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ExuR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
uxaB_mRNA uxaCA_mRNA 2-keto-3-deoxygluconate fructuronate LgoR lgoR ExuR UxaA uxuAB uxaB exuR_mRNA aldehydo-D-galacturonate GlcA_Ext aldehydo-D-glucuronate uxuR_mRNA galaturonate_Ext GlcA uxuR galaturonate ExuT alpha-D-galacturonate exuR UxuR mannonate tagaturonate lgoR_mRNA UxaB UxuA alpha-D-glucuronate ExuR exuT ExuR UxaC alpha-D-galacturonate UxuB uxuAB_mRNA altronate alpha-D-glucuronate uxaCA exuT_mRNA mannonate


Gensor Unit       
Name: ExuR
Classification:
Groups: Transcription
Carbohydrate transport and metabolism
Gene Ontology Terms (GO): biological_process GO:0019698 - D-galacturonate catabolic process
GO:0042840 - D-glucuronate catabolic process
GO:0006974 - cellular response to DNA damage stimulus
GO:0019584 - galactonate catabolic process
GO:0006064 - glucuronate catabolic process
GO:0015736 - hexuronate transmembrane transport
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cellular_component GO:0005829 - cytosol
GO:0016021 - integral component of membrane
GO:0005887 - integral component of plasma membrane
GO:0016020 - membrane
GO:0005886 - plasma membrane
molecular_function GO:0003677 - DNA binding
GO:0003700 - DNA-binding transcription factor activity
GO:0008789 - altronate dehydratase activity
GO:0003824 - catalytic activity
GO:0008198 - ferrous iron binding
GO:0008866 - fructuronate reductase activity
GO:0008880 - glucuronate isomerase activity
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Components:
  Function Name Type
  simple_molecule α-D-galacturonate simple_molecule
  simple_molecule α-D-glucuronate simple_molecule
  simple_molecule 2-keto-3-deoxygluconate simple_molecule
  protein ExuR protein
  complex ExuR-α-D-galacturonate complex
  complex ExuR-α-D-glucuronate complex
  protein ExuT protein
  simple_molecule GlcA simple_molecule
  simple_molecule GlcA_Ext simple_molecule
  protein LgoR protein
  protein UxaA protein
  protein UxaB protein
  protein UxaC protein
  protein UxuA protein
  protein UxuB protein
  protein UxuR protein
  simple_molecule aldehydo-D-galacturonate simple_molecule
  simple_molecule aldehydo-D-glucuronate simple_molecule
  simple_molecule altronate simple_molecule
  gene exuR gene
  RNA exuR_mRNA RNA
  gene exuT gene
  RNA exuT_mRNA RNA
  simple_molecule fructuronate simple_molecule
  simple_molecule galaturonate simple_molecule
  simple_molecule galaturonate_Ext simple_molecule
  gene lgoR gene
  RNA lgoR_mRNA RNA
  simple_molecule mannonate simple_molecule
  simple_molecule tagaturonate simple_molecule
  gene uxaB gene
  RNA uxaB_mRNA RNA
  gene uxaCA gene
  RNA uxaCA_mRNA RNA
  gene uxuAB gene
  RNA uxuAB_mRNA RNA
  gene uxuR gene
  RNA uxuR_mRNA RNA


Reactions       
Showing 26 reactions
ExuR exuR exuR_mRNA
Name: exuR -> exuR_mRNA
Description: Transcription of transcription unit exuR. Reaction inhibition by ExuR.
Type: transcription
Pathway Components: exuR - ExuR -> exuR_mRNA
Components:
Function Name Type
inhibitor ExuR protein
reactant exuR gene
product exuR_mRNA RNA
ExuR exuT exuT_mRNA
Name: exuT -> exuT_mRNA
Description: Transcription of transcription unit exuT. Reaction inhibition by ExuR.
Type: transcription
Pathway Components: exuT - ExuR -> exuT_mRNA
Components:
Function Name Type
inhibitor ExuR protein
reactant exuT gene
product exuT_mRNA RNA
ExuR uxaB uxaB_mRNA
Name: uxaB -> uxaB_mRNA
Description: Transcription of transcription unit uxaB. Reaction inhibition by ExuR.
Type: transcription
Pathway Components: uxaB - ExuR -> uxaB_mRNA
Components:
Function Name Type
inhibitor ExuR protein
reactant uxaB gene
product uxaB_mRNA RNA
ExuR uxaCA uxaCA_mRNA
Name: uxaCA -> uxaCA_mRNA
Description: Transcription of transcription unit uxaCA. Reaction inhibition by ExuR.
Type: transcription
Pathway Components: uxaCA - ExuR -> uxaCA_mRNA
Components:
Function Name Type
inhibitor ExuR protein
reactant uxaCA gene
product uxaCA_mRNA RNA
ExuR uxuAB uxuAB_mRNA
Name: uxuAB -> uxuAB_mRNA
Description: Transcription of transcription unit uxuAB. Reaction inhibition by ExuR.
Type: transcription
Pathway Components: uxuAB - ExuR -> uxuAB_mRNA
Components:
Function Name Type
inhibitor ExuR protein
reactant uxuAB gene
product uxuAB_mRNA RNA
ExuR uxuR uxuR_mRNA
Name: uxuR -> uxuR_mRNA
Description: Transcription of transcription unit uxuR. Reaction inhibition by ExuR.
Type: transcription
Pathway Components: uxuR - ExuR -> uxuR_mRNA
Components:
Function Name Type
inhibitor ExuR protein
reactant uxuR gene
product uxuR_mRNA RNA
α-D-galacturonate + ExuR ExuR-α-D-galacturonate
Name: α-D-galacturonate + ExuR -> ExuR-α-D-galacturonate
Description: Reaction transforming α-D-galacturonate, ExuR into ExuR-α-D-galacturonate
Type: state transition
Pathway Components: α-D-galacturonate + ExuR -> ExuR-α-D-galacturonate
Components:
Function Name Type
reactant α-D-galacturonate simple_molecule
reactant ExuR protein
product ExuR-α-D-galacturonate complex
ExuR-α-D-galacturonate lgoR lgoR_mRNA
Name: lgoR -> lgoR_mRNA
Description: Transcription of transcription unit lgoR. Reaction inhibition by ExuR-α-D-galacturonate.
Type: transcription
Pathway Components: lgoR - ExuR-α-D-galacturonate -> lgoR_mRNA
Components:
Function Name Type
inhibitor ExuR-α-D-galacturonate complex
reactant lgoR gene
product lgoR_mRNA RNA
α-D-glucuronate + ExuR ExuR-α-D-glucuronate
Name: α-D-glucuronate + ExuR -> ExuR-α-D-glucuronate
Description: Reaction transforming α-D-glucuronate, ExuR into ExuR-α-D-glucuronate
Type: state transition
Pathway Components: α-D-glucuronate + ExuR -> ExuR-α-D-glucuronate
Components:
Function Name Type
reactant α-D-glucuronate simple_molecule
reactant ExuR protein
product ExuR-α-D-glucuronate complex
uxaCA_mRNA UxaC
Name: uxaCA_mRNA -> UxaC
Description: Translation of UxaC
Type: translation
Pathway Components: uxaCA_mRNA -> UxaC
Components:
Function Name Type
product UxaC protein
reactant uxaCA_mRNA RNA
UxaC aldehydo-D-glucuronate fructuronate
Name: aldehydo-D-glucuronate -> fructuronate
Description: Reaction transforming aldehydo-D-glucuronate into fructuronate
Type: state transition
Pathway Components: aldehydo-D-glucuronate - UxaC -> fructuronate
Components:
Function Name Type
catalyzer UxaC protein
reactant aldehydo-D-glucuronate simple_molecule
product fructuronate simple_molecule
UxaC aldehydo-D-galacturonate tagaturonate
Name: aldehydo-D-galacturonate -> tagaturonate
Description: Reaction transforming aldehydo-D-galacturonate into tagaturonate
Type: state transition
Pathway Components: aldehydo-D-galacturonate - UxaC -> tagaturonate
Components:
Function Name Type
catalyzer UxaC protein
reactant aldehydo-D-galacturonate simple_molecule
product tagaturonate simple_molecule
uxaCA_mRNA UxaA
Name: uxaCA_mRNA -> UxaA
Description: Translation of UxaA
Type: translation
Pathway Components: uxaCA_mRNA -> UxaA
Components:
Function Name Type
product UxaA protein
reactant uxaCA_mRNA RNA
UxaA altronate 2-keto-3-deoxygluconate
Name: altronate -> 2-keto-3-deoxygluconate
Description: Reaction transforming altronate into 2-keto-3-deoxygluconate
Type: state transition
Pathway Components: altronate - UxaA -> 2-keto-3-deoxygluconate
Components:
Function Name Type
product 2-keto-3-deoxygluconate simple_molecule
catalyzer UxaA protein
reactant altronate simple_molecule
lgoR_mRNA LgoR
Name: lgoR_mRNA -> LgoR
Description: Translation of LgoR
Type: translation
Pathway Components: lgoR_mRNA -> LgoR
Components:
Function Name Type
product LgoR protein
reactant lgoR_mRNA RNA
uxaB_mRNA UxaB
Name: uxaB_mRNA -> UxaB
Description: Translation of UxaB
Type: translation
Pathway Components: uxaB_mRNA -> UxaB
Components:
Function Name Type
product UxaB protein
reactant uxaB_mRNA RNA
UxaB fructuronate mannonate altronate tagaturonate
Name: altronate -> tagaturonate
Description: Reaction transforming altronate into tagaturonate
Type: state transition
Pathway Components: altronate - UxaB - fructuronate - mannonate -> tagaturonate
Components:
Function Name Type
catalyzer UxaB protein
reactant altronate simple_molecule
inhibitor fructuronate simple_molecule
inhibitor mannonate simple_molecule
product tagaturonate simple_molecule
exuR_mRNA ExuR
Name: exuR_mRNA -> ExuR
Description: Translation of ExuR
Type: translation
Pathway Components: exuR_mRNA -> ExuR
Components:
Function Name Type
product ExuR protein
reactant exuR_mRNA RNA
uxuR_mRNA UxuR
Name: uxuR_mRNA -> UxuR
Description: Translation of UxuR
Type: translation
Pathway Components: uxuR_mRNA -> UxuR
Components:
Function Name Type
product UxuR protein
reactant uxuR_mRNA RNA
uxuAB_mRNA UxuA
Name: uxuAB_mRNA -> UxuA
Description: Translation of UxuA
Type: translation
Pathway Components: uxuAB_mRNA -> UxuA
Components:
Function Name Type
product UxuA protein
reactant uxuAB_mRNA RNA
GlcA UxuA altronate galaturonate tagaturonate mannonate 2-keto-3-deoxygluconate
Name: mannonate -> 2-keto-3-deoxygluconate
Description: Reaction transforming mannonate into 2-keto-3-deoxygluconate
Type: state transition
Pathway Components: mannonate - UxuA - GlcA - altronate - galaturonate - tagaturonate -> 2-keto-3-deoxygluconate
Components:
Function Name Type
product 2-keto-3-deoxygluconate simple_molecule
inhibitor GlcA simple_molecule
catalyzer UxuA protein
inhibitor altronate simple_molecule
inhibitor galaturonate simple_molecule
reactant mannonate simple_molecule
inhibitor tagaturonate simple_molecule
uxuAB_mRNA UxuB
Name: uxuAB_mRNA -> UxuB
Description: Translation of UxuB
Type: translation
Pathway Components: uxuAB_mRNA -> UxuB
Components:
Function Name Type
product UxuB protein
reactant uxuAB_mRNA RNA
UxuB mannonate fructuronate
Name: mannonate -> fructuronate
Description: Reaction transforming mannonate into fructuronate
Type: state transition
Pathway Components: mannonate - UxuB -> fructuronate
Components:
Function Name Type
catalyzer UxuB protein
product fructuronate simple_molecule
reactant mannonate simple_molecule
exuT_mRNA ExuT
Name: exuT_mRNA -> ExuT
Description: Translation of ExuT
Type: translation
Pathway Components: exuT_mRNA -> ExuT
Components:
Function Name Type
product ExuT protein
reactant exuT_mRNA RNA
ExuT galaturonate_Ext galaturonate
Name: galaturonate_Ext -> galaturonate
Description: Transport of galaturonate_Ext through a bacterial membrane, leading to the presence of galaturonate inside the cell.
Type: transport
Pathway Components: galaturonate_Ext - ExuT -> galaturonate
Components:
Function Name Type
catalyzer ExuT protein
product galaturonate simple_molecule
reactant galaturonate_Ext simple_molecule
ExuT GlcA_Ext GlcA
Name: GlcA_Ext -> GlcA
Description: Transport of GlcA_Ext through a bacterial membrane, leading to the presence of GlcA inside the cell.
Type: transport
Pathway Components: GlcA_Ext - ExuT -> GlcA
Components:
Function Name Type
catalyzer ExuT protein
product GlcA simple_molecule
reactant GlcA_Ext simple_molecule



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