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EnvR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
hexane_Ext enterobactin_Ext hexane AcrD acrAB AcrA TolC caprate AcrB acrAB_mRNA chenodiol_Ext chenodiol drug_Ext TolC drug enterobactin EnvR AcrA AcrB TolC AcrA acriflavine_Ext AcrD caprate_Ext acriflavine


Gensor Unit       
Name: EnvR
Classification:
Groups: Defense mechanisms
Cell wall/membrane/envelope biogenesis
Gene Ontology Terms (GO): biological_process GO:0015895 - alkane transport
GO:0015721 - bile acid and bile salt transport
GO:0046618 - drug export
GO:0006855 - drug transmembrane transport
GO:0042930 - enterobactin transport
GO:0015908 - fatty acid transport
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cellular_component GO:1990281 - efflux pump complex
GO:0016021 - integral component of membrane
GO:0005887 - integral component of plasma membrane
GO:0031237 - intrinsic component of periplasmic side of plasma membrane
GO:0031226 - intrinsic component of plasma membrane
GO:0016020 - membrane
GO:0030288 - outer membrane-bounded periplasmic space
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molecular_function GO:0015567 - alkane transmembrane transporter activity
GO:0015125 - bile acid transmembrane transporter activity
GO:0015562 - efflux transmembrane transporter activity
GO:0042931 - enterobactin transmembrane transporter activity
GO:0042802 - identical protein binding
GO:0005515 - protein binding
GO:0022857 - transmembrane transporter activity
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Components:
  Function Name Type
  protein AcrA protein
  complex AcrA-TolC-AcrB complex
  protein AcrB protein
  protein AcrD protein
  complex AcrD-AcrA-TolC complex
  protein EnvR protein
  protein TolC protein
  gene acrAB gene
  RNA acrAB_mRNA RNA
  simple_molecule acriflavine simple_molecule
  simple_molecule acriflavine_Ext simple_molecule
  simple_molecule caprate simple_molecule
  simple_molecule caprate_Ext simple_molecule
  simple_molecule chenodiol simple_molecule
  simple_molecule chenodiol_Ext simple_molecule
  simple_molecule drug simple_molecule
  simple_molecule drug_Ext simple_molecule
  simple_molecule enterobactin simple_molecule
  simple_molecule enterobactin_Ext simple_molecule
  simple_molecule hexane simple_molecule
  simple_molecule hexane_Ext simple_molecule


Reactions       
Showing 11 reactions
EnvR acrAB acrAB_mRNA
Name: acrAB -> acrAB_mRNA
Description: Transcription of transcription unit acrAB. Reaction inhibition by EnvR.
Type: transcription
Pathway Components: acrAB - EnvR -> acrAB_mRNA
Components:
Function Name Type
inhibitor EnvR protein
reactant acrAB gene
product acrAB_mRNA RNA
acrAB_mRNA AcrA
Name: acrAB_mRNA -> AcrA
Description: Translation of AcrA
Type: translation
Pathway Components: acrAB_mRNA -> AcrA
Components:
Function Name Type
product AcrA protein
reactant acrAB_mRNA RNA
AcrA + TolC + AcrD AcrD-AcrA-TolC
Name: AcrA + TolC + AcrD -> AcrD-AcrA-TolC
Description: Reaction transforming AcrA, TolC, AcrD into AcrD-AcrA-TolC
Type: state transition
Pathway Components: AcrA + TolC + AcrD -> AcrD-AcrA-TolC
Components:
Function Name Type
reactant AcrA protein
reactant AcrD protein
product AcrD-AcrA-TolC complex
reactant TolC protein
AcrA-TolC-AcrB AcrD-AcrA-TolC drug_Ext drug
Name: drug_Ext -> drug
Description: Transport of drug_Ext through a bacterial membrane, leading to the presence of drug inside the cell.
Type: transport
Pathway Components: drug_Ext - AcrA-TolC-AcrB - AcrD-AcrA-TolC -> drug
Components:
Function Name Type
catalyzer AcrA-TolC-AcrB complex
catalyzer AcrD-AcrA-TolC complex
product drug simple_molecule
reactant drug_Ext simple_molecule
AcrB + AcrA + TolC AcrA-TolC-AcrB
Name: AcrB + AcrA + TolC -> AcrA-TolC-AcrB
Description: Reaction transforming AcrB, AcrA, TolC into AcrA-TolC-AcrB
Type: state transition
Pathway Components: AcrB + AcrA + TolC -> AcrA-TolC-AcrB
Components:
Function Name Type
reactant AcrA protein
product AcrA-TolC-AcrB complex
reactant AcrB protein
reactant TolC protein
AcrA-TolC-AcrB acriflavine_Ext acriflavine
Name: acriflavine_Ext -> acriflavine
Description: Transport of acriflavine_Ext through a bacterial membrane, leading to the presence of acriflavine inside the cell.
Type: transport
Pathway Components: acriflavine_Ext - AcrA-TolC-AcrB -> acriflavine
Components:
Function Name Type
catalyzer AcrA-TolC-AcrB complex
product acriflavine simple_molecule
reactant acriflavine_Ext simple_molecule
AcrA-TolC-AcrB chenodiol_Ext chenodiol
Name: chenodiol_Ext -> chenodiol
Description: Transport of chenodiol_Ext through a bacterial membrane, leading to the presence of chenodiol inside the cell.
Type: transport
Pathway Components: chenodiol_Ext - AcrA-TolC-AcrB -> chenodiol
Components:
Function Name Type
catalyzer AcrA-TolC-AcrB complex
product chenodiol simple_molecule
reactant chenodiol_Ext simple_molecule
AcrA-TolC-AcrB caprate_Ext caprate
Name: caprate_Ext -> caprate
Description: Transport of caprate_Ext through a bacterial membrane, leading to the presence of caprate inside the cell.
Type: transport
Pathway Components: caprate_Ext - AcrA-TolC-AcrB -> caprate
Components:
Function Name Type
catalyzer AcrA-TolC-AcrB complex
product caprate simple_molecule
reactant caprate_Ext simple_molecule
AcrA-TolC-AcrB hexane_Ext hexane
Name: hexane_Ext -> hexane
Description: Transport of hexane_Ext through a bacterial membrane, leading to the presence of hexane inside the cell.
Type: transport
Pathway Components: hexane_Ext - AcrA-TolC-AcrB -> hexane
Components:
Function Name Type
catalyzer AcrA-TolC-AcrB complex
product hexane simple_molecule
reactant hexane_Ext simple_molecule
AcrA-TolC-AcrB enterobactin_Ext enterobactin
Name: enterobactin_Ext -> enterobactin
Description: Transport of enterobactin_Ext through a bacterial membrane, leading to the presence of enterobactin inside the cell.
Type: transport
Pathway Components: enterobactin_Ext - AcrA-TolC-AcrB -> enterobactin
Components:
Function Name Type
catalyzer AcrA-TolC-AcrB complex
product enterobactin simple_molecule
reactant enterobactin_Ext simple_molecule
acrAB_mRNA AcrB
Name: acrAB_mRNA -> AcrB
Description: Translation of AcrB
Type: translation
Pathway Components: acrAB_mRNA -> AcrB
Components:
Function Name Type
product AcrB protein
reactant acrAB_mRNA RNA



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