl-D-galactoside_Ext simple_molecule
  simple_molecule beta-D-galactose simple_molecule
  gene galE gene
  gene galET gene
  gene galETK gene
  gene galETKM gene
  RNA galETKM_mRNA RNA
  RNA galETK_mRNA RNA
  RNA galET_mRNA RNA
  RNA galE_mRNA RNA
  gene galP gene
  RNA galP_mRNA RNA
  gene galR gene
  RNA galR_mRNA RNA
  gene galS gene
  RNA galS_mRNA RNA
  simple_molecule galactopyranose simple_molecule
  simple_molecule galactopyranose_Ext simple_molecule
  simple_molecule galactose-1-P simple_molecule
  simple_molecule glucopyranose simple_molecule
  simple_molecule glucopyranose_Ext simple_molecule
  gene mglBAC gene
  RNA mglBAC_mRNA RNA


Reactions       
Showing 33 reactions
GalS GalS GalS-beta-D-galactose GalS-beta-D-galactose galE galE_mRNA
Name: galE -> galE_mRNA
Description: Transcription of transcription unit galE. Reaction activation by GalS, and GalS-beta-D-galactose. Reaction inhibition by GalS, and GalS-beta-D-galactose.
Type: transcription
Pathway Components: galE - GalS - GalS-beta-D-galactose - GalS - GalS-beta-D-galactose -> galE_mRNA
Components:
Function Name Type
activator GalS protein
inhibitor GalS protein
activator GalS-beta-D-galactose complex
inhibitor GalS-beta-D-galactose complex
reactant galE gene
product galE_mRNA RNA
GalS GalS GalS-beta-D-galactose GalS-beta-D-galactose galET galET_mRNA
Name: galET -> galET_mRNA
Description: Transcription of transcription unit galET. Reaction activation by GalS, and GalS-beta-D-galactose. Reaction inhibition by GalS, and GalS-beta-D-galactose.
Type: transcription
Pathway Components: galET - GalS - GalS-beta-D-galactose - GalS - GalS-beta-D-galactose -> galET_mRNA
Components:
Function Name Type
activator GalS protein
inhibitor GalS protein
activator GalS-beta-D-galactose complex
inhibitor GalS-beta-D-galactose complex
reactant galET gene
product galET_mRNA RNA
GalS GalS GalS-beta-D-galactose GalS-beta-D-galactose galETK galETK_mRNA
Name: galETK -> galETK_mRNA
Description: Transcription of transcription unit galETK. Reaction activation by GalS, and GalS-beta-D-galactose. Reaction inhibition by GalS, and GalS-beta-D-galactose.
Type: transcription
Pathway Components: galETK - GalS - GalS-beta-D-galactose - GalS - GalS-beta-D-galactose -> galETK_mRNA
Components:
Function Name Type
activator GalS protein
inhibitor GalS protein
activator GalS-beta-D-galactose complex
inhibitor GalS-beta-D-galactose complex
reactant galETK gene
product galETK_mRNA RNA
GalS GalS GalS-beta-D-galactose GalS-beta-D-galactose galETKM galETKM_mRNA
Name: galETKM -> galETKM_mRNA
Description: Transcription of transcription unit galETKM. Reaction activation by GalS, and GalS-beta-D-galactose. Reaction inhibition by GalS, and GalS-beta-D-galactose.
Type: transcription
Pathway Components: galETKM - GalS - GalS-beta-D-galactose - GalS - GalS-beta-D-galactose -> galETKM_mRNA
Components:
Function Name Type
activator GalS protein
inhibitor GalS protein
activator GalS-beta-D-galactose complex
inhibitor GalS-beta-D-galactose complex
reactant galETKM gene
product galETKM_mRNA RNA
GalS GalS-beta-D-galactose galP galP_mRNA
Name: galP -> galP_mRNA
Description: Transcription of transcription unit galP. Reaction inhibition by GalS, and GalS-beta-D-galactose.
Type: transcription
Pathway Components: galP - GalS - GalS-beta-D-galactose -> galP_mRNA
Components:
Function Name Type
inhibitor GalS protein
inhibitor GalS-beta-D-galactose complex
reactant galP gene
product galP_mRNA RNA
GalS galS galS_mRNA
Name: galS -> galS_mRNA
Description: Transcription of transcription unit galS. Reaction inhibition by GalS.
Type: transcription
Pathway Components: galS - GalS -> galS_mRNA
Components:
Function Name Type
inhibitor GalS protein
reactant galS gene
product galS_mRNA RNA
GalS mglBAC mglBAC_mRNA
Name: mglBAC -> mglBAC_mRNA
Description: Transcription of transcription unit mglBAC. Reaction inhibition by GalS.
Type: transcription
Pathway Components: mglBAC - GalS -> mglBAC_mRNA
Components:
Function Name Type
inhibitor GalS protein
reactant mglBAC gene
product mglBAC_mRNA RNA
beta-D-galactose + GalS GalS-beta-D-galactose
Name: beta-D-galactose + GalS -> GalS-beta-D-galactose
Description: Reaction transforming beta-D-galactose, GalS into GalS-beta-D-galactose
Type: state transition
Pathway Components: beta-D-galactose + GalS -> GalS-beta-D-galactose
Components:
Function Name Type
reactant GalS protein
product GalS-beta-D-galactose complex
reactant beta-D-galactose simple_molecule
GalS-beta-D-galactose galR galR_mRNA
Name: galR -> galR_mRNA
Description: Transcription of transcription unit galR. Reaction inhibition by GalS-beta-D-galactose.
Type: transcription
Pathway Components: galR - GalS-beta-D-galactose -> galR_mRNA
Components:
Function Name Type
inhibitor GalS-beta-D-galactose complex
reactant galR gene
product galR_mRNA RNA
mglBAC_mRNA MglB
Name: mglBAC_mRNA -> MglB
Description: Translation of MglB
Type: translation
Pathway Components: mglBAC_mRNA -> MglB
Components:
Function Name Type
product MglB protein
reactant mglBAC_mRNA RNA
MglB + MglA + MglC MglA-MglC-MglB
Name: MglB + MglA + MglC -> MglA-MglC-MglB
Description: Reaction transforming MglB, MglA, MglC into MglA-MglC-MglB
Type: state transition
Pathway Components: MglB + MglA + MglC -> MglA-MglC-MglB
Components:
Function Name Type
reactant MglA protein
product MglA-MglC-MglB complex
reactant MglB protein
reactant MglC protein
GalP MglA-MglC-MglB galactopyranose_Ext galactopyranose
Name: galactopyranose_Ext -> galactopyranose
Description: Transport of galactopyranose_Ext through a bacterial membrane, leading to the presence of galactopyranose inside the cell.
Type: transport
Pathway Components: galactopyranose_Ext - GalP - MglA-MglC-MglB -> galactopyranose
Components:
Function Name Type
catalyzer GalP protein
catalyzer MglA-MglC-MglB complex
product galactopyranose simple_molecule
reactant galactopyranose_Ext simple_molecule
MglA-MglC-MglB b-methyl-D-galactoside_Ext b-methyl-D-galactoside
Name: b-methyl-D-galactoside_Ext -> b-methyl-D-galactoside
Description: Transport of b-methyl-D-galactoside_Ext through a bacterial membrane, leading to the presence of b-methyl-D-galactoside inside the cell.
Type: transport
Pathway Components: b-methyl-D-galactoside_Ext - MglA-MglC-MglB -> b-methyl-D-galactoside
Components:
Function Name Type
catalyzer MglA-MglC-MglB complex
product b-methyl-D-galactoside simple_molecule
reactant b-methyl-D-galactoside_Ext simple_molecule
mglBAC_mRNA MglA
Name: mglBAC_mRNA -> MglA
Description: Translation of MglA
Type: translation
Pathway Components: mglBAC_mRNA -> MglA
Components:
Function Name Type
product MglA protein
reactant mglBAC_mRNA RNA
mglBAC_mRNA MglC
Name: mglBAC_mRNA -> MglC
Description: Translation of MglC
Type: translation
Pathway Components: mglBAC_mRNA -> MglC
Components:
Function Name Type
product MglC protein
reactant mglBAC_mRNA RNA
galS_mRNA GalS
Name: galS_mRNA -> GalS
Description: Translation of GalS
Type: translation
Pathway Components: galS_mRNA -> GalS
Components:
Function Name Type
product GalS protein
reactant galS_mRNA RNA
galR_mRNA GalR
Name: galR_mRNA -> GalR
Description: Translation of GalR
Type: translation
Pathway Components: galR_mRNA -> GalR
Components:
Function Name Type
product GalR protein
reactant galR_mRNA RNA
galETKM_mRNA GalE
Name: galETKM_mRNA -> GalE
Description: Translation of GalE
Type: translation
Pathway Components: galETKM_mRNA -> GalE
Components:
Function Name Type
product GalE protein
reactant galETKM_mRNA RNA
GalE UDPG UDP-galactose
Name: UDPG -> UDP-galactose
Description: Reaction transforming UDPG into UDP-galactose
Type: state transition
Pathway Components: UDPG - GalE -> UDP-galactose
Components:
Function Name Type
catalyzer GalE protein
product UDP-galactose simple_molecule
reactant UDPG simple_molecule
galETKM_mRNA GalT
Name: galETKM_mRNA -> GalT
Description: Translation of GalT
Type: translation
Pathway Components: galETKM_mRNA -> GalT
Components:
Function Name Type
product GalT protein
reactant galETKM_mRNA RNA
GalT galactose-1-P + UDPG D-glucose 1-phosphate + UDP-galactose
Name: galactose-1-P + UDPG -> D-glucose 1-phosphate + UDP-galactose
Description: Reaction transforming galactose-1-P, UDPG into D-glucose 1-phosphate, UDP-galactose
Type: state transition
Pathway Components: galactose-1-P + UDPG - GalT -> D-glucose 1-phosphate + UDP-galactose
Components:
Function Name Type
product D-glucose 1-phosphate simple_molecule
catalyzer GalT protein
product UDP-galactose simple_molecule
reactant UDPG simple_molecule
reactant galactose-1-P simple_molecule
galETKM_mRNA GalK
Name: galETKM_mRNA -> GalK
Description: Translation of GalK
Type: translation
Pathway Components: galETKM_mRNA -> GalK
Components:
Function Name Type
product GalK protein
reactant galETKM_mRNA RNA
GalK α-D-galactose galactose-1-P
Name: α-D-galactose -> galactose-1-P
Description: Reaction transforming α-D-galactose into galactose-1-P
Type: state transition
Pathway Components: α-D-galactose - GalK -> galactose-1-P
Components:
Function Name Type
reactant α-D-galactose simple_molecule
catalyzer GalK protein
product galactose-1-P simple_molecule
galETKM_mRNA GalM
Name: galETKM_mRNA -> GalM
Description: Translation of GalM
Type: translation
Pathway Components: galETKM_mRNA -> GalM
Components:
Function Name Type
product GalM protein
reactant galETKM_mRNA RNA
GalM beta-D-galactose α-D-galactose
Name: beta-D-galactose -> α-D-galactose
Description: Reaction transforming beta-D-galactose into α-D-galactose
Type: state transition
Pathway Components: beta-D-galactose - GalM -> α-D-galactose
Components:
Function Name Type
product α-D-galactose simple_molecule
catalyzer GalM protein
reactant beta-D-galactose simple_molecule
galET_mRNA GalE
Name: galET_mRNA -> GalE
Description: Translation of GalE
Type: translation
Pathway Components: galET_mRNA -> GalE
Components:
Function Name Type
product GalE protein
reactant galET_mRNA RNA
galET_mRNA GalT
Name: galET_mRNA -> GalT
Description: Translation of GalT
Type: translation
Pathway Components: galET_mRNA -> GalT
Components:
Function Name Type
product GalT protein
reactant galET_mRNA RNA
galETK_mRNA GalE
Name: galETK_mRNA -> GalE
Description: Translation of GalE
Type: translation
Pathway Components: galETK_mRNA -> GalE
Components:
Function Name Type
product GalE protein
reactant galETK_mRNA RNA
galETK_mRNA GalT
Name: galETK_mRNA -> GalT
Description: Translation of GalT
Type: translation
Pathway Components: galETK_mRNA -> GalT
Components:
Function Name Type
product GalT protein
reactant galETK_mRNA RNA
galETK_mRNA GalK
Name: galETK_mRNA -> GalK
Description: Translation of GalK
Type: translation
Pathway Components: galETK_mRNA -> GalK
Components:
Function Name Type
product GalK protein
reactant galETK_mRNA RNA
galE_mRNA GalE
Name: galE_mRNA -> GalE
Description: Translation of GalE
Type: translation
Pathway Components: galE_mRNA -> GalE
Components:
Function Name Type
product GalE protein
reactant galE_mRNA RNA
galP_mRNA GalP
Name: galP_mRNA -> GalP
Description: Translation of GalP
Type: translation
Pathway Components: galP_mRNA -> GalP
Components:
Function Name Type
product GalP protein
reactant galP_mRNA RNA
GalP glucopyranose_Ext glucopyranose
Name: glucopyranose_Ext -> glucopyranose
Description: Transport of glucopyranose_Ext through a bacterial membrane, leading to the presence of glucopyranose inside the cell.
Type: transport
Pathway Components: glucopyranose_Ext - GalP -> glucopyranose
Components:
Function Name Type
catalyzer GalP protein
product glucopyranose simple_molecule
reactant glucopyranose_Ext simple_molecule



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